{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:20:21Z","timestamp":1790835621562,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["K105962"],"award-info":[{"award-number":["K105962"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["K112939"],"award-info":[{"award-number":["K112939"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["EFOP-3.6.1.-16-2016-00004"],"award-info":[{"award-number":["EFOP-3.6.1.-16-2016-00004"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.clim.2017.05.013","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T19:15:20Z","timestamp":1494875720000},"page":"54-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Increased proportions of functionally impaired regulatory T cell subsets in systemic sclerosis"],"prefix":"10.1016","volume":"184","author":[{"given":"Emese","family":"Ugor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di\u00e1na","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Almanzar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3na","family":"Pap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Najbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"N\u00e9meth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Balogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Prelog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Czirj\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00edmea","family":"Berki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2017.05.013_bb0005","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3+ regulatory T cells in the human immune system","volume":"10","author":"Sakaguchi","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.clim.2017.05.013_bb0010","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.autrev.2011.05.004","article-title":"Human FoxP3+ regulatory T cells in systemic autoimmune diseases","volume":"10","author":"Miyara","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2017.05.013_bb0015","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0140-6736(06)68737-0","article-title":"Systemic sclerosis: hypothesis-driven treatment strategies","volume":"367","author":"Charles","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2017.05.013_bb0020","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrrheum.2011.149","article-title":"Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities","volume":"8","author":"Bhattacharyya","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2017.05.013_bb0025","doi-asserted-by":"crossref","first-page":"15002","DOI":"10.1038\/nrdp.2015.2","article-title":"Systemic sclerosis","volume":"1","author":"Allanore","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"Suppl. 100","key":"10.1016\/j.clim.2017.05.013_bb0030","first-page":"30","article-title":"Reduced non-switched memory B cell subsets cause imbalance in B cell repertoire in systemic sclerosis","volume":"34","author":"Simon","year":"2016","journal-title":"Clin Exp Rheumatol"},{"issue":"Suppl. 3","key":"10.1016\/j.clim.2017.05.013_bb0035","first-page":"iii23","article-title":"Immunological basis of systemic sclerosis","volume":"45","author":"Zuber","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2017.05.013_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cytogfr.2015.12.002","article-title":"New insights into CD4(+) T cell abnormalities in systemic sclerosis","volume":"28","author":"Liu","year":"2016","journal-title":"Cytokine Growth Factor Rev"},{"issue":"Suppl. 3","key":"10.1016\/j.clim.2017.05.013_bb0045","first-page":"iii3","article-title":"Overview of pathogenesis of systemic sclerosis","volume":"48","author":"Abraham","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2017.05.013_bb0050","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.autrev.2012.05.011","article-title":"Autoantibodies in systemic sclerosis","volume":"12","author":"Mehra","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2017.05.013_bb0055","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fimmu.2015.00272","article-title":"Pathogenesis of systemic sclerosis","volume":"6","author":"Pattanaik","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2017.05.013_bb0060","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.it.2015.04.006","article-title":"Regulatory T cell identity: formation and maintenance","volume":"36","author":"Li","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.clim.2017.05.013_bb0065","doi-asserted-by":"crossref","first-page":"e5981","DOI":"10.1371\/journal.pone.0005981","article-title":"Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression","volume":"4","author":"Radstake","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2017.05.013_bb0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cellimm.2009.12.009","article-title":"Regulatory T cells (CD4(+)CD25(bright)FoxP3(+)) expansion in systemic sclerosis correlates with disease activity and severity","volume":"261","author":"Slobodin","year":"2010","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.clim.2017.05.013_bb0075","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1365-2133.2010.09633.x","article-title":"Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea","volume":"162","author":"Antiga","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.clim.2017.05.013_bb0080","first-page":"5","article-title":"Role of cellular immunity in systemic sclerosis pathogenesis: update on CD4+T cells population studies","volume":"68","author":"Be\u015fliu","year":"2009","journal-title":"Roum. Arch. Microbiol. Immunol."},{"key":"10.1016\/j.clim.2017.05.013_bb0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jim.2006.10.008","article-title":"Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells","volume":"319","author":"Hartigan-O'Connor","year":"2007","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.clim.2017.05.013_bb0090","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1182\/blood-2006-01-0177","article-title":"Regulatory T-cell compartmentalization and trafficking","volume":"108","author":"Wei","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.clim.2017.05.013_bb0095","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.4049\/jimmunol.1500801","article-title":"Control of regulatory T cell migration, function, and homeostasis","volume":"195","author":"Campbell","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.clim.2017.05.013_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2015.07.011","article-title":"Transcriptional and epigenetic control of regulatory T cell development","volume":"136","author":"Kitagawa","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.clim.2017.05.013_bb0105","doi-asserted-by":"crossref","first-page":"e1612","DOI":"10.1371\/journal.pone.0001612","article-title":"FOXP3 promoter demethylation reveals the committed Treg population in humans","volume":"3","author":"Janson","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2017.05.013_bb0110","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2017.05.013_bb0115","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4049\/jimmunol.182.1.259","article-title":"Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation","volume":"182","author":"Lal","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2017.05.013_bb0120","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1002\/eji.200737594","article-title":"DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells","volume":"37","author":"Baron","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2017.05.013_bb0125","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.immuni.2013.03.002","article-title":"Development and maintenance of regulatory T cells","volume":"38","author":"Ohkura","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2017.05.013_bb0130","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/imr.12174","article-title":"Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells","volume":"259","author":"Morikawa","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.clim.2017.05.013_bb0135","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy","year":"1988","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.clim.2017.05.013_bb0140","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"van den Hoogen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clim.2017.05.013_bb0145","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.20060468","article-title":"Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells","volume":"203","author":"Seddiki","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2017.05.013_bb0150","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2249.2009.03901.x","article-title":"Immunomagnetic isolation of CD4+CD25+FoxP3+ natural T regulatory lymphocytes for clinical applications","volume":"156","author":"Di Ianni","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2017.05.013_bb0155","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1073\/pnas.0408679102","article-title":"Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion","volume":"102","author":"Zelenay","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2017.05.013_bb0160","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s12016-016-8563-6","article-title":"Regulatory T cells in systemic sclerosis: a comprehensive review","volume":"52","author":"Slobodin","year":"2017","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.clim.2017.05.013_bb0165","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1084\/jem.20060772","article-title":"CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells","volume":"203","author":"Liu","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2017.05.013_bb0170","article-title":"Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2017.05.013_bb0175","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.clim.2010.06.004","article-title":"Analyses of T cell phenotype and function reveal an altered T cell homeostasis in systemic sclerosis. Correlations with disease severity and phenotypes","volume":"137","author":"Giovannetti","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2017.05.013_bb0180","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nri3605","article-title":"Homeostatic control of regulatory T cell diversity","volume":"14","author":"Liston","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.clim.2017.05.013_bb0185","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/imr.12173","article-title":"Once a Treg, always a Treg?","volume":"259","author":"Sawant","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.clim.2017.05.013_bb0190","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1182\/blood-2004-05-2044","article-title":"Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD","volume":"105","author":"Ermann","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.clim.2017.05.013_bb0195","doi-asserted-by":"crossref","first-page":"e68432","DOI":"10.1371\/journal.pone.0068432","article-title":"Changes in natural Foxp3(+)Treg but not mucosally-imprinted CD62L(neg)CD38(+)Foxp3(+)Treg in the circulation of celiac disease patients","volume":"8","author":"van Leeuwen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2017.05.013_bb0200","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","article-title":"Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease","volume":"32","author":"Iyer","year":"2012","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.clim.2017.05.013_bb0205","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5483\/BMBRep.2011.44.4.217","article-title":"Mechanism of T cell exhaustion in a chronic environment","volume":"44","author":"Jin","year":"2011","journal-title":"BMB Rep."},{"key":"10.1016\/j.clim.2017.05.013_bb0210","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2017.05.013_bb0215","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1097\/HJH.0b013e328362feb7","article-title":"CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension","volume":"31","author":"Kassan","year":"2013","journal-title":"J. Hypertens."},{"key":"10.1016\/j.clim.2017.05.013_bb0220","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ni1572","article-title":"The Foxp3+ regulatory T cell: a jack of all trades, master of regulation","volume":"9","author":"Tang","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2017.05.013_bb0225","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biocel.2015.05.023","article-title":"Epigenetic mechanisms: an emerging role in pathogenesis and its therapeutic potential in systemic sclerosis","volume":"67","author":"Luo","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616305575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661616305575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T21:20:51Z","timestamp":1535836851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661616305575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":45,"alternative-id":["S1521661616305575"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2017.05.013","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased proportions of functionally impaired regulatory T cell subsets in systemic sclerosis","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2017.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}