{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:50:31Z","timestamp":1791003031243,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007793","name":"Stiftelsen Kristian Gerhard Jebsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.clim.2020.108621","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T04:23:37Z","timestamp":1605241417000},"page":"108621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["T cell receptor repertoire as a potential diagnostic marker for celiac disease"],"prefix":"10.1016","volume":"222","author":[{"given":"Ying","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asima","family":"Zia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf Stefan","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Pavlovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Balaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut E.A.","family":"Lundin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir Kjetil","family":"Sandve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo-Wang","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2020.108621_bb0005","doi-asserted-by":"crossref","first-page":"a005140","DOI":"10.1101\/cshperspect.a005140","article-title":"Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling","volume":"2","author":"Wucherpfennig","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.clim.2020.108621_bb0010","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/ng.3625","article-title":"Genetic variation in MHC proteins is associated with T cell receptor expression biases","volume":"48","author":"Sharon","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2020.108621_bb0015","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1189\/jlb.0906584","article-title":"Characterization of CD8+ T cell repertoire in identical twins discordant and concordant for multiple sclerosis","volume":"81","author":"Somma","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.clim.2020.108621_bb0020","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.imbio.2012.01.002","article-title":"T-cell receptor repertoire analysis in monozygotic twins concordant and discordant for type 1 diabetes","volume":"217","author":"Fozza","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.clim.2020.108621_bb0025","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/ng.3822","article-title":"Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire","volume":"49","author":"Emerson","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2020.108621_bb0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.immuni.2007.07.007","article-title":"Na\u00efve CD4+ T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude","volume":"27","author":"Moon","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2020.108621_bb0035","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1177\/2050640614540154","article-title":"Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge","volume":"2","author":"Christophersen","year":"2014","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.clim.2020.108621_bb0040","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1002\/eji.201343382","article-title":"Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease","volume":"43","author":"Bodd","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2020.108621_bb0045","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0090-1229(83)90106-X","article-title":"Evidence that celiac disease is primarily associated with a DC locus allelic specificity","volume":"28","author":"Tosi","year":"1983","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.clim.2020.108621_bb0050","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.169.1.345","article-title":"Evidence for a primary association of celiac disease to a particular HLA-DQ alpha\/beta heterodimer","volume":"169","author":"Sollid","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2020.108621_bb0055","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0198-8859(03)00027-2","article-title":"HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European genetics cluster on celiac disease","volume":"64","author":"Karell","year":"2003","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.clim.2020.108621_bb0060","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.4049\/jimmunol.1601693","article-title":"T Cells in Celiac Disease","volume":"198","author":"Jabri","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2020.108621_bb0065","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1172\/JCI98819","article-title":"Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease","volume":"128","author":"Risnes","year":"2018","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.clim.2020.108621_bb0070","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nmeth.2960","article-title":"Towards error-free profiling of immune repertoires","volume":"11","author":"Shugay","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.clim.2020.108621_bb0075","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nmeth.3364","article-title":"MiXCR: software for comprehensive adaptive immunity profiling","volume":"12","author":"Bolotin","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.clim.2020.108621_bb0080","first-page":"2825","article-title":"Scikit-learn: machine learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"10.1016\/j.clim.2020.108621_bb0085","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.4049\/jimmunol.1101526","article-title":"Posttranslational modification of gluten shapes TCR usage in celiac disease","volume":"187","author":"Qiao","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2020.108621_bb0090","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2016-311816","article-title":"T-cell repertoires in refractory coeliac disease","author":"Ritter","year":"2017","journal-title":"Gut"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661620307816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661620307816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:03:16Z","timestamp":1761494596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661620307816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":18,"alternative-id":["S1521661620307816"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2020.108621","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T cell receptor repertoire as a potential diagnostic marker for celiac disease","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2020.108621","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108621"}}