{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T19:33:53Z","timestamp":1768160033862,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["201911006"],"award-info":[{"award-number":["201911006"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.clim.2022.109045","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T11:49:43Z","timestamp":1653306583000},"page":"109045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Cancer germline antigen gene MAGEB2 promotes cell invasion and correlates with immune microenvironment and immunotherapeutic efficiency in laryngeal cancer"],"prefix":"10.1016","volume":"240","author":[{"given":"Jie","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangpeng","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genglong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingquan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longfei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.clim.2022.109045_bb0005","first-page":"115","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.clim.2022.109045_bb0010","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"issue":"19","key":"10.1016\/j.clim.2022.109045_bb0015","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Radiation therapy oncology group 9501\/intergroup. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.clim.2022.109045_bb0020","first-page":"31","article-title":"An update on larynx cancer","volume":"67","author":"Steuer","year":"2017","journal-title":"CA Cancer J. Clin."},{"issue":"19","key":"10.1016\/j.clim.2022.109045_bb0025","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMoa1602252","article-title":"Nivolumab for recurrent squamous-cell carcinoma of the head and neck","volume":"375","author":"Ferris","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.clim.2022.109045_bb0030","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00262-018-2256-3","article-title":"Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma","volume":"68","author":"Mann","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.clim.2022.109045_bb0035","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejca.2019.03.012","article-title":"Single-arm, multicentre, phase II trial of nivolumab for unresectable or recurrent thymic carcinoma: PRIMER study","volume":"113","author":"Katsuya","year":"2019","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.clim.2022.109045_bb0040","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1001\/jamaoncol.2015.3638","article-title":"Quantitative assessment of the heterogeneity of PD-L1 expression in non-small-cell lung Cancer","volume":"2","author":"McLaughlin","year":"2016","journal-title":"JAMA Oncol."},{"issue":"10031","key":"10.1016\/j.clim.2022.109045_bb0045","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/S0140-6736(16)00561-4","article-title":"Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial","volume":"387","author":"Rosenberg","year":"2016","journal-title":"Lancet."},{"issue":"3","key":"10.1016\/j.clim.2022.109045_bb0050","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s10517-018-4175-x","article-title":"Specific features of transcription activity of cancer-testis antigens in patients with metastatic and non-metastatic breast cancer","volume":"165","author":"Vodolazhsky","year":"2018","journal-title":"Bull. Exp. Biol. Med."},{"issue":"10","key":"10.1016\/j.clim.2022.109045_bb0055","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.trecan.2018.08.005","article-title":"Emerging contributions of cancer\/testis antigens to neoplastic behaviors","volume":"4","author":"Gibbs","year":"2018","journal-title":"Trends Cancer."},{"issue":"7","key":"10.1016\/j.clim.2022.109045_bb0060","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/08820139.2016.1197241","article-title":"Cancer\/testis antigens: expression, regulation, tumor invasion, and use in immunotherapy of cancers","volume":"45","author":"Salmaninejad","year":"2016","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.clim.2022.109045_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107889","article-title":"A novel era of cancer\/testis antigen in cancer immunotherapy","volume":"98","author":"Meng","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.clim.2022.109045_bb0070","first-page":"681","article-title":"The expression of cancer-testis antigen in ovarian cancer and the development of immunotherapy","volume":"12","author":"Zhao","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.clim.2022.109045_bb0075","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1186\/s12935-020-01567-3","article-title":"Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis","volume":"20","author":"Cui","year":"2020","journal-title":"Cancer Cell Int."},{"issue":"2","key":"10.1016\/j.clim.2022.109045_bb0080","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1089\/dna.2020.5789","article-title":"Development and validation of epigenetic signature predict survival for patients with laryngeal squamous cell carcinoma","volume":"40","author":"Cui","year":"2021","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.clim.2022.109045_bb0085","article-title":"Three differential expression analysis methods for RNA sequencing: limma, EdgeR, DESeq2","volume":"175","author":"Liu","year":"2021","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.clim.2022.109045_bb0090","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1038\/ncomms3612","article-title":"Inferring tumour purity and stromal and immune cell admixture from expression data","volume":"4","author":"Yoshihara","year":"2013","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.clim.2022.109045_bb0095","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.clim.2022.109045_bb0100","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","article-title":"Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer","volume":"39","author":"Bindea","year":"2013","journal-title":"Immunity."},{"issue":"23","key":"10.1016\/j.clim.2022.109045_bb0105","doi-asserted-by":"crossref","first-page":"6575","DOI":"10.1158\/0008-5472.CAN-18-0689","article-title":"TIP: a web server for resolving tumor immunophenotype profiling","volume":"78","author":"Xu","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.clim.2022.109045_bb0110","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinform."},{"issue":"43","key":"10.1016\/j.clim.2022.109045_bb0115","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.clim.2022.109045_bb0120","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","article-title":"Pan-cancer Immunogenomic analyses reveal genotype-Immunophenotype relationships and predictors of response to checkpoint blockade","volume":"18","author":"Charoentong","year":"2017","journal-title":"Cell Rep."},{"issue":"10","key":"10.1016\/j.clim.2022.109045_bb0125","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1038\/s41591-018-0136-1","article-title":"Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response","volume":"24","author":"Jiang","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2022.109045_bb0130","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.canlet.2017.03.029","article-title":"Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes","volume":"396","author":"Van Tongelen","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.clim.2022.109045_bb0135","series-title":"MAGEB2 is Activated by Promoter Demethylation in Head and Neck Squamous Cell Carcinoma","author":"Pattani","year":"2021"},{"issue":"1","key":"10.1016\/j.clim.2022.109045_bb0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10549-004-6454-7","article-title":"Prevention of metastases with a mage-b DNA vaccine in a mouse breast tumor model: potential for breast cancer therapy","volume":"91","author":"Sypniewska","year":"2005","journal-title":"Breast Cancer Res. Treat."},{"issue":"1","key":"10.1016\/j.clim.2022.109045_bb0145","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1038\/s41467-019-12319-x","article-title":"Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells","volume":"10","author":"Menares","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2022.109045_bb0150","first-page":"1199","article-title":"Assessment of immune status of laryngeal squamous cell carcinoma can predict prognosis and guide treatment","volume":"71(5)","author":"Wang","year":"2021","journal-title":"Cancer Immunol. Immunother."},{"issue":"6","key":"10.1016\/j.clim.2022.109045_bb0155","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.ccell.2019.05.004","article-title":"Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors","volume":"35","author":"Dangaj","year":"2019","journal-title":"Cancer Cell"},{"issue":"7693","key":"10.1016\/j.clim.2022.109045_bb0160","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nature25501","article-title":"TGF\u03b2 attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells","volume":"554","author":"Mariathasan","year":"2018","journal-title":"Nature."},{"key":"10.1016\/j.clim.2022.109045_bb0165","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.semcancer.2019.09.011","article-title":"Translational genomics and recent advances in oral squamous cell carcinoma","volume":"61","author":"Chai","year":"2020","journal-title":"Semin. Cancer Biol."},{"issue":"9","key":"10.1016\/j.clim.2022.109045_bb0170","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1172\/JCI80008","article-title":"Tumor neoantigens: building a framework for personalized cancer immunotherapy","volume":"125","author":"Gubin","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2022.109045_bb0175","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.omtn.2020.08.030","article-title":"Characterization of the immune cell infiltration landscape in head and neck squamous cell carcinoma to aid immunotherapy","volume":"22","author":"Zhang","year":"2020","journal-title":"Mol. Ther. Nucleic Acids."},{"issue":"200","key":"10.1016\/j.clim.2022.109045_bb0180","doi-asserted-by":"crossref","first-page":"200ra116","DOI":"10.1126\/scitranslmed.3006504","article-title":"Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells","volume":"5","author":"Spranger","year":"2013","journal-title":"Sci. Transl. Med."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661622001267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661622001267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:05:39Z","timestamp":1761494739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661622001267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":36,"alternative-id":["S1521661622001267"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2022.109045","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cancer germline antigen gene MAGEB2 promotes cell invasion and correlates with immune microenvironment and immunotherapeutic efficiency in laryngeal cancer","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2022.109045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109045"}}