{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:51:20Z","timestamp":1789717880928,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation Young Investigator Award","doi-asserted-by":"publisher","award":["2011045"],"award-info":[{"award-number":["2011045"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.clim.2014.04.006","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T17:16:08Z","timestamp":1398100568000},"page":"156-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Myeloid-derived suppressor cells are increased in frequency but not maximally suppressive in peripheral blood of Type 1 Diabetes Mellitus patients"],"prefix":"10.1016","volume":"153","author":[{"given":"Fatima","family":"Whitfield-Larry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Felton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Buse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-9982","authenticated-orcid":false,"given":"Maureen A.","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2014.04.006_bb0005","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/nature08933","article-title":"Genetics, pathogenesis and clinical interventions in type 1 diabetes","volume":"464","author":"Bluestone","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.clim.2014.04.006_bb0010","doi-asserted-by":"crossref","first-page":"8000","DOI":"10.1073\/pnas.86.20.8000","article-title":"Pancreatic islet-specific T-cell clones from nonobese diabetic mice","volume":"86","author":"Haskins","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2014.04.006_bb0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1084\/jem.183.1.67","article-title":"CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells","volume":"183","author":"Wong","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2014.04.006_bb0020","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2337\/diab.14.10.619","article-title":"Pathologic anatomy of the pancreas in juvenile diabetes mellitus","volume":"14","author":"Gepts","year":"1965","journal-title":"Diabetes"},{"key":"10.1016\/j.clim.2014.04.006_bb0025","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1158\/1078-0432.CCR-07-0182","article-title":"Pathways mediating the expansion and immunosuppressive activity of myeloid-derived suppressor cells and their relevance to cancer therapy","volume":"13","author":"Talmadge","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.clim.2014.04.006_bb0030","first-page":"162","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat. Publ. Group"},{"key":"10.1016\/j.clim.2014.04.006_bb0035","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-06-3037","article-title":"The terminology issue for myeloid-derived suppressor cells","volume":"67","author":"Gabrilovich","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.clim.2014.04.006_bb0040","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.4049\/jimmunol.179.8.5228","article-title":"CD11b+ Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis","volume":"179","author":"Zhu","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0045","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1750-3639.2011.00495.x","article-title":"Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis","volume":"21","author":"Molin\u00e9-Vel\u00e1zquez","year":"2011","journal-title":"Brain Pathol."},{"key":"10.1016\/j.clim.2014.04.006_bb0050","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2008.06.032","article-title":"Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway","volume":"135","author":"Haile","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clim.2014.04.006_bb0055","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.4049\/jimmunol.0903636","article-title":"Myeloid-derived suppressor cells prevent type 1 diabetes in murine models","volume":"185","author":"Yin","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0060","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4049\/jimmunol.1101590","article-title":"The role of Gr1+ cells after anti-CD20 treatment in type 1 diabetes in nonobese diabetic mice","volume":"188","author":"Hu","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0065","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.intimp.2011.01.026","article-title":"MDSC in autoimmunity","volume":"11","author":"Cripps","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.clim.2014.04.006_bb0070","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.intimp.2011.01.003","article-title":"Myeloid derived suppressor cells in human diseases","volume":"11","author":"Greten","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.clim.2014.04.006_bb0075","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.clim.2012.06.003","article-title":"On the armament and appearances of human myeloid-derived suppressor cells","volume":"144","author":"Poschke","year":"2012","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0080","doi-asserted-by":"crossref","first-page":"7585","DOI":"10.4049\/jimmunol.0901587","article-title":"Cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct","volume":"183","author":"Li","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0085","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.4049\/jimmunol.1000901","article-title":"Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells","volume":"185","author":"Lechner","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0090","doi-asserted-by":"crossref","first-page":"779","DOI":"10.4049\/jimmunol.165.2.779","article-title":"Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3\/CD28 costimulation","volume":"165","author":"Kusmartsev","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0095","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1182\/blood-2013-01-480129","article-title":"Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment","volume":"122","author":"Mussai","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.clim.2014.04.006_bb0100","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.4049\/jimmunol.151.5.2399","article-title":"Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family","volume":"151","author":"Fleming","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0105","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/ni.2233","article-title":"Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging","volume":"13","author":"Fu","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0110","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1600-065X.2008.00608.x","article-title":"Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives","volume":"222","author":"Rodr\u00edguez","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.clim.2014.04.006_bb0115","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.4049\/jimmunol.160.12.5729","article-title":"Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3\/STAT5 signaling pathway","volume":"160","author":"Bingisser","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0120","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4049\/jimmunol.172.2.989","article-title":"Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species","volume":"172","author":"Kusmartsev","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0125","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.4049\/jimmunol.0900092","article-title":"Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells","volume":"182","author":"Corzo","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0130","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1158\/0008-5472.CAN-05-1299","article-title":"Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host","volume":"66","author":"Huang","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.clim.2014.04.006_bb0135","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1182\/blood-2007-07-099226","article-title":"Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity","volume":"111","author":"Movahedi","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.clim.2014.04.006_bb0140","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.4049\/jimmunol.174.8.4880","article-title":"STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion","volume":"174","author":"Kusmartsev","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.04.006_bb0145","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1172\/JCI200215318","article-title":"Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets","volume":"110","author":"Maedler","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2014.04.006_bb0150","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1172\/JCI115055","article-title":"Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD\/Wehi mice","volume":"87","author":"Campbell","year":"1991","journal-title":"J. Clin. Invest."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661614001132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661614001132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T08:43:31Z","timestamp":1689151411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661614001132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1521661614001132"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2014.04.006","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myeloid-derived suppressor cells are increased in frequency but not maximally suppressive in peripheral blood of Type 1 Diabetes Mellitus patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2014.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}