{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:05:39Z","timestamp":1785179139213,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.clim.2021.108854","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T11:37:07Z","timestamp":1631533027000},"page":"108854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Distribution of monocytes subpopulations in the peripheral blood from patients with Beh\u00e7et's disease - Impact of disease status and colchicine use"],"prefix":"10.1016","volume":"231","author":[{"given":"Talita C.","family":"Gazzito Del Padre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joice Moraes F.M.","family":"Belem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Freitas","family":"de Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heron Fernandes Vieira","family":"Torquato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar Julian","family":"Paredes-Gamero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayel H.","family":"Abdulahad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Brouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre W.S.","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.clim.2021.108854_bb0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.rdc.2013.02.010","article-title":"Behcet\u2019s syndrome","volume":"39","author":"Hatemi","year":"2013","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"10.1016\/j.clim.2021.108854_bb0010","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.3389\/fimmu.2019.01067","article-title":"Beh\u00e7et\u2019s disease: an overview of etiopathogenesis","volume":"10","author":"Leccese","year":"2019","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.clim.2021.108854_bb0015","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1684\/ecn.2018.0411","article-title":"Increased IL-1\u03b2 levels are associated with an imbalance of \u201coxidant\/antioxidant\u201d status during Beh\u00e7et\u2019s disease","volume":"29","author":"Chekaoui","year":"2018","journal-title":"Eur Cytokine Netw."},{"issue":"5","key":"10.1016\/j.clim.2021.108854_bb0020","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1080\/08820139.2017.1306865","article-title":"Th17-inducing conditions Lead to in vitro activation of both Th17 and Th1 responses in Behcet\u2019s disease","volume":"46","author":"Deniz","year":"2017","journal-title":"Immunol. Investig."},{"issue":"6","key":"10.1016\/j.clim.2021.108854_bb0025","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.autrev.2017.12.006","article-title":"Beh\u00e7et\u2019s disease: new insights into pathophysiology, clinical features and treatment options","volume":"17","author":"Greco","year":"2018","journal-title":"Autoimmun. Rev."},{"issue":"9","key":"10.1016\/j.clim.2021.108854_bb0030","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1136\/annrheumdis-2018-214335","article-title":"Critical role of neutrophil extracellular traps (NETs) in patients with Behcet\u2019s disease","volume":"78","author":"Le Joncour","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2021.108854_bb0035","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fimmu.2019.01085","article-title":"Beh\u00e7et\u2019s syndrome as a model of thrombo-inflammation: the role of neutrophils","volume":"10","author":"Emmi","year":"2019","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.clim.2021.108854_bb0040","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s13075-017-1443-5","article-title":"Soluble CD40L is associated with increased oxidative burst and neutrophil extracellular trap release in Beh\u00e7et\u2019s disease","volume":"19","author":"Perazzio","year":"2017","journal-title":"Arthritis Res Ther."},{"issue":"6","key":"10.1016\/j.clim.2021.108854_bb0045","first-page":"S85","article-title":"Behcet\u2019s disease heterogeneity: cytokine production and oxidative burst of phagocytes are altered in patients with severe manifestations","volume":"33","author":"Perazzio","year":"2015","journal-title":"Clinical and Experimental Rheumatology"},{"key":"10.1016\/j.clim.2021.108854_bb0050","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","article-title":"Monocyte-mediated defense against microbial pathogens","volume":"26","author":"Serbina","year":"2008","journal-title":"Annu Rev Immunol."},{"issue":"10","key":"10.1016\/j.clim.2021.108854_bb0055","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.it.2011.05.001","article-title":"Monocyte trafficking in acute and chronic inflammation","volume":"32","author":"Ingersoll","year":"2011","journal-title":"Trends Immunol."},{"issue":"16","key":"10.1016\/j.clim.2021.108854_bb0060","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1182\/blood-2010-02-258558","article-title":"Nomenclature of monocytes and dendritic cells in blood","volume":"116","author":"Ziegler-Heitbrock","year":"2010","journal-title":"Blood."},{"key":"10.1016\/j.clim.2021.108854_bb0065","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.3389\/fimmu.2019.02035","article-title":"Human monocyte subsets and phenotypes in major chronic inflammatory diseases","volume":"10","author":"Kapellos","year":"2019","journal-title":"Front Immunol."},{"issue":"7","key":"10.1016\/j.clim.2021.108854_bb0070","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.4049\/jimmunol.168.7.3536","article-title":"The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF","volume":"168","author":"Belge","year":"2002","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.clim.2021.108854_bb0075","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s10067-009-1261-5","article-title":"Neutrophil hyperchemotaxis in Behcet\u2019s disease: a possible role for monocytes orchestrating bacterial-induced innate immune responses","volume":"28","author":"Neves","year":"2009","journal-title":"Clin. Rheumatol."},{"issue":"5","key":"10.1016\/j.clim.2021.108854_bb0080","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/rheumatology\/35.5.424","article-title":"Monocyte activity in Behcet\u2019s disease","volume":"35","author":"Sahin","year":"1996","journal-title":"Br. J. Rheumatol."},{"issue":"12","key":"10.1016\/j.clim.2021.108854_bb0085","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/j.1468-3083.2009.03334.x","article-title":"Is there any relationship between serum and urine neopterin and serum interferon-gamma levels in the activity of Behcet\u2019s disease?","volume":"23","author":"Erturan","year":"2009","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"6","key":"10.1016\/j.clim.2021.108854_bb0090","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1093\/rheumatology\/ken109","article-title":"Effects of vitamin D on expression of toll-like receptors of monocytes from patients with Behcet\u2019s disease","volume":"47","author":"Do","year":"2008","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"10.1016\/j.clim.2021.108854_bb0095","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1007\/s10067-006-0371-6","article-title":"LPS-stimulated production of TNF-alpha by peripheral blood monocytes in patients with Behcet\u2019s disease","volume":"26","author":"Slobodin","year":"2007","journal-title":"Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.clim.2021.108854_bb0100","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ng.2520","article-title":"Genome-wide association analysis identifies new susceptibility loci for Beh\u00e7et\u2019s disease and epistasis between HLA-B*51 and ERAP1","volume":"45","author":"Kirino","year":"2013","journal-title":"Nat Genet."},{"issue":"8","key":"10.1016\/j.clim.2021.108854_bb0105","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ng.625","article-title":"Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet\u2019s disease","volume":"42","author":"Remmers","year":"2010","journal-title":"Nat Genet."},{"issue":"8697","key":"10.1016\/j.clim.2021.108854_bb0110","first-page":"1078","article-title":"International Study Group for Behcet\u2019s Disease","volume":"335","author":"Criteria for diagnosis of Behcet\u2019s disease","year":"1990","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.clim.2021.108854_bb0115","first-page":"20","article-title":"Cross-cultural adaptation of simplified version (s) of Beh\u00e7et's Disease Current Activity Form (BDCAF) and comparison between two different instruments with Brazilian versions for evaluating Beh\u00e7et's Disease Activity: BR-BDCAF and BR-BDCAF(s)","volume":"49","author":"Neves FdS, USP","year":"2009","journal-title":"Rev Bras Reumatol."},{"key":"10.1016\/j.clim.2021.108854_bb0120","doi-asserted-by":"crossref","first-page":"11888","DOI":"10.1038\/srep11888","article-title":"Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1beta secretion in response to anti-MPO antibodies","volume":"5","author":"O\u2019Brien","year":"2015","journal-title":"Sci Rep."},{"issue":"1","key":"10.1016\/j.clim.2021.108854_bb0125","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.1038\/s41598-017-06826-4","article-title":"Involvement of monocyte subsets in the immunopathology of giant cell arteritis","volume":"7","author":"van Sleen","year":"2017","journal-title":"Sci Rep."},{"key":"10.1016\/j.clim.2021.108854_bb0130","doi-asserted-by":"crossref","first-page":"108683","DOI":"10.1016\/j.clim.2021.108683","article-title":"Aberrant monocyte subsets in patients with Beh\u00e7et\u2019s disease","volume":"225","author":"Li","year":"2021","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2021.108854_bb0135","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3389\/fimmu.2019.00665","article-title":"Immunopathogenesis of Behcet\u2019s disease","volume":"10","author":"Tong","year":"2019","journal-title":"Front Immunol."},{"issue":"5","key":"10.1016\/j.clim.2021.108854_bb0140","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1182\/blood-2010-12-326355","article-title":"Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets","volume":"118","author":"Wong","year":"2011","journal-title":"Blood."},{"issue":"3","key":"10.1016\/j.clim.2021.108854_bb0145","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.immuni.2010.08.012","article-title":"Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors","volume":"33","author":"Cros","year":"2010","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.clim.2021.108854_bb0150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1365-2133.2004.06003.x","article-title":"Increased advanced oxidation protein products in Beh\u00e7et\u2019s disease: a new activity marker?","volume":"151","author":"Yazici","year":"2004","journal-title":"Br J Dermatol."},{"issue":"5","key":"10.1016\/j.clim.2021.108854_bb0155","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3109\/03009742.2014.894568","article-title":"Decreased tumour necrosis factor-\u03b1 production by monocytes of granulomatosis with polyangiitis","volume":"43","author":"Park","year":"2014","journal-title":"Scand. J. Rheumatol."},{"issue":"9","key":"10.1016\/j.clim.2021.108854_bb0160","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/art.40520","article-title":"Review: what is the current evidence for disease subsets in giant cell arteritis?","volume":"70","author":"van der Geest","year":"2018","journal-title":"Arthritis Rheumatol."},{"issue":"4","key":"10.1016\/j.clim.2021.108854_bb0165","doi-asserted-by":"crossref","first-page":"e0176460","DOI":"10.1371\/journal.pone.0176460","article-title":"Phenotype, function, and differentiation potential of human monocyte subsets","volume":"12","author":"Boyette","year":"2017","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.clim.2021.108854_bb0170","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s10067-011-1694-5","article-title":"Diagnostic value of pathergy test in Behcet\u2019s disease according to the change of incidence over the time","volume":"30","author":"Davatchi","year":"2011","journal-title":"Clin Rheumatol."},{"issue":"11","key":"10.1016\/j.clim.2021.108854_bb0175","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.4049\/jimmunol.1402409","article-title":"CD14++CD16+ Monocytes Are Enriched by Glucocorticoid Treatment and Are Functionally Attenuated in Driving Effector T Cell Responses","volume":"194","author":"Liu","year":"2015","journal-title":"J Immunol."},{"issue":"3","key":"10.1016\/j.clim.2021.108854_bb0180","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1515\/CCLM.1999.039","article-title":"CD14++ monocytes, CD14+\/CD16+ subset and soluble CD14 as biological markers of inflammatory systemic diseases and monitoring immunosuppressive therapy","volume":"37","author":"Scherberich","year":"1999","journal-title":"Clin. Chem. Lab. Med."},{"issue":"2","key":"10.1016\/j.clim.2021.108854_bb0185","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/bjh.17205","article-title":"Glucocorticoid treatment in patients with newly diagnosed immune thrombocytopenia switches CD14(++) CD16(+) intermediate monocytes from a pro-inflammatory to an anti-inflammatory phenotype","volume":"192","author":"Williams","year":"2021","journal-title":"Br. J. Haematol."},{"issue":"8","key":"10.1016\/j.clim.2021.108854_bb0190","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/anae.14306","article-title":"The early in-vivo effects of a single anti-emetic dose of dexamethasone on innate immune cell gene expression and activation in healthy volunteers","volume":"73","author":"Bain","year":"2018","journal-title":"Anaesthesia."},{"key":"10.1016\/j.clim.2021.108854_bb0195","doi-asserted-by":"crossref","first-page":"106117","DOI":"10.1016\/j.dib.2020.106117","article-title":"Data on the modulatory effects of a single bolus dexamethasone on the surface marker expression of various leucocyte subsets","volume":"32","author":"Draxler","year":"2020","journal-title":"Data Brief"},{"key":"10.1016\/j.clim.2021.108854_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2016.09.011","article-title":"CD14(+)CD16(++) monocytes are increased in patients with NMO and are selectively suppressed by glucocorticoids therapy","volume":"300","author":"Zeng","year":"2016","journal-title":"J. Neuroimmunol."},{"issue":"3","key":"10.1016\/j.clim.2021.108854_bb0205","first-page":"531","article-title":"The effect of azathioprine (Imuran) on the cell cycle of promonocytes and the production of monocytes in the bone marrow","volume":"141","author":"van Furth","year":"1975","journal-title":"J Exp Med."},{"issue":"2","key":"10.1016\/j.clim.2021.108854_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20020291","article-title":"TNF-\u03b1 Inhibitors Decrease Classical CD14(hi)CD16- Monocyte Subsets in Highly Active, Conventional Treatment Refractory Rheumatoid Arthritis and Ankylosing Spondylitis","volume":"20","author":"Batko","year":"2019","journal-title":"Int J Mol Sci."},{"issue":"20","key":"10.1016\/j.clim.2021.108854_bb0215","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.jacc.2013.08.726","article-title":"Colchicine and the heart: pushing the envelope","volume":"62","author":"Deftereos","year":"2013","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661621001911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661621001911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:04:20Z","timestamp":1761494660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661621001911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":43,"alternative-id":["S1521661621001911"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2021.108854","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distribution of monocytes subpopulations in the peripheral blood from patients with Beh\u00e7et's disease - Impact of disease status and colchicine use","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2021.108854","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108854"}}