{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:52:36Z","timestamp":1774533156857,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.clim.2022.108956","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T12:20:48Z","timestamp":1644841248000},"page":"108956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Changes of CD3+CD56+ \u03b3\u03b4 T cell number and apoptosis during hospital admission are related to mortality in septic patients"],"prefix":"10.1016","volume":"236","author":[{"given":"J.C.","family":"Andreu-Ballester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Arribas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Garc\u00eda-Ballesteros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Galindo-Regal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sorando-Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Albert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"L\u00f3pez-Chuli\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Peydr\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cu\u00e9llar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2022.108956_bb0005","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2017.17687","article-title":"Enhancing recovery from sepsis: a review","volume":"319","author":"Prescott","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.clim.2022.108956_bb0010","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"International forum of acute care trialists. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.clim.2022.108956_bb0015","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.4049\/jimmunol.1701618","article-title":"Sepsis-induced T cell immunoparalysis: the ins and outs of impaired T cell immunity","volume":"200","author":"Jensen","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2022.108956_bb0020","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.4049\/jimmunol.152.10.5014","article-title":"Sepsis-induced apoptosis of the thymocytes in mice","volume":"152","author":"Wang","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2022.108956_bb0025","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1097\/00003246-199708000-00015","article-title":"Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice","volume":"25","author":"Hotchkiss","year":"1997","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.clim.2022.108956_bb0030","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.4049\/jimmunol.166.11.6952","article-title":"Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans","volume":"166","author":"Hotchkiss","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2022.108956_bb0035","doi-asserted-by":"crossref","first-page":"R128","DOI":"10.1186\/cc7088","article-title":"Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis","volume":"12","author":"Weber","year":"2008","journal-title":"Crit. Care"},{"key":"10.1016\/j.clim.2022.108956_bb0040","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10495-016-1325-3","article-title":"Apoptosis-induced lymphopenia in sepsis and other severe injuries","volume":"22","author":"Girardot","year":"2017","journal-title":"Apoptosis"},{"issue":"11","key":"10.1016\/j.clim.2022.108956_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.488","article-title":"Revisiting caspases in sepsis","volume":"5","author":"Aziz","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.clim.2022.108956_bb0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13049-019-0596-4","article-title":"Sepsis: mechanisms of bacterial injury to the patient","volume":"27","author":"Minasyan","year":"2019","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"10.1016\/j.clim.2022.108956_bb0055","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nri.2017.101","article-title":"\u03b3\u03b4 T cells in homeostasis and host defence of epithelial barrier tissues","volume":"17","author":"Nielsen","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2022.108956_bb0060","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2022.108956_bb0065","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.molimm.2018.09.026","article-title":"Innate T cells in the intensive care unit","volume":"105","author":"Kim","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.clim.2022.108956_bb0070","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/cyto.b.21020","article-title":"Values for \u03b1\u03b2 and \u03b3\u03b4 T-lymphocytes and CD4+, CD8+, and CD56+ subsets in healthy adult subjects: assessment by age and gender","volume":"82","author":"Andreu-Ballester","year":"2012","journal-title":"Cytometry B Clin. Cytom."},{"key":"10.1016\/j.clim.2022.108956_bb0075","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1007\/s13577-021-00531-1","article-title":"Proposal for the designation of the natural killer antigens-positive \u03b3\u03b4 T-cell subset as \u03b3\u03b4 NKT-cells: nomenclature based on immunoprofile","volume":"34","author":"Matsuo","year":"2021","journal-title":"Hum. Cell"},{"issue":"1","key":"10.1016\/j.clim.2022.108956_bb0080","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1186\/cc11157","article-title":"Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern","volume":"16","author":"Heffernan","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.clim.2022.108956_bb0085","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/SHK.0000000000000234","article-title":"Persistent lymphopenia after diagnosis of sepsis predicts mortality","volume":"42","author":"Drewry","year":"2014","journal-title":"Shock"},{"key":"10.1016\/j.clim.2022.108956_bb0090","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1128\/CVI.00752-12","article-title":"Association of \u03b3\u03b4 T cells with disease severity and mortality in septic patients","volume":"20","author":"Andreu-Ballester","year":"2013","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.clim.2022.108956_bb0095","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.clim.2022.108956_bb0100","first-page":"R1338","article-title":"Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis","volume":"291","author":"Chung","year":"2006","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.clim.2022.108956_bb0105","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1189\/jlb.0707507","article-title":"Gammadelta T cells mitigate the organ injury and mortality of sepsis","volume":"83","author":"Tsch\u00f6p","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.clim.2022.108956_bb0110","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cellimm.2015.04.008","article-title":"Human gamma delta T cells: evolution and ligand recognition","volume":"296","author":"Adams","year":"2015","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.clim.2022.108956_bb0115","first-page":"3698","article-title":"Characterization of human peripheral blood \u03b3\u03b4 T cells in patients with sepsis","volume":"19","author":"Wang","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.clim.2022.108956_bb0120","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00024382-200212000-00001","article-title":"Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome","volume":"18","author":"Le Tulzo","year":"2002","journal-title":"Shock"},{"key":"10.1016\/j.clim.2022.108956_bb0125","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1084\/jem.174.1.139","article-title":"Use of a SCID mouse\/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity","volume":"174","author":"Schmidt-Wolf","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2022.108956_bb0130","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3389\/fimmu.2017.00774","article-title":"Cytokine-induced killer cells as pharmacological tools for cancer immunotherapy","volume":"8","author":"Gao","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.108956_bb0135","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-2249.2006.03078.x","article-title":"Activated gammadelta T cells express the natural cytotoxicity receptor natural killer p 44 and show cytotoxic activity against myeloma cells","volume":"144","author":"von Lilienfeld-Toal","year":"2006","journal-title":"Clin. Exp. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661622000365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661622000365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:05:40Z","timestamp":1761494740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661622000365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":27,"alternative-id":["S1521661622000365"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2022.108956","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes of CD3+CD56+ \u03b3\u03b4 T cell number and apoptosis during hospital admission are related to mortality in septic patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2022.108956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108956"}}