{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T07:52:14Z","timestamp":1766908334298},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.clim.2017.07.024","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T18:45:41Z","timestamp":1501181141000},"page":"10-14","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Six years' experience of tolerance induction in renal transplantation using stem cell therapy"],"prefix":"10.1016","volume":"187","author":[{"given":"Aruna V.","family":"Vanikar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hargovind L.","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umang G.","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2017.07.024_bb0005","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","article-title":"Human mesenchymal stem cells modulate allogeneic immune cell responses","volume":"4","author":"Aggarwal","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.clim.2017.07.024_bb0010","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1034\/j.1600-6143.2001.010103.x","article-title":"In search of the elusive Holy Grail: the mechanisms and prospects for achieving clinical transplantation tolerance","volume":"1","author":"Auchincloss","year":"2001","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.clim.2017.07.024_bb0015","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1182\/blood-2004-07-2921","article-title":"Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness","volume":"105","author":"Beyth","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.clim.2017.07.024_bb0020","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/172603a0","article-title":"Actively acquired tolerance of foreign cells","volume":"172","author":"Billingham","year":"1953","journal-title":"Nature"},{"key":"10.1016\/j.clim.2017.07.024_bb0025","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/j.1432-2277.2008.00783.x","article-title":"Clinical experience with mixed chimerism to induce transplantation tolerance","volume":"21","author":"Fehr","year":"2008","journal-title":"Transpl. Int."},{"key":"10.1016\/j.clim.2017.07.024_bb0030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1001\/jama.2011.2014","article-title":"Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants","volume":"307","author":"Feng","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.clim.2017.07.024_bb0035","first-page":"381","article-title":"Osteogenesis in transplants of bone marrow cells","volume":"16","author":"Friedenstein","year":"1966","journal-title":"J. Embryol. Exp. Morpholog."},{"key":"10.1016\/j.clim.2017.07.024_bb0040","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1097\/TP.0b013e3181fed001","article-title":"Regulatory T-cell generation and kidney allograft tolerance induced by mesenchymal stem cells associated with indoleamine 2,3-dioxygenase expression","volume":"90","author":"Ge","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2017.07.024_bb0045","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/TP.0b013e3182708ea8","article-title":"Kidney graft survival in Europe and the United States: strikingly different long-term outcomes","volume":"95","author":"Gondos","year":"2013","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.clim.2017.07.024_bb0050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0165-2478(92)90095-6","article-title":"Immunosuppression induced by hepatic portal venous immunization spares reactivity in IL-4 producing T lymphocytes","volume":"33","author":"Gorczynski","year":"1992","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.clim.2017.07.024_bb0055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","article-title":"Pluripotency of mesenchymal stem cells derived from adult marrow","volume":"418","author":"Jiang","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.clim.2017.07.024_bb0060","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1097\/TP.0b013e31818bd83d","article-title":"Renal transplantation in identical twins in United States and United Kingdom","volume":"86","author":"Kessaris","year":"2008","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2017.07.024_bb0065","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/01.tp.0000174341.49741.8f","article-title":"Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin","volume":"80","author":"Kirk","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2017.07.024_bb0070","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/TP.0b013e3182782fc1","article-title":"Tolerance induction in HLA disparate living donor kidney transplantation by donor stem cell infusion: durable chimerism predicts outcome","volume":"95","author":"Leventhal","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2017.07.024_bb0075","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/lt.22265","article-title":"Operational tolerance: past lessons and future prospects","volume":"17","author":"Levitsky","year":"2011","journal-title":"Liver Transpl."},{"key":"10.1016\/j.clim.2017.07.024_bb0080","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1084\/jem.165.6.1468","article-title":"Alloantigen persistence in induction and maintenance of transplantation tolerance","volume":"165","author":"Morecki","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2017.07.024_bb0085","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.2337\/diabetes.50.7.1546","article-title":"Indirect allorecognition in acquired thymic tolerance induction of donor-specific permanent acceptance of rat islets by adoptive transfer of allopeptide-pulsed host myeloid and thymic dendritic cells","volume":"50","author":"Oluwole","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.clim.2017.07.024_bb0090","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1097\/SLA.0b013e3181f3efb0","article-title":"Clinical operational tolerance after renal transplantation: current status and future challenges","volume":"252","author":"Orlando","year":"2010","journal-title":"Ann. Surg."},{"key":"10.1016\/j.clim.2017.07.024_bb0095","unstructured":"Patent number 269775, 17th July, 2008. Smt. G.R. Doshi and Smt. K.M. Mehta Institute of Kidney Diseases and Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences. \u201cA method of preparing mesenchymal stem cells from adipose tissue\u201d. Intellectual Property India. Granted on 5th November, 2015."},{"key":"10.1016\/j.clim.2017.07.024_bb0100","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.clim.2017.07.024_bb0105","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1749-6632.2001.tb03593.x","article-title":"Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells","volume":"938","author":"Reyes","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.clim.2017.07.024_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/210506","article-title":"Transplant tolerance: new insights and strategies for long-term allograft acceptance","author":"Ruiz","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.clim.2017.07.024_bb0115","doi-asserted-by":"crossref","DOI":"10.1186\/1476-9255-2-8","article-title":"Mesenchymal stem cells avoid allogeneic rejection","author":"Ryan","year":"2005","journal-title":"J. Inflamm."},{"key":"10.1016\/j.clim.2017.07.024_bb0120","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1056\/NEJMc1107841","article-title":"Induced immune tolerance for kidney transplantation","volume":"365","author":"Scandling","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2017.07.024_bb0125","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/ajt.13091","article-title":"Chimerism, graft survival, and withdrawal of immunosuppressive drugs in HLA matched and mismatched patients after living donor kidney and hematopoietic cell transplantation","volume":"15","author":"Scandling","year":"2015","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.clim.2017.07.024_bb0130","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1074-7613(01)00122-4","article-title":"Mixed chimerism and transplant tolerance","volume":"14","author":"Sykes","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2017.07.024_bb0135","first-page":"123","article-title":"Mesenchymal stem cells and solid organ transplantation","volume":"1","author":"Trivedi","year":"2013","journal-title":"CellR4"},{"key":"10.1016\/j.clim.2017.07.024_bb0140","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.transproceed.2005.01.028","article-title":"Allogeneic hematopoietic stem cell transplantation, mixed chimerism and tolerance in living related donor renal allograft recipients","volume":"37","author":"Trivedi","year":"2005","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.clim.2017.07.024_bb0145","first-page":"265","article-title":"Clonal deletion using total lymphoid irradiation with no maintenance immunosuppression in renal allograft recipients","volume":"2009","author":"Trivedi","year":"2009","journal-title":"Clin. Transpl."},{"key":"10.1016\/j.clim.2017.07.024_bb0150","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/TP.0b013e3181dde912","article-title":"Clonal deletion with bortezomib followed by low or no maintenance immunosuppression in renal allograft recipients","volume":"90","author":"Trivedi","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2017.07.024_bb0155","first-page":"18","article-title":"Transplantation tolerance; myth or reality?","volume":"3","author":"Vanikar","year":"2014","journal-title":"J. Nephropathol."},{"key":"10.1016\/j.clim.2017.07.024_bb0160","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/TP.0b013e3182664000","article-title":"Stem cell transplantation in living donor renal transplantation for minimization of immunosuppression","volume":"94","author":"Vanikar","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2017.07.024_bb0165","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.transproceed.2011.01.161","article-title":"Operational tolerance in living-related renal transplantation: a single-center experience","volume":"43","author":"Vanikar","year":"2011","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.clim.2017.07.024_bb0170","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11255-009-9659-1","article-title":"Effect of co-transplantation of mesenchymal stem cells and hematopoietic stem cells as compared to hematopoietic stem cell transplantation alone in renal transplantation to achieve donor hypo-responsiveness","volume":"43","author":"Vanikar","year":"2011","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.clim.2017.07.024_bb0175","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/nep.12258","article-title":"Mesenchymal stem cells and transplant tolerance","volume":"19","author":"Vanikar","year":"2014","journal-title":"Nephrology (Carlton)"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661617305454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661617305454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T22:58:31Z","timestamp":1535583511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661617305454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":35,"alternative-id":["S1521661617305454"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2017.07.024","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Six years' experience of tolerance induction in renal transplantation using stem cell therapy","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2017.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}