{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:47:02Z","timestamp":1780418822996,"version":"3.54.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.clim.2016.07.001","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T04:25:12Z","timestamp":1467779112000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Chemokine, cytokine and type I interferon production induced by Toll-like receptor activation in common variable immune deficiency"],"prefix":"10.1016","volume":"169","author":[{"given":"Camila de","family":"Lollo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewton","family":"de Moraes Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luanda Mara da Silva","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana","family":"Domingues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Costa de","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Jos\u00e9 da Silva","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Notomi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2016.07.001_bb0005","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0010","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.4049\/jimmunol.165.8.4725","article-title":"Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency","volume":"165","author":"Bonhomme","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0015","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1023\/A:1012241117984","article-title":"Physiology of IgA and IgA deficiency","volume":"21","author":"Cunningham-Rundles","year":"2001","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0020","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1182\/blood-2004-04-1325","article-title":"Common variable immunodeficiency is associated with defective functions of dendritic cells","volume":"104","author":"Bayry","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.clim.2016.07.001_bb0025","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1365-2249.2012.04655.x","article-title":"Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia","volume":"170","author":"Litzman","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0030","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1084\/jem.20140039","article-title":"Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders","volume":"211","author":"Perreau","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2016.07.001_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075199","article-title":"IVIg immune reconstitution treatment alleviates the state of persistent immune activation and suppressed CD4 T cell counts in CVID","volume":"8","author":"Paquin-Proulx","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2016.07.001_bb0040","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.2174\/138161206778743484","article-title":"\u2018Toll\u2019 gates for future immunotherapy","volume":"12","author":"Ishii","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.clim.2016.07.001_bb0045","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nri2215","article-title":"How dying cells alert the immune system to danger","volume":"8","author":"Kono","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxh186","article-title":"Toll-like receptors in innate immunity","volume":"17","author":"Takeda","year":"2005","journal-title":"Int. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0055","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0060","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/s00109-006-0084-y","article-title":"Toll-like receptors and innate immunity","volume":"84","author":"Uematsu","year":"2006","journal-title":"J. Mol. Med. (Berlin)"},{"key":"10.1016\/j.clim.2016.07.001_bb0065","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0070","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1126\/science.1093620","article-title":"Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8","volume":"303","author":"Heil","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.clim.2016.07.001_bb0075","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1073\/pnas.0400937101","article-title":"Recognition of single-stranded RNA viruses by Toll-like receptor 7","volume":"101","author":"Lund","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2016.07.001_bb0080","first-page":"207","article-title":"Quantitative and functional evaluation of innate immune responses in patients with common variable immunodeficiency","volume":"21","author":"Trujillo","year":"2011","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0085","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaci.2009.05.019","article-title":"Toll-like receptor 7 and 9 defects in common variable immunodeficiency","volume":"124","author":"Yu","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cellimm.2010.01.002","article-title":"Defective B cell response to TLR9 ligand (CpG-ODN), Streptococcus pneumoniae and Haemophilus influenzae extracts in common variable immunodeficiency patients","volume":"262","author":"Escobar","year":"2010","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/nyas.12763","article-title":"Toll-like receptor signaling in primary immune deficiencies","volume":"1356","author":"Maglione","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.clim.2016.07.001_bb0100","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1073\/pnas.96.12.6873","article-title":"CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions","volume":"96","author":"Balashov","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2016.07.001_bb0105","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1182\/blood.V99.9.3119","article-title":"Increased expression of the inflammatory chemokine CXC chemokine ligand 9\/monokine induced by interferon-gamma in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome","volume":"99","author":"Reinhart","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.clim.2016.07.001_bb0110","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2249.2011.04488.x","article-title":"Discrimination of agonist and antagonist forms of CXCL10 in biological samples","volume":"167","author":"Casrouge","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0115","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies. Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies)","volume":"93","author":"Conley","year":"1999","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0120","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","article-title":"Clinical picture and treatment of 2212 patients with common variable immunodeficiency","volume":"134","author":"Gathmann","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0125","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s10875-014-0099-z","article-title":"Altered serum cytokine signature in common variable immunodeficiency","volume":"34","author":"Hel","year":"2014","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0130","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.rmed.2003.10.012","article-title":"In vitro study of regulation of IL-6 production in bronchiectasis","volume":"98","author":"Ho","year":"2004","journal-title":"Respir. Med."},{"key":"10.1016\/j.clim.2016.07.001_bb0135","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1006\/cbir.1993.1106","article-title":"In patients with common variable immunodeficiency, interleukin-6 and expression of its receptor on B-cells are normal","volume":"17","author":"Junker","year":"1993","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.clim.2016.07.001_bb0140","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-3083.2006.01753.x","article-title":"Costimulatory molecules and cytokine production by T lymphocytes in common variable immunodeficiency disease","volume":"63","author":"Pons","year":"2006","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0145","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0091-6749(05)80207-6","article-title":"Elevated serum interleukin-6 associated with a failure in B cell differentiation in common variable immunodeficiency","volume":"86","author":"Adelman","year":"1990","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0150","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1365-2249.1993.tb03386.x","article-title":"Increased IL-6 gene expression and production in patients with common variable immunodeficiency","volume":"92","author":"Pandolfi","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0155","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/clin.1994.1032","article-title":"Elevated serum levels of interleukin-4 and interleukin-6 in patients with common variable immunodeficiency (CVI) are associated with chronic immune activation and low numbers of CD4+ lymphocytes","volume":"70","author":"Aukrust","year":"1994","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.clim.2016.07.001_bb0160","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2165\/00063030-200519010-00007","article-title":"Modulating effects of intravenous immunoglobulins on serum cytokine levels in patients with primary hypogammaglobulinemia","volume":"19","author":"Ibanez","year":"2005","journal-title":"BioDrugs"},{"key":"10.1016\/j.clim.2016.07.001_bb0165","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3109\/00365513.2013.819523","article-title":"Lung disease, T-cells and inflammation in common variable immunodeficiency disorders","volume":"73","author":"Gregersen","year":"2013","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.clim.2016.07.001_bb0170","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.4049\/jimmunol.174.8.5074","article-title":"Bone marrow clonogenic capability, cytokine production, and thymic output in patients with common variable immunodeficiency","volume":"174","author":"Isgr\u00f2","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0175","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1182\/blood.V87.2.674.bloodjournal872674","article-title":"Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency\u2013possible immunologic and clinical consequences","volume":"87","author":"Aukrust","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.clim.2016.07.001_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000210374","article-title":"Cytokine gene polymorphisms in common variable immunodeficiency","volume":"150","author":"Rezaei","year":"2009","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067036","article-title":"TLR7\/TLR8 activation restores defective cytokine secretion by myeloid dendritic cells but not by plasmacytoid dendritic cells in HIV-infected pregnant women and newborns","volume":"8","author":"Cardoso","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2016.07.001_bb0195","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/bjd.13214","article-title":"The dysfunctional innate immune response triggered by Toll-like receptor activation is restored by TLR7\/TLR8 and TLR9 ligands in cutaneous lichen planus","volume":"172","author":"Domingues","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.clim.2016.07.001_bb0200","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1177\/1753425912443903","article-title":"The role of microRNAs miR-200b and miR-200c in TLR4 signaling and NF-kappaB activation","volume":"18","author":"Wendlandt","year":"2012","journal-title":"Innate Immun."},{"key":"10.1016\/j.clim.2016.07.001_bb0205","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1189\/jlb.1209775","article-title":"Endogenous ligands of TLR2 and TLR4: agonists or assistants?","volume":"87","author":"Erridge","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.clim.2016.07.001_bb0210","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.4049\/jimmunol.1501684","article-title":"Sex differences in plasmacytoid dendritic cell levels of IRF5 drive higher IFN-alpha production in women","volume":"195","author":"Griesbeck","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0215","article-title":"Interferon signature in the blood in inflammatory common variable immune deficiency","volume":"8","author":"Park","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2016.07.001_bb0220","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1182\/blood-2008-04-151712","article-title":"Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology","volume":"113","author":"Baenziger","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.clim.2016.07.001_bb0225","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s10875-011-9602-y","article-title":"TLR-mediated B cell defects and IFN-\u03b1 in common variable immunodeficiency","volume":"32","author":"Yu","year":"2012","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0230","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.4049\/jimmunol.176.3.1978","article-title":"TLR9 activation is defective in common variable immune deficiency","volume":"176","author":"Cunningham-Rundles","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0235","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s10875-011-9602-y","article-title":"TLR-mediated B cell defects and IFN-alpha in common variable immunodeficiency","volume":"32","author":"Yu","year":"2012","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.07.001_bb0240","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/cei.12239","article-title":"Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9","volume":"175","author":"Taraldsrud","year":"2014","journal-title":"Clin. Exp. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616301486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616301486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T13:30:14Z","timestamp":1600867814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661616301486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":47,"alternative-id":["S1521661616301486"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2016.07.001","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemokine, cytokine and type I interferon production induced by Toll-like receptor activation in common variable immune deficiency","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2016.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}