{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:03:32Z","timestamp":1778605412047,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ZIA AR041199"],"award-info":[{"award-number":["ZIA AR041199"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI097134"],"award-info":[{"award-number":["R01AI097134"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI110502"],"award-info":[{"award-number":["U19AI110502"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.clim.2018.11.011","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T09:24:40Z","timestamp":1542878680000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Genome-wide DNA methylation analysis in primary antiphospholipid syndrome neutrophils"],"prefix":"10.1016","volume":"196","author":[{"given":"Emma","family":"Weeding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Coit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srilakshmi","family":"Yalavarthi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana J.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason S.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr H.","family":"Sawalha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2018.11.011_bb0005","doi-asserted-by":"crossref","unstructured":"J.A. G\u00f3mez-Puerta, R. Cervera, Diagnosis and classification of the antiphospholipid syndrome., J. Autoimmun. 48\u201349 (n.d.) 20\u20135. doi:https:\/\/doi.org\/10.1016\/j.jaut.2014.01.006.","DOI":"10.1016\/j.jaut.2014.01.006"},{"key":"10.1016\/j.clim.2018.11.011_bb0010","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/art.10187","article-title":"Euro-Phospholipid Project Group, Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients","volume":"46","author":"Cervera","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2018.11.011_bb0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/01.md.0000172074.53583.ea","article-title":"Long-term follow-up in 128 patients with primary antiphospholipid syndrome: do they develop lupus?","volume":"84","author":"G\u00f3mez-Puerta","year":"2005","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.clim.2018.11.011_bb0020","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1177\/0961203310374336","article-title":"Clinical and immunoserological characteristics of the transition from primary to overlap antiphospholipid syndrome","volume":"19","author":"Veres","year":"2010","journal-title":"Lupus"},{"key":"10.1016\/j.clim.2018.11.011_bb0025","first-page":"20","article-title":"The antiphospholipid syndrome: immunologic and clinical aspects. Clinical spectrum and treatment","volume":"58","author":"Myones","year":"2000","journal-title":"J. Rheumatol. Suppl."},{"key":"10.1016\/j.clim.2018.11.011_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00875","article-title":"Deoxyribonucleic Acid Methylation in Systemic Lupus Erythematosus: Implications for Future Clinical Practice","volume":"9","author":"Weeding","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2018.11.011_bb0035","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaut.2015.01.004","article-title":"Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils","volume":"58","author":"Coit","year":"2015","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2018.11.011_bb0040","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93897","article-title":"Activated signature of antiphospholipid syndrome neutrophils reveals potential therapeutic target","volume":"2","author":"Knight","year":"2017","journal-title":"JCI Insight."},{"key":"10.1016\/j.clim.2018.11.011_bb0045","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1136\/annrheumdis-2015-208410","article-title":"IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus","volume":"75","author":"Zhao","year":"2016","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.clim.2018.11.011_bb0050","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","author":"Miyakis","year":"2006","journal-title":"J. Thromb. Haemost. JTH."},{"issue":"2011","key":"10.1016\/j.clim.2018.11.011_bb0055","first-page":"538","article-title":"Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus","volume":"187","author":"Villanueva","year":"1950","journal-title":"J. Immunol. Baltim. Md"},{"key":"10.1016\/j.clim.2018.11.011_bb0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jaut.2013.04.003","article-title":"Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in na\u00efve CD4+ T cells from lupus patients","volume":"43","author":"Coit","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2018.11.011_bb0065","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinforma. Oxf. Engl."},{"key":"10.1016\/j.clim.2018.11.011_bb0070","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4161\/epi.23470","article-title":"Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray","volume":"8","author":"Chen","year":"2013","journal-title":"Epigenetics."},{"key":"10.1016\/j.clim.2018.11.011_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2018.11.011_bb0080","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.clim.2018.11.011_bb0085","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics."},{"key":"10.1016\/j.clim.2018.11.011_bb0090","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1172\/JCI59492","article-title":"T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice","volume":"121","author":"Wiede","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2018.11.011_bb0095","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ncb1519","article-title":"PGC7\/Stella protects against DNA demethylation in early embryogenesis","volume":"9","author":"Nakamura","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.clim.2018.11.011_bb0100","doi-asserted-by":"crossref","first-page":"D733","DOI":"10.1093\/nar\/gkv1189","article-title":"Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation","volume":"44","author":"O'Leary","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2018.11.011_bb0105","doi-asserted-by":"crossref","first-page":"e1003678","DOI":"10.1371\/journal.pgen.1003678","article-title":"Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations","volume":"9","author":"Absher","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.clim.2018.11.011_bb0110","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0002-9343(99)00413-1","article-title":"Autoimmune hemolytic anemia in patients with systemic lupus erythematosus","volume":"108","author":"Kokori","year":"2000","journal-title":"Am. J. Med."},{"key":"10.1016\/j.clim.2018.11.011_bb0115","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1002\/art.39256","article-title":"Protein tyrosine phosphatase nonreceptor type 2: an important regulator of lnterleukin-6 production in rheumatoid arthritis synovial fibroblasts","volume":"67","author":"Aradi","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.clim.2018.11.011_bb0120","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","author":"Wellcome Trust Case Control Consortium","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.clim.2018.11.011_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033682","article-title":"PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background","volume":"7","author":"Glas","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2018.11.011_bb0130","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/ng.2231","article-title":"Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population","volume":"44","author":"Okada","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2018.11.011_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066456","article-title":"Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans","volume":"8","author":"Cobb","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2018.11.011_bb0140","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.4161\/epi.32087","article-title":"DPPA3 prevents cytosine hydroxymethylation of the maternal pronucleus and is required for normal development in bovine embryos","volume":"9","author":"Bakhtari","year":"2014","journal-title":"Epigenetics."},{"key":"10.1016\/j.clim.2018.11.011_bb0145","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ng.472","article-title":"Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus","volume":"41","author":"Han","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2018.11.011_bb0150","doi-asserted-by":"crossref","unstructured":"W. Yang, N. Shen, D.-Q. Ye, Q. Liu, Y. Zhang, X.-X. Qian, N. Hirankarn, D. Ying, H.-F. Pan, C.C. Mok, T.M. Chan, R.W.S. Wong, K.W. Lee, M.Y. Mok, S.N. Wong, A.M.H. Leung, X.-P. Li, Y. Avihingsanon, C.-M. Wong, T.L. Lee, M.H.K. Ho, P.P.W. Lee, Y.K. Chang, P.H. Li, R.-J. Li, L. Zhang, W.H.S. Wong, I.O.L. Ng, C.S. Lau, P.C. Sham, Y.L. Lau, Asian Lupus Genetics Consortium, Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus, PLoS Genet. 6 (2010) e1000841. doi:https:\/\/doi.org\/10.1371\/journal.pgen.1000841.","DOI":"10.1371\/journal.pgen.1000841"},{"key":"10.1016\/j.clim.2018.11.011_bb0155","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1074\/jbc.M408356200","article-title":"Interleukins 2 and 15 regulate Ets1 expression via ERK1\/2 and MNK1 in human natural killer cells","volume":"280","author":"Grund","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2018.11.011_bb0160","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.3760\/cma.j.issn.0366-6999.2010.16.025","article-title":"Expression analysis of ETS1 gene in peripheral blood mononuclear cells with systemic lupus erythematosus by real-time reverse transcription PCR","volume":"123","author":"Li","year":"2010","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.clim.2018.11.011_bb0165","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10238-013-0263-4","article-title":"Expression of Ets-1 and FOXP3 mRNA in CD4(+)CD25 (+) T regulatory cells from patients with systemic lupus erythematosus","volume":"14","author":"Xiang","year":"2014","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.clim.2018.11.011_bb0170","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1615\/CritRevImmunol.2017020284","article-title":"The Role of the Transcription factor Ets1 in Lupus and Other Autoimmune Diseases","volume":"36","author":"Garrett-Sinha","year":"2016","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.clim.2018.11.011_bb0175","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/intimm\/dxh295","article-title":"Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease","volume":"17","author":"Wang","year":"2005","journal-title":"Int. Immunol."},{"key":"10.1016\/j.clim.2018.11.011_bb0180","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000087855","article-title":"Expression of c-Ets1 protein in normal human placenta","volume":"61","author":"Takai","year":"2006","journal-title":"Gynecol. Obstet. Investig."},{"key":"10.1016\/j.clim.2018.11.011_bb0185","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ydbio.2006.01.015","article-title":"Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse","volume":"292","author":"Wadehra","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.clim.2018.11.011_bb0190","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/path.4893","article-title":"Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency","volume":"242","author":"Williams","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.clim.2018.11.011_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2012.00362","article-title":"Neutrophil NETs in reproduction: from infertility to preeclampsia and the possibility of fetal loss","volume":"3","author":"Hahn","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2018.11.011_bb0200","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1084\/jem.200116116","article-title":"Complement C3 activation is required for antiphospholipid antibody-induced fetal loss","volume":"195","author":"Holers","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2018.11.011_bb0205","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1172\/JCI200318817","article-title":"Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome","volume":"112","author":"Girardi","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2018.11.011_bb0210","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1182\/blood-2007-01-070631","article-title":"Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury","volume":"110","author":"Redecha","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.clim.2018.11.011_bb0215","first-page":"3276","article-title":"Tracing the molecular pathogenesis of antiphospholipid syndrome","volume":"118","author":"Weiler","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2018.11.011_bb0220","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1538-7836.2010.04135.x","article-title":"Role of tissue factor in feto-maternal development: a xiphos","volume":"9","author":"Girardi","year":"2011","journal-title":"J. Thromb. Haemost. JTH."},{"key":"10.1016\/j.clim.2018.11.011_bb0225","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1095\/biolreprod.116.140293","article-title":"PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy loss in a Mouse Model","volume":"95","author":"Erpenbeck","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.clim.2018.11.011_bb0230","first-page":"5577","article-title":"Neutrophil extracellular traps are critical for pregnancy loss in sphingosine kinase-deficient mice on 129Sv\/C57BL\/6 background","volume":"31","author":"Mizugishi","year":"2017","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152166161830620X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152166161830620X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T17:20:27Z","timestamp":1720804827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152166161830620X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":46,"alternative-id":["S152166161830620X"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2018.11.011","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide DNA methylation analysis in primary antiphospholipid syndrome neutrophils","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2018.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}