{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:18:26Z","timestamp":1789615106528,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.clim.2016.11.003","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T03:30:21Z","timestamp":1479094221000},"page":"53-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Cyr61\/CCN1 is involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"174","author":[{"given":"Pinru","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfen","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihua","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2016.11.003_bb0005","doi-asserted-by":"crossref","first-page":"a015354","DOI":"10.1101\/cshperspect.a015354","article-title":"Psoriasis","volume":"4","author":"Di Meglio","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.clim.2016.11.003_bb0010","doi-asserted-by":"crossref","unstructured":"Langley RG, Krueger GG, Griffiths CE. Psoriasis: epidemiology, clinical features, and quality of life. Ann. Rheum. Dis. 2005; 64 Suppl 2:ii18\u201323; discussion ii24\u20135.","DOI":"10.1136\/ard.2004.033217"},{"issue":"Suppl. 1","key":"10.1016\/j.clim.2016.11.003_bb0015","first-page":"40","article-title":"Clinical presentation of psoriasis","volume":"59","author":"Ayala","year":"2007","journal-title":"Reumatismo"},{"key":"10.1016\/j.clim.2016.11.003_bb0020","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1600-0625.2007.00629.x","article-title":"Immunopathogenesis of psoriasis","volume":"16","author":"Sabat","year":"2007","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0025","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nature05663","article-title":"Pathogenesis and therapy of psoriasis","volume":"445","author":"Lowes","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.clim.2016.11.003_bb0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00000372-197900130-00002","article-title":"Evolution, maturation, and regression of lesions of psoriasis","volume":"1","author":"Ragaz","year":"1979","journal-title":"Am. J. Dermatopathol."},{"key":"10.1016\/j.clim.2016.11.003_bb0035","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.clindermatol.2007.08.012","article-title":"Immunopathogenesis and role of T cells in psoriasis","volume":"25","author":"Ghoreschi","year":"2007","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0040","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1358\/dot.1999.35.12.564038","article-title":"The pathophysiological role of cytokines in psoriasis","volume":"35","author":"As adullah","year":"1999","journal-title":"Drugs Today (Barc.)"},{"key":"10.1016\/j.clim.2016.11.003_bb0045","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2613.2009.00669.x","article-title":"Angiogenesis drives psoriasis pathogenesis","volume":"90","author":"Heidenreich","year":"2009","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.clim.2016.11.003_bb0050","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cca.2008.04.005","article-title":"Cytokines and anticytokines in psoriasis","volume":"394","author":"Pietrzak","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.clim.2016.11.003_bb0055","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1155\/MI.2005.273","article-title":"Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity","volume":"2005","author":"Arican","year":"2005","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.clim.2016.11.003_bb0060","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/1523-1747.ep12514689","article-title":"Localization of neutrophil-activating peptide-1\/interleukin-8-immunoreactivity in normal and psoriatic skin","volume":"96","author":"Sticherling","year":"1991","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0065","doi-asserted-by":"crossref","first-page":"908468","DOI":"10.4061\/2011\/908468","article-title":"Recent advances in underlying pathologies provide insight into interleukin-8 expression-mediated inflammation and angiogenesis","volume":"2011","author":"Qazi","year":"2011","journal-title":"Int. J. Inflamm."},{"key":"10.1016\/j.clim.2016.11.003_bb0070","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/107999099313866","article-title":"Regulation of interleukin-8 gene expression","volume":"19","author":"Roebuck","year":"1999","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.clim.2016.11.003_bb0075","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/1523-1747.ep12478128","article-title":"Upper keratinocytes of psoriatic skin lesions express high levels of NAP-1\/IL-8 mRNA in situ","volume":"97","author":"Gillitzer","year":"1991","journal-title":"J Invest Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0080","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/000155599750011606","article-title":"Interleukin-8 plays its role at local level in psoriasis vulgaris","volume":"79","author":"Sticherling","year":"1999","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.clim.2016.11.003_bb0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/1568010043343840","article-title":"Chemokines and chemokine receptors as targets in the therapy of psoriasis","volume":"3","author":"Homey","year":"2004","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"key":"10.1016\/j.clim.2016.11.003_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1067\/mjd.2002.120568","article-title":"The immunologic basis for the treatment of psoriasis with new biologic agents","volume":"46","author":"Kruger","year":"2002","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0095","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/jid.2014.295","article-title":"Immunogenicity of biotherapy used in psoriasis: the science behind the scenes","volume":"135","author":"Jullien","year":"2015","journal-title":"J Invest Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0100","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1128\/MCB.16.4.1326","article-title":"Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion","volume":"16","author":"Kireeva","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.clim.2016.11.003_bb0105","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nrd3599","article-title":"Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets","volume":"10","author":"Jun","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.clim.2016.11.003_bb0110","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1007\/s00018-011-0778-3","article-title":"CCN1\/CYR61: the very model of a modern matricellular protein","volume":"68","author":"Lau","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.clim.2016.11.003_bb0115","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.4049\/jimmunol.1103201","article-title":"Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis","volume":"188","author":"Lin","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2016.11.003_bb0120","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1002\/art.24999","article-title":"A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"60","author":"Zhang","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2016.11.003_bb0125","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1186\/ar4377","article-title":"Cyr61 involved in neutrophil infiltration in joints via inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis","volume":"15","author":"Zhu","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2016.11.003_bb0130","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1074\/jbc.272.4.2396","article-title":"Oct-1 and CCAT\/enhancer-binding protein (C\/EBP) bind to overlapping elements within the interleukin-8 promoter. The role of Oct-1 as a transcriptional repressor","volume":"272","author":"Wu","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2016.11.003_bb0135","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1155\/MI.2005.298","article-title":"Repeated doses of UVR cause minor alteration in cytokine serum levels in humans","volume":"2005","author":"Narbutt","year":"2005","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.clim.2016.11.003_bb0140","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/09629350310001619753","article-title":"Simultaneous measurement of multiple Th1 and Th2 serum cytokines in psoriasis and correlation with disease severity","volume":"12","author":"Jacob","year":"2003","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.clim.2016.11.003_bb0145","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1365-4632.2004.02082.x","article-title":"Serum levels of proinflammatory cytokines in psoriasis patients from Saudi Arabia","volume":"44","author":"Abanmi","year":"2005","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0150","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-0625.2006.00406.x","article-title":"Surfactant protein D in atopic dermatitis and psoriasis","volume":"15","author":"Hohwy","year":"2006","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0155","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1189\/jlb.72.5.847","article-title":"Multiple control of interleukin-8 gene expression","volume":"72","author":"Hoffmann","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.clim.2016.11.003_bb0160","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.biochi.2010.11.010","article-title":"The CCN family: a new class of inflammation modulators?","volume":"93","author":"Kular","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.clim.2016.11.003_bb0165","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/sj.onc.1208238","article-title":"A novel CYR61-triggered \u2018CYR61-alphavbeta3 integrin loop\u2019 regulates breast cancer cell survival and chemosensitivity through activation of ERK1\/ERK2 MAPK signaling pathway","volume":"24","author":"Menendez","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.clim.2016.11.003_bb0170","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1038\/jid.2015.231","article-title":"CCN1, a pro-inflammatory factor, aggravates psoriasis skin lesions by promoting keratinocyte activation","volume":"135","author":"Sun","year":"2015","journal-title":"J Invest Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0175","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1128\/MCB.19.10.6742","article-title":"Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways","volume":"19","author":"Holtmann","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.clim.2016.11.003_bb0180","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.ijporl.2007.06.003","article-title":"Interleukin-8 induction via NF-kappaB, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1\/2 pathways in human peripheral blood mononuclear cells by Alloiococcus otitidis","volume":"71","author":"Harimaya","year":"2007","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.clim.2016.11.003_bb0185","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/jcb.21194","article-title":"Functional properties and intracellular signaling of CCN1\/Cyr61","volume":"100","author":"Chen","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.clim.2016.11.003_bb0190","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-5793(99)01717-2","article-title":"The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha- or IL-1beta-stimulated rheumatoid synovial fibroblasts","volume":"465","author":"Suzuki","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.clim.2016.11.003_bb0195","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/BOR.0b013e3283031c99","article-title":"Psoriasis and metabolic disease: epidemiology and pathophysiology","volume":"20","author":"Azfar","year":"2008","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0200","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1001\/jama.296.14.1735","article-title":"Risk of myocardial infarction in patients with psoriasis","volume":"296","author":"Gelfand","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.clim.2016.11.003_bb0205","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/eurheartj\/ehp567","article-title":"Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the general practice research database","volume":"31","author":"Mehta","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.clim.2016.11.003_bb0210","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1038\/jid.2010.103","article-title":"Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions","volume":"130","author":"Davidovici","year":"2010","journal-title":"J Invest Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0215","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00403-011-1200-6","article-title":"Psoriasis increased the risk of diabetes: a meta-analysis","volume":"304","author":"Cheng","year":"2012","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.clim.2016.11.003_bb0220","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1038\/jid.2012.184","article-title":"Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis","volume":"132","author":"Suarez-Farinas","year":"2012","journal-title":"J Invest Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0225","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-5945-2-12","article-title":"Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy","volume":"2","author":"Breuckmann","year":"2002","journal-title":"BMC Dermatol."},{"key":"10.1016\/j.clim.2016.11.003_bb0230","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/000155599750011606","article-title":"Interleukin-8 plays its role at local level in psoriasis vulgaris","volume":"79","author":"Sticherling","year":"1999","journal-title":"Acta Derm. Venereol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616305927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616305927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T18:14:14Z","timestamp":1692555254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661616305927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":46,"alternative-id":["S1521661616305927"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2016.11.003","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyr61\/CCN1 is involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2016.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}