{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T04:29:24Z","timestamp":1794198564347,"version":"4.8.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21Y11905200"],"award-info":[{"award-number":["21Y11905200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602757"],"award-info":[{"award-number":["81602757"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.clim.2023.109805","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T19:11:08Z","timestamp":1697051468000},"page":"109805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Neutrophil recruitment by CD4 tissue-resident memory T cells induces chronic recurrent inflammation in atopic dermatitis"],"prefix":"10.1016","volume":"256","author":[{"given":"Chunjiao","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10247","key":"10.1016\/j.clim.2023.109805_bb0005","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0140-6736(20)31286-1","article-title":"Atopic dermatitis","volume":"396","author":"Langan","year":"2020","journal-title":"Lancet."},{"issue":"4","key":"10.1016\/j.clim.2023.109805_bb0010","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/ced.13853","article-title":"What\u2019s new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: epidemiology, aetiology and risk factors","volume":"44","author":"Lloyd-Lavery","year":"2019","journal-title":"Clin. Exp. Dermatol."},{"issue":"1","key":"10.1016\/j.clim.2023.109805_bb0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","article-title":"Atopic dermatitis: an expanding therapeutic pipeline for a complex disease","volume":"21","author":"Bieber","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"issue":"11","key":"10.1016\/j.clim.2023.109805_bb0020","doi-asserted-by":"crossref","first-page":"587","DOI":"10.5694\/mja2.51560","article-title":"Management of atopic dermatitis: a narrative review","volume":"216","author":"Goh","year":"2022","journal-title":"Med. J. Aust."},{"issue":"8","key":"10.1016\/j.clim.2023.109805_bb0025","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5694\/mja17.00463","article-title":"Atopic dermatitis: the new frontier","volume":"207","author":"Harris","year":"2017","journal-title":"Med. J. Aust."},{"issue":"12","key":"10.1016\/j.clim.2023.109805_bb0030","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra2023911","article-title":"Atopic dermatitis","volume":"384","author":"St\u00e4nder","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"5, Supplement","key":"10.1016\/j.clim.2023.109805_bb0035","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jid.2018.03.026","article-title":"022 Distinct transcriptome signature of skin-resident memory T cells and migratory memory T cells in atopic dermatitis","volume":"138","author":"Kim","year":"2018","journal-title":"J. Investig. Dermatol."},{"issue":"5, Supplement 1","key":"10.1016\/j.clim.2023.109805_bb0040","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.jid.2016.02.074","article-title":"049 Multicytokine-producing tissue resident memory (TRM) cells in atopic dermatitis patient","volume":"136","author":"Kim","year":"2016","journal-title":"J. Investig. Dermatol."},{"issue":"12","key":"10.1016\/j.clim.2023.109805_bb0045","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/all.13223","article-title":"Nonlesional atopic dermatitis skin shares similar T-cell clones with lesional tissues","volume":"72","author":"Brunner","year":"2017","journal-title":"Allergy."},{"issue":"6","key":"10.1016\/j.clim.2023.109805_bb0050","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.immuni.2014.12.007","article-title":"Tissue-resident memory T cells","volume":"41","author":"Schenkel","year":"2014","journal-title":"Immunity."},{"issue":"3","key":"10.1016\/j.clim.2023.109805_bb0055","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00011-020-01320-6","article-title":"Tissue-resident memory T cells in the skin","volume":"69","author":"Khalil","year":"2020","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.clim.2023.109805_bb0060","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.3389\/fimmu.2018.02394","article-title":"CD4+ memory T cells at home in the tissue: mechanisms for health and disease","volume":"9","author":"Schreiner","year":"2018","journal-title":"Front. Immunol."},{"issue":"269","key":"10.1016\/j.clim.2023.109805_bb0065","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3010641","article-title":"Resident memory T cells in human health and disease","volume":"7","author":"Clark","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"13","key":"10.1016\/j.clim.2023.109805_bb0070","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1016\/j.celrep.2019.11.103","article-title":"Bystander activation of pulmonary Trm cells attenuates the severity of bacterial pneumonia by enhancing neutrophil recruitment","volume":"29","author":"Ge","year":"2019","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.clim.2023.109805_bb0075","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/all.14986","article-title":"CD8(+) tissue-resident memory T cells recruit neutrophils that are essential for flare-ups in contact dermatitis","volume":"77","author":"Funch","year":"2022","journal-title":"Allergy."},{"issue":"9","key":"10.1016\/j.clim.2023.109805_bb0080","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1084\/jem.20142101","article-title":"Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection","volume":"212","author":"Glennie","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2023.109805_bb0085","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev-immunol-042617-053214","article-title":"Tissue-resident T cells and other resident leukocytes","volume":"37","author":"Masopust","year":"2019","journal-title":"Annu. Rev. Immunol."},{"issue":"6205","key":"10.1016\/j.clim.2023.109805_bb0090","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1254536","article-title":"T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses","volume":"346","author":"Schenkel","year":"2014","journal-title":"Science."},{"issue":"1","key":"10.1016\/j.clim.2023.109805_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaci.2018.10.032","article-title":"Atopic dermatitis endotypes and implications for targeted therapeutics","volume":"143","author":"Czarnowicki","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"31","key":"10.1016\/j.clim.2023.109805_bb0100","doi-asserted-by":"crossref","first-page":"11736","DOI":"10.1073\/pnas.0604575103","article-title":"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis","volume":"103","author":"Li","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.clim.2023.109805_bb0105","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1016\/j.jid.2018.06.168","article-title":"Eosinophils determine dermal thickening and water loss in an MC903 model of atopic dermatitis","volume":"138","author":"Naidoo","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.clim.2023.109805_bb0110","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/cod.12715","article-title":"Rapid allergen-induced interleukin-17 and interferon-\u03b3 secretion by skin-resident memory CD8(+) T cells","volume":"76","author":"Schmidt","year":"2017","journal-title":"Contact Dermatitis"},{"issue":"6","key":"10.1016\/j.clim.2023.109805_bb0115","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.jaci.2018.11.048","article-title":"Inhibitory checkpoint receptors control CD8(+) resident memory T cells to prevent skin allergy","volume":"143","author":"Gamradt","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.clim.2023.109805_bb0120","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.pharmthera.2005.05.002","article-title":"FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors","volume":"108","author":"Chiba","year":"2005","journal-title":"Pharmacol. Ther."},{"issue":"11","key":"10.1016\/j.clim.2023.109805_bb0125","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nrd3248","article-title":"Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis","volume":"9","author":"Brinkmann","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.clim.2023.109805_bb0130","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.jid.2019.02.014","article-title":"Research techniques made simple: mouse models of atopic dermatitis","volume":"139","author":"Kim","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.clim.2023.109805_bb0135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/exd.14270","article-title":"Mouse models of atopic dermatitis: a critical reappraisal","volume":"30","author":"Gilhar","year":"2021","journal-title":"Exp. Dermatol."},{"issue":"23","key":"10.1016\/j.clim.2023.109805_bb0140","doi-asserted-by":"crossref","first-page":"10466","DOI":"10.7150\/thno.45211","article-title":"Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8(+) T-cell memory in wild-type and humanized mice","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics."},{"issue":"19","key":"10.1016\/j.clim.2023.109805_bb0145","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.3390\/ijms21197228","article-title":"Immunological memory in imiquimod-induced murine model of psoriasiform dermatitis","volume":"21","author":"Fenix","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.clim.2023.109805_bb0150","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jid.2019.07.722","article-title":"Pathogenic CD8(+) epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis","volume":"140","author":"Gadsb\u00f8ll","year":"2020","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.clim.2023.109805_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2014.01.021","article-title":"Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis","volume":"133","author":"Noti","year":"2014","journal-title":"J Allergy Clin Immunol."},{"key":"10.1016\/j.clim.2023.109805_bb0160","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48448","article-title":"Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis","volume":"8","author":"Walsh","year":"2019","journal-title":"Elife."},{"issue":"6","key":"10.1016\/j.clim.2023.109805_bb0165","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.jaci.2012.06.044","article-title":"Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation","volume":"130","author":"Choy","year":"2012","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661623005685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661623005685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:09:28Z","timestamp":1761494968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661623005685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":33,"alternative-id":["S1521661623005685"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2023.109805","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil recruitment by CD4 tissue-resident memory T cells induces chronic recurrent inflammation in atopic dermatitis","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2023.109805","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109805"}}