{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T01:47:47Z","timestamp":1767145667752,"version":"build-2238731810"},"reference-count":10,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.clim.2013.08.004","type":"journal-article","created":{"date-parts":[[2013,8,15]],"date-time":"2013-08-15T10:01:54Z","timestamp":1376560914000},"page":"440-441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"PB","title":["Combination therapy with anti-CD6 and oral insulin immunization reverses recent onset diabetes in non obese diabetic mice but fails to induce lasting tolerance"],"prefix":"10.1016","volume":"149","author":[{"given":"Matthias G.","family":"von Herrath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2013.08.004_bb0005","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.4049\/jimmunol.158.6.2947","article-title":"CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice","volume":"158","author":"Chatenoud","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2013.08.004_bb0010","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1172\/JCI118919","article-title":"Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice","volume":"98","author":"von Herrath","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2013.08.004_bb0015","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.drudis.2006.08.007","article-title":"New therapeutics that treat rheumatoid arthritis by blocking T-cell activation","volume":"11","author":"MacKenzie","year":"2006","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.clim.2013.08.004_bb0020","doi-asserted-by":"crossref","first-page":"18187","DOI":"10.1074\/jbc.270.31.18187","article-title":"The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site","volume":"270","author":"Whitney","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2013.08.004_bb0025","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1182\/blood-2005-09-3881","article-title":"Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells","volume":"107","author":"Zimmerman","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.clim.2013.08.004_bb0030","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1365-2249.2010.04235.x","article-title":"CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction","volume":"162","author":"Nair","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2013.08.004_bb0035","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1212\/WNL.36.6.777","article-title":"Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12","volume":"36","author":"Hafler","year":"1986","journal-title":"Neurology"},{"key":"10.1016\/j.clim.2013.08.004_bb0040","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/08916939908995386","article-title":"CD6 molecule may be important in the pathological mechanisms of lymphocytes adhesion to human skin in psoriasis and ior t1 MAb a possible new approach to treat this disease","volume":"29","author":"Montero","year":"1999","journal-title":"Autoimmunity"},{"key":"10.1016\/j.clim.2013.08.004_bb0045","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.rinim.2012.11.001","article-title":"A clinical exploratory study with itolizumab, an anti-CD6 monoclonal antibody, in patients with rheumatoid arthritis","volume":"2","author":"Rodriguez","year":"2012","journal-title":"Res. Immunol."},{"key":"10.1016\/j.clim.2013.08.004_bb0050","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1172\/JCI27191","article-title":"Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs","volume":"116","author":"Bresson","year":"2006","journal-title":"J. Clin. Invest."}],"updated-by":[{"DOI":"10.1016\/j.clim.2014.01.008","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000}}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661613002179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661613002179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T17:37:50Z","timestamp":1688405870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661613002179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1521661613002179"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2013.08.004","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination therapy with anti-CD6 and oral insulin immunization reverses recent onset diabetes in non obese diabetic mice but fails to induce lasting tolerance","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2013.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Author. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}