{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:54:23Z","timestamp":1793145263921,"version":"4.5.0"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530021"],"award-info":[{"award-number":["81530021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770694"],"award-info":[{"award-number":["81770694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000630"],"award-info":[{"award-number":["82000630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014764","name":"China International Medical Foundation","doi-asserted-by":"publisher","award":["Z-2017\u201324\u20132037"],"award-info":[{"award-number":["Z-2017\u201324\u20132037"]}],"id":[{"id":"10.13039\/501100014764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.clim.2023.109857","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T11:19:09Z","timestamp":1701515949000},"page":"109857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Recent advances in the involvement of epigenetics in the pathogenesis of systemic lupus erythematosus"],"prefix":"10.1016","volume":"258","author":[{"given":"Hong-Yan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Ning","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Jianing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Si","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2023.109857_bb0005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/ard-2022-223035","article-title":"Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study","volume":"82","author":"Tian","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2023.109857_bb0010","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1080\/1744666X.2018.1538789","article-title":"Mortality in systemic lupus erythematosus: causes, predictors and interventions","volume":"14","author":"Ocampo-Piraquive","year":"2018","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12519-019-00229-3","article-title":"Immunological pathogenesis and treatment of systemic lupus erythematosus","volume":"16","author":"Pan","year":"2020","journal-title":"World J. Pediatr."},{"key":"10.1016\/j.clim.2023.109857_bb0020","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New insights into the immunopathogenesis of systemic lupus erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2023.109857_bb0025","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.intimp.2015.10.036","article-title":"Therapeutic targeting of BET protein BRD4 delays murine lupus","volume":"29","author":"Wei","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.clim.2023.109857_bb0030","series-title":"Fc Receptor Type I Chain Replaces the Deficient T Cell Receptor Chain in T Cells of Patients With Systemic Lupus Erythematosus","volume":"44","author":"Enyedy","year":"2001"},{"key":"10.1016\/j.clim.2023.109857_bb0035","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1172\/JCI1457","article-title":"Altered pattern of TCR\/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain","volume":"101","author":"Liossis","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2023.109857_bb0040","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1002\/eji.201445219","article-title":"Increased expression of TLR2 in CD4+ T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications","volume":"45","author":"Liu","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0045","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/art.39020","article-title":"Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity","volume":"67","author":"Choi","year":"2015","journal-title":"Arthritis and Rheumatology"},{"key":"10.1016\/j.clim.2023.109857_bb0050","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/cei.12703","article-title":"A comprehensive investigation on the distribution of circulating follicular T helper cells and B cell subsets in primary Sj\u00f6gren\u2019s syndrome and systemic lupus erythematosus","volume":"183","author":"Szab\u00f3","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0055","first-page":"8","article-title":"Circulating TFH subset distribution is strongly affected in lupus patients with an active disease","author":"Le Coz","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.clim.2023.109857_bb0060","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jbspin.2014.03.004","article-title":"Epigenetics and lupus","volume":"82","author":"Miceli-Richard","year":"2015","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.clim.2023.109857_bb0065","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1177\/0961203313499419","article-title":"Environmental exposures, epigenetic changes and the risk of lupus","volume":"23","author":"Somers","year":"2014","journal-title":"Lupus"},{"key":"10.1016\/j.clim.2023.109857_bb0070","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New insights into the immunopathogenesis of systemic lupus erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2023.109857_bb0075","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41584-019-0356-x","article-title":"T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy","volume":"16","author":"Sharabi","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2023.109857_bb0080","first-page":"9","article-title":"IL-6\/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation","author":"Zhao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2023.109857_bb0085","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s12016-020-08798-2","article-title":"Type I interferons in the pathogenesis and treatment of autoimmune diseases","volume":"59","author":"Jiang","year":"2020","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.clim.2023.109857_bb0090","first-page":"22","article-title":"The pathogenesis, molecular mechanisms, and therapeutic potential of the interferon pathway in systemic lupus erythematosus and other autoimmune diseases","author":"Ramaswamy","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.clim.2023.109857_bb0095","first-page":"7","article-title":"Clearance deficiency and cell death pathways: a model for the pathogenesis of SLE","author":"Mahajan","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0100","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.4049\/jimmunol.1100631","article-title":"Induction of type I IFN is a physiological immune reaction to apoptotic cell-derived membrane microparticles","volume":"189","author":"Schiller","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0105","first-page":"12","article-title":"Gut microbiome and metabolites in systemic lupus erythematosus: link, mechanisms and intervention","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0110","first-page":"11","article-title":"Understanding the relevance of DNA methylation changes in immune differentiation and disease","author":"de la Calle-Fabregat","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.clim.2023.109857_bb0115","doi-asserted-by":"crossref","first-page":"E5302","DOI":"10.1073\/pnas.1421126111","article-title":"Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing","volume":"111","author":"Chan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2023.109857_bb0120","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2217\/epi-2016-0096","article-title":"DNA methylation in systemic lupus erythematosus","volume":"9","author":"Hedrich","year":"2017","journal-title":"Epigenomics"},{"key":"10.1016\/j.clim.2023.109857_bb0125","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1177\/0961203311413412","article-title":"Histone modifications and methyl-CpG-binding domain protein levels at the TNFSF7 (CD70) promoter in SLE CD4+ T cells","volume":"20","author":"Zhou","year":"2011","journal-title":"Lupus"},{"key":"10.1016\/j.clim.2023.109857_bb0130","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molimm.2014.05.002","article-title":"Demethylation within the proximal promoter region of human estrogen receptor alpha gene correlates with its enhanced expression: implications for female bias in lupus","volume":"61","author":"Liu","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0135","doi-asserted-by":"crossref","first-page":"13457","DOI":"10.1073\/pnas.1408023111","article-title":"Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling","volume":"111","author":"Hedrich","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2023.109857_bb0140","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/annrheumdis-2017-212379","article-title":"DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus","volume":"77","author":"Imgenberg-Kreuz","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2023.109857_bb0145","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/art.40422","article-title":"Twin DNA methylation profiling reveals flare-dependent interferon signature and B cell promoter Hypermethylation in systemic lupus erythematosus","volume":"70","author":"Ulff-M\u00f8ller","year":"2018","journal-title":"Arthritis and Rheumatology"},{"key":"10.1016\/j.clim.2023.109857_bb0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/cei.12877","article-title":"DNA methylation alterations in the pathogenesis of lupus","volume":"187","author":"Chen","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0155","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.4049\/jimmunol.0900034","article-title":"Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cells","volume":"183","author":"Basu","year":"2009","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.clim.2023.109857_bb0160","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jaut.2015.06.004","article-title":"CD4+ T cells epigenetically modified by oxidative stress cause lupus-like autoimmunity in mice","volume":"62","author":"Strickland","year":"2015","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2023.109857_bb0165","first-page":"9","article-title":"Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent Hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations","author":"Absher","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.clim.2023.109857_bb0170","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/art.41598","article-title":"Long-term safety and efficacy of Anifrolumab in adults with systemic lupus erythematosus: results of a phase II open-label extension study","volume":"73","author":"Chatham","year":"2021","journal-title":"Arthritis and Rheumatology"},{"key":"10.1016\/j.clim.2023.109857_bb0175","series-title":"The long-term safety and tolerability of anifrolumab for patients with systemic lupus erythematosus in Japan: TULIP-LTE subgroup analysis","author":"Tanaka","year":"2023"},{"key":"10.1016\/j.clim.2023.109857_bb0180","first-page":"221","article-title":"Immunophenotyping reveals distinct subgroups of lupus patients based on their activated T cell subsets","author":"Perry","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0185","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1136\/annrheumdis-2018-214323","article-title":"Hypomethylation of STAT1 and HLA-DRB1 is associated with type-I interferon-dependent HLA-DRB1 expression in lupus CD8+ T cells","volume":"78","author":"Miller","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2023.109857_bb0190","first-page":"10","article-title":"Genome-wide assessment of differential DNA methylation associated with autoantibody production in systemic lupus erythematosus","author":"Chung","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.clim.2023.109857_bb0195","first-page":"3","article-title":"Precision DNA demethylation ameliorates disease in lupus-prone mice. JCI","author":"Li","year":"2018","journal-title":"Insight"},{"key":"10.1016\/j.clim.2023.109857_bb0200","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1038\/sj.onc.1205699","article-title":"5-Azacytidine and 5-aza-2\u2032-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy","volume":"21","author":"Christman","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.clim.2023.109857_bb0205","series-title":"Treating Activated CD4+ T Cells with either of Two Distinct DNA Methyltransferase Inhibitors, 5-Azacytidine or Procainamide, Is Sufficient to Cause a Lupus-Like Disease in Syngeneic Mice","author":"Quddus","year":"2023"},{"key":"10.1016\/j.clim.2023.109857_bb0210","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/art.20255","article-title":"Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors","volume":"50","author":"Oelke","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2023.109857_bb0215","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2608605","article-title":"The histone modification code in the pathogenesis of autoimmune diseases","volume":"2017","author":"Araki","year":"2017","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.clim.2023.109857_bb0220","first-page":"19","article-title":"The impact of protein acetylation\/deacetylation on systemic lupus erythematosus","author":"Ren","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.clim.2023.109857_bb0225","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.imlet.2021.09.007","article-title":"Global histone modification analysis reveals hypoacetylated H3 and H4 histones in B cells from systemic lupus erythematosus patients","volume":"240","author":"Gautam","year":"2021","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.clim.2023.109857_bb0230","article-title":"Personal non-commercial use only","volume":"35","author":"Hu","year":"2008","journal-title":"The Journal of Rheumatology Conclusion."},{"key":"10.1016\/j.clim.2023.109857_bb0235","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jaut.2010.02.002","article-title":"Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells","volume":"35","author":"Zhao","year":"2010","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2023.109857_bb0240","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clim.2014.01.002","article-title":"Class I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis in vivo","volume":"151","author":"Regna","year":"2014","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0245","first-page":"21","article-title":"Histone deacetylation inhibitors as modulators of regulatory t cells","author":"von Knethen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.clim.2023.109857_bb0250","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1021\/pr050188r","article-title":"Resetting the epigenetic histone code in the MRL-lpr\/lpr mouse model of lupus by histone deacetylase inhibition","volume":"4","author":"Garcia","year":"2005","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.clim.2023.109857_bb0255","first-page":"1317","article-title":"Treatment with a selective histone deacetylase 6 inhibitor decreases lupus nephritis in NZB\/W mice","volume":"32","author":"Vieson","year":"2017","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.clim.2023.109857_bb0260","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrg3173","article-title":"Histone methylation: a dynamic mark in health, disease and inheritance","volume":"13","author":"Greer","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.clim.2023.109857_bb0265","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.it.2009.05.007","article-title":"The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology","volume":"30","author":"Vereecke","year":"2009","journal-title":"Trends Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0270","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/rheumatology\/kew508","article-title":"TNFAIP3 downregulation mediated by histone modification contributes to T-cell dysfunction in systemic lupus erythematosus","volume":"56","author":"Zhao","year":"2017","journal-title":"Rheumatology (United Kingdom)"},{"key":"10.1016\/j.clim.2023.109857_bb0275","first-page":"13","article-title":"UHRF1 downregulation promotes T follicular helper cell differentiation by increasing BCL6 expression in SLE. Clin","author":"Liu","year":"2021","journal-title":"Epigenetics"},{"key":"10.1016\/j.clim.2023.109857_bb0280","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","article-title":"Regulation of mRNA translation and stability by microRNAs","volume":"79","author":"Fabian","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.clim.2023.109857_bb0285","first-page":"14","article-title":"Integrated analysis of microRNA regulation and its interaction with mechanisms of epigenetic regulation in the etiology of systemic lupus erythematosus","author":"Quiroz","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.clim.2023.109857_bb0290","doi-asserted-by":"crossref","first-page":"327","DOI":"10.5507\/bp.2016.004","article-title":"Micrornas in the key events of systemic lupus erythematosus pathogenesis","volume":"160","author":"Husakova","year":"2016","journal-title":"Biomedical Papers"},{"key":"10.1016\/j.clim.2023.109857_bb0295","first-page":"9","article-title":"Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b","author":"Cho","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2023.109857_bb0300","first-page":"88","article-title":"MicroRNA-10a-3p mediates Th17\/Treg cell balance and improves renal injury by inhibiting REG3A in lupus nephritis","author":"You","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.clim.2023.109857_bb0305","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1007\/s00296-016-3550-z","article-title":"The role of microRNA-31 and microRNA-21 as regulatory biomarkers in the activation of T lymphocytes of Egyptian lupus patients","volume":"36","author":"Amr","year":"2016","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.clim.2023.109857_bb0310","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.4049\/jimmunol.1401702","article-title":"Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses","volume":"193","author":"White","year":"2014","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.clim.2023.109857_bb0315","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/gene.2009.66","article-title":"Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes","volume":"11","author":"Zhang","year":"2010","journal-title":"Genes Immun."},{"key":"10.1016\/j.clim.2023.109857_bb0320","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4053038","article-title":"Epigenetic regulation of IFI44L expression in monocytes affects the functions of monocyte-derived dendritic cells in systemic lupus erythematosus","volume":"2022","author":"Luo","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.clim.2023.109857_bb0325","first-page":"25222","article-title":"Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus","volume":"116","author":"Mistry","year":"2019"},{"key":"10.1016\/j.clim.2023.109857_bb0330","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.clim.2006.12.008","article-title":"The TNF\u03b1 locus is altered in monocytes from patients with systemic lupus erythematosus","volume":"123","author":"Sullivan","year":"2007","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0335","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/15592294.2015.1009764","article-title":"Interferon regulatory factor 1 and histone H4 acetylation in systemic lupus erythematosus","volume":"10","author":"Tak Leung","year":"2015","journal-title":"Epigenetics"},{"key":"10.1016\/j.clim.2023.109857_bb0340","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1080\/14397595.2019.1620999","article-title":"Prolactin activates IRF1 and leads to altered balance of histone acetylation: implications for systemic lupus erythematosus","volume":"30","author":"Leung","year":"2020","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.clim.2023.109857_bb0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-016-0179-4","article-title":"H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus","volume":"8","author":"Zhang","year":"2016","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.clim.2023.109857_bb0350","first-page":"12","article-title":"Decreased miR-4512 levels in monocytes and macrophages of individuals with systemic lupus erythematosus contribute to innate immune activation and Neutrsophil NETosis by targeting TLR4 and CXCL2","author":"Yang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000511268","article-title":"Update on lupus nephritis: looking for a new vision","volume":"145","author":"Morales","year":"2021","journal-title":"Nephron"},{"key":"10.1016\/j.clim.2023.109857_bb0360","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2215\/CJN.05780616","article-title":"Update on lupus nephritis","volume":"12","author":"Almaani","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.clim.2023.109857_bb0365","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2016-000183","article-title":"Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responses","volume":"3","author":"Mok","year":"2016","journal-title":"Lupus Sci Med"},{"key":"10.1016\/j.clim.2023.109857_bb0370","first-page":"10","article-title":"Transcriptomic and epigenetic alterations in dendritic cells correspond with chronic kidney disease in lupus nephritis","author":"Wardowska","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0375","first-page":"189","article-title":"Down-regulation of let-7a and miR-21 in urine exosomes from lupus nephritis patients during disease flare","volume":"37","author":"Tangtanatakul","year":"2019","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.6061\/clinics\/2020\/e1528","article-title":"Circulating exosomal micrornas as biomarkers of systemic lupus erythematosus","volume":"75","author":"Li","year":"2020","journal-title":"Clinics"},{"key":"10.1016\/j.clim.2023.109857_bb0385","first-page":"9","article-title":"B cell-related circulating microRNAs with the potential value of biomarkers in the differential diagnosis, and distinguishment between the disease activity and lupus nephritis for systemic lupus erythematosus","author":"Zhang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0390","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.molimm.2018.10.003","article-title":"microRNA-199a may be involved in the pathogenesis of lupus nephritis via modulating the activation of NF-\u03baB by targeting klotho","volume":"103","author":"Ye","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0395","first-page":"3796","article-title":"MiR-663a MiR-423-5p are involved in the pathogenesis of lupus nephritis via modulating the activation of NF \u03baB by targeting TNIP2","volume":"9","author":"Weisong Wang","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.clim.2023.109857_bb0400","first-page":"114","article-title":"miR-133 inhibits proliferation and promotes apoptosis by targeting LASP1 in lupus nephritis","author":"Huang","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.clim.2023.109857_bb0405","first-page":"88","article-title":"MicroRNA-16 directly binds to DEC2 and inactivates the TLR4 signaling pathway to inhibit lupus nephritis-induced kidney tissue hyperplasia and mesangial cell proliferation","author":"Qi","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.clim.2023.109857_bb0410","first-page":"12","article-title":"IFN-I mediates lupus nephritis from the beginning to renal fibrosis","author":"Ding","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0415","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1440-1797.2012.01573.x","article-title":"Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis","volume":"17","author":"Lu","year":"2012","journal-title":"Nephrology"},{"key":"10.1016\/j.clim.2023.109857_bb0420","first-page":"10","article-title":"Increased urinary exosomal micrornas in patients with systemic lupus erythematosus","author":"Perez-Hernandez","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.clim.2023.109857_bb0425","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.autrev.2017.05.009","article-title":"Pathogenesis of cutaneous lupus erythema associated with and without systemic lupus erythema","volume":"16","author":"Zhang","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2023.109857_bb0430","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-3-319-22671-2_16","article-title":"Essential role of microRNA in skin physiology and disease","volume":"888","author":"Glava\u010d","year":"2015","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.clim.2023.109857_bb0435","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jaut.2014.07.002","article-title":"DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype","volume":"54","author":"Zhao","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2023.109857_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108578","article-title":"Administration of a microRNA-21 inhibitor improves the lupus-like phenotype in MRL\/lpr mice by repressing Tfh cell-mediated autoimmune responses","volume":"106","author":"Gao","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.clim.2023.109857_bb0445","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/imm.13434","article-title":"MicroRNA-590-3p inhibits T helper 17 cells and ameliorates inflammation in lupus mice","volume":"165","author":"Huang","year":"2022","journal-title":"Immunology"},{"key":"10.1016\/j.clim.2023.109857_bb0450","first-page":"12","article-title":"Identification of microRNAs associated with human fragile X syndrome using next-generation sequencing","author":"Sotoudeh Anvari","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.clim.2023.109857_bb0455","first-page":"9","article-title":"Translating epigenetics into clinic: focus on lupus. Clin","author":"Wang","year":"2017","journal-title":"Epigenetics"},{"key":"10.1016\/j.clim.2023.109857_bb0460","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10875-014-0008-5","article-title":"Differential microRNA profile and post-transcriptional regulation exist in systemic lupus erythematosus patients with distinct autoantibody specificities","volume":"34","author":"Chauhan","year":"2014","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2023.109857_bb0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0014302","article-title":"Identification of a common lupus disease-associated microRNA expression pattern in three different murine models of lupus","volume":"5","author":"Dai","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.clim.2023.109857_bb0470","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1136\/ard.2010.139857","article-title":"Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: MiR-21 regulates aberrant T cell responses through regulation of PDCD4 expression","volume":"70","author":"Stagakis","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2023.109857_bb0475","first-page":"12","article-title":"SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression","author":"Hou","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2023.109857_bb0480","first-page":"169","article-title":"The emerging roles of exosomes in autoimmune diseases, with special emphasis on microRNAs in exosomes","author":"Miao","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.clim.2023.109857_bb0485","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.4049\/jimmunol.1203301","article-title":"Autoantibody induction by DNA-containing immune complexes requires HMGB1 with the TLR2\/MicroRNA-155 pathway","volume":"190","author":"Wen","year":"2013","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.clim.2023.109857_bb0490","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrrheum.2013.75","article-title":"Connective tissue diseases: HMGB1 helps elicit anti-dsDNA antibody production in SLE","volume":"9","author":"Cully","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2023.109857_bb0495","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.imlet.2015.01.007","article-title":"Heat shock protein 27 and its regulatory molecules express differentially in SLE patients with distinct autoantibody profiles","volume":"164","author":"Rai","year":"2015","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.clim.2023.109857_bb0500","first-page":"18","article-title":"Elevated expression of miR-142-3p is related to the pro-inflammatory function of monocyte-derived dendritic cells in SLE","author":"Wang","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2023.109857_bb0505","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jaut.2017.03.003","article-title":"MicroRNA-302d targets IRF9 to regulate the IFN-induced gene expression in SLE","volume":"79","author":"Smith","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2023.109857_bb0510","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s10753-017-0514-8","article-title":"miRNA-451a targets IFN regulatory factor 8 for the progression of systemic lupus erythematosus","volume":"40","author":"Cheng","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.clim.2023.109857_bb0515","doi-asserted-by":"crossref","first-page":"7382","DOI":"10.1111\/jcmm.14598","article-title":"Establishment and characterization of induced pluripotent stem cells (iPSCs) from central nervous system lupus erythematosus","volume":"23","author":"De Angelis","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.clim.2023.109857_bb0520","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3892\/mmr.2020.11166","article-title":"Downregulated miR-29a promotes B cell overactivation by upregulating Crk-like protein in systemic lupus erythematosus","volume":"22","author":"Shi","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.clim.2023.109857_bb0525","first-page":"8","article-title":"miR-29b and miR-29c are involved in toll-like receptor control of glucocorticoid-induced apoptosis in human Plasmacytoid dendritic cells","author":"Hong","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.clim.2023.109857_bb0530","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.4049\/jimmunol.0904060","article-title":"MicroRNA-21 and MicroRNA-148a contribute to DNA Hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1","volume":"184","author":"Pan","year":"2010","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.clim.2023.109857_bb0535","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00011-020-01433-y","article-title":"Regulation of toll-like receptor-mediated inflammatory response by microRNA-152-3p-mediated demethylation of MyD88 in systemic lupus erythematosus","volume":"70","author":"Tao","year":"2021","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.clim.2023.109857_bb0540","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1042\/CS20180403","article-title":"The down-regulation of hsa circ 0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous","volume":"132","author":"Zhang","year":"2018","journal-title":"Clin. Sci."},{"key":"10.1016\/j.clim.2023.109857_bb0545","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/art.30196","article-title":"MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1","volume":"63","author":"Zhao","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2023.109857_bb0550","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jdermsci.2012.10.011","article-title":"MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1","volume":"69","author":"Qin","year":"2013","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.clim.2023.109857_bb0555","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41423-019-0268-3","article-title":"BCL-6 suppresses miR-142-3p\/5p expression in SLE CD4+ T cells by modulating histone methylation and acetylation of the miR-142 promoter","volume":"17","author":"Ding","year":"2020","journal-title":"Cell. Mol. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661623006216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661623006216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:11:44Z","timestamp":1761495104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661623006216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":111,"alternative-id":["S1521661623006216"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2023.109857","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent advances in the involvement of epigenetics in the pathogenesis of systemic lupus erythematosus","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2023.109857","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109857"}}