{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:57:58Z","timestamp":1793383078151,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770982"],"award-info":[{"award-number":["81770982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81920108011"],"award-info":[{"award-number":["81920108011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130030"],"award-info":[{"award-number":["82130030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171115"],"award-info":[{"award-number":["82171115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.clim.2023.109856","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T12:06:45Z","timestamp":1701173205000},"page":"109856","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The potential roles and mechanisms of Chitinase-3-like-1 in the pathogenesis of type 2-biased airway diseases"],"prefix":"10.1016","volume":"257","author":[{"given":"Yian","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2023.109856_bb0005","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/alr.22083","article-title":"Distinct gene expression profiles and regulation networks of nasal polyps in eosinophilic and non-eosinophilic chronic rhinosinusitis","volume":"8","author":"Okada","year":"2018","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.clim.2023.109856_bb0010","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1016\/j.jaci.2009.12.989","article-title":"Rhinitis and sinusitis","volume":"125","author":"Dykewicz","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2023.109856_bb0015","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0140-6736(08)61452-X","article-title":"Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease","volume":"372","author":"Anderson","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2023.109856_bb0020","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4168\/aair.2017.9.4.299","article-title":"Emerging endotypes of chronic rhinosinusitis and its application to precision medicine","volume":"9","author":"Kim","year":"2017","journal-title":"Allergy, Asthma Immunol. Res."},{"key":"10.1016\/j.clim.2023.109856_bb0025","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41577-018-0006-6","article-title":"Targeting cytokines to treat asthma and chronic obstructive pulmonary disease","volume":"18","author":"Barnes","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2023.109856_bb0030","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJMoa1403290","article-title":"Mepolizumab treatment in patients with severe eosinophilic asthma","volume":"371","author":"Ortega","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2023.109856_bb0035","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jaci.2013.11.026","article-title":"Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: a 12-month follow-up analysis","volume":"133","author":"Haldar","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2023.109856_bb0040","first-page":"56","article-title":"Anti-alarmins in asthma: targeting the airway epithelium with next-generation biologics","author":"Porsbjerg","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.clim.2023.109856_bb0045","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1056\/NEJMoa2024257","article-title":"Efficacy and safety of Itepekimab in patients with moderate-to-severe asthma","volume":"385","author":"Wechsler","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2023.109856_bb0050","first-page":"A2621","article-title":"Tezepelumab treatment effect on annualized rate of exacerbations by baseline biomarkers in uncontrolled severe asthma patients: phase 2b PATHWAY study","volume":"199","author":"Corren","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.clim.2023.109856_bb0055","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1164\/rccm.200904-0597OC","article-title":"Clara cell 10-kD protein suppresses chitinase 3-like 1 expression associated with eosinophilic chronic rhinosinusitis","volume":"181","author":"Wang","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.clim.2023.109856_bb0060","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11882-016-0637-2","article-title":"New insights into the relationship between chitinase-3-like-1 and asthma","volume":"16","author":"Komi","year":"2016","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.clim.2023.109856_bb0065","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4168\/aair.2010.2.1.20","article-title":"Role of breast regression protein-39\/YKL-40 in asthma and allergic responses","volume":"2","author":"Lee","year":"2010","journal-title":"Allergy, Asthma Immunol. Res."},{"key":"10.1016\/j.clim.2023.109856_bb0070","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1074\/jbc.M116.764985","article-title":"Inhibition of mammalian glycoprotein YKL-40: identification of the physiological ligand","volume":"292","author":"Kognole","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2023.109856_bb0075","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1164\/rccm.201504-0760OC","article-title":"Increased YKL-40 and chitotriosidase in asthma and chronic obstructive pulmonary disease","volume":"193","author":"James","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.clim.2023.109856_bb0080","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1056\/NEJMoa073600","article-title":"A chitinase-like protein in the lung and circulation of patients with severe asthma","volume":"357","author":"Chupp","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2023.109856_bb0085","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-physiol-012110-142250","article-title":"Role of chitin and chitinase\/chitinase-like proteins in inflammation, tissue remodeling, and injury","volume":"73","author":"Lee","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.clim.2023.109856_bb0090","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1084\/jem.20081271","article-title":"Role of breast regression protein 39 (BRP-39)\/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis","volume":"206","author":"Lee","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2023.109856_bb0095","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1038\/aps.2012.154","article-title":"Breast regression protein-39 (BRP-39) promotes dendritic cell maturation in vitro and enhances Th2 inflammation in murine model of asthma","volume":"33","author":"Xu","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.clim.2023.109856_bb0100","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000444855","article-title":"Chitinase 3 Like-1: an emerging molecule involved in diabetes and diabetic complications","volume":"83","author":"Di Rosa","year":"2016","journal-title":"Pathobiology"},{"key":"10.1016\/j.clim.2023.109856_bb0105","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.celrep.2013.07.032","article-title":"Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor \u03b12","volume":"4","author":"He","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.clim.2023.109856_bb0110","doi-asserted-by":"crossref","first-page":"17180","DOI":"10.1073\/pnas.0407704101","article-title":"Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis","volume":"101","author":"van Bilsen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2023.109856_bb0115","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-1-59745-447-6_7","article-title":"YKL-40: a novel marker shared by chronic inflammation and oncogenic transformation","volume":"511","author":"Roslind","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.clim.2023.109856_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2013.03.003","article-title":"The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodelling in severe pediatric asthma","volume":"132","author":"Konradsen","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2023.109856_bb0125","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41392-020-00303-7","article-title":"Chitinase-3 like-protein-1 function and its role in diseases","volume":"5","author":"Zhao","year":"2020","journal-title":"Signal. Transduct. Target Ther."},{"key":"10.1016\/j.clim.2023.109856_bb0130","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1053\/joca.2000.0377","article-title":"Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology","volume":"9","author":"Volck","year":"2001","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.clim.2023.109856_bb0135","first-page":"655","article-title":"Serum YKL-40 levels in rheumatoid arthritis: correlations between clinical and laborarory parameters","volume":"19","author":"Matsumoto","year":"2001","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2023.109856_bb0140","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/art.1780400616","article-title":"Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoidarthritis","volume":"40","author":"Verheijden","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2023.109856_bb0145","doi-asserted-by":"crossref","first-page":"17180","DOI":"10.1073\/pnas.0407704101","article-title":"Functional regulatory immune responses against human cartilageglycoprotein-39 in health vs. proinflammatory responses in rheumatoidarthritis","volume":"101","author":"van Bilsen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2023.109856_bb0150","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/21681805.2017.1327885","article-title":"High YKL-40 is associated with poor survival in patients with renal cellcarcinoma: a novel independent prognostic marker","volume":"51","author":"V\u00e4\u00e4n\u00e4nen","year":"2017","journal-title":"Scand. J. Urol."},{"key":"10.1016\/j.clim.2023.109856_bb0155","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13046-018-0876-2","article-title":"Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through beta-catenin\/Erk\/Akt signaling in gastric cancer","volume":"37","author":"Geng","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.clim.2023.109856_bb0160","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/alz.12612","article-title":"Potential role of chitinase-3-like protein 1 (CHI3L1\/YKL-40) in neurodegeneration and Alzheimer\u2019s disease","volume":"19","author":"Connolly","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.clim.2023.109856_bb0165","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.692","article-title":"Multi-omic landscaping of human midbrains identifies disease-relevant molecular targets and pathways in advanced-stage Parkinson\u2019s disease","volume":"12","author":"Caldi Gomes","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.clim.2023.109856_bb0170","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13024-017-0226-4","article-title":"YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias","volume":"12","author":"Llorens","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.clim.2023.109856_bb0175","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12974-017-0893-7","article-title":"YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer\u2019sdisease and other tauopathies","volume":"14","author":"Querol-Vilaseca","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.clim.2023.109856_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2022.577977","article-title":"Sex-dependent neuro-deconvolution analysis of Alzheimer\u2019s disease brain transcriptomes according to CHI3L1 expression levels","volume":"373","author":"Sanfilippo","year":"2022","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.clim.2023.109856_bb0185","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1172\/JCI79792","article-title":"Chitinase 3-like-1 and its receptors in Hermansky-Pudlak syndrome-associated lung disease","volume":"125","author":"Zhou","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.clim.2023.109856_bb0190","doi-asserted-by":"crossref","first-page":"240ra276","DOI":"10.1126\/scitranslmed.3007096","article-title":"Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in mammalian lung fibrosis","volume":"6","author":"Zhou","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.clim.2023.109856_bb0195","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/art.41887","article-title":"A distinct macrophage subset mediating tissue destruction and neovascularization in giant cell arteritis: implication of the YKL-40\/Interleukin-13 receptor 2 axis","volume":"73","author":"van Sleen","year":"2021","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2023.109856_bb0200","doi-asserted-by":"crossref","first-page":"12752","DOI":"10.1038\/ncomms12752","article-title":"IL-13R\u03b12 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses","volume":"7","author":"Lee","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2023.109856_bb0205","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.4049\/jimmunol.1400874","article-title":"RelB\/p50 complexes regulate cytokine-induced YKL-40 expression","volume":"194","author":"Bhardwaj","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2023.109856_bb0210","doi-asserted-by":"crossref","first-page":"44058","DOI":"10.1074\/jbc.M306792200","article-title":"Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation","volume":"278","author":"Rehli","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2023.109856_bb0215","doi-asserted-by":"crossref","first-page":"63038","DOI":"10.18632\/oncotarget.18593","article-title":"Circulating miRNA-24 and its target YKL-40 as potential biomarkers in patients with coronary heart disease and type 2 diabetes mellitus","volume":"8","author":"Deng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.clim.2023.109856_bb0220","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/jcb.25225","article-title":"The role of microRNA, miR-24, and its target CHI3L1 in osteomyelitis caused by Staphylococcus aureus","volume":"116","author":"Jin","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.clim.2023.109856_bb0225","doi-asserted-by":"crossref","first-page":"749","DOI":"10.7150\/thno.20183","article-title":"Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice","volume":"8","author":"Jung","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.clim.2023.109856_bb0230","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1158\/0008-5472.CAN-13-3339","article-title":"Role of chitinase 3-like-1 and semaphorin 7a in pulmonary melanomametastasis","volume":"75","author":"Ma","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.clim.2023.109856_bb0235","doi-asserted-by":"crossref","first-page":"340","DOI":"10.7150\/thno.65522","article-title":"Targeting protumor factor chitinase-3-like-1 secreted by Rab37 vesicles for cancer immunotherapy","volume":"12","author":"Yang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.clim.2023.109856_bb0240","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00405-017-4859-2","article-title":"The role of YKL40 in the pathogenesis of CRS with nasal polyps","volume":"275","author":"Ma","year":"2018","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.clim.2023.109856_bb0245","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2500\/ajra.2013.27.3941","article-title":"Increased expression of YKL-40 in mild and moderate\/severe persistent allergic rhinitis and its possible contribution to remodelling of nasal mucosa","volume":"27","author":"Park","year":"2013","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.clim.2023.109856_bb0250","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1398-9995.2011.02596.x","article-title":"Serum YKL-40 levels are correlated with symptom severity in patients with allergic rhinitis","volume":"66","author":"Kwon","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.clim.2023.109856_bb0255","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/08820139.2019.1634096","article-title":"Local expression of mucosal YKL-40; correlation of YKL-40 with clinical manifestations and immunopathogenesis of moderate\/severe persistent allergic rhinitis patients","volume":"49","author":"Pirayesh","year":"2020","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.clim.2023.109856_bb0260","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2350-15-86","article-title":"CHI3L1 polymorphisms associate with asthma in a Taiwanese population","volume":"15","author":"Tsai","year":"2014","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.clim.2023.109856_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006106","article-title":"Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults","volume":"4","author":"Rathcke","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2023.109856_bb0270","article-title":"Functional study of the association of CHI3L1 polymorphisms with asthma susceptibility in the southwest Chinese Han population","volume":"39","author":"Chen","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.clim.2023.109856_bb0275","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1056\/NEJMoa0708801","article-title":"Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function","volume":"358","author":"Ober","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2023.109856_bb0280","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/cea.12032","article-title":"Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma","volume":"43","author":"Gavala","year":"2013","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.clim.2023.109856_bb0285","doi-asserted-by":"crossref","first-page":"1700800","DOI":"10.1183\/13993003.00800-2017","article-title":"Characterisation of asthma subgroups associated with circulating YKL-40 levels","volume":"50","author":"Gomez","year":"2017","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.clim.2023.109856_bb0290","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0140-6736(17)33311-1","article-title":"Asthma","volume":"391","author":"Papi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2023.109856_bb0295","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11882-016-0637-2","article-title":"New insights into the relationship between chitinase-3-like-1 and asthma","volume":"16","author":"Komi","year":"2016","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.clim.2023.109856_bb0300","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1164\/rccm.201105-0915OC","article-title":"Role of YKL-40 in bronchial smooth muscle remodeling in asthma","volume":"185","author":"Bara","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.clim.2023.109856_bb0305","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12931-019-1051-9","article-title":"Chitinase-like protein YKL-40 correlates with inflammatory phenotypes, anti-asthma responsiveness and future exacerbations","volume":"20","author":"Liu","year":"2019","journal-title":"Respir. Res."},{"key":"10.1016\/j.clim.2023.109856_bb0310","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa1701632","article-title":"Airway mucin concentration as a marker of chronic bronchitis","volume":"377","author":"Kesimer","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2023.109856_bb0315","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1016\/j.yexcr.2013.08.009","article-title":"The chitinase-like protein YKL-40 increases mucin5AC production in human bronchial epithelial cells","volume":"319","author":"Liu","year":"2013","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.clim.2023.109856_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.101333","article-title":"Immunologic mechanisms in asthma","volume":"46","author":"Boonpiyathad","year":"2019","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.clim.2023.109856_bb0325","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaci.2017.06.030","article-title":"Genetic and epigenetic regulation of YKL-40 in childhood","volume":"141","author":"Guerra","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2023.109856_bb0330","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11626-013-9698-x","article-title":"Ovalbumin enhances YKL-40, IL-5, GM-CSF, and eotaxin expression simultaneously in primarily cultured mouse tracheal epithelial cells","volume":"50","author":"Ben","year":"2014","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.clim.2023.109856_bb0335","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.2147\/JAA.S335964","article-title":"Serum YKL-40 levels predict endotypes and associate with postoperative recurrence in patients with chronic rhinosinusitis with nasal polyps","volume":"14","author":"Wen","year":"2021","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.clim.2023.109856_bb0340","article-title":"Targeting chitinase 1 and chitinase 3-like 1 as novel therapeutic strategy of pulmonary fibrosis","volume":"13","author":"Lee","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.clim.2023.109856_bb0345","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159578","article-title":"Chitinase 3-like 1 contributes to the development of pulmonary vascular remodeling in pulmonary hypertension","volume":"7","author":"Sun","year":"2022","journal-title":"JCI Insight"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661623006204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661623006204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:13:32Z","timestamp":1761495212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661623006204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":69,"alternative-id":["S1521661623006204"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2023.109856","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential roles and mechanisms of Chitinase-3-like-1 in the pathogenesis of type 2-biased airway diseases","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2023.109856","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109856"}}