{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:13:17Z","timestamp":1768882397619,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Myasthenia Gravis Foundation of America Pilot Research","award":["60271"],"award-info":[{"award-number":["60271"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.clim.2017.01.005","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T15:31:35Z","timestamp":1484494295000},"page":"122-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["High-dose BAFF receptor specific mAb-siRNA conjugate generates Fas-expressing B cells in lymph nodes and high-affinity serum autoantibody in a myasthenia mouse model"],"prefix":"10.1016","volume":"176","author":[{"given":"Naazneen","family":"Ibtehaj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruksana","family":"Huda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2017.01.005_bb0005","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1212\/WNL.26.11.1054","article-title":"Antibody to acetylcholine receptor in myasthenia gravis: prevalence, clinical correlates, and diagnostic value","volume":"26","author":"Lindstrom","year":"1976","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.clim.2017.01.005_bb0010","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1515\/revneuro-2014-0021","article-title":"Targeting complement system to treat myasthenia gravis","volume":"25","author":"Huda","year":"2014","journal-title":"Rev. Neurosci."},{"issue":"6","key":"10.1016\/j.clim.2017.01.005_bb0015","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nbt1101","article-title":"Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors","volume":"23","author":"Song","year":"2005","journal-title":"Nat. Biotechnol."},{"issue":"11","key":"10.1016\/j.clim.2017.01.005_bb0020","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.4049\/jimmunol.1403012","article-title":"A new approach for the treatment of arthritis in mice with a novel conjugate of an anti-C5aR1 antibody and C5 small interfering RNA","volume":"194","author":"Mehta","year":"2015","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.clim.2017.01.005_bb0025","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1073\/pnas.0608491104","article-title":"Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1","volume":"104","author":"Peer","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.clim.2017.01.005_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005456","article-title":"Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells","volume":"4","author":"Rauch","year":"2009","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.clim.2017.01.005_bb0035","doi-asserted-by":"crossref","first-page":"807","DOI":"10.4049\/jimmunol.173.2.807","article-title":"B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells","volume":"173","author":"Ng","year":"2004","journal-title":"J. Immunol."},{"issue":"19","key":"10.1016\/j.clim.2017.01.005_bb0040","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1182\/blood-2008-10-183467","article-title":"BAFF-R promotes cell proliferation and survival through interaction with IKK beta and NF-kappa B\/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells","volume":"113","author":"Fu","year":"2009","journal-title":"Blood"},{"issue":"19","key":"10.1016\/j.clim.2017.01.005_bb0045","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/S0960-9822(01)00481-X","article-title":"Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency","volume":"11","author":"Yan","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.clim.2017.01.005_bb0050","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-61779-188-8_8","article-title":"Antibody targeted siRNA delivery","volume":"764","author":"Toloue","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.clim.2017.01.005_bb0055","first-page":"1","article-title":"Experimental autoimmune myasthenia gravis in the mouse","author":"Wu","year":"2013","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.clim.2017.01.005_bb0060","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jaut.2013.01.003","article-title":"Complement C2 siRNA mediated therapy of myasthenia gravis in mice","volume":"42","author":"Huda","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2017.01.005_bb0065","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fimmu.2012.00207","article-title":"The Fas\/CD95 receptor regulates the death of autoreactive B cells and the selection of antigen-specific B cells","volume":"3","author":"Koncz","year":"2012","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.clim.2017.01.005_bb0070","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/jcp.21136","article-title":"Promotion of Fas-mediated apoptosis in type II cells by high doses of hepatocyte growth factor bypasses the mitochondrial requirement","volume":"213","author":"Zhao","year":"2007","journal-title":"J. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.clim.2017.01.005_bb0075","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1128\/MCB.02047-06","article-title":"Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation","volume":"27","author":"Naito","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.clim.2017.01.005_bb0080","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jaut.2011.05.006","article-title":"Complement and cytokine based therapeutic strategies in myasthenia gravis","volume":"37","author":"T\u00fcz\u00fcn","year":"2011","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2017.01.005_bb0085","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jaut.2013.12.016","article-title":"Central role of interferon-beta in thymic events leading to myasthenia gravis","volume":"52","author":"Cufi","year":"2014","journal-title":"J. Autoimmun."},{"issue":"416","key":"10.1016\/j.clim.2017.01.005_bb0090","doi-asserted-by":"crossref","first-page":"pe70","DOI":"10.1126\/stke.4162007pe70","article-title":"Type I interferons as anti-inflammatory mediators","volume":"2007","author":"Benveniste","year":"2007","journal-title":"Sci. STKE"},{"issue":"9","key":"10.1016\/j.clim.2017.01.005_bb0095","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/eji.201343418","article-title":"Peritoneal cavity B-1a cells promote peripheral CD4+ T-cell activation","volume":"43","author":"Margry","year":"2013","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"10.1016\/j.clim.2017.01.005_bb0100","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1002\/art.20254","article-title":"Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG","volume":"50","author":"L\u00f6vgren","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.clim.2017.01.005_bb0105","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.4049\/jimmunol.161.6.2856","article-title":"The Th2 cytokine IL-4 is not required for the progression of antibody-dependent autoimmune myasthenia gravis","volume":"161","author":"Balasa","year":"1998","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2017.01.005_bb0110","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4049\/jimmunol.170.1.604","article-title":"Absence of IL-4 facilitates the development of chronic autoimmune myasthenia gravis in C57BL\/6 mice","volume":"170","author":"Ostlie","year":"2003","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.clim.2017.01.005_bb0115","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/mus.23951","article-title":"Interleukin-10 producing-B cells and their association with responsiveness to rituximab in myasthenia gravis","volume":"49","author":"Sun","year":"2014","journal-title":"Muscle Nerve"},{"issue":"1","key":"10.1016\/j.clim.2017.01.005_bb0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12013-014-9903-x","article-title":"Targeting IL-10 in auto-immune diseases","volume":"70","author":"Tian","year":"2014","journal-title":"Cell Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.clim.2017.01.005_bb0125","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.4049\/jimmunol.1501339","article-title":"Autoreactive T cells from patients with myasthenia gravis are characterized by elevated IL-17, IFN-\u03b3, and GM-CSF and diminished IL-10 production","volume":"196","author":"Cao","year":"2016","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2017.01.005_bb0135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","article-title":"Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease","volume":"32","author":"Iyer","year":"2012","journal-title":"Crit. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.clim.2017.01.005_bb0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jaut.2010.12.001","article-title":"Blocking of IL-6 suppresses experimental autoimmune myasthenia gravis","volume":"36","author":"Aricha","year":"2011","journal-title":"J. Autoimmun."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616306180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616306180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T13:33:09Z","timestamp":1749907989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661616306180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":27,"alternative-id":["S1521661616306180"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2017.01.005","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-dose BAFF receptor specific mAb-siRNA conjugate generates Fas-expressing B cells in lymph nodes and high-affinity serum autoantibody in a myasthenia mouse model","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2017.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}