{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:01:37Z","timestamp":1791144097732,"version":"4.1.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T00:00:00Z","timestamp":1410393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"National Cancer Institute, National Institutes of Health"},{"name":"NIH\/NIAID\/DAIDS","award":["HHSN272200800063C"],"award-info":[{"award-number":["HHSN272200800063C"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.clim.2014.09.005","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T07:56:37Z","timestamp":1410854197000},"page":"91-107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques"],"prefix":"10.1016","volume":"155","author":[{"given":"Antonio","family":"Valentin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"McKinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Rosati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viraj","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy R.","family":"Pilkington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenifer","family":"Bear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candido","family":"Alicea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego A.","family":"Vargas-Inchaustegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Jean Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Pegu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namal P.M.","family":"Liyanage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari N.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Vaccari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison E.","family":"Hogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan Y.","family":"Sardesai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay A.","family":"Berzofsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genoveffa","family":"Franchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Robert-Guroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara K.","family":"Felber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George N.","family":"Pavlakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 3","key":"10.1016\/j.clim.2014.09.005_bb0005","first-page":"S277","article-title":"Development of bivalent rgp120 vaccines to prevent HIV type 1 infection","volume":"14","author":"Berman","year":"1998","journal-title":"AIDS Res. Hum. Retroviruses"},{"issue":"Suppl. 3","key":"10.1016\/j.clim.2014.09.005_bb0010","first-page":"S325","article-title":"Advancing AIDSVAX to phase 3. Safety, immunogenicity, and plans for phase 3","volume":"14","author":"Francis","year":"1998","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.clim.2014.09.005_bb0015","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1086\/508748","article-title":"Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand","volume":"194","author":"Pitisuttithum","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.clim.2014.09.005_bb0020","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1086\/428404","article-title":"Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection","volume":"191","author":"Flynn","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.clim.2014.09.005_bb0025","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/S0140-6736(08)61592-5","article-title":"HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case\u2013cohort analysis","volume":"372","author":"McElrath","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2014.09.005_bb0030","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nm.2316","article-title":"Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial","volume":"17","author":"Rolland","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2014.09.005_bb0035","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0140-6736(08)61591-3","article-title":"Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial","volume":"372","author":"Buchbinder","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2014.09.005_bb0040","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1056\/NEJMoa1310566","article-title":"Efficacy trial of a DNA\/rAd5 HIV-1 preventive vaccine","volume":"369","author":"Hammer","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2014.09.005_bb0045","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa0908492","article-title":"Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand","volume":"361","author":"Rerks-Ngarm","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2014.09.005_bb0050","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature11519","article-title":"Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2","volume":"490","author":"Rolland","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.clim.2014.09.005_bb0055","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1056\/NEJMoa1113425","article-title":"Immune-correlates analysis of an HIV-1 vaccine efficacy trial","volume":"366","author":"Haynes","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2014.09.005_bb0060","doi-asserted-by":"crossref","first-page":"e75665","DOI":"10.1371\/journal.pone.0075665","article-title":"Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial","volume":"8","author":"Gottardo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2014.09.005_bb0065","doi-asserted-by":"crossref","first-page":"e53629","DOI":"10.1371\/journal.pone.0053629","article-title":"Analysis of V2 antibody responses induced in vaccinees in the ALVAC\/AIDSVAX HIV-1 vaccine efficacy trial","volume":"8","author":"Zolla-Pazner","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2014.09.005_bb0070","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1089\/aid.2012.0103","article-title":"The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120","volume":"28","author":"Karasavvas","year":"2012","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.clim.2014.09.005_bb0075","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1128\/JVI.76.1.292-302.2002","article-title":"ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency","volume":"76","author":"Pal","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0080","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1128\/JVI.80.8.3732-3742.2006","article-title":"Systemic immunization with an ALVAC-HIV-1\/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels","volume":"80","author":"Pal","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0085","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/viro.2002.1722","article-title":"Equivalent immunogenicity of the highly attenuated poxvirus-based ALVAC-SIV and NYVAC-SIV vaccine candidates in SIVmac251-infected macaques","volume":"304","author":"Hel","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.clim.2014.09.005_bb0090","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1128\/JVI.02544-12","article-title":"Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial","volume":"87","author":"Pegu","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0095","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1128\/JVI.02863-12","article-title":"Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure","volume":"87","author":"Vaccari","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0100","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1517\/14712598.8.9.1347","article-title":"Replicating adenovirus vector prime\/protein boost strategies for HIV vaccine development","volume":"8","author":"Patterson","year":"2008","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.clim.2014.09.005_bb0105","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nm0697-651","article-title":"Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization","volume":"3","author":"Lubeck","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2014.09.005_bb0110","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.virol.2006.05.012","article-title":"Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime\/protein boost vaccine regimen against a second SIVmac251 rectal challenge: role of SIV-specific CD8+ T cell responses","volume":"353","author":"Malkevitch","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.clim.2014.09.005_bb0115","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1128\/JVI.02453-06","volume":"81","author":"Demberg","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.virol.2008.09.016","article-title":"Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge","volume":"382","author":"Bogers","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.clim.2014.09.005_bb0125","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1128\/JVI.06812-11","volume":"86","author":"Xiao","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0130","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.4161\/hv.21407","article-title":"IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques","volume":"8","author":"Jalah","year":"2012","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.clim.2014.09.005_bb0135","doi-asserted-by":"crossref","first-page":"15831","DOI":"10.1073\/pnas.0902628106","article-title":"DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge","volume":"06","author":"Rosati","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2014.09.005_bb0140","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1016\/j.vaccine.2008.03.090","article-title":"Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation","volume":"26","author":"Rosati","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.clim.2014.09.005_bb0145","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1016\/j.vaccine.2010.12.056","article-title":"Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques","volume":"29","author":"Kulkarni","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.clim.2014.09.005_bb0150","doi-asserted-by":"crossref","first-page":"e86254","DOI":"10.1371\/journal.pone.0086254","article-title":"Altered immunodominance hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques","volume":"9","author":"Kulkarni","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2014.09.005_bb0155","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1016\/j.vaccine.2013.04.037","article-title":"HIV\/SIV DNA vaccine combined with protein in a co-immunization protocol elicits highest humoral responses to envelope in mice and macaques","volume":"31","author":"Li","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.clim.2014.09.005_bb0160","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1073\/pnas.1215393110","article-title":"DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous SIV challenge","volume":"110","author":"Patel","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2014.09.005_bb0165","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1016\/j.vaccine.2010.04.064","article-title":"Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization","volume":"28","author":"Patel","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.clim.2014.09.005_bb0170","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1182\/blood-2005-11-4374","article-title":"Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa","volume":"107","author":"Belyakov","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.clim.2014.09.005_bb0175","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/nm1201-1320","article-title":"Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques","volume":"7","author":"Belyakov","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2014.09.005_bb0180","doi-asserted-by":"crossref","first-page":"9843","DOI":"10.1073\/pnas.0911932107","article-title":"Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques","volume":"107","author":"Sui","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2014.09.005_bb0185","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.vaccine.2011.10.043","article-title":"TLR agonists and\/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4(+) memory T cell loss in SIVmac251-challenged rhesus macaques","volume":"30","author":"Sui","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.clim.2014.09.005_bb0190","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.clim.2014.05.008","article-title":"Humoral immunity induced by mucosal and\/or systemic SIV-specific vaccine platforms suggest novel combinatorial approaches for enhancing responses","volume":"153","author":"Vargas-Inchaustegui","year":"2014","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2014.09.005_bb0195","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nm1520","article-title":"CD8+ T-cell responses to different HIV proteins have discordant associations with viral load","volume":"13","author":"Kiepiela","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2014.09.005_bb0200","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1128\/JVI.02689-06","article-title":"Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes","volume":"81","author":"Honeyborne","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0205","doi-asserted-by":"crossref","first-page":"12382","DOI":"10.1128\/JVI.01543-07","article-title":"Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication","volume":"81","author":"Schneidewind","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0210","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1089\/aid.2007.0124","article-title":"Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure","volume":"24","author":"Ngumbela","year":"2008","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.clim.2014.09.005_bb0215","doi-asserted-by":"crossref","first-page":"e1424","DOI":"10.1371\/journal.pone.0001424","article-title":"Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads","volume":"3","author":"Rolland","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2014.09.005_bb0220","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1128\/JVI.78.7.3233-3243.2004","article-title":"Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral load","volume":"78","author":"Masemola","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0225","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1155\/2009\/360362","article-title":"Virological, immune and host genetics markers in the control of HIV infection","volume":"27","author":"Mothe","year":"2009","journal-title":"Dis. Markers"},{"key":"10.1016\/j.clim.2014.09.005_bb0230","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1128\/JVI.80.6.3122-3125.2006","article-title":"Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control","volume":"80","author":"Zuniga","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0235","doi-asserted-by":"crossref","first-page":"e29717","DOI":"10.1371\/journal.pone.0029717","article-title":"CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control","volume":"7","author":"Mothe","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2014.09.005_bb0240","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/1479-5876-9-208","article-title":"Definition of the viral targets of protective HIV-1-specific T cell responses","volume":"9","author":"Mothe","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.clim.2014.09.005_bb0245","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature10766","article-title":"Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys","volume":"482","author":"Barouch","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.clim.2014.09.005_bb0250","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nature07469","article-title":"Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys","volume":"457","author":"Liu","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.clim.2014.09.005_bb0255","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1128\/JVI.02523-13","article-title":"Resistance to infection, early and persistent suppression of simian immunodeficiency virus SIVmac251 viremia, and significant reduction of tissue viral burden after mucosal vaccination in female rhesus macaques","volume":"88","author":"Manrique","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0260","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.4049\/jimmunol.1002594","article-title":"Long-term control of simian immunodeficiency virus mac251 viremia to undetectable levels in half of infected female rhesus macaques nasally vaccinated with simian immunodeficiency virus DNA\/recombinant modified vaccinia virus Ankara","volume":"186","author":"Manrique","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.09.005_bb0265","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/1743-422X-9-160","article-title":"Increased cellular immune responses and CD4+ T-cell proliferation correlate with reduced plasma viral load in SIV challenged recombinant simian varicella virus\u2013simian immunodeficiency virus (rSVV-SIV) vaccinated rhesus macaques","volume":"9","author":"Pahar","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.clim.2014.09.005_bb0270","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1742-4690-8-24","article-title":"Strong mucosal immune responses in SIV infected macaques contribute to viral control and preserved CD4+ T-cell levels in blood and mucosal tissues","volume":"8","author":"Schultheiss","year":"2011","journal-title":"Retrovirology"},{"key":"10.1016\/j.clim.2014.09.005_bb0275","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1128\/JVI.02881-06","article-title":"Long-term control of simian immunodeficiency virus replication with central memory CD4+ T-cell preservation after nonsterile protection by a cytotoxic T-lymphocyte-based vaccine","volume":"81","author":"Kawada","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0280","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-0684.2006.00170.x","article-title":"Systemic vaccination prevents the total destruction of mucosal CD4 T cells during acute SIV challenge","volume":"35","author":"Mattapallil","year":"2006","journal-title":"J. Med. Primatol."},{"key":"10.1016\/j.clim.2014.09.005_bb0285","doi-asserted-by":"crossref","first-page":"5875","DOI":"10.1128\/JVI.00171-06","article-title":"Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239","volume":"80","author":"Wilson","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0290","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1128\/JVI.00315-12","article-title":"Virus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infection","volume":"86","author":"Yamamoto","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0295","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1016\/j.vaccine.2005.08.016","article-title":"Rhesus macaques with high levels of vaccine induced IFN-gamma producing cells better control viral set-point following challenge with SIV239","volume":"24","author":"Boyer","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.clim.2014.09.005_bb0300","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.4049\/jimmunol.169.9.4778","article-title":"Containment of simian immunodeficiency virus infection in vaccinated macaques: correlation with the magnitude of virus-specific pre- and postchallenge CD4+ and CD8+ T cell responses","volume":"169","author":"Hel","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.09.005_bb0305","doi-asserted-by":"crossref","first-page":"9629","DOI":"10.1128\/JVI.00893-08","article-title":"Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency","volume":"82","author":"Vaccari","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0310","doi-asserted-by":"crossref","first-page":"8480","DOI":"10.1128\/JVI.79.13.8480-8492.2005","article-title":"DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge","volume":"79","author":"Rosati","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0315","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1128\/JVI.78.5.2212-2221.2004","article-title":"Protection against mucosal simian immunodeficiency virus SIV(mac251) challenge by using replicating adenovirus-SIV multigene vaccine priming and subunit boosting","volume":"78","author":"Patterson","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0320","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.virol.2010.12.033","article-title":"Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge","volume":"411","author":"Patterson","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.clim.2014.09.005_bb0325","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature12519","article-title":"Immune clearance of highly pathogenic SIV infection","volume":"502","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.clim.2014.09.005_bb0330","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nm.1935","article-title":"Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge","volume":"15","author":"Hansen","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2014.09.005_bb0335","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature10003","article-title":"Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine","volume":"473","author":"Hansen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.clim.2014.09.005_bb0340","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1128\/JVI.00272-09","article-title":"Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge","volume":"83","author":"Wilson","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0345","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nature11443","article-title":"Vaccine-induced CD8+ T cells control AIDS virus replication","volume":"491","author":"Mudd","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.clim.2014.09.005_bb0350","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.1128\/JVI.00601-14","article-title":"Vaccination with gene fragments of gag, vif, and nef affords partial control of viral replication after mucosal challenge with SIVmac239","volume":"88","author":"Martins","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0355","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00251-010-0473-9","article-title":"Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid","volume":"62","author":"Giraldo-Vela","year":"2010","journal-title":"Immunogenetics"},{"key":"10.1016\/j.clim.2014.09.005_bb0360","doi-asserted-by":"crossref","first-page":"10199","DOI":"10.1128\/JVI.01103-08","article-title":"Gag-specific cytotoxic T-lymphocyte-based control of primary simian immunodeficiency virus replication in a vaccine trial","volume":"82","author":"Kawada","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0365","doi-asserted-by":"crossref","first-page":"e91550","DOI":"10.1371\/journal.pone.0091550","article-title":"DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in rhesus macaques","volume":"9","author":"Jalah","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2014.09.005_bb0370","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/mi.2008.6","article-title":"Protective attenuated lentivirus immunization induces SIV-specific T cells in the genital tract of rhesus monkeys","volume":"1","author":"Genesca","year":"2008","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.clim.2014.09.005_bb0375","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2796.2008.02051.x","article-title":"Antiviral CD8+ T cells in the genital tract control viral replication and delay progression to AIDS after vaginal SIV challenge in rhesus macaques immunized with virulence attenuated SHIV 89.6","volume":"265","author":"Genesca","year":"2009","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.clim.2014.09.005_bb0380","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1128\/JVI.03531-12","article-title":"Immunogenicity of a vaccine regimen composed of simian immunodeficiency virus DNA, rMVA, and viral particles administered to female rhesus macaques via four different mucosal routes","volume":"87","author":"Manrique","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2014.09.005_bb0385","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1016\/j.vaccine.2011.01.044","article-title":"Gp96 SIV Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa","volume":"29","author":"Strbo","year":"2011","journal-title":"Vaccine"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661614002162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661614002162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T20:01:24Z","timestamp":1538251284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661614002162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S1521661614002162"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2014.09.005","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2014.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}