{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:01:09Z","timestamp":1770152469215,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"IGA MZ \u010cR NT","award":["13287-4\/2012"],"award-info":[{"award-number":["13287-4\/2012"]}]},{"name":"EU \u2014 Prague","award":["CZ.2.16\/3.1.00\/24022"],"award-info":[{"award-number":["CZ.2.16\/3.1.00\/24022"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.clim.2015.08.013","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T05:54:51Z","timestamp":1441173291000},"page":"144-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Low marginal zone-like B lymphocytes and natural antibodies characterize skewed B-lymphocyte subpopulations in del22q11 DiGeorge patients"],"prefix":"10.1016","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1526-4557","authenticated-orcid":false,"given":"Adam","family":"Klocperk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester","family":"Mejst\u0159\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Kayserov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Kalina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"\u0160ediv\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2015.08.013_bb0005","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1093\/hmg\/2.12.2099","article-title":"Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease","volume":"2","author":"Halford","year":"1993","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.clim.2015.08.013_bb0010","article-title":"Absence of thymus","volume":"289","author":"DiGeorge","year":"1967","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2015.08.013_bb0015","series-title":"Illustrated Pathology of the Spleen","author":"Wilkins","year":"2000"},{"key":"10.1016\/j.clim.2015.08.013_bb0020","first-page":"1","article-title":"Clinical and immunologic spectrum of the DiGeorge syndrome","volume":"6","author":"Barrett","year":"1981","journal-title":"J. Clin. Lab. Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0025","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jaci.2008.03.033","article-title":"Immunologic defects in 22q11.2 deletion syndrome","volume":"122","author":"McLean-Tooke","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0030","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1399-3038.2006.00409.x","article-title":"Humoral immune responses and CD27+ B cells in children with DiGeorge syndrome (22q11.2 deletion syndrome)","volume":"17","author":"Finocchi","year":"2006","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0035","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.clim.2010.04.011","article-title":"Secondary immunologic consequences in chromosome 22q11.2 deletion syndrome (DiGeorge syndrome\/velocardiofacial syndrome)","volume":"136","author":"Zemble","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0040","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2249.2005.02693.x","article-title":"Phenotypic perturbation of B cells in the Wiskott\u2013Aldrich syndrome","volume":"139","author":"Park","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0045","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1172\/JCI3409","article-title":"Absence of IgD-CD27(+) memory B cell population in X-linked hyper-IgM syndrome","volume":"102","author":"Agematsu","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2015.08.013_bb0050","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jpeds.2012.06.018","article-title":"Immunoglobulin deficiencies: the B-lymphocyte side of DiGeorge syndrome","volume":"161","author":"Patel","year":"2012","journal-title":"J. Pediatr."},{"key":"10.1016\/j.clim.2015.08.013_bb0055","first-page":"422","article-title":"Antibody deficiency and autoimmunity in 22q11.2 deletion syndrome","volume":"86","author":"Gennery","year":"2002"},{"key":"10.1016\/j.clim.2015.08.013_bb0060","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/1521-4141(200202)32:2<561::AID-IMMU561>3.0.CO;2-H","article-title":"Reduction of marginal zone B cells in CD22-deficient mice","volume":"32","author":"Samardzic","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0065","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1074-7613(01)00135-2","article-title":"The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21","volume":"14","author":"Cariappa","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.08.013_bb0070","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/ni1075","article-title":"Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo","volume":"5","author":"Hozumi","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0075","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1084\/jem.20071088","article-title":"Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation","volume":"205","author":"Meyer-Bahlburg","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2015.08.013_bb0080","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1084\/jem.192.10.1453","article-title":"BAFF mediates survival of peripheral immature B lymphocytes","volume":"192","author":"Batten","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2015.08.013_bb0085","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1074-7613(01)00183-2","article-title":"TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease: impaired B cell maturation in mice lacking BLyS","volume":"15","author":"Gross","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.08.013_bb0090","first-page":"1313","article-title":"Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases","volume":"44","author":"Cheema","year":"2001"},{"key":"10.1016\/j.clim.2015.08.013_bb0095","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4049\/jimmunol.166.1.6","article-title":"Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus","volume":"166","author":"Zhang","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0100","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.clim.2013.05.007","article-title":"B-cell activating factor (BAFF) is elevated in chronic granulomatous disease","volume":"148","author":"Matharu","year":"2013","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0105","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/1074-7613(94)90095-7","article-title":"The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation","volume":"1","author":"Kawabe","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.08.013_bb0110","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1172\/JCI46125","article-title":"Evidence for a step-wise program of T cell development within the human tonsil","volume":"122","author":"McClory","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2015.08.013_bb0115","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jaci.2003.07.003","article-title":"Lymphocyte subsets in healthy children from birth through 18years of age: the pediatric AIDS clinical trials group P1009 study","volume":"112","author":"Shearer","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0120","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1038\/leu.2012.122","article-title":"EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols","volume":"26","author":"Kalina","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.clim.2015.08.013_bb0125","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/cyto.b.20536","article-title":"B cell subsets in healthy children: reference values for evaluation of B cell maturation process in peripheral blood","volume":"78","author":"Pi\u0105tosa","year":"2010","journal-title":"Cytometry B Clin. Cytom."},{"key":"10.1016\/j.clim.2015.08.013_bb0130","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1067\/mpd.2001.118534","article-title":"Immunologic features of chromosome 22q11.2 deletion syndrome (DiGeorge syndrome\/velocardiofacial syndrome)","volume":"139","author":"Jawad","year":"2001","journal-title":"J. Pediatr."},{"key":"10.1016\/j.clim.2015.08.013_bb0135","first-page":"2326","article-title":"Juvenile idiopathic polyarticular arthritis and IgA deficiency in the 22q11 deletion syndrome","volume":"28","author":"Davies","year":"2001","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.clim.2015.08.013_bb0140","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1136\/jmg.35.11.943","article-title":"Juvenile rheumatoid arthritis and del(22q11) syndrome: a non-random association","volume":"35","author":"Verloes","year":"1998","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.clim.2015.08.013_bb0145","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.clim.2007.04.012","article-title":"High serum levels of BAFF, APRIL and TACI in common variable immunodeficiency","volume":"124","author":"Knight","year":"2007","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0150","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1182\/blood-2011-04-345579","article-title":"Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways","volume":"118","author":"Berkowska","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.clim.2015.08.013_bb0155","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","article-title":"The EUROclass trial: defining subgroups in common variable immunodeficiency","volume":"111","author":"Wehr","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.clim.2015.08.013_bb0160","first-page":"3647","article-title":"Human Blood IgM Memory B Cells are Circulating Splenic Marginal Zone B Cells Harboring a Prediversified Immunoglobulin Repertoire","volume":"104","author":"Weller","year":"2013"},{"key":"10.1016\/j.clim.2015.08.013_bb0165","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nri3383","article-title":"Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes","volume":"13","author":"Cerutti","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2015.08.013_bb0170","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1084\/jem.192.8.1175","article-title":"Nuclear factor kappa B is required for the development of marginal zone B lymphocytes","volume":"192","author":"Cariappa","year":"2000","journal-title":"J. Exp. Med."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661615300292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661615300292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T16:20:32Z","timestamp":1537374032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661615300292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S1521661615300292"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2015.08.013","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low marginal zone-like B lymphocytes and natural antibodies characterize skewed B-lymphocyte subpopulations in del22q11 DiGeorge patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2015.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}