{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:46:32Z","timestamp":1781603192571,"version":"3.54.5"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.clim.2016.09.009","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T19:52:01Z","timestamp":1474487521000},"page":"124-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Impaired Akt phosphorylation in B-cells of patients with common variable immunodeficiency"],"prefix":"10.1016","volume":"175","author":[{"given":"Reza","family":"Yazdani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazdak","family":"Ganjalikhani-Hakemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Esmaeili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Abolhassani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Vaeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohre","family":"Sharifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asghar","family":"Aghamohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2016.09.009_bb0005","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0010","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1128\/CDLI.12.7.825-832.2005","article-title":"Clinical and immunological features of 65 Iranian patients with common variable immunodeficiency","volume":"12","author":"Aghamohammadi","year":"2005","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0015","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10875-006-9047-x","article-title":"Frequency and clinical manifestations of patients with primary immunodeficiency disorders in Iran: update from the Iranian primary immunodeficiency registry","volume":"26","author":"Rezaei","year":"2006","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0020","first-page":"372","article-title":"Correlation between common variable immunodeficiency clinical phenotypes and parental consanguinity in children and adults","volume":"20","author":"Aghamohammadi","year":"2010","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0025","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1046\/j.1365-2249.2002.02004.x","article-title":"Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study","volume":"130","author":"Mellemkjaer","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0030","first-page":"323","article-title":"Autoimmune phenotype in patients with common variable immunodeficiency","volume":"23","author":"Abolhassani","year":"2013","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.18176\/jiaci.0062","article-title":"Asthma and allergic diseases in a selected group of patients with common variable immunodeficiency","volume":"26","author":"Yazdani","year":"2016","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1182\/blood-2010-01-254417","article-title":"How I treat common variable immune deficiency","volume":"116","author":"Cunningham-Rundles","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.clim.2016.09.009_bb0045","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jaip.2013.09.015","article-title":"The variable in common variable immunodeficiency: a disease of complex phenotypes","volume":"1","author":"Jolles","year":"2013","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.clim.2016.09.009_bb0050","first-page":"449","article-title":"T-helper 1 and 2 cytokine assay in patients with common variable immunodeficiency","volume":"18","author":"Rezaei","year":"2008","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0055","first-page":"S30","article-title":"Evaluation of the T helper 17 cell specific genes and the innate lymphoid cells counts in the peripheral blood of patients with the common variable immunodeficiency","volume":"19","author":"Ganjalikhani-Hakemi","year":"2014","journal-title":"J. Res. Med. Sci."},{"key":"10.1016\/j.clim.2016.09.009_bb0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s10875-007-9135-6","article-title":"Increased serum levels of soluble CD30 in patients with common variable immunodeficiency and its clinical implications","volume":"28","author":"Rezaei","year":"2008","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0065","first-page":"2","article-title":"Genetic defects and the role of helper T-cells in the pathogenesis of common variable immunodeficiency","volume":"9","author":"Yazdani","year":"2014","journal-title":"Adv. Biomed. Res."},{"key":"10.1016\/j.clim.2016.09.009_bb0070","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12026-012-8318-2","article-title":"Human B cell defects in perspective","volume":"54","author":"Cunningham-Rundles","year":"2012","journal-title":"Immunol. Res."},{"key":"10.1016\/j.clim.2016.09.009_bb0075","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ajhg.2012.04.015","article-title":"Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity","volume":"90","author":"Lopez-Herrera","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clim.2016.09.009_bb0080","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaip.2015.07.025","article-title":"International consensus document (ICON): common variable immunodeficiency disorders","volume":"4","author":"Bonilla","year":"2016","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.clim.2016.09.009_bb0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-065X.2010.00934.x","article-title":"Role of PI3K in the generation and survival of B cells","volume":"237","author":"Werner","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.clim.2016.09.009_bb0090","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.coi.2004.03.014","article-title":"Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling","volume":"16","author":"Fruman","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2012.00228","article-title":"Akt and mTOR in B cell activation and differentiation","volume":"3","author":"Limon","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2012.00256","article-title":"Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies","volume":"3","author":"Puri","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0105","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.it.2006.12.007","article-title":"Antigen receptor signalling: a distinctive role for the p110\u03b4 isoform of PI3K","volume":"28","author":"Okkenhaug","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0110","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1182\/blood-2005-07-3041","article-title":"Key role of the p110\u03b4 isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110\u03b4 function in B cells","volume":"107","author":"Bilancio","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.clim.2016.09.009_bb0115","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1182\/blood-2009-09-241638","article-title":"Akt1 and Akt2 promote peripheral B-cell maturation and survival","volume":"115","author":"Calamito","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.clim.2016.09.009_bb0120","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","article-title":"AKT\/PKB signaling: navigating downstream","volume":"129","author":"Manning","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.clim.2016.09.009_bb0125","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1182\/blood-2003-09-3071","article-title":"Optimal B-cell proliferation requires phosphoinositide 3-kinase\u2013dependent inactivation of FOXO transcription factors","volume":"104","author":"Yusuf","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.clim.2016.09.009_bb0130","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/onc.2008.24","article-title":"FOXOs, cancer and regulation of apoptosis","volume":"27","author":"Fu","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.clim.2016.09.009_bb0135","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies","volume":"93","author":"Conley","year":"1999","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0140","first-page":"69","article-title":"Evaluation of humoral immune function in patients with bronchiectasis","volume":"7","author":"Tabatabaie","year":"2008","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0145","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/08830185.2015.1136306","article-title":"Evaluation of known defective signaling-associated molecules in patients who primarily diagnosed as common variable immunodeficiency","volume":"35","author":"Yazdani","year":"2016","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0150","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","article-title":"The EUROclass trial: defining subgroups in common variable immunodeficiency","volume":"111","author":"Wehr","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.clim.2016.09.009_bb0155","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/cyto.b.20432","article-title":"Flowcytometric phenotyping of common variable immunodeficiency","volume":"74","author":"Warnatz","year":"2008","journal-title":"Cytometry B Clin. Cytom."},{"key":"10.1016\/j.clim.2016.09.009_bb0160","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.4049\/jimmunol.175.8.5498","article-title":"Defined blocks in terminal plasma cell differentiation of common variable immunodeficiency patients","volume":"175","author":"Taubenheim","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0165","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8335","article-title":"Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naive-to-memory B-cell transition","volume":"6","author":"Rodr\u00edguez-Cortez","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2016.09.009_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2015.12.016","article-title":"Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency","volume":"71","author":"Yazdani","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0175","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/cei.12150","article-title":"CD27+ B cells from a subgroup of common variable immunodeficiency patients are less sensitive to apoptosis rescue regardless of interleukin-21 signalling","volume":"174","author":"Clemente","year":"2013","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0180","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2249.1995.tb06630.x","article-title":"B cells from a distinct subset of patients with common variable immunodeficiency (CVID) have increased CD95 (Apo-1\/fas), diminished CD38 expression, and undergo enhanced apoptosis","volume":"102","author":"Saxon","year":"1995","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/cimm.1995.0010","article-title":"B cell lines from a subset of patients with common variable immunodeficiency undergo enhanced apoptosis associated with an increased display of CD95 (Apo-1\/fas), diminished CD38 expression, and decreased IgG and IgA production","volume":"166","author":"Guo","year":"1995","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0190","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1084\/jem.20112533","article-title":"Agammaglobulinemia and absent B lineage cells in a patient lacking the p85\u03b1 subunit of PI3K","volume":"209","author":"Conley","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2016.09.009_bb0195","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1172\/JCI81746","article-title":"A human immunodeficiency caused by mutations in the PIK3R1 gene","volume":"125","author":"Deau","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2016.09.009_bb0200","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.2001.5197","article-title":"Absence of memory B cells in patients with common variable immunodeficiency","volume":"103","author":"Agematsu","year":"2002","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0205","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1744-313X.2006.00627.x","article-title":"Identification of variations in the human phosphoinositide 3-kinase p110\u03b4 gene in children with primary B-cell immunodeficiency of unknown aetiology","volume":"33","author":"Jou","year":"2006","journal-title":"Int. J. Immunogenet."},{"key":"10.1016\/j.clim.2016.09.009_bb0210","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s10875-014-0012-9","article-title":"Mutations in PIK3CD can cause hyper IgM syndrome (HIGM) associated with increased cancer susceptibility","volume":"34","author":"Crank","year":"2014","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0215","doi-asserted-by":"crossref","DOI":"10.1136\/jmedgenet-2015-103690","article-title":"Genes associated with common variable immunodeficiency: one diagnosis to rule them all?","author":"Bogaert","year":"2016","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.clim.2016.09.009_bb0220","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/cei.12706","article-title":"Activating PI3K\u03b4 mutations in a cohort of 669 patients with primary immunodeficiency","volume":"183","author":"Elgizouli","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0225","first-page":"106","article-title":"Akt: versatile mediator of cell survival and beyond","volume":"35","author":"Kim","year":"2002","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.clim.2016.09.009_bb0230","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2016.3634","article-title":"XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC","author":"Qin","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.clim.2016.09.009_bb0235","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10875-015-0141-9","article-title":"X-linked inhibitor of apoptosis protein deficiency: more than an X-linked lymphoproliferative syndrome","volume":"35","author":"Aguilar","year":"2015","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0240","first-page":"27354","article-title":"Negative regulation of the serine\/threonine kinase B-Raf by Akt","volume":"275","author":"Guan","year":"2000","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.clim.2016.09.009_bb0245","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1126\/science.286.5445.1738","article-title":"Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt","volume":"286","author":"Rommel","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.clim.2016.09.009_bb0250","doi-asserted-by":"crossref","DOI":"10.1177\/1759091415602463","article-title":"Crosstalk between MAPK\/ERK and PI3K\/AKT signal pathways during brain ischemia\/reperfusion","volume":"7","author":"Zhou","year":"2015","journal-title":"ASN Neuro"},{"key":"10.1016\/j.clim.2016.09.009_bb0255","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jaci.2014.03.017","article-title":"Dysregulated extracellular signal-regulated kinase signaling associated with impaired B-cell receptor endocytosis in patients with common variable immunodeficiency","volume":"134","author":"Visentini","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0260","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/25147","article-title":"Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway","volume":"396","author":"Yano","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.clim.2016.09.009_bb0265","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0968-0004(99)01383-3","article-title":"The Ca2+\u2212calmodulin-dependent protein kinase cascade","volume":"24","author":"Soderling","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.clim.2016.09.009_bb0270","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.4049\/jimmunol.1000434","article-title":"B cell receptor-mediated calcium signaling is impaired in B lymphocytes of type Ia patients with common variable immunodeficiency","volume":"184","author":"Foerster","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0275","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jaci.2011.10.020","article-title":"Defective calcium signaling and disrupted CD20\u2013B-cell receptor dissociation in patients with common variable immunodeficiency disorders","volume":"129","author":"van de Ven","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40591-015-0041-7","article-title":"Cross talk of the first-line defense TLRs with PI3K\/Akt pathway, in preconditioning therapeutic approach","volume":"3","author":"Pourrajab","year":"2015","journal-title":"Mol. Cell. Ther."},{"key":"10.1016\/j.clim.2016.09.009_bb0285","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaci.2009.05.019","article-title":"Toll-like receptor 7 and 9 defects in common variable immunodeficiency","volume":"124","author":"Joyce","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0290","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.4049\/jimmunol.176.3.1978","article-title":"TLR9 activation is defective in common variable immune deficiency","volume":"176","author":"Cunningham-Rundles","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0295","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cellimm.2010.01.002","article-title":"Defective B cell response to TLR9 ligand (CpG-ODN), Streptococcus pneumoniae and Haemophilus influenzae extracts in common variable immunodeficiency patients","volume":"262","author":"Escobar","year":"2010","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0300","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s10875-011-9602-y","article-title":"TLR-mediated B cell defects and IFN-\u03b1 in common variable immunodeficiency","volume":"32","author":"Joyce","year":"2012","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0305","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1021\/cr000091i","article-title":"Phosphoinositide-regulated kinases and phosphoinositide phosphatases","volume":"101","author":"Leslie","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1016\/j.clim.2016.09.009_bb0310","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature13079","article-title":"Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus","volume":"508","author":"Liu","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.clim.2016.09.009_bb0315","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molcel.2005.03.008","article-title":"PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth","volume":"18","author":"Gao","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.clim.2016.09.009_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2016.07.010","article-title":"Increased PI3K\/Akt activity and deregulated humoral immune response in human PTEN deficiency","author":"Driessen","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2016.09.009_bb0325","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1074\/mcp.M600026-MCP200","article-title":"Interdomain conformational changes in Akt activation revealed by chemical cross-linking and tandem mass spectrometry","volume":"5","author":"Huang","year":"2006","journal-title":"Mol. Cell. Proteomics"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616303990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616303990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T01:30:36Z","timestamp":1601083836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661616303990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":65,"alternative-id":["S1521661616303990"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2016.09.009","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired Akt phosphorylation in B-cells of patients with common variable immunodeficiency","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2016.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}