{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:08:57Z","timestamp":1772111337892,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Birjand and Mashhad Universities of Medical Sciences"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.clim.2019.05.013","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T15:33:42Z","timestamp":1559144022000},"page":"125-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Evaluation of the frequency of invariant natural killer T (iNKT) cells in nasal polyps"],"prefix":"10.1016","volume":"205","author":[{"given":"Mohammad","family":"Fereidouni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afshin","family":"Derakhshani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Nasseri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Farid Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Bakhshaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Vahidian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Exley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.clim.2019.05.013_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161013","article-title":"Role of interleukin-10 on nasal polypogenesis in patients with chronic rhinosinusitis with nasal polyps","volume":"11","author":"Xu","year":"2016","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.clim.2019.05.013_bb0010","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2147\/TCRM.S2379","article-title":"A review of nasal polyposis","volume":"4","author":"Newton","year":"2008","journal-title":"Ther. Clin. Risk Manag."},{"issue":"4","key":"10.1016\/j.clim.2019.05.013_bb0015","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaip.2016.04.012","article-title":"Chronic rhinosinusitis with nasal polyps","volume":"4","author":"Stevens","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"10.1016\/j.clim.2019.05.013_bb0020","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3109\/00016489609137813","article-title":"Eosinophils in the pathophysiology of nasal polyposis","volume":"116","author":"Jankowski","year":"1996","journal-title":"Acta Otolaryngol."},{"issue":"12","key":"10.1016\/j.clim.2019.05.013_bb0030","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/j.1398-9995.2007.01464.x","article-title":"Detection of natural killer T cells in the sinus mucosa from asthmatics with chronic sinusitis","volume":"62","author":"Yamamoto","year":"2007","journal-title":"Allergy."},{"key":"10.1016\/j.clim.2019.05.013_bb0025","doi-asserted-by":"crossref","DOI":"10.1038\/srep12781","article-title":"Human IL-21+IFN-\u03b3+CD4+ T cells in nasal polyps are regulated by IL-12","volume":"5","author":"Xiao","year":"2015","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.clim.2019.05.013_bb0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2500\/ajr.2008.22.3136","article-title":"Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells","volume":"22","author":"Ramanathan","year":"2008","journal-title":"Am. J. Rhinol."},{"key":"10.1016\/j.clim.2019.05.013_bb0040","series-title":"International Forum of Allergy & Rhinology","article-title":"T regulatory and Th17 cells in chronic rhinosinusitis with polyps","year":"2016"},{"issue":"8","key":"10.1016\/j.clim.2019.05.013_bb0045","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/j.1398-9995.2006.01124.x","article-title":"The role of iNKT cells in development of bronchial asthma: a translational approach from animal models to human","volume":"61","author":"Akbari","year":"2006","journal-title":"Allergy."},{"issue":"14","key":"10.1016\/j.clim.2019.05.013_bb0050","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1056\/NEJMoa064691","article-title":"Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease","volume":"356","author":"Vijayanand","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2019.05.013_bb8000","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2019.05.011","article-title":"iNKT cells and hematopoietic stem cell transplantation: Two-phase activation of iNKT cells may improve outcome","author":"Derakhshani","year":"2019","journal-title":"Clinical Immunology"},{"issue":"1","key":"10.1016\/j.clim.2019.05.013_bb0055","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/cyto.b.20489","article-title":"Frequency of circulating iNKT cells among Iranian healthy adults","volume":"78","author":"Fereidouni","year":"2010","journal-title":"Cytometry B Clin. Cytom."},{"issue":"11","key":"10.1016\/j.clim.2019.05.013_bb0060","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1056\/NEJMoa053614","article-title":"CD4+ invariant T-cell\u2013receptor+ natural killer T cells in bronchial asthma","volume":"354","author":"Akbari","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.clim.2019.05.013_bb0065","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1084\/jem.184.4.1285","article-title":"Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells","volume":"184","author":"Bendelac","year":"1996","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.clim.2019.05.013_bb0070","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jaci.2011.02.026","article-title":"Invariant natural killer T cells from food allergic versus non-allergic children exhibit differential responsiveness to milk-derived sphingomyelin","volume":"128","author":"Jyonouchi","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2019.05.013_bb0075","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/cea.12201","article-title":"Invariant natural killer T cells in children with eosinophilic esophagitis","volume":"44","author":"Jyonouchi","year":"2014","journal-title":"Clin. Exp. Allergy"},{"issue":"5","key":"10.1016\/j.clim.2019.05.013_bb0080","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/ajg.2014.12","article-title":"Involvement of the iNKT cell pathway is associated with early-onset eosinophilic esophagitis and response to allergen avoidance therapy","volume":"109","author":"Lexmond","year":"2014","journal-title":"Am. J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.clim.2019.05.013_bb0085","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jaci.2010.05.024","article-title":"Thymic stromal lymphopoietin\u2013activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis","volume":"126","author":"Wu","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2019.05.013_bb8005","article-title":"Efficient Production of Functional Human NKT Cells from Induced Pluripotent Stem Cells\u2212 Reprogramming of Human V\u03b124 iNKT Cells","author":"Yamada","year":"2016","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.clim.2019.05.013_bb0095","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2500\/ajra.2009.23.3284","article-title":"Relationships between severity of chronic rhinosinusitis and nasal polyposis, asthma, and atopy","volume":"23","author":"Pearlman","year":"2009","journal-title":"Am. J. Rhinol. Allergy"},{"issue":"4","key":"10.1016\/j.clim.2019.05.013_bb0100","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2332\/allergolint.O-08-545","article-title":"Correlation between the prostaglandin D2\/E2 ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma","volume":"57","author":"Yoshimura","year":"2008","journal-title":"Allergol. Int."},{"key":"10.1016\/j.clim.2019.05.013_bb0105","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1001\/jama.1997.03550220055009","article-title":"Nasal polyps and sinusitis","volume":"278","author":"Slavin","year":"1997","journal-title":"J. Am. Med. Assoc."},{"issue":"1","key":"10.1016\/j.clim.2019.05.013_bb0110","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40733-015-0002-6","article-title":"The patient with rhinitis in the pharmacy. A cross-sectional study in real life","volume":"1","author":"Lombardi","year":"2015","journal-title":"Asthma Res. Pract."},{"issue":"4","key":"10.1016\/j.clim.2019.05.013_bb0115","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1398-9995.2007.01323.x","article-title":"Nasal polyposis: a cellular-based approach to answering questions","volume":"62","author":"Rinia","year":"2007","journal-title":"Allergy."},{"issue":"3","key":"10.1016\/j.clim.2019.05.013_bb0120","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/MOO.0b013e3283382082","article-title":"T cells in chronic rhinosinusitis with nasal polyposis","volume":"18","author":"Ryan","year":"2010","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.clim.2019.05.013_bb0130","first-page":"45","article-title":"Nasal polyps in patients with asthma: prevalence, impact, and management challenges","volume":"9","author":"Langdon","year":"2016","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.clim.2019.05.013_bb0135","series-title":"Allergy and Asthma Proceedings","article-title":"The clinical relationship of nasal polyps to asthma","year":"1996"},{"issue":"1","key":"10.1016\/j.clim.2019.05.013_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1258\/002221503321046577","article-title":"Nasal polyps: still more questions than answers","volume":"117","author":"Bateman","year":"2003","journal-title":"J. Laryngol. Otol."},{"issue":"2","key":"10.1016\/j.clim.2019.05.013_bb0145","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1365-3083.2011.02546.x","article-title":"Impaired balance of Th17\/Treg in patients with nasal polyposis","volume":"74","author":"Shen","year":"2011","journal-title":"Scand. J. Immunol."},{"issue":"5","key":"10.1016\/j.clim.2019.05.013_bb0150","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1084\/jem.20011786","article-title":"Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining","volume":"195","author":"Gumperz","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2019.05.013_bb0155","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev.med.59.061506.154139","article-title":"T cells and NKT cells in the pathogenesis of asthma","volume":"59","author":"Meyer","year":"2008","journal-title":"Annu. Rev. Med."},{"issue":"1","key":"10.1016\/j.clim.2019.05.013_bb0160","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2332\/allergolint.R-06-137","article-title":"Invariant natural killer T (iNKT) cells in asthma: a novel insight into the pathogenesis of asthma and the therapeutic implication of glycolipid ligands for allergic diseases","volume":"56","author":"Oki","year":"2007","journal-title":"Allergol. Int."},{"issue":"3","key":"10.1016\/j.clim.2019.05.013_bb0165","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000314364","article-title":"Association between sputum natural killer T cells and eosinophilic airway inflammation in human asthma","volume":"153","author":"Koh","year":"2010","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.clim.2019.05.013_bb0170","doi-asserted-by":"crossref","DOI":"10.1155\/MI\/2006\/71214","article-title":"NKT cells in the induced sputum of severe asthmatics","volume":"2006","author":"Hamzaoui","year":"2006","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.clim.2019.05.013_bb0185","first-page":"194","article-title":"Invariant natural killer T cells in obstructive pulmonary diseases","volume":"357","author":"Bratke","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.clim.2019.05.013_bb0190","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jaci.2010.01.032","article-title":"NKT cells are not the predominant T cell in asthma and likely modulate, not cause, asthma","volume":"125","author":"Thomas","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2019.05.013_bb0195","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1038\/cti.2013.13","article-title":"Invariant natural killer T-cell neutralization is a possible novel therapy for human eosinophilic esophagitis","volume":"3","author":"Rayapudi","year":"2014","journal-title":"Clin. Transl. Immunol."},{"issue":"8","key":"10.1016\/j.clim.2019.05.013_bb0200","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1398-9995.2004.00469.x","article-title":"Cytokine-regulated accumulation of eosinophils in inflammatory disease","volume":"59","author":"Lampinen","year":"2004","journal-title":"Allergy."},{"issue":"5","key":"10.1016\/j.clim.2019.05.013_bb0205","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.jaci.2010.02.006","article-title":"Current perspectives: focused commentary: key cells in asthma","volume":"125","author":"Umetsu","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"8","key":"10.1016\/j.clim.2019.05.013_bb0210","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.4049\/jimmunol.175.8.4914","article-title":"V\u03b124-invariant NKT cells from patients with allergic asthma express CCR9 at high frequency and induce Th2 bias of CD3+ T cells upon CD226 engagement","volume":"175","author":"Sen","year":"2005","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.clim.2019.05.013_bb0215","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1002\/eji.200525994","article-title":"Suppression of eosinophilic airway inflammation by treatment with \u03b1-galactosylceramide","volume":"35","author":"Morishima","year":"2005","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2019.05.013_bb0220","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.imlet.2006.07.001","article-title":"Modulation of murine experimental allergic conjunctivitis by treatment with \u03b1-Galactosylceramide","volume":"107","author":"Fukushima","year":"2006","journal-title":"Immunol. Lett."},{"issue":"4","key":"10.1016\/j.clim.2019.05.013_bb0225","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1084\/jem.184.4.1295","article-title":"Beta 2-microglobulin-dependent NK1. 1+ T cells are not essential for T helper cell 2 immune responses","volume":"184","author":"Brown","year":"1996","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.clim.2019.05.013_bb0230","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1084\/jem.189.3.553","article-title":"Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice","volume":"189","author":"Korsgren","year":"1999","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.clim.2019.05.013_bb0235","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.jaci.2007.02.021","article-title":"Bronchoalveolar lavage invariant natural killer T cells are not increased in asthma","volume":"119","author":"Mutalithas","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.clim.2019.05.013_bb0240","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S1081-1206(10)60517-0","article-title":"Effect of allergen challenge on the percentage of natural killer T cells in patients with atopic asthma","volume":"102","author":"Rock","year":"2009","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"10","key":"10.1016\/j.clim.2019.05.013_bb0245","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1001\/archotol.1996.01890220037007","article-title":"CD4+ lymphocytes are increased in the sinus mucosa of children with chronic sinusitis","volume":"122","author":"Driscoll","year":"1996","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"issue":"1","key":"10.1016\/j.clim.2019.05.013_bb0250","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0385-8146(99)00038-3","article-title":"Inflammatory cells in nasal mucosa and nasal polyps","volume":"27","author":"Morinaka","year":"2000","journal-title":"Auris Nasus Larynx"},{"issue":"5","key":"10.1016\/j.clim.2019.05.013_bb0255","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.otohns.2003.12.022","article-title":"Lymphocyte subpopulations and cytokines in nasal polyps: is there a local immune system in the nasal polyp?","volume":"130","author":"Bernstein","year":"2004","journal-title":"Otolaryngol. Head Neck Surg."},{"issue":"1","key":"10.1016\/j.clim.2019.05.013_bb0260","first-page":"1","article-title":"Comparison of two flow cytometric methods for detection of human invariant natural killer T cells (iNKT)","volume":"7","author":"Fereidouni","year":"2010","journal-title":"Iran. J. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2019.05.013_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2007.02647.x","article-title":"Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11","volume":"122","author":"Montoya","year":"2007","journal-title":"Immunology."},{"issue":"6","key":"10.1016\/j.clim.2019.05.013_bb0270","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1002\/eji.200737389","article-title":"Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR \u03b1-chain CDR3 loop","volume":"38","author":"Exley","year":"2008","journal-title":"Eur. J. Immunol."},{"issue":"14","key":"10.1016\/j.clim.2019.05.013_bb0275","first-page":"1.1","article-title":"Isolation and functional use of human NKT cells","volume":"119","author":"Exley","year":"2017","journal-title":"Curr. Protoc. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661618306193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661618306193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T20:50:54Z","timestamp":1721335854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661618306193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":53,"alternative-id":["S1521661618306193"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2019.05.013","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the frequency of invariant natural killer T (iNKT) cells in nasal polyps","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2019.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}