{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:36:42Z","timestamp":1771263402139,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.clim.2014.10.003","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T18:14:23Z","timestamp":1414174463000},"page":"154-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Primary immunodeficiencies in the Netherlands: National patient data demonstrate the increased risk of malignancy"],"prefix":"10.1016","volume":"156","author":[{"given":"B.M.","family":"Jonkman-Berk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.J.M.","family":"ten Berge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.G.M.","family":"Bredius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.J.","family":"Driessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.A.S.H.","family":"Dalm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.T.","family":"van Dissel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"van Deuren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.M.","family":"Ellerbroek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"van der Flier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.M.","family":"van Hagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"van Montfrans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rutgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.H.","family":"Sch\u00f6lvinck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.T.","family":"van Beem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.W.","family":"Kuijpers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2014.10.003_bb0005","first-page":"54","article-title":"Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency","volume":"2","author":"Al-Herz","year":"2011","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.clim.2014.10.003_bb0010","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jaci.2012.11.051","article-title":"Primary immunodeficiencies: a rapidly evolving story","volume":"131","author":"Parvaneh","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.clim.2014.10.003_bb0015","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.clim.2010.02.021","article-title":"The French national registry of primary immunodeficiency diseases","volume":"135","author":"Group CTFPs","year":"2010","journal-title":"Clin. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2014.10.003_bb0020","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s10875-012-9763-3","article-title":"The prevalences and patient characteristics of primary immunodeficiency diseases in Turkey\u2014two centers study","volume":"33","author":"Kilic","year":"2013","journal-title":"J. Clin. Immunol."},{"issue":"2","key":"10.1016\/j.clim.2014.10.003_bb0025","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/cei.12105","article-title":"The German national registry for primary immunodeficiencies (PID)","volume":"173","author":"Gathmann","year":"2013","journal-title":"Clin. Exp. Immunol."},{"issue":"4","key":"10.1016\/j.clim.2014.10.003_bb0030","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1023\/A:1027382916924","article-title":"Primary immunodeficiency syndrome in Spain: first report of the National Registry in Children and Adults","volume":"17","author":"Matamoros Flori","year":"1997","journal-title":"J. Clin. Immunol."},{"issue":"5","key":"10.1016\/j.clim.2014.10.003_bb0035","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s10875-007-9105-z","article-title":"Primary immunodeficiency diseases in Australia and New Zealand","volume":"27","author":"Kirkpatrick","year":"2007","journal-title":"J. Clin. Immunol."},{"issue":"Suppl. 1","key":"10.1016\/j.clim.2014.10.003_bb0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2249.2009.03954.x","article-title":"The European internet-based patient and research database for primary immunodeficiencies: results 2006\u20132008","volume":"157","author":"Gathmann","year":"2009","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.clim.2014.10.003_bb0045","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/bioinformatics\/btl675","article-title":"The ESID Online Database network","volume":"23","author":"Guzman","year":"2007","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.clim.2014.10.003_bb0060","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10875-008-9260-x","article-title":"Primary immunodeficiency diseases in Egyptian children: a single-center study","volume":"29","author":"Reda","year":"2009","journal-title":"J. Clin. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2014.10.003_bb0065","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10875-005-0360-9","article-title":"Primary immunodeficiency disorders in the Republic of Ireland: first report of the national registry in children and adults","volume":"25","author":"Abuzakouk","year":"2005","journal-title":"J. Clin. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2014.10.003_bb0070","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","article-title":"Clinical picture and treatment of 2212 patients with common variable immunodeficiency","volume":"134","author":"Gathmann","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.clim.2014.10.003_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2010.06.015","article-title":"Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: entering a new century, do we do better?","volume":"126","author":"Gennery","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2014.10.003_bb0080","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.pcl.2009.12.004","article-title":"Bone marrow transplantation for primary immunodeficiency diseases","volume":"57","author":"Szabolcs","year":"2010","journal-title":"Pediatr. Clin. North Am."},{"issue":"6","key":"10.1016\/j.clim.2014.10.003_bb0085","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jaci.2008.09.045","article-title":"Allogeneic hematopoietic cell transplantation for primary immune deficiency diseases: current status and critical needs","volume":"122","author":"Griffith","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"issue":"9357","key":"10.1016\/j.clim.2014.10.003_bb0090","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0140-6736(03)12513-5","article-title":"Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968\u201399","volume":"361","author":"Antoine","year":"2003","journal-title":"Lancet"},{"issue":"1 Suppl. 1","key":"10.1016\/j.clim.2014.10.003_bb0095","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbmt.2007.10.017","article-title":"Hematopoietic stem cell transplantation for severe combined immunodeficiency diseases","volume":"14","author":"Cowan","year":"2008","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"4","key":"10.1016\/j.clim.2014.10.003_bb0100","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/petr.12081","article-title":"Hematopoietic stem cell transplantation for children with primary immunodeficiency diseases: single center experience in Jordan","volume":"17","author":"Amayiri","year":"2013","journal-title":"Pediatr. Transplant."},{"issue":"Suppl. 1","key":"10.1016\/j.clim.2014.10.003_bb0105","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1038\/bmt.2008.115","article-title":"Stem cell transplantation for primary immunodeficiencies: King Faisal Specialist Hospital experience from 1993 to 2006","volume":"42","author":"Al-Ghonaium","year":"2008","journal-title":"Bone Marrow Transplant."},{"issue":"3","key":"10.1016\/j.clim.2014.10.003_bb0110","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bbmt.2012.11.619","article-title":"Outcomes of hematopoietic stem cell transplantation in primary immunodeficiency: a report from the Australian and New Zealand Children's Haematology Oncology Group and the Australasian Bone Marrow Transplant Recipient Registry","volume":"19","author":"Mitchell","year":"2013","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"5","key":"10.1016\/j.clim.2014.10.003_bb0115","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/S0041-1345(03)00713-9","article-title":"Lung transplantation in patients with X-linked agammaglobulinemia","volume":"35","author":"Morales","year":"2003","journal-title":"Transplant. Proc."},{"issue":"1","key":"10.1016\/j.clim.2014.10.003_bb0120","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3109\/0886022X.2010.528115","article-title":"An unusual cause of renomegaly and renal insufficiency: a case report of renal involvement in common variable immunodeficiency disease","volume":"33","author":"Liu","year":"2011","journal-title":"Ren. Fail."},{"issue":"6","key":"10.1016\/j.clim.2014.10.003_bb0125","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/0272-6386(95)90580-4","article-title":"Common variable immunodeficiency in a renal transplant patient with severe recurrent bacterial infection: a case report and review of the literature","volume":"25","author":"Miller","year":"1995","journal-title":"Am. J. Kidney Dis."},{"issue":"6","key":"10.1016\/j.clim.2014.10.003_bb0130","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1016\/S0272-6386(99)70174-5","article-title":"Renal transplantation in a patient with common variable immunodeficiency","volume":"33","author":"Hogan","year":"1999","journal-title":"Am. J. Kidney Dis."},{"issue":"2","key":"10.1016\/j.clim.2014.10.003_bb0135","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1053\/ajkd.2001.26117","article-title":"Granulomatous renal disease in a patient with common variable immunodeficiency","volume":"38","author":"Fakhouri","year":"2001","journal-title":"Am. J. Kidney Dis."},{"issue":"1","key":"10.1016\/j.clim.2014.10.003_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3476(95)70491-4","article-title":"Cancer in children with primary or secondary immunodeficiencies","volume":"126","author":"Mueller","year":"1995","journal-title":"J. Pediatr."},{"issue":"8","key":"10.1016\/j.clim.2014.10.003_bb0145","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1182\/blood-2010-03-272351","article-title":"Are antibody deficiency disorders associated with a narrower range of cancers than other forms of immunodeficiency?","volume":"116","author":"Vajdic","year":"2010","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.clim.2014.10.003_bb0150","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1046\/j.1365-2249.2002.02004.x","article-title":"Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study","volume":"130","author":"Mellemkjaer","year":"2002","journal-title":"Clin. Exp. Immunol."},{"issue":"2B","key":"10.1016\/j.clim.2014.10.003_bb0155","first-page":"1263","article-title":"Development of cancer in patients with primary immunodeficiencies","volume":"28","author":"Salavoura","year":"2008","journal-title":"Anticancer Res."},{"issue":"1","key":"10.1016\/j.clim.2014.10.003_bb0160","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ajh.21903","article-title":"Malignancies in the setting of primary immunodeficiency: implications for hematologists\/oncologists","volume":"86","author":"Shapiro","year":"2011","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.clim.2014.10.003_bb0165","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.immunol.19.1.657","article-title":"X-linked lymphoproliferative disease: a progressive immunodeficiency","volume":"19","author":"Morra","year":"2001","journal-title":"Annu. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.clim.2014.10.003_bb0170","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s00431-002-1083-9","article-title":"Mutations of the X-linked lymphoproliferative disease gene SH2D1A mimicking common variable immunodeficiency","volume":"161","author":"Soresina","year":"2002","journal-title":"Eur. J. Pediatr."},{"issue":"18","key":"10.1016\/j.clim.2014.10.003_bb0175","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1182\/blood-2010-03-275909","article-title":"X-linked lymphoproliferative syndromes: brothers or distant cousins?","volume":"116","author":"Filipovich","year":"2010","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.clim.2014.10.003_bb0180","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1182\/blood-2010-06-284935","article-title":"X-linked lymphoproliferative disease due to SAP\/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease","volume":"117","author":"Booth","year":"2011","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.clim.2014.10.003_bb0185","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1365-2249.2004.02581.x","article-title":"Prevalence of SAP gene defects in male patients diagnosed with common variable immunodeficiency","volume":"137","author":"Eastwood","year":"2004","journal-title":"Clin. Exp. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661614002393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661614002393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T03:51:42Z","timestamp":1538106702000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661614002393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S1521661614002393"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2014.10.003","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary immunodeficiencies in the Netherlands: National patient data demonstrate the increased risk of malignancy","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2014.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}