{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:45:51Z","timestamp":1788410751823,"version":"build-2803163510"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.clim.2016.01.002","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T12:29:34Z","timestamp":1452688174000},"page":"108-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Next generation sequencing revealed DNA ligase IV deficiency in a \u201cdevelopmentally normal\u201d patient with massive brain Epstein\u2013Barr virus-positive diffuse large B-cell lymphoma"],"prefix":"10.1016","volume":"163","author":[{"given":"Svetlana O.","family":"Sharapova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Yenhui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina E.","family":"Guryanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna V.","family":"Proleskovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina S.","family":"Fedorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena A.","family":"Rutskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga V.","family":"Aleinikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2016.01.002_bb0005","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399410001419","article-title":"Primary immunodeficiencies associated with DNA-repair disorders","volume":"12","author":"Slatter","year":"2010","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.clim.2016.01.002_bb0010","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-1-4419-6448-9_16","article-title":"Ligase IV syndrome","volume":"685","author":"Chistiakov","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.clim.2016.01.002_bb0015","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.blre.2008.03.009","article-title":"Immunodeficiency-associated lymphomas","volume":"22","author":"Tran","year":"2008","journal-title":"Blood Rev."},{"key":"10.1016\/j.clim.2016.01.002_bb0020","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/humu.22461","article-title":"Extreme growth failure is a common presentation of ligase IV deficiency","volume":"35","author":"Murray","year":"2014","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.clim.2016.01.002_bb0025","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/humu.22436","article-title":"Clinical spectrum of LIG4 deficiency is broadened with severe dysmaturity, primordial dwarfism, and neurological abnormalities","volume":"34","author":"Jspeert","year":"2013","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.clim.2016.01.002_bb0030","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/ajmg.a.31644","article-title":"Epstein\u2013Barr virus-associated B-cell lymphoma in a patient with DNA ligase IV (LIG4) syndrome","volume":"143A","author":"Toita","year":"2007","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.clim.2016.01.002_bb0035","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jaci.2012.10.027","article-title":"Epstein\u2013Barr virus-independent diffuse large B cell lymphoma in DNA ligase 4 deficiency","volume":"131","author":"Bacon","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2016.01.002_bb0040","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3324\/haematol.2014.113456","article-title":"Genomic analysisof bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity","volume":"100","author":"Zhang","year":"2015","journal-title":"Haematologica"},{"key":"10.1016\/j.clim.2016.01.002_bb0045","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0960-9822(99)80311-X","article-title":"Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient","volume":"9","author":"Riballo","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.clim.2016.01.002_bb0050","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.clim.2015.07.004","article-title":"Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly-progressing radiosensitive severe combined immunodeficiency","volume":"160","author":"Tamura","year":"2015","journal-title":"Clin. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152166161630002X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152166161630002X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T02:29:20Z","timestamp":1537064960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152166161630002X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":10,"alternative-id":["S152166161630002X"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2016.01.002","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Next generation sequencing revealed DNA ligase IV deficiency in a \u201cdevelopmentally normal\u201d patient with massive brain Epstein\u2013Barr virus-positive diffuse large B-cell lymphoma","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2016.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}