{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:47:01Z","timestamp":1777355221195,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.clim.2016.08.002","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T20:15:21Z","timestamp":1479932121000},"page":"39-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Novel mutation in DOCK8-HIES with severe phenotype and successful transplantation"],"prefix":"10.1016","volume":"178","author":[{"given":"Latifa","family":"Al Shekaili","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farrukh","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulaiman","family":"Al Gazlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Al Dhekri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamoud","family":"Al Mousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz","family":"Al Ghonaium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bander","family":"Al Saud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh","family":"Al Mohsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agha M","family":"Rehan Khaliq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safiah","family":"Al Sumayli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mufarreh","family":"Al Zahrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas","family":"Dababo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ammar","family":"AlKawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Hawwari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rand","family":"Arnaout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7445","key":"10.1016\/j.clim.2016.08.002_bb0005","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0140-6736(66)90119-X","article-title":"Job's syndrome: recurrent, \u201ccold\u201d, staphylococcal abscesses","volume":"287","author":"Davis","year":"1966","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.clim.2016.08.002_bb0010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/2229-5178.126038","article-title":"Hyper IgE syndrome","volume":"5","author":"Dang","year":"2014","journal-title":"Indian Dermatol. Online J."},{"issue":"5","key":"10.1016\/j.clim.2016.08.002_bb0015","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.jaci.2014.02.013","article-title":"Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment","volume":"133","author":"Zhang","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.clim.2016.08.002_bb0020","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10875-014-9988-4","article-title":"Variable clinical expressivity of STAT3 mutation in hyperimmunoglobulin E syndrome: genetic and clinical studies of six patients","volume":"34","author":"Wolach","year":"2014","journal-title":"J. Clin. Immunol."},{"issue":"16","key":"10.1016\/j.clim.2016.08.002_bb0025","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJMoa073687","article-title":"STAT3 mutations in the hyper-IgE syndrome","volume":"357","author":"Holland","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.clim.2016.08.002_bb0030","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.jaci.2009.10.038","article-title":"Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome","volume":"124","author":"Engelhardt","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.clim.2016.08.002_bb0035","doi-asserted-by":"crossref","DOI":"10.4161\/jkst.23435","article-title":"STAT3 and the Hyper-IgE syndrome: clinical presentation, genetic origin, pathogenesis, novel findings and remaining uncertainties","volume":"2","author":"Mogensen","year":"2013","journal-title":"Jak-Stat."},{"issue":"1","key":"10.1016\/j.clim.2016.08.002_bb0040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10875-012-9769-x","article-title":"Clinical, immunological and molecular characterization of DOCK8 and DOCK8-like deficient patients: single center experience of twenty five patients","volume":"33","author":"Alsum","year":"2013","journal-title":"J. Clin. Immunol."},{"issue":"2","key":"10.1016\/j.clim.2016.08.002_bb0045","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ygeno.2007.10.011","article-title":"Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities","volume":"91","author":"Griggs","year":"2008","journal-title":"Genomics"},{"issue":"1\u20133","key":"10.1016\/j.clim.2016.08.002_bb0050","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.febslet.2004.06.095","article-title":"Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology","volume":"572","author":"Ruusala","year":"2004","journal-title":"FEBS Lett."},{"issue":"12","key":"10.1016\/j.clim.2016.08.002_bb0055","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1002\/eji.201141759","article-title":"DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory","volume":"41","author":"Lambe","year":"2011","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"10.1016\/j.clim.2016.08.002_bb0060","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3109\/15513819509027028","article-title":"Adrenal gland leiomyoma in a child with acquired immunodeficiency syndrome","volume":"15","author":"Jimenez-Heffernan","year":"1995","journal-title":"Pediatr. Pathol. Lab. Med."},{"issue":"3","key":"10.1016\/j.clim.2016.08.002_bb0065","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00203522","article-title":"Leiomyoma of the adrenal gland in a patient with AIDS","volume":"19","author":"Dahan","year":"1994","journal-title":"Abdom. Imaging"},{"issue":"3","key":"10.1016\/j.clim.2016.08.002_bb0070","first-page":"345","article-title":"Laparoscopic management of an adrenal leiomyoma in an AIDS patient: a case report and review of the literature","volume":"9","author":"Gibbs","year":"2005","journal-title":"J. Soc. Laparoendosc. Surg."},{"issue":"3","key":"10.1016\/j.clim.2016.08.002_bb0075","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/00002030-199603000-00016","article-title":"Symptomatic leiomyoma of the adrenal gland in a woman with AIDS","volume":"10","author":"Parola","year":"1996","journal-title":"AIDS"},{"issue":"5","key":"10.1016\/j.clim.2016.08.002_bb0080","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s002470050611","article-title":"Bilateral smooth-muscle tumors of the adrenals in a child with AIDS","volume":"29","author":"Rosenfeld","year":"1999","journal-title":"Pediatr. Radiol."},{"issue":"3","key":"10.1016\/j.clim.2016.08.002_bb0085","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2214\/ajr.159.3.1503021","article-title":"Multiple smooth-muscle tumors of the colon and adrenal gland in an adult with AIDS","volume":"159","author":"Radin","year":"1992","journal-title":"AJR Am. J. Roentgenol."},{"issue":"4","key":"10.1016\/j.clim.2016.08.002_bb0090","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12022-008-9013-7","article-title":"Leiomyoma of the adrenal gland presenting as a non-functioning adrenal incidentaloma: case report and review of the literature","volume":"18","author":"Lin","year":"2007","journal-title":"Endocr. Pathol."},{"issue":"5","key":"10.1016\/j.clim.2016.08.002_bb0095","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1055\/s-2001-19119","article-title":"Progressive multifocal leukoencephalopathy in a child with hyperimmunoglobulin E recurrent infection syndrome and review of the literature","volume":"32","author":"Angelini","year":"2001","journal-title":"Neuropediatrics"},{"issue":"12","key":"10.1016\/j.clim.2016.08.002_bb0100","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1080\/10428190400004463","article-title":"Non-Hodgkin's lymphoma in Job's syndrome: a case report and literature review","volume":"45","author":"Leonard","year":"2004","journal-title":"Leuk. Lymphoma"},{"issue":"6","key":"10.1016\/j.clim.2016.08.002_bb0105","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s10875-010-9452-z","article-title":"Diffuse large B cell lymphoma in hyper-IgE syndrome due to STAT3 mutation","volume":"30","author":"Kum\u00e1novics","year":"2010","journal-title":"J. Clin. Immunol."},{"issue":"9","key":"10.1016\/j.clim.2016.08.002_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2010.01.024","article-title":"Diffuse large B-cell lymphoma in a patient with hyper-IgE syndrome: successful treatment with risk-adapted rituximab-based immunochemotherapy","volume":"34","author":"Belada","year":"2010","journal-title":"Leuk. Res."},{"issue":"3","key":"10.1016\/j.clim.2016.08.002_bb0115","first-page":"501","article-title":"Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25. 3 in hepatocellular carcinoma","volume":"10","author":"Saelee","year":"2009","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"2","key":"10.1016\/j.clim.2016.08.002_bb0120","first-page":"321","article-title":"Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer","volume":"28","author":"Takahashi","year":"2006","journal-title":"Int. J. Oncol."},{"issue":"11","key":"10.1016\/j.clim.2016.08.002_bb0125","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/gcc.20485","article-title":"Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution","volume":"46","author":"Nagayama","year":"2007","journal-title":"Genes Chromosom. Cancer"},{"issue":"6","key":"10.1016\/j.clim.2016.08.002_bb0130","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.jaci.2009.10.022","article-title":"Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management","volume":"124","author":"Griffith","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.clim.2016.08.002_bb0135","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.jaci.2011.02.047","article-title":"Primary immunodeficiency diseases associated with increased susceptibility to viral infections and malignancies","volume":"127","author":"Rezaei","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2016.08.002_bb0140","first-page":"112","article-title":"Resolution of food-induced anaphylaxis in DOCK8-deficient patients following bone marrow transplantation","volume":"57","author":"Azik","year":"2015","journal-title":"Turk. J. Pediatr."},{"issue":"4","key":"10.1016\/j.clim.2016.08.002_bb0145","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1399-3046.2011.01641.x","article-title":"Successful bone marrow transplantation for DOCK8 deficient hyper IgE syndrome","volume":"16","author":"Metin","year":"2012","journal-title":"Pediatr. Transplant."},{"issue":"6","key":"10.1016\/j.clim.2016.08.002_bb0150","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-0030-1265135","article-title":"Successful long-term correction of autosomal recessive hyper-IgE syndrome due to DOCK8 deficiency by hematopoietic stem cell transplantation","volume":"222","author":"Bittner","year":"2010","journal-title":"Klin. Padiatr."},{"issue":"7","key":"10.1016\/j.clim.2016.08.002_bb0155","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3109\/08880018.2012.714844","article-title":"Clinical and immunological correction of DOCK8 deficiency by allogeneic hematopoietic stem cell transplantation following a reduced toxicity conditioning regimen","volume":"29","author":"Boztug","year":"2012","journal-title":"Pediatr. Hematol. Oncol."},{"issue":"4","key":"10.1016\/j.clim.2016.08.002_bb0160","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/bmt.2010.169","article-title":"Curative treatment of autosomal-recessive hyper-IgE syndrome by hematopoietic cell transplantation","volume":"46","author":"Gatz","year":"2011","journal-title":"Bone Marrow Transplant."},{"issue":"2","key":"10.1016\/j.clim.2016.08.002_bb0165","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jaci.2011.03.025","article-title":"Successful allogeneic hematopoietic stem cell transplantation for DOCK8 deficiency","volume":"128","author":"Barlogis","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.clim.2016.08.002_bb0170","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1399-3046.2011.01641.x","article-title":"Successful bone marrow transplantation for DOCK8 deficient hyper IgE syndrome","volume":"16","author":"Metin","year":"2012","journal-title":"Pediatr. Transplant."},{"issue":"6","key":"10.1016\/j.clim.2016.08.002_bb0175","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.jaci.2010.07.034","article-title":"Successful engraftment of donor marrow following allogeneic hematopoietic cell transplantation in autosomal recessive Hyper IgE syndrome due to DOCK8 deficiency","volume":"126","author":"McDonald","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.clim.2016.08.002_bb0180","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.jaci.2012.12.663","article-title":"In DOCK8 deficiency donor cell engraftment post-genoidentical hematopoietic stem cell transplantation is possible without conditioning","volume":"131","author":"Al-Mousa","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.clim.2016.08.002_bb0185","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.clim.2012.10.003","article-title":"Treosulfan-based conditioning in DOCK8 deficiency: complete lympho-hematopoietic reconstitution with minimal toxicity","volume":"145","author":"Ghosh","year":"2012","journal-title":"Clin. Immunol. (Orlando, Fla)"},{"issue":"3","key":"10.1016\/j.clim.2016.08.002_bb0190","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1086\/302547","article-title":"Genetic linkage of hyper-IgE syndrome to chromosome 4","volume":"65","author":"Grimbacher","year":"1999","journal-title":"Am. J. Hum. Genet."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616302583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616302583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T12:50:41Z","timestamp":1536238241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661616302583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":38,"alternative-id":["S1521661616302583"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2016.08.002","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel mutation in DOCK8-HIES with severe phenotype and successful transplantation","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2016.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}