{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:08:26Z","timestamp":1790284106719,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001908","name":"Wasie Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001908","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001068","name":"Dana Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001068","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Child Health Research Program of Stanford University"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR061297"],"award-info":[{"award-number":["R01AR061297"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Becton Dickinson Immunology Grant"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.clim.2015.12.011","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T02:15:23Z","timestamp":1451528123000},"page":"66-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Altered signaling in systemic juvenile idiopathic arthritis monocytes"],"prefix":"10.1016","volume":"163","author":[{"given":"Claudia","family":"Macaubas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoa D.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Milojevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Shenoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Ilowite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Saper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzielan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth D.","family":"Mellins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2015.12.011_bb0005","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nrrheum.2011.68","article-title":"Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions","volume":"7","author":"Mellins","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2015.12.011_bb0010","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrrheum.2009.209","article-title":"Oligoarticular and polyarticular JIA: epidemiology and pathogenesis","volume":"5","author":"Macaubas","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2015.12.011_bb0015","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/art.24601","article-title":"Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis","volume":"60","author":"Barnes","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.12.011_bb0020","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1741-7015-10-125","article-title":"Correlation analyses of clinical and molecular findings identify candidate biological pathways in systemic juvenile idiopathic arthritis","volume":"10","author":"Ling","year":"2012","journal-title":"BMC Med."},{"key":"10.1016\/j.clim.2015.12.011_bb0025","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.0906-6705.2005.00271.x","article-title":"Early activation of cutaneous vessels and epithelial cells is characteristic of acute systemic onset juvenile idiopathic arthritis","volume":"14","author":"Frosch","year":"2005","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.clim.2015.12.011_bb0030","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1002\/art.22981","article-title":"Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome","volume":"56","author":"Fall","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.12.011_bb0035","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.clim.2011.12.008","article-title":"Alternative activation in systemic juvenile idiopathic arthritis monocytes","volume":"142","author":"Macaubas","year":"2012","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0040","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1084\/jem.20050473","article-title":"Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade","volume":"201","author":"Pascual","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2015.12.011_bb0045","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"Martinez","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0050","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/ard.2006.061853","article-title":"Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study","volume":"66","author":"de Jager","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2015.12.011_bb0055","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1002\/art.23437","article-title":"The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis","volume":"58","author":"Gattorno","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.12.011_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020014","article-title":"Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients","volume":"6","author":"Lasiglie","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2015.12.011_bb0065","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/rheumatology\/kes162","article-title":"Th1 and Th17 cell subpopulations are enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis","volume":"51","author":"Omoyinmi","year":"2012","journal-title":"Rheumatology"},{"key":"10.1016\/j.clim.2015.12.011_bb0070","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1002\/art.22644","article-title":"Specific gene expression profiles in systemic juvenile idiopathic arthritis","volume":"56","author":"Ogilvie","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.12.011_bb0075","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/ard.2010.134254","article-title":"A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)","volume":"70","author":"Quartier","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2015.12.011_bb0080","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1136\/ard.2007.079533","article-title":"Abnormal expression of the genes involved in cytokine networks and mitochondrial function in systemic juvenile idiopathic arthritis identified by DNA microarray analysis","volume":"68","author":"Ishikawa","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2015.12.011_bb0085","first-page":"23","article-title":"Interferon system in patients with systemic juvenile chronic arthritis: in vivo and in vitro studies","volume":"54","author":"Bacon","year":"1983","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/ard.43.1.1","article-title":"Infection and interferon production in systemic juvenile chronic arthritis: a prospective study","volume":"43","author":"de Vere-Tyndall","year":"1984","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2015.12.011_bb0095","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.0105-2896.2006.00364.x","article-title":"Phospho-proteomic immune analysis by flow cytometry: from mechanism to translational medicine at the single-cell level","volume":"210","author":"Perez","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.clim.2015.12.011_bb0100","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.clim.2015.12.011_bb0105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.clim.2009.09.010","article-title":"Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states","volume":"134","author":"Macaubas","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0110","first-page":"2322","article-title":"Candidate early predictors for progression to joint damage in systemic juvenile idiopathic arthritis","volume":"33","author":"Sandborg","year":"2006","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.clim.2015.12.011_bb0115","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1128\/JVI.01582-07","article-title":"Single-cell, phosphoepitope-specific analysis demonstrates cell type- and pathway-specific dysregulation of Jak\/STAT and MAPK signaling associated with in vivo human immunodeficiency virus type 1 infection","volume":"82","author":"Lee","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2015.12.011_bb0120","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.4049\/jimmunol.171.5.2374","article-title":"Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor","volume":"171","author":"Hornell","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0125","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.molcel.2009.11.017","article-title":"Evidence that fold-change, and not absolute level, of \u03b2-catenin dictates Wnt signaling","volume":"36","author":"Goentoro","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.clim.2015.12.011_bb0130","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.molcel.2009.11.025","article-title":"Dynamics and variability of ERK2 response to EGF in individual living cells","volume":"36","author":"Cohen-Saidon","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.clim.2015.12.011_bb0135","doi-asserted-by":"crossref","first-page":"9554","DOI":"10.1073\/pnas.1017296108","article-title":"Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate toll-like receptor-induced STAT1 activation","volume":"108","author":"Bhattacharyya","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2015.12.011_bb0140","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1172\/JCI2901","article-title":"Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection","volume":"101","author":"Dorman","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2015.12.011_bb0145","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1002\/art.38699","article-title":"Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritis","volume":"66","author":"Ilowite","year":"2014","journal-title":"Arthritis Rheumatol. (Hoboken, N.J.)"},{"key":"10.1016\/j.clim.2015.12.011_bb0150","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/art.38359","article-title":"Systemic juvenile idiopathic arthritis-like syndrome in mice following stimulation of the immune system with Freund's complete adjuvant: regulation by interferon-gamma","volume":"66","author":"Avau","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.12.011_bb0155","doi-asserted-by":"crossref","first-page":"14978","DOI":"10.1073\/pnas.0809784106","article-title":"Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB","volume":"106","author":"Porta","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2015.12.011_bb0160","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1016\/j.molimm.2008.04.006","article-title":"Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFNgamma response","volume":"45","author":"Parsa","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0165","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.12.011_bb0170","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0092-8674(00)80047-1","article-title":"SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine","volume":"98","author":"Alexander","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.clim.2015.12.011_bb0175","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1128\/IAI.72.3.1257-1264.2004","article-title":"STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection","volume":"72","author":"Gavrilescu","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.clim.2015.12.011_bb0180","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1189\/jlb.1110644","article-title":"Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function","volume":"90","author":"Whyte","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.clim.2015.12.011_bb0185","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.4049\/jimmunol.180.9.6270","article-title":"Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo","volume":"180","author":"Liu","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0190","doi-asserted-by":"crossref","first-page":"e6756","DOI":"10.1371\/journal.pone.0006756","article-title":"Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus","volume":"4","author":"Hale","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2015.12.011_bb0195","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1038\/onc.2009.169","article-title":"SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis","volume":"28","author":"Oh","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.clim.2015.12.011_bb0200","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.clim.2010.04.003","article-title":"Monocytes are resistant to apoptosis in systemic juvenile idiopathic arthritis","volume":"136","author":"Srivastava","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0205","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1189\/jlb.0905503","article-title":"IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells","volume":"79","author":"Strengell","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.clim.2015.12.011_bb0210","doi-asserted-by":"crossref","first-page":"34605","DOI":"10.1074\/jbc.M705100200","article-title":"IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner","volume":"282","author":"Wei","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2015.12.011_bb0215","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ni1496","article-title":"Interleukins 1[beta] and 6 but not transforming growth factor-[beta] are essential for the differentiation of interleukin 17-producing human T helper cells","volume":"8","author":"Acosta-Rodriguez","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0220","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.4049\/jimmunol.180.6.3746","article-title":"Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-\u03b3 on STAT3 and Smads","volume":"180","author":"Tanaka","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0225","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1002\/art.34604","article-title":"The limited role of interferon-\u03b3 in systemic juvenile idiopathic arthritis cannot be explained by cellular hyporesponsiveness","volume":"64","author":"Sikora","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2015.12.011_bb0230","first-page":"89","article-title":"Anakinra restores the defective IL-18 NK cell axis in steroid naive systemic onset JIA patients","volume":"70","author":"De Jager","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2015.12.011_bb0235","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1074-7613(00)00078-9","article-title":"Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1","volume":"13","author":"Diehl","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.12.011_bb0240","doi-asserted-by":"crossref","first-page":"R191","DOI":"10.1186\/ar4381","article-title":"Cytokine signaling-1 suppressor is inducible by IL-1beta and inhibits the catabolic effects of IL-1beta in chondrocytes: its implication in the paradoxical joint-protective role of IL-1beta","volume":"15","author":"Choi","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2015.12.011_bb0245","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.immuni.2011.02.006","article-title":"Type I interferon inhibits interleukin-1 production and inflammasome activation","volume":"34","author":"Guarda","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2015.12.011_bb0250","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/ni.2474","article-title":"Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta","volume":"14","author":"Mishra","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0255","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4049\/jimmunol.175.1.131","article-title":"Homeostatic role of interferons conferred by inhibition of IL-1-mediated inflammation and tissue destruction","volume":"175","author":"Hu","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2015.12.011_bb0260","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1186\/ar2960","article-title":"Interferon-gamma inhibits interleukin-1beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis","volume":"12","author":"Page","year":"2010","journal-title":"Arthritis Res. Ther."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661615300796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661615300796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T08:50:12Z","timestamp":1537087812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661615300796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":52,"alternative-id":["S1521661615300796"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2015.12.011","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered signaling in systemic juvenile idiopathic arthritis monocytes","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2015.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}