{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:21:11Z","timestamp":1787318471056,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","award":["005\/2019"],"award-info":[{"award-number":["005\/2019"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.clim.2023.109321","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T11:36:18Z","timestamp":1680521778000},"page":"109321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Serum soluble mediators as prognostic biomarkers for morbidity, disease outcome, and late-relapsing hepatitis in yellow fever patients"],"prefix":"10.1016","volume":"251","author":[{"given":"Jordana Rodrigues Barbosa","family":"Fradico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Campi-Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Speziali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis Ribeiro","family":"do Valle Antonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Peruhype-Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela Maur\u00edcio","family":"de Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Augusto","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Ant\u00f4nio","family":"Pascoal-Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Soares","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rita Teixeira","family":"Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario Brock","family":"Ramalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Cenachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayrine Araujo","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Fabiano","family":"do Carmo Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Calzavara-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana Grazziela Alves","family":"Coelho-dos-Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Ramos","family":"de Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Lu\u00edza Cer\u00e1volo","family":"Rabelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria","family":"Valim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim Pedro","family":"Brito-de-Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael Artur","family":"da Costa-Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus","family":"de Souza Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence Rodrigues","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila Maria Barbosa","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela Freitas","family":"Trindade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Tourinho","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Fernandes Amorim","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Monath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelle Desiree","family":"LaBeaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00e2nia Paiva","family":"Drumond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olindo Assis","family":"Martins-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Teixeira-Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2023.109321_bb0005","doi-asserted-by":"crossref","DOI":"10.1590\/0037-8682-0787-2020","article-title":"The obscurance of the greatest sylvatic yellow fever epidemic and the cooperation of the Pan American health organization during the COVID-19 pandemic","volume":"53","author":"Melo","year":"2020","journal-title":"Rev. Soc. Bras. Med. Trop."},{"issue":"10","key":"10.1016\/j.clim.2023.109321_bb0010","doi-asserted-by":"crossref","DOI":"10.1590\/0074-02760180278","article-title":"Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunisation","volume":"113","author":"Possas","year":"2018","journal-title":"Mem. Inst. Oswaldo Cruz"},{"issue":"11","key":"10.1016\/j.clim.2023.109321_bb0015","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3390\/v12111233","article-title":"Re-emergence of yellow fever in Brazil during 2016-2019: challenges, lessons learned, and perspectives","volume":"12","author":"de Oliveira","year":"2020","journal-title":"Viruses."},{"issue":"1","key":"10.1016\/j.clim.2023.109321_bb0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12985-019-1277-7","article-title":"Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease","volume":"17","author":"Silva","year":"2020","journal-title":"Virol. J."},{"issue":"2","key":"10.1016\/j.clim.2023.109321_bb0025","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1590\/S0037-86822003000200012","article-title":"Febre amarela [yellow fever]","volume":"36","author":"Vasconcelos","year":"2003","journal-title":"Rev. Soc. Bras. Med. Trop."},{"issue":"11","key":"10.1016\/j.clim.2023.109321_bb0030","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.tim.2018.05.012","article-title":"Yellow fever virus: knowledge gaps impeding the fight against an old foe","volume":"26","author":"Douam","year":"2018","journal-title":"Trends Microbiol."},{"issue":"6","key":"10.1016\/j.clim.2023.109321_bb0035","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.3201\/eid2506.190069","article-title":"Hepatitis rebound after infection with yellow fever virus","volume":"25","author":"Denis","year":"2019","journal-title":"Emerg. Infect. Dis."},{"issue":"8","key":"10.1016\/j.clim.2023.109321_bb0040","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.3201\/eid2508.181479","article-title":"Wild-type yellow fever virus RNA in cerebrospinal fluid of child","volume":"25","author":"Marinho","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.clim.2023.109321_bb0045","doi-asserted-by":"crossref","DOI":"10.1590\/0037-8682-0152-2020","article-title":"Hepatitis relapse after yellow fever infection: is there another wave?","volume":"53","author":"Os\u00f3rio","year":"2020","journal-title":"Rev. Soc. Bras. Med. Trop."},{"issue":"2","key":"10.1016\/j.clim.2023.109321_bb0050","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3390\/v12020222","article-title":"Late-relapsing hepatitis after yellow fever","volume":"12","author":"Rezende","year":"2020","journal-title":"Viruses."},{"issue":"21","key":"10.1016\/j.clim.2023.109321_bb0055","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMc1913036","article-title":"Late-onset relapsing hepatitis associated with yellow fever","volume":"382","author":"Casadio","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.clim.2023.109321_bb0060","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S1473-3099(19)30125-2","article-title":"Predictors of mortality in patients with yellow fever: an observational cohort study","volume":"19","author":"Kallas","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.clim.2023.109321_bb0065","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijid.2020.01.039","article-title":"Clinical profiles and factors associated with mortality in adults with yellow fever admitted to an intensive care unit in Minas Gerais, Brazil","volume":"93","author":"de \u00c1vila","year":"2020","journal-title":"Int. J. Infect. Dis."},{"issue":"10","key":"10.1016\/j.clim.2023.109321_bb0070","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1086\/425016","article-title":"Activation of the cytokine network and unfavorable outcome in patients with yellow fever","volume":"190","author":"ter Meulen","year":"2004","journal-title":"J. Infect. Dis."},{"issue":"12","key":"10.1016\/j.clim.2023.109321_bb0075","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1128\/JCM.01799-12","article-title":"Advanced yellow fever virus genome detection in point-of-care facilities and reference laboratories","volume":"50","author":"Domingo","year":"2012","journal-title":"J. Clin. Microbiol."},{"issue":"1","key":"10.1016\/j.clim.2023.109321_bb0080","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jviromet.2008.03.026","article-title":"Standardized quantitative RT-PCR assays for quantitation of yellow fever and chimeric yellow fever-dengue vaccines","volume":"151","author":"Mantel","year":"2008","journal-title":"J. Virol. Methods"},{"issue":"11","key":"10.1016\/j.clim.2023.109321_bb0085","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"1","key":"10.1016\/j.clim.2023.109321_bb0090","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01956-15","article-title":"Vaccine and wild-type strains of yellow fever virus engage distinct entry mechanisms and differentially stimulate antiviral immune responses","volume":"7","author":"Fernandez-Garcia","year":"2016","journal-title":"mBio."},{"key":"10.1016\/j.clim.2023.109321_bb0095","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/1471-2334-14-391","article-title":"Subdoses of 17DD yellow fever vaccine elicit equivalent virological\/immunological kinetics timeline","volume":"14","author":"Campi-Azevedo","year":"2014","journal-title":"BMC Infect. Dis."},{"issue":"5","key":"10.1016\/j.clim.2023.109321_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004709","article-title":"Characterization of yellow fever virus infection of human and non-human primate antigen presenting cells and their interaction with CD4+ T cells","volume":"10","author":"Cong","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"1","key":"10.1016\/j.clim.2023.109321_bb0105","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.virol.2011.01.012","article-title":"Differential cytokine responses from primary human Kupffer cells following infection with wild-type or vaccine strain yellow fever virus","volume":"412","author":"Woodson","year":"2011","journal-title":"Virology."},{"issue":"1","key":"10.1016\/j.clim.2023.109321_bb0110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1172\/JCI6642","article-title":"Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease","volume":"104","author":"Murai","year":"1999","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.clim.2023.109321_bb0115","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/rmv.1752","article-title":"Immunity and immune response, pathology and pathologic changes: progress and challenges in the immunopathology of yellow fever","volume":"23","author":"Quaresma","year":"2013","journal-title":"Rev. Med. Virol."},{"issue":"1","key":"10.1016\/j.clim.2023.109321_bb0120","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1473-3099(01)00016-0","article-title":"Yellow fever: an update","volume":"1","author":"Monath","year":"2001","journal-title":"Lancet Infect. Dis."},{"issue":"1","key":"10.1016\/j.clim.2023.109321_bb0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.virol.2005.09.058","article-title":"Revisiting the liver in human yellow fever: virus-induced apoptosis in hepatocytes associated with TGF-beta, TNF-alpha and NK cells activity","volume":"345","author":"Quaresma","year":"2006","journal-title":"Virology."},{"issue":"53","key":"10.1016\/j.clim.2023.109321_bb0130","article-title":"Hepatitis relapse after yellow fever infection: is there another wave?","volume":"22","author":"Os\u00f3rio","year":"2020","journal-title":"Rev. Soc. Bras. Med. Trop."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661623001006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661623001006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:09:26Z","timestamp":1761494966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661623001006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":26,"alternative-id":["S1521661623001006"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2023.109321","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum soluble mediators as prognostic biomarkers for morbidity, disease outcome, and late-relapsing hepatitis in yellow fever patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2023.109321","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109321"}}