{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T22:20:09Z","timestamp":1787091609634,"version":"build-2736575974"},"reference-count":143,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2014ZX09508007"],"award-info":[{"award-number":["2014ZX09508007"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2012ZX09103301-004"],"award-info":[{"award-number":["2012ZX09103301-004"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011360","name":"State Key Laboratory of Natural Medicines","doi-asserted-by":"publisher","award":["SKLNMBZ201403"],"award-info":[{"award-number":["SKLNMBZ201403"]}],"id":[{"id":"10.13039\/501100011360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.clim.2019.06.006","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T03:07:41Z","timestamp":1560913661000},"page":"116-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Potential therapeutic applications of exosomes in different autoimmune diseases"],"prefix":"10.1016","volume":"205","author":[{"given":"Hui","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaochang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanmei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2019.06.006_bb0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.12691\/ijcd-3-4-8","article-title":"The world incidence and prevalence of autoimmune diseases is increasing","volume":"3","author":"Lerner","year":"2016","journal-title":"Int. J. Celiac. Dis."},{"key":"10.1016\/j.clim.2019.06.006_bb0010","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jaut.2009.09.008","article-title":"Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases","volume":"33","author":"Cooper","year":"2009","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2019.06.006_bb0015","first-page":"A592","article-title":"Autoimmune disease and the environment","volume":"106","author":"Germolec","year":"1998","journal-title":"NIEHS News"},{"key":"10.1016\/j.clim.2019.06.006_bb0020","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1172\/JCI12673","article-title":"Infection, mimics, and autoimmune disease","volume":"107","author":"Noel","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2019.06.006_bb0025","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3109\/08820139.2015.1099409","article-title":"An overview of organ-specific autoimmune diseases including immunotherapy","volume":"44","author":"Mastrandrea","year":"2015","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.clim.2019.06.006_bb0030","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrneurol.2010.71","article-title":"Systemic inflammatory cells fight off neurodegenerative disease","volume":"6","author":"Schwartz","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.clim.2019.06.006_bb0035","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0140-6736(13)60954-X","article-title":"Immunopathogenic mechanisms of systemic autoimmune disease","volume":"382","author":"Wahren-Herlenius","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2019.06.006_bb0040","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1172\/JCI78088","article-title":"Mechanisms of human autoimmunity","volume":"125","author":"Rosenblum","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2019.06.006_bb0045","doi-asserted-by":"crossref","first-page":"30087","DOI":"10.3402\/jev.v4.30087","article-title":"Applying extracellular vesicles based therapeutics in clinical trials-an ISEV position paper","volume":"4","author":"Lener","year":"2015","journal-title":"J. Extracell. Vesicles."},{"key":"10.1016\/j.clim.2019.06.006_bb0050","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1021\/acsnano.5b08015","article-title":"Evidence-based clinical use of nanoscale extracellular vesicles in nanomedicine","volume":"10","author":"Fais","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.clim.2019.06.006_bb0055","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.addr.2012.08.008","article-title":"Exosomes for targeted siRNA delivery across biological barriers","volume":"65","author":"El Andaloussi","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.clim.2019.06.006_bb0060","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.addr.2016.02.006","article-title":"Extracellular vesicles for drug delivery","volume":"106","author":"Vader","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.clim.2019.06.006_bb0065","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jconrel.2016.09.016","article-title":"Good things come in small packages: overcoming challenges to harness extracellular vesicles for therapeutic delivery","volume":"241","author":"Ingato","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.clim.2019.06.006_bb0070","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.phrs.2016.07.006","article-title":"Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: new nanotools for cancer treatment","volume":"111","author":"Kooijmans","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.clim.2019.06.006_bb0075","first-page":"228","article-title":"Exosomes and microvesicles: methods and protocols","volume":"1545","author":"Hill","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.clim.2019.06.006_bb0080","doi-asserted-by":"crossref","first-page":"22519","DOI":"10.1038\/srep22519","article-title":"Cells release sub-populations of exosomes with distinct molecular and biological properties","volume":"6","author":"Willms","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.clim.2019.06.006_bb0085","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3390\/ijms18030538","article-title":"Exosomes: from garbage bins to promising therapeutic targets","volume":"18","author":"Rashed","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.clim.2019.06.006_bb0090","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: composition, biogenesis and function","volume":"2","author":"Thery","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0095","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/prca.200900103","article-title":"Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples","volume":"4","author":"Conde-Vancells","year":"2010","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.clim.2019.06.006_bb0100","doi-asserted-by":"crossref","first-page":"201","DOI":"10.7717\/peerj.201","article-title":"Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing","volume":"5","author":"Jenjaroenpun","year":"2013","journal-title":"PeerJ."},{"key":"10.1016\/j.clim.2019.06.006_bb0105","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.vetimm.2008.04.002","article-title":"Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid","volume":"124","author":"Vella","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.clim.2019.06.006_bb0110","doi-asserted-by":"crossref","first-page":"13368","DOI":"10.1073\/pnas.0403453101","article-title":"Identification and proteomic profiling of exosomes in human urine","volume":"101","author":"Pisitkun","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2019.06.006_bb0115","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/intimm\/dxh267","article-title":"Exosomal-like vesicles are present in human blood plasma","volume":"17","author":"Caby","year":"2005","journal-title":"Int. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ygyno.2008.04.033","article-title":"MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer","volume":"110","author":"Taylor","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.clim.2019.06.006_bb0125","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.imlet.2006.09.005","article-title":"Exosomes: from biogenesis and secretion to biological function","volume":"107","author":"Keller","year":"2006","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.clim.2019.06.006_bb0130","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jneuroim.2015.04.009","article-title":"Immature dendritic cell exosomes suppress experimental autoimmune myasthenia gravis","volume":"285","author":"Bu","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0135","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.semcdb.2015.02.009","article-title":"Exosomes and their roles in immune regulation and cancer","volume":"40","author":"Greening","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.clim.2019.06.006_bb0140","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3390\/ph6050659","article-title":"Exosomes: engineering therapeutic biological nanoparticles that truly deliver","volume":"6","author":"Marcus","year":"2013","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.clim.2019.06.006_bb0145","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3109\/00365521.2010.490596","article-title":"Exosomes derived from interleukin-10-treated dendritic cells can inhibit trinitrobenzene sulfonic acid-induced rat colitis","volume":"45","author":"Yang","year":"2010","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.clim.2019.06.006_bb0150","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s10753-012-9539-1","article-title":"Immature dendritic cell-derived exosomes: a promise subcellular vaccine for autoimmunity","volume":"36","author":"Yin","year":"2013","journal-title":"Inflammation"},{"key":"10.1016\/j.clim.2019.06.006_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/smll.201702153","article-title":"Biological functions and current advances in isolation and detection strategies for exosome nanovesicles","volume":"14","author":"Boriachek","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.clim.2019.06.006_bb0160","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/jth.12254","article-title":"Innovation in detection of microparticles and exosomes","volume":"11","author":"Van der Pol","year":"2013","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.clim.2019.06.006_bb0165","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/labinvest.2009.94","article-title":"Paracrine induction of endothelium by tumor exosomes","volume":"89","author":"Hood","year":"2009","journal-title":"Lab. Investig."},{"key":"10.1016\/j.clim.2019.06.006_bb0170","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1158\/0008-5472.CAN-10-4455","article-title":"Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis","volume":"71","author":"Hood","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.clim.2019.06.006_bb0175","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.colsurfb.2011.05.013","article-title":"Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy","volume":"87","author":"Sokolova","year":"2011","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.clim.2019.06.006_bb0180","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1111\/j.1538-7836.2010.04074.x","article-title":"Optical and non-optical methods for detection and characterization of microparticles and exosomes","volume":"8","author":"Van der Pol","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.clim.2019.06.006_bb0185","doi-asserted-by":"crossref","first-page":"878","DOI":"10.5551\/jat.2642","article-title":"Assessment of an ELISA kit for platelet-derived microparticles by joint research at many institutes in Japan","volume":"16","author":"Nomura","year":"2009","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.clim.2019.06.006_bb0190","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.clinthera.2014.05.008","article-title":"Diagnostic and prognostic potential of extracellular vesicles in peripheral blood","volume":"36","author":"Revenfeld","year":"2014","journal-title":"Clin. Ther."},{"key":"10.1016\/j.clim.2019.06.006_bb0195","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.nano.2011.04.003","article-title":"Sizing and phenotyping of cellular vesiclesusing nanoparticle tracking analysis","volume":"7","author":"Dragovic","year":"2011","journal-title":"Nanomedicine. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.clim.2019.06.006_bb0200","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/jth.12602","article-title":"Particle size distribution of exosomes and microvesicles determined by trans mission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing","volume":"12","author":"Van der Pol","year":"2014","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.clim.2019.06.006_bb0205","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.bcp.2011.12.037","article-title":"The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities","volume":"83","author":"Pant","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.clim.2019.06.006_bb0210","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1034\/j.1600-0854.2002.30502.x","article-title":"The biogenesis and functions of exosomes","volume":"3","author":"Stoorvogel","year":"2002","journal-title":"Traffic."},{"key":"10.1016\/j.clim.2019.06.006_bb0215","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1165\/rcmb.2003-0238OC","article-title":"Proteomic analysis of exosomes isolated from human malignant pleural effusions","volume":"31","author":"Bard","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.clim.2019.06.006_bb0220","doi-asserted-by":"crossref","first-page":"20121","DOI":"10.1074\/jbc.273.32.20121","article-title":"Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes","volume":"273","author":"Escola","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2019.06.006_bb0225","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bcmd.2005.05.009","article-title":"The potential of exosomes in immunotherapy of cancer","volume":"35","author":"Chaput","year":"2005","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.clim.2019.06.006_bb0230","doi-asserted-by":"crossref","first-page":"7309","DOI":"10.4049\/jimmunol.166.12.7309","article-title":"Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles","volume":"166","author":"Thery","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0235","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/nar\/gkp857","article-title":"Mesenchymal stem cell secretes microparticles enriched in pre-micrornas","volume":"38","author":"Chen","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2019.06.006_bb0240","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1194\/jlr.M003657","article-title":"Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins","volume":"51","author":"Subra","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.clim.2019.06.006_bb0245","doi-asserted-by":"crossref","first-page":"531","DOI":"10.5483\/BMBRep.2014.47.10.164","article-title":"Extracellular vesicles as emerging intercellular communications","volume":"47","author":"Yoon","year":"2014","journal-title":"BMB Rep."},{"key":"10.1016\/j.clim.2019.06.006_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/842849","article-title":"The roles of tumor-derived exosomes in cancer pathogenesis","volume":"2011","author":"Yang","year":"2011","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0255","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ki.2010.278","article-title":"Exosomes\/microvesicles as a mechanism of cell-to-cell communication","volume":"78","author":"Camussi","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.clim.2019.06.006_bb0260","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.3402\/jev.v3.24641","article-title":"Routes and mechanisms of extracellular vesicle uptake","volume":"3","author":"Mulcahy","year":"2014","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.clim.2019.06.006_bb0265","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3389\/fphar.2017.00300","article-title":"Exosomes: a novel strategy for treatment and prevention of diseases","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.clim.2019.06.006_bb0270","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bbadis.2015.09.020","article-title":"Exosomes as new diagnostic tools in CNS diseases","volume":"1862","author":"Kanninen","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.clim.2019.06.006_bb0275","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.mam.2017.11.006","article-title":"Extracellular vesicles in neurodegenerative diseases","volume":"60","author":"Croese","year":"2018","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.clim.2019.06.006_bb0280","doi-asserted-by":"crossref","first-page":"23586","DOI":"10.1074\/jbc.M113.489302","article-title":"Microvesicle-mediated transfer of microRNA-150 from monocytes to endothelial cells promotes angiogenesis","volume":"288","author":"Li","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2019.06.006_bb0285","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Skog","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.clim.2019.06.006_bb0290","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1159\/000445588","article-title":"Thrombin stimulated platelet-derived exosomes inhibit platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells","volume":"38","author":"Tan","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.clim.2019.06.006_bb0295","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3389\/fimmu.2014.00518","article-title":"Immunotherapeutic potential of extracellular vesicles","volume":"5","author":"Zhang","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0300","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/08916934.2016.1191477","article-title":"Recent advances of exosomes in immune modulation and autoimmune diseases","volume":"49","author":"Tan","year":"2016","journal-title":"Autoimmunity"},{"key":"10.1016\/j.clim.2019.06.006_bb0305","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1002\/ijc.24249","article-title":"Induction of myeloid-derived suppressor cells by tumor exosomes","volume":"124","author":"Xiang","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.clim.2019.06.006_bb0310","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.4049\/jimmunol.0900970","article-title":"Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8+ T lymphocytes","volume":"183","author":"Wieckowski","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0315","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jconrel.2017.07.001","article-title":"Extracellular vesicles: novel promising delivery systems for therapy of brain diseases","volume":"262","author":"Rufino-Ramos","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.clim.2019.06.006_bb0320","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.clim.2019.06.006_bb0325","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/nar\/gks463","article-title":"Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes","volume":"40","author":"Wahlgren","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2019.06.006_bb0330","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1021\/nn402232g","article-title":"Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors","volume":"7","author":"Jang","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.clim.2019.06.006_bb0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.07.011","article-title":"Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain","volume":"142","author":"Yuan","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.clim.2019.06.006_bb0340","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biomaterials.2017.10.012","article-title":"Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy","volume":"150","author":"Tian","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.clim.2019.06.006_bb0345","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s11095-014-1593-y","article-title":"Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in danio rerio","volume":"32","author":"Yang","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.clim.2019.06.006_bb0350","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jconrel.2014.07.042","article-title":"Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery","volume":"192","author":"Pascucci","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.clim.2019.06.006_bb0355","first-page":"1525","article-title":"Exosome mimetics: a novel class of drug delivery systems","volume":"7","author":"Kooijmans","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.clim.2019.06.006_bb0360","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s12035-014-9054-5","article-title":"Exosomes as a nanodelivery system: a key to the future of neuromedicine","volume":"53","author":"Aryani","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.clim.2019.06.006_bb0365","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-016-1159-y","article-title":"Circulating exosomes from patients with systemic lupus erythematosus induce a proinflammatory immune response","volume":"18","author":"Lee","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2019.06.006_bb0370","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00526","article-title":"Therapeutic development of mesenchymal stem cells or their extracellular vesicles to inhibit autoimmune-mediated inflammatory processes in Systemic Lupus Erythematosus","volume":"8","author":"Sharma","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0375","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-02406-2","article-title":"Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis","volume":"9","author":"Kimura","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2019.06.006_bb0380","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-21497-5","article-title":"Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients","volume":"8","author":"Pieragostino","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.clim.2019.06.006_bb0385","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.rdc.2016.03.004","article-title":"The proteomics of saliva in Sj\u00f6gren's Syndrome","volume":"42","author":"Katsiougiannis","year":"2016","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"10.1016\/j.clim.2019.06.006_bb0390","doi-asserted-by":"crossref","first-page":"7458","DOI":"10.1158\/0008-5472.CAN-06-3456","article-title":"Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2","volume":"67","author":"Clayton","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.clim.2019.06.006_bb0395","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.4049\/jimmunol.180.11.7249","article-title":"Human tumor-derived exosomes down-modulate NKG2D expression","volume":"180","author":"Clayton","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0400","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.4049\/jimmunol.176.3.1375","article-title":"Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function","volume":"176","author":"Liu","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0405","doi-asserted-by":"crossref","first-page":"6867","DOI":"10.4049\/jimmunol.178.11.6867","article-title":"Tumor exosomes inhibit differentiation of bone marrow dendritic cells","volume":"178","author":"Yu","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0410","doi-asserted-by":"crossref","first-page":"817","DOI":"10.4049\/jimmunol.180.2.817","article-title":"Polymorphonuclear neutrophil-derived ectosomes interfere with the maturation of monocyte-derived dendritic cells","volume":"180","author":"Eken","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0415","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.4049\/jimmunol.181.8.5242","article-title":"Thymus exosomes-like particles induce regulatory T cells","volume":"181","author":"Wang","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0420","doi-asserted-by":"crossref","first-page":"293","DOI":"10.15171\/apb.2016.041","article-title":"Mesenchymal stem cell-derived exosomes: new opportunity in cell-free therapy","volume":"6","author":"Sarvar","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.clim.2019.06.006_bb0425","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2017.00039","article-title":"Mesenchymal stem cell-derived exosomes: immunomodulatory evaluation in an antigen-induced synovitis porcine model","volume":"4","author":"Casado","year":"2017","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.clim.2019.06.006_bb0430","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.7150\/thno.21072","article-title":"Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis","volume":"8","author":"Cosenza","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.clim.2019.06.006_bb0435","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molimm.2017.11.008","article-title":"BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis","volume":"93","author":"Chen","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0440","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1530\/JME-17-0080","volume":"59","author":"Newton","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.clim.2019.06.006_bb0445","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.2337\/dc17-S005","article-title":"Classification and diagnosis of diabetes","volume":"40","author":"American Diabetes Association (ADA)","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clim.2019.06.006_bb0450","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.2337\/diacare.24.8.1397","article-title":"Postchallenge hyperglycemia and mortality in a national sample of U.S. adults","volume":"24","author":"Saydah","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clim.2019.06.006_bb0455","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1399-5448.2007.00326.x","article-title":"Executive summary","volume":"8","author":"Aanstoot","year":"2007","journal-title":"Pediatr. Diabetes"},{"key":"10.1016\/j.clim.2019.06.006_bb0460","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S2213-8587(14)70248-7","article-title":"Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis","volume":"3","author":"Huxley","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.clim.2019.06.006_bb0465","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073798","article-title":"Urinary exosomal MicroRNAs in incipient diabetic nephropathy","volume":"8","author":"Barutta","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2019.06.006_bb0470","first-page":"2940","article-title":"Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus","volume":"21","author":"Garcia-Contreras","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.clim.2019.06.006_bb0475","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/leu.2014.41","article-title":"MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease","volume":"453","author":"Kordelas","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.clim.2019.06.006_bb0480","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3727\/096368911X627534","article-title":"Microvesicles derived from endothelial progenitor cells enhance neoangiogenesis of human 381 pancreatic islets","volume":"21","author":"Cantaluppi","year":"2012","journal-title":"Cell transplantat"},{"key":"10.1016\/j.clim.2019.06.006_bb0485","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13287-016-0287-2","article-title":"Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats","volume":"7","author":"Jiang","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.clim.2019.06.006_bb0490","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1002\/ana.410360716","article-title":"McFarlin memorial lecture: the immunology of the multiple sclerosis lesion","volume":"36","author":"Raine","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.clim.2019.06.006_bb0495","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/1352458514561911","article-title":"The Charcot Lecture | beating MS: a story of B cells, with twists and turns","volume":"21","author":"Hauser","year":"2015","journal-title":"Mult. Scler."},{"key":"10.1016\/j.clim.2019.06.006_bb0500","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1172\/JCI58649","article-title":"Multiple sclerosis","volume":"122","author":"Nylander","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2019.06.006_bb0505","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri3871","article-title":"Immunopathology of multiple sclerosis","volume":"15","author":"Dendrou","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0510","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/B978-0-444-52001-2.00011-X","article-title":"Multiple sclerosis: diagnosis, differential diagnosis, and clinical presentation","volume":"122","author":"Gelfand","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.clim.2019.06.006_bb0515","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/glia.22606","article-title":"Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination","volume":"62","author":"Pusic","year":"2014","journal-title":"J. Glia."},{"key":"10.1016\/j.clim.2019.06.006_bb0520","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jneuroim.2013.10.014","article-title":"IFN gamma-stimulated dendritic cell exosomes as a potential therapeutic for remyelination","volume":"266","author":"Pusic","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0525","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1002\/eji.201243295","article-title":"Exosomes with membrane-associated TGF-beta from gene-modified dendritic cells inhibit murine EAE independently of MHC restriction","volume":"43","author":"Yu","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0530","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.imlet.2012.06.001","article-title":"Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling","volume":"147","author":"Mokarizadeh","year":"2012","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.clim.2019.06.006_bb0535","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/mt.2011.164","article-title":"Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain","volume":"19","author":"Zhuang","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.clim.2019.06.006_bb0540","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMra071297","article-title":"Systemic lupus erythematosus","volume":"358","author":"Rahman","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2019.06.006_bb0545","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0092-8674(00)81108-3","article-title":"Systemic lupus erythematosus","volume":"85","author":"Kotzin","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.clim.2019.06.006_bb0550","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1155\/2012\/532497","article-title":"Antibodies against 4-hydroxy-2-nonenal modified epitopes recognized chromatin and its oxidized forms: role of chromatin, oxidized forms of chromatin and 4-hydroxy-2-nonenal modified epitopes in the etiopathogenesis of SLE","volume":"33","author":"Al-Shobaili","year":"2012","journal-title":"Dis. Markers"},{"key":"10.1016\/j.clim.2019.06.006_bb0555","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/art.33400","article-title":"Autoantibodies to estrogen receptor alpha interfere with T lymphocyte homeostasis and are associated with disease activity in systemic lupus erythematosus","volume":"64","author":"Colasanti","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2019.06.006_bb0560","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2019.06.006_bb0565","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/rheumatology\/ker410","article-title":"Glucocorticoid use and abuse in SLE","volume":"51","author":"Ruiz-Irastorza","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2019.06.006_bb0570","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/03009740510017706","article-title":"The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis","volume":"34","author":"Buttgereit","year":"2005","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.clim.2019.06.006_bb0575","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/BOR.0000000000000369","article-title":"From mechanism to therapies in systemic lupus erythematosus","volume":"29","author":"Paley","year":"2017","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.clim.2019.06.006_bb0580","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.biopha.2016.08.020","article-title":"Application of nanoparticle technology in the treatment of systemic lupus erythematous","volume":"83","author":"Rostamzadeh","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.clim.2019.06.006_bb0585","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/annrheumdis-2014-206090","article-title":"A phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-\u03b1) in patients with systemic lupus erythematosus (ROSE)","volume":"75","author":"Kalunian","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2019.06.006_bb0590","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/art.39722","article-title":"A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of treatment with sirukumab (CNTO 136) in patients with active lupus nephritis","volume":"68","author":"Rovin","year":"2016","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2019.06.006_bb0595","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/art.24545","article-title":"Long-term medical costs and resource utilization in systemic lupus erythematosus and lupus nephritis: a five-year analysis of a large Medicaid population","volume":"61","author":"Li","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2019.06.006_bb0600","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1056\/NEJMct1207259","article-title":"Belimumab for systemic lupus erythematosus","volume":"368","author":"Hahn","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2019.06.006_bb0605","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1517\/17460441.2014.897692","article-title":"Novel approaches to lupus drug discovery using stem cell therapy. Role of mesenchymal-stem-cell-secreted factors","volume":"9","author":"Figueroa","year":"2014","journal-title":"Expert. Opin. Drug Discov."},{"key":"10.1016\/j.clim.2019.06.006_bb0610","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nrrheum.2015.170","article-title":"Extracellular vesicles\u2014new tool for joint repair and regeneration","volume":"12","author":"Malda","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2019.06.006_bb0615","doi-asserted-by":"crossref","first-page":"vi28","DOI":"10.1093\/rheumatology\/kes278","article-title":"Evolution of treatment for rheumatoid arthritis","volume":"51","author":"Upchurch","year":"2012","journal-title":"Rheumatology (Oxford, England)"},{"key":"10.1016\/j.clim.2019.06.006_bb0620","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2174\/1574888X11666151203223251","article-title":"Extracellular vesicles as drug delivery vehicles for rheumatoid arthritis","volume":"11","author":"Kim","year":"2016","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.clim.2019.06.006_bb0625","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/ar2666","article-title":"Treatment options in patients with rheumatoid arthritis failing initial TNF inhibitor therapy: a critical review","volume":"11","author":"Rubbert-Roth","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2019.06.006_bb0630","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/intimm\/dxu102","article-title":"Anti-TNF therapy: past, present and future","volume":"27","author":"Monaco","year":"2015","journal-title":"Int. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0635","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.4049\/jimmunol.179.4.2242","article-title":"Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4","volume":"179","author":"Kim","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0640","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.4049\/jimmunol.174.10.6440","article-title":"Exosomes Derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis","volume":"174","author":"Kim","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0645","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/art.24229","article-title":"Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase\u2013positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models","volume":"60","author":"Bianco","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2019.06.006_bb0650","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1002\/art.27501","article-title":"Liposome-bound apo2l\/trail is an effective treatment in a rabbit model of rheumatoid arthritis","volume":"62","author":"Martinez-Lostao","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2019.06.006_bb0655","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1001\/jama.2010.1014","article-title":"Treatment of primary Sj\u00f6gren Syndrome","volume":"304","author":"Ramos-Casals","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.clim.2019.06.006_bb0660","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/art.21005","article-title":"Salivary gland epithelial cell exosomes: a source of autoantigenic ribonucleoproteins","volume":"52","author":"Kapsogeorgou","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2019.06.006_bb0665","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1182\/blood-2011-11-391144","article-title":"Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sj\u00f6gren syndrome","volume":"120","author":"Xu","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.clim.2019.06.006_bb0670","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2217\/bmm.13.63","article-title":"Exosomes: the future of biomarkers in medicine","volume":"7","author":"Properzi","year":"2013","journal-title":"Biomark. Med"},{"key":"10.1016\/j.clim.2019.06.006_bb0675","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008577","article-title":"Nanostructural and transcriptomic analyses of human saliva derived exosomes","volume":"5","author":"Palanisamy","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2019.06.006_bb0680","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1601-0825.2009.01604.x","article-title":"Exosomes from human saliva as a source of microRNA biomarkers","volume":"16","author":"Michael","year":"2010","journal-title":"Oral Dis."},{"key":"10.1016\/j.clim.2019.06.006_bb0685","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1002\/art.22954","article-title":"Salivary proteomic and genomic biomarkers for primary Sjogren's syndrome","volume":"56","author":"Hu","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2019.06.006_bb0690","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev-pathol-011110-130312","article-title":"The pathogenesis of systemic sclerosis","volume":"6","author":"Katsumoto","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.clim.2019.06.006_bb0695","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/cr.2017.11","article-title":"Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis","volume":"27","author":"Chen","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.clim.2019.06.006_bb0700","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1038\/s41598-017-04559-y","article-title":"Effects of mesenchymal stem cell-derived exosomes on experimental autoimmune uveitis","volume":"7","author":"Bai","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.clim.2019.06.006_bb0705","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3389\/fimmu.2018.01279","article-title":"Immunoregulatory effects of Myeloid-Derived suppressor cell exosomes in Mouse Model of autoimmune alopecia areata","volume":"9","author":"Z\u00f6ller","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2019.06.006_bb0710","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.semcdb.2016.11.008","article-title":"MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment","volume":"67","author":"Toh","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.clim.2019.06.006_bb0715","article-title":"Immunomodulatory properties of MSC-derived exosomes armed with high affinity aptamer toward mylein as a platform for reducing multiple sclerosis clinical score","author":"Shamili","year":"2019","journal-title":"J. Control. Rel."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661619301548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661619301548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:59:35Z","timestamp":1761494375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661619301548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":143,"alternative-id":["S1521661619301548"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2019.06.006","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential therapeutic applications of exosomes in different autoimmune diseases","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2019.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}