{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:36:50Z","timestamp":1785843410570,"version":"3.56.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RO1 AI-101175"],"award-info":[{"award-number":["RO1 AI-101175"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"English, Bonter, Mitchell Foundation"},{"name":"Ounsworth-Fitzgerald Foundation"},{"name":"Eshe Fund"},{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AR-007258"],"award-info":[{"award-number":["AR-007258"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K01-AR-062098"],"award-info":[{"award-number":["K01-AR-062098"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.clim.2015.07.005","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T23:29:50Z","timestamp":1437002990000},"page":"336-341","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis"],"prefix":"10.1016","volume":"160","author":[{"given":"Annalisa","family":"Pianta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise E.","family":"Drouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameson T.","family":"Crowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Arvikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemen","family":"Strle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Costello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Steere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2015.07.005_bb0005","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM200107123450207","article-title":"Lyme disease","volume":"345","author":"Steere","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2015.07.005_bb0010","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/0003-4819-107-5-725","article-title":"The clinical evolution of Lyme arthritis","volume":"107","author":"Steere","year":"1987","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.clim.2015.07.005_bb0015","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1086\/589242","article-title":"Prospective study of serologic tests for Lyme disease","volume":"47","author":"Steere","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.clim.2015.07.005_bb0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.clim.2009.03.510","article-title":"Strong IgG antibody responses to Borrelia burgdorferi glycolipids in patients with Lyme arthritis, a late manifestation of the infection","volume":"132","author":"Jones","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2015.07.005_bb0025","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1002\/art.38756","article-title":"Review: unraveling Lyme disease","volume":"66","author":"Bockenstedt","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.07.005_bb0030","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1002\/art.22131","article-title":"Therapy for Lyme arthritis: strategies for the treatment of antibiotic-refractory arthritis","volume":"54","author":"Steere","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.07.005_bb0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nri1267","article-title":"Elucidation of Lyme arthritis","volume":"4","author":"Steere","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2015.07.005_bb0040","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2741\/e379","article-title":"Development and deployment of antigen arrays for investigation of B-cell fine specificity in autoimmune disease","volume":"4","author":"Sokolove","year":"2012","journal-title":"Front. Biosci. (Elite Ed.)"},{"key":"10.1016\/j.clim.2015.07.005_bb0045","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/art.21269","article-title":"Antigen microarray profiling of autoantibodies in rheumatoid arthritis","volume":"52","author":"Hueber","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.07.005_bb0050","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nm0302-295","article-title":"Autoantigen microarrays for multiplex characterization of autoantibody responses","volume":"8","author":"Robinson","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2015.07.005_bb0055","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1002\/art.38754","article-title":"Barcode-enabled sequencing of plasmablast antibody repertoires in rheumatoid arthritis","volume":"66","author":"Tan","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.07.005_bb0060","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M110.002477","article-title":"Peptides presented by HLA-DR molecules in synovia of patients with rheumatoid arthritis or antibiotic-refractory Lyme arthritis","volume":"10","author":"Seward","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.clim.2015.07.005_bb0065","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/art.37732","article-title":"A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease","volume":"65","author":"Drouin","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.07.005_bb0070","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiv310","article-title":"A highly expressed human protein, apolipoprotein B-100, serves as an autoantigen in a subgroup of patients with Lyme disease","author":"Crowley","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.clim.2015.07.005_bb0075","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1002\/art.38618","article-title":"Antibodies to endothelial cell growth factor and obliterative microvascular lesions in the synovium of patients with antibiotic-refractory Lyme arthritis","volume":"66","author":"Londono","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.07.005_bb0080","first-page":"S437","article-title":"Identification of annexin A-2 as an autoantigen in rheumatoid arthritis and in Lyme arthritis","volume":"66","author":"Pianta","year":"2014","journal-title":"Arthritis Rheum."},{"issue":"Suppl. 2","key":"10.1016\/j.clim.2015.07.005_bb0085","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/annrheumdis-2015-eular.2159","article-title":"Identification of N-acetylglucosamine-6-sulfatase and filamin A as novel targets of autoimmune T and B cell responses in rheumatoid arthritis","volume":"74","author":"Pianta","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2015.07.005_bb0090","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1177\/0961203308095329","article-title":"Annexin A2: biology and relevance to the antiphospholipid syndrome","volume":"17","author":"Cockrell","year":"2008","journal-title":"Lupus"},{"key":"10.1016\/j.clim.2015.07.005_bb0095","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00296-010-1379-4","article-title":"Anti-annexin II antibody is associated with thrombosis and\/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis","volume":"31","author":"Ao","year":"2011","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.clim.2015.07.005_bb0100","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10875-008-9188-1","article-title":"Anti-annexin II antibodies in systemic autoimmune diseases and antiphospholipid syndrome","volume":"28","author":"Salle","year":"2008","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2015.07.005_bb0105","first-page":"1","article-title":"Case definitions for public health surveillance","volume":"39","author":"Wharton","year":"1990","journal-title":"MMWR Recomm. Rep."},{"key":"10.1016\/j.clim.2015.07.005_bb0110","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1152\/physrev.00030.2001","article-title":"Annexins: from structure to function","volume":"82","author":"Gerke","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.clim.2015.07.005_bb0115","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrm1661","article-title":"Annexins: linking Ca2+ signalling to membrane dynamics","volume":"6","author":"Gerke","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.clim.2015.07.005_bb0120","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.autrev.2011.04.007","article-title":"Anti-annexins autoantibodies: their role as biomarkers of autoimmune diseases","volume":"10","author":"Iaccarino","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2015.07.005_bb0125","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1055\/s-0033-1334143","article-title":"Annexin A2 system in human biology: cell surface and beyond","volume":"39","author":"Luo","year":"2013","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.clim.2015.07.005_bb0130","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1182\/blood-2005-07-2636","article-title":"Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome","volume":"107","author":"Cesarman-Maus","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.clim.2015.07.005_bb0135","first-page":"A2031","article-title":"Extracellular annexin A2 mediates lung fibroblast cytokine production and proliferation: a potential role in pulmonary fibrosis","volume":"189","author":"Schuliga","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.clim.2015.07.005_bb0140","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/jcb.22529","article-title":"Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis","volume":"110","author":"Zhang","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.clim.2015.07.005_bb0145","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1002\/art.38696","article-title":"The discoidin domain receptor 2\/annexin A2\/matrix metalloproteinase 13 loop promotes joint destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes","volume":"66","author":"Zhao","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.07.005_bb0150","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0092-8674(00)80298-6","article-title":"Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice","volume":"89","author":"Coleman","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.clim.2015.07.005_bb0155","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1128\/IAI.63.9.3491-3496.1995","article-title":"Binding of human plasminogen to Borrelia burgdorferi","volume":"63","author":"Hu","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.clim.2015.07.005_bb0160","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/art.22441","article-title":"High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory Lyme arthritis","volume":"56","author":"Shin","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.07.005_bb0165","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/art.34383","article-title":"Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis","volume":"64","author":"Strle","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.07.005_bb0170","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nm.3085","article-title":"Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis","volume":"19","author":"Nie","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2015.07.005_bb0175","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2389","article-title":"Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease","volume":"17","author":"Dominguez-Villar","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2015.07.005_bb0180","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/art.27468","article-title":"Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis","volume":"62","author":"Shen","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.07.005_bb0185","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/art.37910","article-title":"Dysregulation of CD4+CD25(high) T cells in the synovial fluid of patients with antibiotic-refractory Lyme arthritis","volume":"65","author":"Vudattu","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.07.005_bb0190","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661615300097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661615300097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T07:47:03Z","timestamp":1748504823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661615300097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1521661615300097"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2015.07.005","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2015.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}