{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:08:51Z","timestamp":1760267331161},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK050824-20","HL114408","ES022625","ES021464"],"award-info":[{"award-number":["DK050824-20","HL114408","ES022625","ES021464"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.clim.2014.11.003","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T03:04:45Z","timestamp":1415675085000},"page":"65-73","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus"],"prefix":"10.1016","volume":"156","author":[{"given":"Christian J.","family":"Maine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristi","family":"Marquardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Scatizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Michael","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwight H.","family":"Kono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda A.","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2014.11.003_bb0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ng1323","article-title":"A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes","volume":"36","author":"Bottini","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2014.11.003_bb0010","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1086\/422827","article-title":"A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis","volume":"75","author":"Begovich","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clim.2014.11.003_bb0015","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1086\/423790","article-title":"Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE","volume":"75","author":"Kyogoku","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clim.2014.11.003_bb0020","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1126\/science.1092138","article-title":"PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector\/memory T cells","volume":"303","author":"Hasegawa","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.clim.2014.11.003_bb0025","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/ng.904","article-title":"The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp\/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness","volume":"43","author":"Zhang","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2014.11.003_bb0030","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2337\/db12-0929","article-title":"PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant","volume":"62","author":"Zheng","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.clim.2014.11.003_bb0035","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4049\/jimmunol.1203380","article-title":"Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice","volume":"191","author":"Yeh","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0040","doi-asserted-by":"crossref","first-page":"e86677","DOI":"10.1371\/journal.pone.0086677","article-title":"Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2014.11.003_bb0045","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.468","article-title":"A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus","volume":"41","author":"Gateva","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2014.11.003_bb0050","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/0961203310381774","article-title":"The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update","volume":"20","author":"Lea","year":"2011","journal-title":"Lupus"},{"key":"10.1016\/j.clim.2014.11.003_bb0055","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/gene.2012.46","article-title":"Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue","volume":"13","author":"Zheng","year":"2012","journal-title":"Genes Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0060","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/sj.gene.6364350","article-title":"Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population","volume":"7","author":"Baca","year":"2006","journal-title":"Genes Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0065","doi-asserted-by":"crossref","first-page":"e69404","DOI":"10.1371\/journal.pone.0069404","article-title":"PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes","volume":"8","author":"Namjou","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2014.11.003_bb0070","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1021\/jm101202j","article-title":"Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells","volume":"54","author":"Stanford","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.clim.2014.11.003_bb0075","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nchembio.916","article-title":"LYP inhibits T-cell activation when dissociated from CSK","volume":"8","author":"Vang","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.clim.2014.11.003_bb0080","doi-asserted-by":"crossref","first-page":"ra87","DOI":"10.1126\/scisignal.2003365","article-title":"Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function","volume":"5","author":"Brownlie","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.clim.2014.11.003_bb0085","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.4049\/jimmunol.1200150","article-title":"PTPN22 alters the development of regulatory T cells in the thymus","volume":"188","author":"Maine","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0090","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.4049\/jimmunol.0713370","article-title":"Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling","volume":"182","author":"Arechiga","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0095","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1172\/JCI66963","article-title":"A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models","volume":"123","author":"Dai","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2014.11.003_bb0100","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4049\/jimmunol.1102176","article-title":"Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant","volume":"188","author":"Habib","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0105","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1172\/JCI45790","article-title":"The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans","volume":"121","author":"Menard","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2014.11.003_bb0110","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.4049\/jimmunol.179.7.4704","article-title":"Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes","volume":"179","author":"Rieck","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0115","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.4049\/jimmunol.1302418","article-title":"PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells","volume":"192","author":"Maine","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0120","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.immuni.2013.06.013","article-title":"The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity","volume":"39","author":"Wang","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2014.11.003_bb0125","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.4049\/jimmunol.0803317","article-title":"PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background","volume":"182","author":"Zikherman","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0130","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0065-2776(08)60342-9","article-title":"Murine models of systemic lupus erythematosus","volume":"37","author":"Theofilopoulos","year":"1985","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0135","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1002\/art.1780210909","article-title":"Etiology and pathogenesis of a spontaneous lupus-like syndrome in mice","volume":"21","author":"Dixon","year":"1978","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2014.11.003_bb0140","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.1124978","article-title":"Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication","volume":"312","author":"Pisitkun","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.clim.2014.11.003_bb0145","doi-asserted-by":"crossref","first-page":"9970","DOI":"10.1073\/pnas.0603912103","article-title":"A Tlr7 translocation accelerates systemic autoimmunity in murine lupus","volume":"103","author":"Subramanian","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2014.11.003_bb0150","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/1529-0131(200002)43:2<349::AID-ANR14>3.0.CO;2-M","article-title":"Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice","volume":"43","author":"Haywood","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2014.11.003_bb0155","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.4049\/jimmunol.173.7.4277","article-title":"Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease","volume":"173","author":"Haywood","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0160","doi-asserted-by":"crossref","first-page":"12061","DOI":"10.1073\/pnas.0905441106","article-title":"Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus","volume":"106","author":"Kono","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2014.11.003_bb0165","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.4049\/jimmunol.134.6.3849","article-title":"Studies of consomic mice bearing the Y chromosome of the BXSB mouse","volume":"134","author":"Hudgins","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0170","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.4049\/jimmunol.1002795","article-title":"Type I, interferon in the pathogenesis of lupus","volume":"192","author":"Crow","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0175","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.coi.2013.10.006","article-title":"TLRs and interferons: a central paradigm in autoimmunity","volume":"25","author":"Kono","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0180","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jaut.2012.04.003","article-title":"Definition of IFN-gamma-related pathways critical for chemically-induced systemic autoimmunity","volume":"39","author":"Pollard","year":"2012","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2014.11.003_bb0185","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1084\/jem.148.5.1198","article-title":"Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains","volume":"148","author":"Andrews","year":"1978","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2014.11.003_bb0190","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.4049\/jimmunol.1201477","article-title":"Anti-IFN-alpha\/beta receptor antibody treatment ameliorates disease in lupus-predisposed mice","volume":"189","author":"Baccala","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0195","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1089\/jir.2011.0071","article-title":"Interferon alpha as a primary pathogenic factor in human lupus","volume":"31","author":"Niewold","year":"2011","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.clim.2014.11.003_bb0200","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/ard.2004.025858","article-title":"Preliminary results of safety and efficacy of the interleukin 1 receptor antagonist anakinra in patients with severe lupus arthritis","volume":"64","author":"Ostendorf","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2014.11.003_bb0205","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/978-0-387-84828-0_46","article-title":"The role of Tumor Necrosis Factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus","volume":"56","author":"Postal","year":"2011","journal-title":"Cytokine"},{"issue":"10","key":"10.1016\/j.clim.2014.11.003_bb0210","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nrrheum.2014.109","article-title":"PTPN22: the archetypal non-HLA autoimmunity gene","volume":"10","author":"Stanford","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2014.11.003_bb0215","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1182\/blood-2011-01-331462","article-title":"Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c(+) B-cell population is important for the development of autoimmunity","volume":"118","author":"Rubtsov","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.clim.2014.11.003_bb0220","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1084\/jem.20031519","article-title":"Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis","volume":"199","author":"Waters","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2014.11.003_bb0225","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.clim.2014.06.008","article-title":"Interferon alpha on NZM2328.Lc1R27: enhancing autoimmunity and immune complex-mediated glomerulonephritis without end stage renal failure","volume":"154","author":"Dai","year":"2014","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2014.11.003_bb0230","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1084\/jem.20130731","article-title":"Cgnz1 allele confers kidney resistance to damage preventing progression of immune complex-mediated acute lupus glomerulonephritis","volume":"210","author":"Ge","year":"2013","journal-title":"J. Exp. Med."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661614002496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661614002496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T01:08:08Z","timestamp":1689642488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661614002496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1521661614002496"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2014.11.003","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2014.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}