{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:52:58Z","timestamp":1788839578771,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100015542","name":"GSK Japan","doi-asserted-by":"crossref","award":["14B003"],"award-info":[{"award-number":["14B003"]}],"id":[{"id":"10.13039\/100015542","id-type":"DOI","asserted-by":"crossref"}]},{"name":"JSPS KAKENHI","award":["15K20200"],"award-info":[{"award-number":["15K20200"]}]},{"name":"JSPS KAKENHI","award":["16K11212"],"award-info":[{"award-number":["16K11212"]}]},{"name":"JSPS KAKENHI","award":["26462581"],"award-info":[{"award-number":["26462581"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.clim.2017.11.010","type":"journal-article","created":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T21:32:17Z","timestamp":1511731937000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways"],"prefix":"10.1016","volume":"188","author":[{"given":"Shino","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Takezawa-Yasuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Tojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Kouzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2017.11.010_bb0005","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s11882-007-0073-4","article-title":"Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps","volume":"7","author":"Pawankar","year":"2007","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.clim.2017.11.010_bb0010","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jaci.2011.04.047","article-title":"Remodeling in asthma","volume":"128","author":"Al-Muhsen","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2017.11.010_bb0015","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1513\/pats.201008-057RN","article-title":"Pathophysiology of allergic and nonallergic rhinitis","volume":"8","author":"Sin","year":"2011","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.clim.2017.11.010_bb0020","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1165\/rcmb.2011-0013TR","article-title":"Targeting eosinophil biology in asthma therapy","volume":"45","author":"Wegmann","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.clim.2017.11.010_bb0025","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.humimm.2008.05.010","article-title":"Serum vascular endothelial growth factor in allergic rhinitis and systemic lupus erythematosus","volume":"69","author":"Ciprandi","year":"2008","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.clim.2017.11.010_bb0030","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/PL00007645","article-title":"Thrombin in the airways of asthmatic patients","volume":"177","author":"Gabazza","year":"1999","journal-title":"Lung"},{"key":"10.1016\/j.clim.2017.11.010_bb0035","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.clim.2008.07.020","article-title":"Role of the coagulation system in allergic inflammation in the upper airways","volume":"129","author":"Shimizu","year":"2008","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2017.11.010_bb0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2500\/ajra.2011.25.3535","article-title":"Role of thrombin in chronic rhinosinusitis-associated tissue remodeling","volume":"25","author":"Shimizu","year":"2011","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.clim.2017.11.010_bb0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1532\/IJH97.03165","article-title":"Progress in the understanding of protease-activated receptors","volume":"79","author":"Gabazza","year":"2004","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.clim.2017.11.010_bb0050","first-page":"L503","article-title":"Thrombin stimulates the expression of PDGF in lung epithelial cells","volume":"279","author":"Shimizu","year":"2000","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.clim.2017.11.010_bb0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2500\/ajra.2017.31.4400","article-title":"Thrombin and activated coagulation factor X stimulate the release of cytokines and fibronectin from nasal polyp fibroblasts via protease-activated receptors","volume":"31","author":"Shimizu","year":"2017","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.clim.2017.11.010_bb0060","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2500\/ajra.2014.28.4018","article-title":"Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling","volume":"28","author":"Shimizu","year":"2014","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.clim.2017.11.010_bb0065","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1183\/09031936.00172007","article-title":"Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases","volume":"32","author":"Burgel","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.clim.2017.11.010_bb0070","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1067\/mai.2000.110931","article-title":"Expression of c-erbB receptors and ligands in human nasal epithelium","volume":"106","author":"Polosa","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2017.11.010_bb0075","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1164\/ajrccm.157.6.9609040","article-title":"Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway","volume":"157","author":"Amishima","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.clim.2017.11.010_bb0080","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1034\/j.1398-9995.2003.00156.x","article-title":"Epidermal growth factor receptor - but not histamine receptor - is upregulated in seasonal allergic rhinitis","volume":"58","author":"Matovinovic","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.clim.2017.11.010_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2500\/ajra.2016.30.4263","article-title":"Epidermal growth factor receptor inhibitor AG1478 inhibits mucus hypersecretion in airway epithelium","volume":"30","author":"Takezawa","year":"2016","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.clim.2017.11.010_bb0090","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1164\/rccm.200212-1437OC","article-title":"In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells","volume":"168","author":"Shimizu","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.clim.2017.11.010_bb0095","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1475-0961.2003.00519.x","article-title":"Airway microvascular extravasation and luminal entry of plasma","volume":"23","author":"Greiff","year":"2003","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"10.1016\/j.clim.2017.11.010_bb0100","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1172\/JCI200422288","article-title":"Coagulation-dependent mechanisms and asthma","volume":"114","author":"Matthay","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2017.11.010_bb0105","doi-asserted-by":"crossref","first-page":"4S","DOI":"10.1378\/chest.124.3_suppl.4S","article-title":"Thrombin formation","volume":"124","author":"Mann","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.clim.2017.11.010_bb0110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2500\/ajra.2015.29.4183","article-title":"Tissue factor and tissue factor pathway inhibitor in nasal mucosa and nasal secretions of chronic rhinosinusitis with nasal polyp","volume":"29","author":"Shimizu","year":"2015","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.clim.2017.11.010_bb0115","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.jaci.2004.07.060","article-title":"The role of protease activation of inflammation in allergic respiratory diseases","volume":"114","author":"Reed","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2017.11.010_bb0125","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000080037","article-title":"Thrombin affects eosinophil migration via protease-activated receptor-1","volume":"135","author":"Feistritzer","year":"2004","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.clim.2017.11.010_bb0130","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1165\/ajrcmb\/4.3.255","article-title":"Monocyte-macrophage differentiation induced by human upper airway epithelial cells","volume":"4","author":"Ohtoshi","year":"1991","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.clim.2017.11.010_bb0135","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1055\/s-0035-1570746","article-title":"Granulocyte-macrophage colony-stimulating factor production and tissue eosinophilia in chronic rhinitis","volume":"20","author":"Peric","year":"2016","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.clim.2017.11.010_bb0140","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/rccm.201412-2278OC","article-title":"Cytokines in chronic rhinosinusitis. Role in eosinophilia and aspirin-exacerbated respiratory disease","volume":"192","author":"Stevens","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.clim.2017.11.010_bb0145","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1080\/00016489950180478","article-title":"Eotaxin synthesis by nasal polyp fibroblasts","volume":"119","author":"Nonaka","year":"1999","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.clim.2017.11.010_bb0150","first-page":"235","article-title":"IL-4 and TNF-alpha increased the secretion of eotaxin from cultured fibroblasts of nasal polyps with eosinophil infiltration","volume":"45","author":"Yoshifuku","year":"2007","journal-title":"Rhinology"},{"key":"10.1016\/j.clim.2017.11.010_bb0155","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1165\/ajrcmb.20.5.3308","article-title":"Expression of c-erbB receptors and ligands in human bronchial mucosa","volume":"20","author":"Polosa","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.clim.2017.11.010_bb0160","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archotol.133.11.1097","article-title":"Up-regulation of the mucosal epidermal growth factor receptor gene in chronic rhinosinusitis and nasal polyposis","volume":"133","author":"Ding","year":"2007","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.clim.2017.11.010_bb0165","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/379557a0","article-title":"Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors","volume":"379","author":"Daub","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.clim.2017.11.010_bb0170","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jaci.2006.08.028","article-title":"Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts","volume":"119","author":"Yoshisue","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2017.11.010_bb0175","first-page":"L569","article-title":"Lipopolysaccharide disrupts the directional persistence of alveolar myofibroblast migration through EGF receptor","volume":"302","author":"Li","year":"2012","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.clim.2017.11.010_bb0180","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1365-2222.2008.02951.x","article-title":"Role of epidermal growth factor receptor in maintaining airway goblet cell hyperplasia in rats sensitized to allergen","volume":"38","author":"Takeyama","year":"2008","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.clim.2017.11.010_bb0185","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/emm.2007.41","article-title":"Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation","volume":"39","author":"Hur","year":"2007","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.clim.2017.11.010_bb0190","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nrclinonc.2011.192","article-title":"Tumor control versus adverse events with targeted anticancer therapies","volume":"9","author":"Keefe","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661617304278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661617304278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T16:00:57Z","timestamp":1589817657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661617304278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":37,"alternative-id":["S1521661617304278"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2017.11.010","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2017.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}