{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:26:03Z","timestamp":1790727963841,"version":"4.1.0"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004561","name":"Ministry of Education and Science of the Republic of Kazakhstan","doi-asserted-by":"publisher","award":["AP09259390"],"award-info":[{"award-number":["AP09259390"]}],"id":[{"id":"10.13039\/501100004561","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.clim.2022.109024","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T01:55:09Z","timestamp":1651024509000},"page":"109024","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Myeloid-derived suppressor cells in COVID-19: A review"],"prefix":"10.1016","volume":"238","author":[{"given":"Yuliya V.","family":"Perfilyeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yekaterina O.","family":"Ostapchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raikhan","family":"Tleulieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aykin","family":"Kali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurshat","family":"Abdolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir K.","family":"Krasnoshtanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastassiya V.","family":"Perfilyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai N.","family":"Belyaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2022.109024_bb0005","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0010","article-title":"Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression","author":"Rendeiro","year":"2020","journal-title":"MedRxiv."},{"key":"10.1016\/j.clim.2022.109024_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.697622","article-title":"The dynamic immunological parameter landscape in coronavirus disease 2019 patients with different outcomes","volume":"12","author":"Tang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0020","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2020.08.002","article-title":"Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19","volume":"182","author":"Silvin","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.clim.2022.109024_bb0025","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.cell.2020.08.001","article-title":"Severe COVID-19 is marked by a dysregulated myeloid cell compartment","volume":"182","author":"Schulte-Schrepping","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.clim.2022.109024_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","author":"Veglia","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112346","article-title":"Role of myeloid-derived suppressor cells in viral respiratory infections; hints for discovering therapeutic targets for COVID-19","author":"Koushki","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.clim.2022.109024_bb0040","article-title":"Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans","volume":"2008","author":"De Santo","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2022.109024_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025242","article-title":"Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice","author":"Jeisy-Scott","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2022.109024_bb0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/path.4232","article-title":"Pathways mediating resolution of inflammation: when enough is too much","volume":"231","author":"Fullerton","year":"2013","journal-title":"J. Pathol."},{"key":"10.1016\/j.clim.2022.109024_bb0055","author":"COVID-19 mortality overview"},{"key":"10.1016\/j.clim.2022.109024_bb0060","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01661-20","article-title":"Pervasive RNA secondary structure in the genomes of SARS-CoV-2 and other coronaviruses","volume":"11","author":"Simmonds","year":"2020","journal-title":"MBio."},{"key":"10.1016\/j.clim.2022.109024_bb0065","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.clim.2022.109024_bb0070","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11684-020-0754-0","article-title":"Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection","volume":"14","author":"Zou","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.clim.2022.109024_bb0075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41421-021-00249-2","article-title":"SARS-CoV-2 cell tropism and multiorgan infection","volume":"7","author":"Liu","year":"2021","journal-title":"Cell Discov."},{"key":"10.1016\/j.clim.2022.109024_bb0080","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fmicb.2019.00050","article-title":"Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.clim.2022.109024_bb0085","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41590-021-00942-0","article-title":"RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells","volume":"22","author":"Yamada","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108628","article-title":"MDA5 governs the innate immune response to SARS-CoV-2 in lung epithelial cells","volume":"34","author":"Yin","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.clim.2022.109024_bb0095","article-title":"Critical determinants of cytokine storm and type I interferon response in COVID-19 pathogenesis","volume":"34","author":"Ramasamy","year":"2021","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.clim.2022.109024_bb0100","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021107826","article-title":"SARS-CoV-2 sensing by RIGI and MDA5 links epithelial infection to macrophage inflammation","author":"Thorne","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.clim.2022.109024_bb0105","doi-asserted-by":"crossref","first-page":"8874339","DOI":"10.1155\/2021\/8874339","article-title":"COVID-19 and toll-like receptor 4 (TLR4): SARS-CoV-2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation","volume":"2021","author":"Aboudounya","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.clim.2022.109024_bb0110","article-title":"SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation","author":"Pan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2022.109024_bb0115","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/s41423-020-0492-x","article-title":"Elevated serum levels of S100A8\/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients","volume":"17","author":"Chen","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0120","article-title":"Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19","volume":"6","author":"Scozzi","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.clim.2022.109024_bb0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.trsl.2020.12.008","article-title":"Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury","volume":"232","author":"Bime","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.clim.2022.109024_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/ni.3123","article-title":"Control of adaptive immunity by the innate immune system","author":"Iwasaki","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/s41435-021-00140-w","article-title":"Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome\u2014with a preliminary reference to SARS-CoV-2 pneumonia","author":"Land","year":"2021","journal-title":"Genes Immun."},{"key":"10.1016\/j.clim.2022.109024_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.668507","article-title":"Interleukin-6, CXCL10 and infiltrating macrophages in COVID-19-related cytokine storm: not one for all but all for one!","author":"Coperchini","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0145","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200674","article-title":"Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies","volume":"217","author":"Zhou","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2022.109024_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.05.015","article-title":"Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals","author":"Grifoni","year":"2020","journal-title":"Cell."},{"key":"10.1016\/j.clim.2022.109024_bb0155","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1093\/cid\/ciaa344","article-title":"Antibody responses to SARS-CoV-2 in patients with novel coronavirus disease 2019","volume":"71","author":"Zhao","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.clim.2022.109024_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrm.2020.100040","article-title":"Rapid generation of neutralizing antibody responses in COVID-19 patients","author":"Suthar","year":"2020","journal-title":"Cell Rep. Med."},{"issue":"2020","key":"10.1016\/j.clim.2022.109024_bb0165","first-page":"759","article-title":"Case surveillance - United States, January 22-May 30, 2020","volume":"69","author":"Stokes","year":"2019","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"10.1016\/j.clim.2022.109024_bb0170","doi-asserted-by":"crossref","DOI":"10.1080\/00325481.2020.1786964","article-title":"COVID-19 and comorbidities: a systematic review and meta-analysis","author":"Gold","year":"2020","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.clim.2022.109024_bb0175","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.trsl.2021.12.001","article-title":"Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection","volume":"241","author":"Latif","year":"2022","journal-title":"Transl. Res."},{"key":"10.1016\/j.clim.2022.109024_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8019360","article-title":"Arterial hypertension as a risk comorbidity associated with COVID-19 pathology","volume":"2020","author":"Kamyshnyi","year":"2020","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.clim.2022.109024_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.571416","article-title":"Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?","volume":"11","author":"Bajaj","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.clim.2022.109024_bb0190","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00985-20","article-title":"Type I and Type III interferons restrict SARS-CoV-2 infection of human airway epithelial cultures","volume":"94","author":"Vanderheiden","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2022.109024_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27318-0","article-title":"Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2","volume":"12","author":"Hatton","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2022.109024_bb0200","article-title":"A comparative analysis of coronavirus nucleocapsid (N) proteins reveals the SADS-CoV N protein antagonizes IFN-\u03b2 production by inducing ubiquitination of RIG-I","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0205","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02143-16","article-title":"The severe acute respiratory syndrome coronavirus nucleocapsid inhibits type I interferon production by interfering with TRIM25-mediated RIG-I ubiquitination","volume":"91","author":"Hu","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2022.109024_bb0210","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1128\/JVI.79.4.2079-2086.2005","article-title":"Inhibition of beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3","volume":"79","author":"Spiegel","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2022.109024_bb0215","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.virol.2017.12.028","article-title":"Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3","volume":"515","author":"Wong","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.clim.2022.109024_bb0220","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2022.109024_bb0225","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13000-020-00999-9","article-title":"The spectrum of pathological findings in coronavirus disease (COVID-19) and the pathogenesis of SARS-CoV-2","volume":"15","author":"Barth","year":"2020","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.clim.2022.109024_bb0230","first-page":"79","article-title":"Immunopathogenesis of pneumonia in COVID-19","volume":"19","author":"Alipoor","year":"2020","journal-title":"Tanaffos."},{"key":"10.1016\/j.clim.2022.109024_bb0235","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13613-021-00896-4","article-title":"Myeloid phenotypes in severe COVID-19 predict secondary infection and mortality: a pilot study","volume":"11","author":"Marais","year":"2021","journal-title":"Ann. Intensive Care"},{"key":"10.1016\/j.clim.2022.109024_bb0240","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41590-017-0022-x","article-title":"Myeloid-derived suppressor cells coming of age review-article","volume":"19","author":"Veglia","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0245","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4049\/jimmunol.1701019","article-title":"Myeloid-derived suppressor cells: immune-suppressive cells that impair antitumor immunity and are sculpted by their environment","volume":"200","author":"Ostrand-Rosenberg","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2022.109024_bb0255","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1158\/2326-6066.CIR-19-0556","article-title":"Quantification of early-stage myeloid-derived suppressor cells in cancer requires excluding basophils","volume":"8","author":"Khan","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.clim.2022.109024_bb0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciimmunol.aaf8943","article-title":"Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients","volume":"1","author":"Condamine","year":"2016","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0265","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aay6017","article-title":"Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics","volume":"5","author":"Alshetaiwi","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0270","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001223","article-title":"Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation","volume":"8","author":"Cassetta","year":"2020","journal-title":"J. Immunother. Cancer."},{"key":"10.1016\/j.clim.2022.109024_bb0275","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3389\/fimmu.2019.00771","article-title":"Myeloid derived suppressor cells interactions with natural killer cells and pro-angiogenic activities: roles in tumor progression","volume":"10","author":"Bruno","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0280","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3390\/ijms19051468","article-title":"Immunomodulatory function of myeloid-derived suppressor cells during B cell-mediated immune responses","volume":"19","author":"\u00d6zkan","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.clim.2022.109024_bb0285","doi-asserted-by":"crossref","DOI":"10.4110\/in.2021.21.e21","article-title":"Mechanisms underlying the role of myeloid-derived suppressor cells in clinical diseases: good or bad","volume":"21","author":"Ge","year":"2021","journal-title":"Immune Netw."},{"key":"10.1016\/j.clim.2022.109024_bb0290","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.3389\/fimmu.2018.02499","article-title":"Reactive oxygen species as regulators of MDSC-mediated immune suppression","volume":"9","author":"Ohl","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0295","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nm1609","article-title":"Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer","volume":"13","author":"Nagaraj","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2022.109024_bb0300","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1182\/blood-2006-06-031856","article-title":"L-arginine availability regulates T-lymphocyte cell-cycle progression","volume":"109","author":"Rodriguez","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.clim.2022.109024_bb0305","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1002\/ijc.30232","article-title":"Myeloid-derived suppressor cells as effectors of immune suppression in cancer","volume":"139","author":"Pyzer","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.clim.2022.109024_bb0310","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.20131916","article-title":"PD-L1 is a novel direct target of HIF-1\u03b1, and its blockade under hypoxia enhanced: MDSC-mediated T cell activation","volume":"211","author":"Noman","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2022.109024_bb0315","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144734","article-title":"Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity","volume":"131","author":"Falck-Jones","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2022.109024_bb0320","article-title":"Transcriptome and functions of granulocytic myeloid-derived suppressor cells determine their association with disease severity of COVID-19","author":"Dean","year":"2021","journal-title":"MedRxiv Prepr. Serv. Heal. Sci."},{"key":"10.1016\/j.clim.2022.109024_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108863","article-title":"Metabolic programs define dysfunctional immune responses in severe COVID-19 patients","volume":"34","author":"Thompson","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.clim.2022.109024_bb0330","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/JLB.4COVBCR0321-129R","article-title":"Emergence of immunosuppressive LOX-1+ PMN-MDSC in septic shock and severe COVID-19 patients with acute respiratory distress syndrome","volume":"111","author":"Coudereau","year":"2022","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.clim.2022.109024_bb0335","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1038\/s41418-020-0572-6","article-title":"Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)","volume":"27","author":"Agrati","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.clim.2022.109024_bb0340","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.748097","article-title":"Mild and asymptomatic COVID-19 convalescents present long-term endotype of immunosuppression associated with neutrophil subsets possessing regulatory functions","volume":"12","author":"Siemi\u0144ska","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0345","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-021-02228-6","article-title":"Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection","volume":"20","author":"Ryan","year":"2022","journal-title":"BMC Med."},{"key":"10.1016\/j.clim.2022.109024_bb0350","doi-asserted-by":"crossref","DOI":"10.1111\/sji.13108","article-title":"Correlation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19","volume":"95","author":"Emsen","year":"2022","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0355","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41419-020-03125-1","article-title":"Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome","volume":"11","author":"Sacchi","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.clim.2022.109024_bb0360","doi-asserted-by":"crossref","DOI":"10.1093\/intimm\/dxab005","article-title":"Myeloid cell dynamics correlating with clinical outcomes of severe COVID-19 in Japan","author":"Takano","year":"2021","journal-title":"Int. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0365","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1089\/vim.2021.0044","article-title":"Increased blood monocytic myeloid derived suppressor cells but low regulatory T lymphocytes in patients with mild COVID-19","volume":"34","author":"Jim\u00e9nez-Cortegana","year":"2021","journal-title":"Viral Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0370","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.557586","article-title":"The development and homing of myeloid-derived suppressor cells: from a two-stage model to a multistep narrative","author":"Karin","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0375","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s10875-020-00920-5","article-title":"SARS-CoV-2-induced ARDS associates with MDSC expansion, lymphocyte dysfunction, and arginine shortage","volume":"41","author":"Reizine","year":"2021","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0380","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.614599","article-title":"Reduced expression of autophagy markers and expansion of myeloid-derived suppressor cells correlate with poor T cell response in severe COVID-19 patients","volume":"12","author":"Tomi\u0107","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0385","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1126\/science.abc6261","article-title":"Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans","volume":"369","author":"Arunachalam","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.clim.2022.109024_bb0390","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/s41591-020-0944-y","article-title":"A single-cell atlas of the peripheral immune response in patients with severe COVID-19","volume":"26","author":"Wilk","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2022.109024_bb0395","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41421-020-00225-2","article-title":"The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing","volume":"6","author":"Xu","year":"2020","journal-title":"Cell Discov."},{"key":"10.1016\/j.clim.2022.109024_bb0400","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mam.2010.03.002","article-title":"VDAC, a multi-functional mitochondrial protein regulating cell life and death","volume":"31","author":"Shoshan-Barmatz","year":"2010","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.clim.2022.109024_bb0405","doi-asserted-by":"crossref","first-page":"24986","DOI":"10.1074\/jbc.M116.744284","article-title":"Novel compounds targeting the mitochondrial protein VDAC1 inhibit apoptosis and protect against mitochondrial dysfunction","volume":"291","author":"Ben-Hail","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2022.109024_bb0410","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav4011","article-title":"VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease","author":"Kim","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.clim.2022.109024_bb0415","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1800129","article-title":"IFNAR1 controls autocrine type I IFN regulation of PD-L1 expression in myeloid-derived suppressor cells","author":"Xiao","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0420","series-title":"MedRxiv","first-page":"PA2318","article-title":"Myeloid-derived suppressor cells in the blood of COVID-19 patients","author":"Mortaz","year":"2021"},{"key":"10.1016\/j.clim.2022.109024_bb0425","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1093\/cid\/ciaa577","article-title":"An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019","volume":"71","author":"Bordoni","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.clim.2022.109024_bb0430","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.18632\/aging.202571","article-title":"Elevated frequencies of CD14+HLA-DRlo\/neg MDSCs in COVID-19 patients","volume":"13","author":"Xue","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.clim.2022.109024_bb0435","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.it.2010.10.002","article-title":"Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function","volume":"32","author":"Condamine","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0440","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1038\/s41467-021-24360-w","article-title":"Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity","volume":"12","author":"Vanderbeke","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2022.109024_bb0445","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.3389\/fimmu.2020.02145","article-title":"Re-analysis of single cell transcriptome reveals that the NR3C1-CXCL8-neutrophil axis determines the severity of COVID-19","volume":"11","author":"Park","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0450","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe9599","article-title":"Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro","volume":"13","author":"Reyes","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.clim.2022.109024_bb0455","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abg9873","article-title":"Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19","volume":"6","author":"Thwaites","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0460","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1089\/vim.2016.0125","article-title":"The role of myeloid-derived suppressor cells in viral infection","volume":"30","author":"O\u2019Connor","year":"2017","journal-title":"Viral Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/S2352-3026(20)30217-9","article-title":"Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study","author":"Liao","year":"2020","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.clim.2022.109024_bb0470","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.3390\/cells10082111","article-title":"Expansion of myeloid derived suppressor cells contributes to platelet activation by L-arginine deprivation during SARS-CoV-2 infection","volume":"10","author":"Sacchi","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.clim.2022.109024_bb0475","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2005.03.013","article-title":"GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase","volume":"22","author":"Munn","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2022.109024_bb0480","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255335","article-title":"Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease","volume":"16","author":"Ricke-Hoch","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2022.109024_bb0485","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2047-1440-1-15","article-title":"Generation of myeloid-derived suppressor cells using prostaglandin E2","volume":"1","author":"Obermajer","year":"2012","journal-title":"Transp. Res."},{"key":"10.1016\/j.clim.2022.109024_bb0490","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.medj.2020.07.002","article-title":"Virus-host interactome and proteomic survey reveal potential virulence factors influencing SARS-CoV-2 pathogenesis","volume":"2","author":"Li","year":"2021","journal-title":"Med"},{"key":"10.1016\/j.clim.2022.109024_bb0495","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/s41587-020-0602-4","article-title":"COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis","volume":"38","author":"Chua","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.clim.2022.109024_bb0500","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s41232-020-00148-1","article-title":"Immunopathogenesis of SARS-CoV-2-induced pneumonia: lessons from influenza virus infection","volume":"40","author":"Miyazawa","year":"2020","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.clim.2022.109024_bb0505","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1128\/IAI.00239-12","article-title":"Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response","volume":"80","author":"Brudecki","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.clim.2022.109024_bb0510","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/s00134-012-2574-4","article-title":"Myeloid-derived suppressor cells control microbial sepsis","volume":"38","author":"Derive","year":"2012","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.clim.2022.109024_bb0515","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.801410","article-title":"Low levels of granulocytic myeloid-derived suppressor cells may be a good marker of survival in the follow-up of patients with severe COVID-19","volume":"12","author":"Jim\u00e9nez-Cortegana","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0520","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.691725","article-title":"Severe COVID-19 recovery is associated with timely acquisition of a myeloid cell immune-regulatory phenotype","volume":"12","author":"Trombetta","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2022.109024_bb0525","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-021-02852-1","article-title":"Deep dissection of the antiviral immune profile of patients with COVID-19","volume":"4","author":"Atanackovic","year":"2021","journal-title":"Commun. Biol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152166162200105X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152166162200105X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:06:48Z","timestamp":1761494808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152166162200105X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":105,"alternative-id":["S152166162200105X"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2022.109024","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myeloid-derived suppressor cells in COVID-19: A review","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2022.109024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109024"}}