{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:34:14Z","timestamp":1792056854438,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T00:00:00Z","timestamp":1494374400000},"content-version":"am","delay-in-days":313,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000072","name":"NATIONAL INSTITUTE OF DENTAL CRANIOFACIAL RESEARCH","doi-asserted-by":"publisher","award":["1R21DE021801-01A1"],"award-info":[{"award-number":["1R21DE021801-01A1"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"NATIONAL INSTITUTE OF DENTAL CRANIOFACIAL RESEARCH","doi-asserted-by":"publisher","award":["NSFC-81272623"],"award-info":[{"award-number":["NSFC-81272623"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.clim.2016.04.008","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T13:14:33Z","timestamp":1462108473000},"page":"30-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Central role for marginal zone B cells in an animal model of Sjogren's syndrome"],"prefix":"10.1016","volume":"168","author":[{"given":"Long","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmanan","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee D.","family":"Chaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Julian L.","family":"Ambrus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2016.04.008_bb0005","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00005792-200207000-00003","article-title":"Primary Sjogren syndrome \u2014 clinical and immunologic disease patterns in a cohort of 400 patients","volume":"81","author":"Garcia Carrasco","year":"2002","journal-title":"Medicine"},{"key":"10.1016\/j.clim.2016.04.008_bb0010","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sjogren's syndrome","volume":"366","author":"Fox","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2016.04.008_bb0015","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.2741\/2219","article-title":"Role of B cells in Sjogren's syndrome \u2014 from benign lymphoproliferation to overt malignancy","volume":"12","author":"Jonsson","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.clim.2016.04.008_bb0020","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1586\/1744666X.2014.891439","article-title":"B-cell hyperactivity in primary Sjogren's syndrome","volume":"10","author":"Kroese","year":"2014","journal-title":"Expert. Rev. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0025","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/odi.12153","article-title":"Are the B cells cast with the leading part in the Sjogren's syndrome scenario?","volume":"20","author":"Pers","year":"2014","journal-title":"Oral Dis."},{"key":"10.1016\/j.clim.2016.04.008_bb0030","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1002\/art.21936","article-title":"Identification of transitional type IIB cells in the salivary glands of patients with Sjogren's syndrome","volume":"54","author":"Daridon","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2016.04.008_bb0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2249.2011.04460.x","article-title":"Translational mini-review series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjogren's syndrome: clinical implications and effects of B cell-targeted therapies","volume":"167","author":"Vossenkamper","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0040","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1002\/eji.200636270","article-title":"Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells","volume":"36","author":"Fletcher","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0045","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.clim.2008.10.006","article-title":"IL-14alpha, the nexus for primary Sjogren's disease in mice and humans","volume":"130","author":"Shen","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0050","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.4049\/jimmunol.1001520","article-title":"A role for lymphotoxin in primary Sjogren's disease","volume":"185","author":"Shen","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0055","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.clim.2012.09.013","article-title":"Novel autoantibodies in Sjogren's syndrome","volume":"145","author":"Shen","year":"2012","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0060","doi-asserted-by":"crossref","first-page":"608","DOI":"10.4049\/jimmunol.1203440","article-title":"Different stages of primary Sjogren's syndrome involving lymphotoxin and type 1 IFN","volume":"191","author":"Shen","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0065","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/ni793","article-title":"Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells","volume":"3","author":"Tanigaki","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0070","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/1074-7613(95)90114-0","article-title":"Defective B cell development and function in btk-deficient mice","volume":"3","author":"Khan","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2016.04.008_bb0075","doi-asserted-by":"crossref","unstructured":"Shen, L., C. Zhang, T. Wang, S. Brooks, R. J. Ford, Y. C. Lin-Lee, A. Kasianowicz, V. Kumar, L. Martin, P. Liang, J. Cowell, and J. Ambrus, JL. 2006. Development of autoimmunity in interleukin-14alpha transgenic mice. J. Immunol. 177: 5676\u20135686.","DOI":"10.4049\/jimmunol.177.8.5676"},{"key":"10.1016\/j.clim.2016.04.008_bb0080","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.4049\/jimmunol.1001520","article-title":"A role for lymphotoxin in primary Sjogren's disease","volume":"185","author":"Shen","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0085","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/ni1453","article-title":"Regulation of lymphocyte development by notch signaling","volume":"8","author":"Tanigaki","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0090","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6831-13-51","article-title":"Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren's syndrome","volume":"13","author":"Xuan","year":"2013","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.clim.2016.04.008_bb0095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev.immunol.23.021704.115728","article-title":"Marginal zone B cells","volume":"23","author":"Pillai","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0100","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/BOR.0b013e3283025ed4","article-title":"The role of innate immunity in autoimmune tissue injury","volume":"20","author":"Allam","year":"2008","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.clim.2016.04.008_bb0105","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nri2787","article-title":"Immune cell crosstalk in type 1 diabetes","volume":"10","author":"Lehuen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0110","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/BOR.0b013e32832eba21","article-title":"Pathogenesis of Sjogren's syndrome","volume":"21","author":"Nikolov","year":"2009","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.clim.2016.04.008_bb0115","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1586\/1744666X.2014.883920","article-title":"The value of animal models to study immunopathology of primary human Sjogren's syndrome symptoms","volume":"10","author":"Donate","year":"2014","journal-title":"Expert. Rev. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0120","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.4049\/jimmunol.1002059","article-title":"CR2(+) marginal zone B cell production of pathogenic natural antibodies is C3 independent","volume":"186","author":"Woods","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0125","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.4049\/jimmunol.1002106","article-title":"Marginal zone B cells regulate antigen capture by marginal zone macrophages","volume":"186","author":"You","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0130","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.immunol.021908.132607","article-title":"Human marginal zone B cells","volume":"27","author":"Weill","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0135","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1182\/blood-2004-01-0346","article-title":"Human blood IgM \u201cmemory\u201d B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire","volume":"104","author":"Weller","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.clim.2016.04.008_bb0140","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S1074-7613(01)00251-5","article-title":"Editors and editing of anti-DNA receptors","volume":"15","author":"Li","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2016.04.008_bb0145","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.4049\/jimmunol.0803588","article-title":"Ectopic germinal centers are rare in Sjogren's syndrome salivary glands and do not exclude autoreactive B cells","volume":"182","author":"Le Pottier","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0150","doi-asserted-by":"crossref","first-page":"803","DOI":"10.4049\/jimmunol.172.2.803","article-title":"Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells","volume":"172","author":"Attanavanich","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0155","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1002\/art.23487","article-title":"Regulatory B lymphocytes in humans \u2014 a potential role in autoimmunity","volume":"58","author":"Jamin","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2016.04.008_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.rdc.2008.08.014","article-title":"Therapeutic potential for B-cell modulation in Sjogren's syndrome","volume":"34","author":"Mariette","year":"2008","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"10.1016\/j.clim.2016.04.008_bb0165","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12016-007-8000-y","article-title":"A conspicuous role for B cells in Sjogren's syndrome","volume":"32","author":"Youinou","year":"2007","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.clim.2016.04.008_bb0170","series-title":"Contemporary Challenges in Autoimmunity","first-page":"701","article-title":"Rituximab therapy in primary Sjogren's syndrome","author":"Alcantara","year":"2009"},{"key":"10.1016\/j.clim.2016.04.008_bb0175","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1002\/art.21260","article-title":"Rituximab treatment in patients with primary Sjogren's syndrome","volume":"52","author":"Pijpe","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2016.04.008_bb0180","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1084\/jem.190.11.1697","article-title":"Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations","volume":"190","author":"Mackay","year":"1999","journal-title":"J. Exp. Med."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616300675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616300675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T17:42:44Z","timestamp":1690047764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661616300675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":36,"alternative-id":["S1521661616300675"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2016.04.008","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Central role for marginal zone B cells in an animal model of Sjogren's syndrome","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2016.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}