{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:27:41Z","timestamp":1790872061277,"version":"4.1.0"},"reference-count":109,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NYSTEM-funded Cornell Mammalian Cell Reprogramming Core"},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["C024174"],"award-info":[{"award-number":["C024174"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP2OD007216"],"award-info":[{"award-number":["DP2OD007216"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.clim.2015.05.005","type":"journal-article","created":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T16:06:52Z","timestamp":1431792412000},"page":"261-276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Bone marrow transcriptome and epigenome profiles of equine common variable immunodeficiency patients unveil block of B lymphocyte differentiation"],"prefix":"10.1016","volume":"160","author":[{"given":"Rebecca L.","family":"Tallmadge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishuang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia T.","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Julia B.","family":"Felippe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2015.05.005_bb0005","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJM195406172502403","article-title":"Absence of serum gamma globulins in an adult","volume":"250","author":"Sanford","year":"1954","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2015.05.005_bb0010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1182\/asheducation.V2012.1.301.3798316","article-title":"The many faces of common variable immunodeficiency","volume":"2012","author":"Cunningham-Rundles","year":"2012","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.clim.2015.05.005_bb0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","article-title":"The EUROclass trial: defining subgroups in common variable immunodeficiency","volume":"111","author":"Wehr","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.clim.2015.05.005_bb0020","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/s10875-010-9424-3","article-title":"B-cell and T-cell phenotypes in CVID patients correlate with the clinical phenotype of the disease","volume":"30","author":"Mouillot","year":"2010","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0025","first-page":"285","article-title":"Common variable immunodeficiency \u2014 new insight into the pathogenesis and the quest for a workable classification","volume":"27","author":"Pandolfi","year":"2013","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.clim.2015.05.005_bb0030","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/ni902","article-title":"Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency","volume":"4","author":"Grimbacher","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0035","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1056\/NEJMoa051568","article-title":"An antibody-deficiency syndrome due to mutations in the CD19 gene","volume":"354","author":"van Zelm","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2015.05.005_bb0040","doi-asserted-by":"crossref","first-page":"13945","DOI":"10.1073\/pnas.0903543106","article-title":"B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans","volume":"106","author":"Warnatz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2015.05.005_bb0045","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1172\/JCI39748","article-title":"CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency","volume":"120","author":"van Zelm","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2015.05.005_bb0050","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1172\/JCI40231","article-title":"CD20 deficiency in humans results in impaired T cell-independent antibody responses","volume":"120","author":"Kuijpers","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2015.05.005_bb0055","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jaci.2011.09.027","article-title":"Genetic CD21 deficiency is associated with hypogammaglobulinemia","volume":"129","author":"Thiel","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0060","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1056\/NEJMoa1102140","article-title":"Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions","volume":"366","author":"Ombrello","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2015.05.005_bb0065","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ajhg.2012.04.015","article-title":"Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity","volume":"90","author":"Lopez-Herrera","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clim.2015.05.005_bb0070","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.jaci.2011.11.013","article-title":"CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia","volume":"129","author":"van Montfrans","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0075","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng0407-429","article-title":"Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency","volume":"39","author":"Pan-Hammarstrom","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2015.05.005_bb0080","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1073\/pnas.0700815104","article-title":"Role for Msh5 in the regulation of Ig class switch recombination","volume":"104","author":"Sekine","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2015.05.005_bb0085","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.autrev.2012.10.017","article-title":"Chipping away at a mountain: genomic studies in common variable immunodeficiency","volume":"12","author":"Keller","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2015.05.005_bb0090","doi-asserted-by":"crossref","first-page":"1360-7","DOI":"10.1016\/j.jaci.2011.02.039","article-title":"Genome-wide association identifies diverse causes of common variable immunodeficiency","volume":"127","author":"Orange","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0095","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.2460\/javma.2002.221.1296","article-title":"Common variable immunodeficiency in a horse","volume":"221","author":"Flaminio","year":"2002","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.clim.2015.05.005_bb0100","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2460\/javma.2005.227.114","article-title":"Common variable immunodeficiency in three horses with presumptive bacterial meningitis","volume":"227","author":"Pellegrini-Masini","year":"2005","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.clim.2015.05.005_bb0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10875-008-9221-4","article-title":"Common variable immunodeficiency in horses is characterized by B cell depletion in primary and secondary lymphoid tissues","volume":"29","author":"Flaminio","year":"2009","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0110","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molimm.2012.03.018","article-title":"Expression of essential B cell development genes in horses with common variable immunodeficiency","volume":"51","author":"Tallmadge","year":"2012","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0115","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/ni.1891","article-title":"A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate","volume":"11","author":"Lin","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0120","doi-asserted-by":"crossref","first-page":"21028","DOI":"10.1073\/pnas.1211427109","article-title":"Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate","volume":"109","author":"Mansson","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2015.05.005_bb0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/MOH.0b013e3283612628","article-title":"Early events in lymphopoiesis: an update","volume":"20","author":"Zhang","year":"2013","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.clim.2015.05.005_bb0130","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1101\/sqb.2013.78.020057","article-title":"Establishment and maintenance of B cell identity","volume":"78","author":"Grosschedl","year":"2013","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.clim.2015.05.005_bb0135","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.immuni.2009.01.012","article-title":"Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis","volume":"30","author":"Decker","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.05.005_bb0140","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.immuni.2010.04.013","article-title":"Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription-independent poising of chromatin","volume":"32","author":"Treiber","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.05.005_bb0145","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1038\/emboj.2011.140","article-title":"The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells","volume":"30","author":"McManus","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.clim.2015.05.005_bb0150","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/ni.1626","article-title":"Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros","volume":"9","author":"Reynaud","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0155","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.4049\/jimmunol.1002346","article-title":"E2A and CBP\/p300 act in synergy to promote chromatin accessibility of the immunoglobulin kappa locus","volume":"188","author":"Sakamoto","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0160","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/ni1119","article-title":"Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription","volume":"5","author":"Maier","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0165","doi-asserted-by":"crossref","first-page":"11258","DOI":"10.1073\/pnas.0809485106","article-title":"Opposing effects of SWI\/SNF and Mi-2\/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5","volume":"106","author":"Gao","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2015.05.005_bb0170","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1182\/blood-2008-02-142786","article-title":"Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus","volume":"112","author":"Walter","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.clim.2015.05.005_bb0175","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1093\/emboj\/19.10.2292","article-title":"Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family","volume":"19","author":"Eberhard","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.clim.2015.05.005_bb0180","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.embor.7400089","article-title":"Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes","volume":"5","author":"Linderson","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.clim.2015.05.005_bb0185","doi-asserted-by":"crossref","first-page":"11339","DOI":"10.1093\/nar\/gks957","article-title":"A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network","volume":"40","author":"Lee","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2015.05.005_bb0190","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-Seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.clim.2015.05.005_bb0195","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nbt.2450","article-title":"Differential analysis of gene regulation at transcript resolution with RNA-seq","volume":"31","author":"Trapnell","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.clim.2015.05.005_bb0200","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.clim.2015.05.005_bb0205","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.806","article-title":"A framework for variation discovery and genotyping using next-generation DNA sequencing data","volume":"43","author":"DePristo","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2015.05.005_bb0210","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.clim.2015.05.005_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2015.05.005_bb0220","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3390\/v3060620","article-title":"Characterization of a full-length endogenous beta-retrovirus, EqERV-beta1, in the genome of the horse","volume":"3","author":"van der Kuyl","year":"2011","journal-title":"Viruses"},{"key":"10.1016\/j.clim.2015.05.005_bb0225","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.virol.2012.08.047","article-title":"Detection and characterization of endogenous retroviruses in the horse genome by in silico analysis","volume":"434","author":"Garcia-Etxebarria","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.clim.2015.05.005_bb0230","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.virol.2012.07.010","article-title":"Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing","volume":"433","author":"Brown","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.clim.2015.05.005_bb0235","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","article-title":"Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications","volume":"27","author":"Krueger","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.clim.2015.05.005_bb0240","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/biostatistics\/kxq005","article-title":"Redefining CpG islands using hidden Markov models","volume":"11","author":"Wu","year":"2010","journal-title":"Biostatistics"},{"key":"10.1016\/j.clim.2015.05.005_bb0245","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/bioinformatics\/18.11.1427","article-title":"MethPrimer: designing primers for methylation PCRs","volume":"18","author":"Li","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1016\/j.clim.2015.05.005_bb0250","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/bioinformatics\/bts199","article-title":"Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data","volume":"28","author":"Kearse","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.clim.2015.05.005_bb0255","doi-asserted-by":"crossref","first-page":"W170","DOI":"10.1093\/nar\/gkn294","article-title":"QUMA: quantification tool for methylation analysis","volume":"36","author":"Kumaki","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2015.05.005_bb0260","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ejcb.2009.10.016","article-title":"Keratins regulate yolk sac hematopoiesis and vasculogenesis through reduced BMP-4 signaling","volume":"89","author":"Vijayaraj","year":"2010","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.clim.2015.05.005_bb0265","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.stem.2014.07.005","article-title":"Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis","volume":"15","author":"Cabezas-Wallscheid","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.clim.2015.05.005_bb0270","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.4049\/jimmunol.180.4.2045","article-title":"Kit regulates maintenance of quiescent hematopoietic stem cells","volume":"180","author":"Thoren","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0275","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1084\/jem.20121846","article-title":"Bcl11a is essential for lymphoid development and negatively regulates p53","volume":"209","author":"Yu","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2015.05.005_bb0280","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ni925","article-title":"Bcl11a is essential for normal lymphoid development","volume":"4","author":"Liu","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0285","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)80076-8","article-title":"The T cell leukemia oncoprotein SCL\/tal-1 is essential for development of all hematopoietic lineages","volume":"86","author":"Porcher","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.clim.2015.05.005_bb0290","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1002\/j.1460-2075.1992.tb05500.x","article-title":"The SCL gene product: a positive regulator of erythroid differentiation","volume":"11","author":"Aplan","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.clim.2015.05.005_bb0295","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.exphem.2013.11.013","article-title":"Flk2\/Flt3 promotes both myeloid and lymphoid development by expanding non-self-renewing multipotent hematopoietic progenitor cells","volume":"42","author":"Beaudin","year":"2014","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.clim.2015.05.005_bb0300","doi-asserted-by":"crossref","first-page":"e64800","DOI":"10.1371\/journal.pone.0064800","article-title":"Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo","volume":"8","author":"Wu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2015.05.005_bb0305","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/j.yexcr.2012.07.009","article-title":"Molecular signature and in vivo behavior of bone marrow endosteal and subendosteal stromal cell populations and their relevance to hematopoiesis","volume":"318","author":"Balduino","year":"2012","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.clim.2015.05.005_bb0310","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.exphem.2004.06.012","article-title":"Hepatocyte growth factor plays roles in the induction and autocrine maintenance of bone marrow stromal cell IL-11, SDF-1 alpha, and stem cell factor","volume":"32","author":"Matsuda-Hashii","year":"2004","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.clim.2015.05.005_bb0315","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008250","article-title":"Hematopoiesis","volume":"4","author":"Rieger","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.clim.2015.05.005_bb0320","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1538-7836.2007.02472.x","article-title":"From hematopoietic stem cells to platelets","volume":"5","author":"Chang","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.clim.2015.05.005_bb0325","doi-asserted-by":"crossref","first-page":"6258","DOI":"10.1182\/blood-2011-07-356006","article-title":"From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications","volume":"118","author":"Hattangadi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.clim.2015.05.005_bb0330","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00018-013-1322-4","article-title":"Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks","volume":"71","author":"Huber","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.clim.2015.05.005_bb0335","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.4049\/jimmunol.1301348","article-title":"Tyrosine phosphorylation of CD13 regulates inflammatory cell\u2013cell adhesion and monocyte trafficking","volume":"191","author":"Subramani","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0340","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1128\/IAI.64.5.1762-1769.1996","article-title":"Human monocyte CD14 is upregulated by lipopolysaccharide","volume":"64","author":"Landmann","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.clim.2015.05.005_bb0345","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1182\/blood.V84.6.1737.1737","article-title":"Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization","volume":"84","author":"Lieschke","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.clim.2015.05.005_bb0350","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.4049\/jimmunol.0903136","article-title":"Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1","volume":"184","author":"Bayat","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0355","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1182\/blood.V71.3.646.646","article-title":"Human eosinophil hematopoiesis studied in vitro by means of murine eosinophil differentiation factor (IL5): production of functionally active eosinophils from normal human bone marrow","volume":"71","author":"Clutterbuck","year":"1988","journal-title":"Blood"},{"key":"10.1016\/j.clim.2015.05.005_bb0360","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1398-9995.2010.02431.x","article-title":"Robust expression of CCR3 as a single basophil selection marker in flow cytometry","volume":"66","author":"Hausmann","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.clim.2015.05.005_bb0365","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-1-4939-1016-8_12","article-title":"Human eosinophil adhesion and receptor expression","volume":"1178","author":"Curran","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.clim.2015.05.005_bb0370","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1084\/jem.181.4.1519","article-title":"Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine","volume":"181","author":"von Freeden-Jeffry","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2015.05.005_bb0375","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/eji.200737688","article-title":"Notch signaling is necessary for GATA3 function in the initiation of T cell development","volume":"38","author":"Hozumi","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0380","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1002\/eji.1830221016","article-title":"Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes","volume":"22","author":"Lane","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0385","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.4049\/jimmunol.0901508","article-title":"Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development","volume":"184","author":"Schotte","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0390","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/cyto.a.20789","article-title":"Identification of a NCR+\/NKG2D+\/LFA-1(low)\/CD94(\u2212) immature human NK cell subset","volume":"75","author":"Zamai","year":"2009","journal-title":"Cytometry A"},{"key":"10.1016\/j.clim.2015.05.005_bb0395","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1146\/annurev.iy.07.040189.003051","article-title":"The biologic roles of CD2, CD4, and CD8 in T-cell activation","volume":"7","author":"Bierer","year":"1989","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0400","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4049\/jimmunol.151.1.100","article-title":"Characterization of a novel CD2+ human thymic B cell subset","volume":"151","author":"Punnonen","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0405","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/44076","article-title":"Commitment to the B-lymphoid lineage depends on the transcription factor Pax5","volume":"401","author":"Nutt","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.clim.2015.05.005_bb0410","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.4049\/jimmunol.136.12.4470","article-title":"HD39 (B3), a B lineage-restricted antigen whose cell surface expression is limited to resting and activated human B lymphocytes","volume":"136","author":"Dorken","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0415","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1016\/j.febslet.2010.09.042","article-title":"Ikaros in immune receptor signaling, lymphocyte differentiation, and function","volume":"584","author":"Merkenschlager","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.clim.2015.05.005_bb0420","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1182\/blood-2008-01-129049","article-title":"IRF8 regulates B-cell lineage specification, commitment, and differentiation","volume":"112","author":"Wang","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.clim.2015.05.005_bb0425","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3850::AID-IMMU3850>3.0.CO;2-R","article-title":"Acquisition of CD24 expression by Lin-CD43+B220(low)ckit(hi) cells coincides with commitment to the B cell lineage","volume":"28","author":"Hunte","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0430","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.4049\/jimmunol.181.9.5885","article-title":"E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors","volume":"181","author":"Yang","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0435","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.immuni.2008.05.015","article-title":"E2A proteins promote development of lymphoid-primed multipotent progenitors","volume":"29","author":"Dias","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.05.005_bb0440","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.immuni.2007.05.019","article-title":"Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function","volume":"27","author":"Schebesta","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.05.005_bb0445","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.immuni.2006.01.012","article-title":"Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells","volume":"24","author":"Delogu","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.05.005_bb0450","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1128\/MCB.01192-06","article-title":"Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5","volume":"27","author":"Roessler","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.clim.2015.05.005_bb0455","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/intimm\/dxh009","article-title":"Mouse CD20 expression and function","volume":"16","author":"Uchida","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0460","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.4049\/jimmunol.175.9.5912","article-title":"Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression","volume":"175","author":"van Zelm","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0465","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.4049\/jimmunol.179.6.3662","article-title":"Characterization of early stages of human B cell development by gene expression profiling","volume":"179","author":"Hystad","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0470","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.4049\/jimmunol.1401275","article-title":"Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm\/Ighd locus","volume":"193","author":"Pioli","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0475","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.smim.2011.08.010","article-title":"The genetic network controlling plasma cell differentiation","volume":"23","author":"Nutt","year":"2011","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0480","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fimmu.2014.00137","article-title":"Immunophenotype of normal and myelomatous plasma-cell subsets","volume":"5","author":"Robillard","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0485","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nature06159","article-title":"Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors","volume":"449","author":"Cobaleda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.clim.2015.05.005_bb0490","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nri2507","article-title":"E and ID proteins branch out","volume":"9","author":"Kee","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2015.05.005_bb0495","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/S0301-472X(02)00953-0","article-title":"Levels of E2A protein expression in B cell precursors are stage-dependent and inhibited by stem cell factor","volume":"30","author":"Riley","year":"2002","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.clim.2015.05.005_bb0500","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ccr.2004.05.023","article-title":"TAL1\/SCL induces leukemia by inhibiting the transcriptional activity of E47\/HEB","volume":"5","author":"O'Neil","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.clim.2015.05.005_bb0505","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(94)90076-0","article-title":"The helix\u2013loop\u2013helix gene E2A is required for B cell formation","volume":"79","author":"Zhuang","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.clim.2015.05.005_bb0510","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0092-8674(94)90077-9","article-title":"E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements","volume":"79","author":"Bain","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.clim.2015.05.005_bb0515","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1074-7613(00)80421-5","article-title":"Both E12 and E47 allow commitment to the B cell lineage","volume":"6","author":"Bain","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.05.005_bb0520","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1128\/MCB.22.3.886-900.2002","article-title":"Gradient of E2A activity in B-cell development","volume":"22","author":"Herblot","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.clim.2015.05.005_bb0525","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1084\/jem.20032202","article-title":"Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A","volume":"199","author":"Seet","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2015.05.005_bb0530","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1182\/blood-2009-08-236398","article-title":"Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity","volume":"115","author":"Mansson","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.clim.2015.05.005_bb0535","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/nbt.1681","article-title":"Quantitative comparison of genome-wide DNA methylation mapping technologies","volume":"28","author":"Bock","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.clim.2015.05.005_bb0540","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1182\/blood-2010-11-321695","article-title":"T and B lymphocyte abnormalities in bone marrow biopsies of common variable immunodeficiency","volume":"118","author":"Ochtrop","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.clim.2015.05.005_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2014.12.1943","article-title":"Key stages of bone marrow B-cell maturation are defective in patients with common variable immunodeficiency disorders","author":"Anzilotti","year":"2015","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661615001679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661615001679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T16:44:21Z","timestamp":1691685861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661615001679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":109,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1521661615001679"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2015.05.005","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone marrow transcriptome and epigenome profiles of equine common variable immunodeficiency patients unveil block of B lymphocyte differentiation","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2015.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}