{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:37:33Z","timestamp":1787593053557,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"am","delay-in-days":324,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100015060","name":"Nagasaki University","doi-asserted-by":"publisher","award":["2021-02"],"award-info":[{"award-number":["2021-02"]}],"id":[{"id":"10.13039\/100015060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.clim.2024.110177","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:19:39Z","timestamp":1709857179000},"page":"110177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Understanding the pathogenic significance of altered calcium-calmodulin signaling in T cells in autoimmune diseases"],"prefix":"10.1016","volume":"262","author":[{"given":"Tomohiro","family":"Koga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2024.110177_bb0005","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4 T cells (TFH)","volume":"29","author":"Crotty","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0010","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0015","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0020","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1136\/ard-2023-224225","article-title":"T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases","volume":"82","author":"Akiyama","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2024.110177_bb0025","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","article-title":"Th17 and regulatory T cell balance in autoimmune and inflammatory diseases","volume":"13","author":"Noack","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2024.110177_bb0030","article-title":"Current insights and future prospects for targeting IL-17 to treat patients with systemic lupus erythematosus","volume":"11","author":"Koga","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.946786","article-title":"Peripheral helper T cell responses in human diseases","volume":"13","author":"Yoshitomi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0040","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.immunol.021908.132706","article-title":"T cell activation","volume":"27","author":"Smith-Garvin","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0045","doi-asserted-by":"crossref","first-page":"31028","DOI":"10.1074\/jbc.M109.052712","article-title":"The alphabeta T cell receptor is an anisotropic mechanosensor","volume":"284","author":"Kim","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2024.110177_bb0050","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.autrev.2015.09.006","article-title":"Tacrolimus use in lupus nephritis: a systematic review and meta-analysis","volume":"15","author":"Hannah","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2024.110177_bb0055","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1093\/rheumatology\/kev192","article-title":"The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis","volume":"54","author":"Kurita","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2024.110177_bb0060","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1007\/s00018-008-8086-2","article-title":"Ca(2+)\/calmodulin-dependent protein kinases","volume":"65","author":"Swulius","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.clim.2024.110177_bb0065","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.4049\/jimmunol.174.9.5583","article-title":"A pivotal role for the multifunctional calcium\/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness","volume":"174","author":"Lin","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0070","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1038\/sj.emboj.7600685","article-title":"Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation","volume":"24","author":"Pan","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.clim.2024.110177_bb0075","doi-asserted-by":"crossref","first-page":"656","DOI":"10.4049\/jimmunol.175.2.656","article-title":"Active Ca2+\/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling","volume":"175","author":"McGargill","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0080","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.4049\/jimmunol.167.11.6270","article-title":"Requirement for Ca2+\/calmodulin-dependent kinase type IV\/gr in setting the thymocyte selection threshold","volume":"167","author":"Raman","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0085","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1128\/MCB.02469-05","article-title":"Ca2+\/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation","volume":"26","author":"Ishiguro","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.clim.2024.110177_bb0090","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1600-065X.2008.00756.x","article-title":"Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation","volume":"228","author":"Liu","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.clim.2024.110177_bb0095","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.it.2008.08.005","article-title":"Calcium\/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller","volume":"29","author":"Racioppi","year":"2008","journal-title":"Trends Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0100","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.4049\/jimmunol.1201785","article-title":"Calcium\/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus","volume":"189","author":"Koga","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0105","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/14397595.2017.1413964","article-title":"The role of CaMK4 in immune responses","volume":"28","author":"Koga","year":"2018","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.clim.2024.110177_bb0110","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1182\/blood-2011-03-343251","article-title":"Functional heterogeneity of human effector CD8+ T cells","volume":"119","author":"Takata","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.clim.2024.110177_bb0115","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1038\/s41467-022-31935-8","article-title":"Calcium\/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice","volume":"13","author":"Yong","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2024.110177_bb0120","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/BOR.0000000000000685","article-title":"Metabolic control of T cells in autoimmunity","volume":"32","author":"Kono","year":"2020","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.clim.2024.110177_bb0125","doi-asserted-by":"crossref","first-page":"20055","DOI":"10.1016\/S0021-9258(20)80693-0","article-title":"Expression of a Ca2+\/calmodulin-dependent protein kinase, CaM kinase-Gr, in human T lymphocytes. Regulation of kinase activity by T cell receptor signaling","volume":"268","author":"Hanissian","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2024.110177_bb0130","doi-asserted-by":"crossref","first-page":"43429","DOI":"10.1074\/jbc.M111.299339","article-title":"cAMP-responsive element modulator (CREM)alpha protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus","volume":"286","author":"Hedrich","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2024.110177_bb0135","doi-asserted-by":"crossref","first-page":"16606","DOI":"10.1073\/pnas.1210129109","article-title":"cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus","volume":"109","author":"Hedrich","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2024.110177_bb0140","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1172\/JCI73411","article-title":"CaMK4-dependent activation of AKT\/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance","volume":"124","author":"Koga","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2024.110177_bb0145","first-page":"100","article-title":"T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy, nature reviews","volume":"16","author":"Sharabi","year":"2020","journal-title":"Rheumatology"},{"key":"10.1016\/j.clim.2024.110177_bb0150","doi-asserted-by":"crossref","DOI":"10.20900\/immunometab20200009","article-title":"T cell metabolism in lupus","volume":"2","author":"Vukelic","year":"2020","journal-title":"Immunometabolism"},{"key":"10.1016\/j.clim.2024.110177_bb0155","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/art.40785","article-title":"Promotion of calcium\/calmodulin-dependent protein kinase 4 by GLUT1-dependent glycolysis in systemic lupus erythematosus","volume":"71","author":"Koga","year":"2019","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2024.110177_bb0160","article-title":"Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation, JCI","volume":"4","author":"Kono","year":"2019","journal-title":"Insight"},{"key":"10.1016\/j.clim.2024.110177_bb0165","doi-asserted-by":"crossref","first-page":"eadc9657","DOI":"10.1126\/sciadv.adc9657","article-title":"Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity","volume":"8","author":"Scherlinger","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.clim.2024.110177_bb0170","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2024.110177_bb0175","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.clim.2016.04.010","article-title":"T cells and IL-17 in lupus nephritis","volume":"185","author":"Koga","year":"2017","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0180","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1172\/JCI78087","article-title":"T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity","volume":"125","author":"Moulton","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2024.110177_bb0185","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI22854","article-title":"Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV","volume":"115","author":"Juang","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2024.110177_bb0190","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.4049\/jimmunol.1102357","article-title":"Cutting edge: calcium\/calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis","volume":"187","author":"Ichinose","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0195","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/art.30085","article-title":"Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium\/calmodulin-dependent protein kinase type IV","volume":"63","author":"Ichinose","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2024.110177_bb0200","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3109\/08916934.2014.915954","article-title":"KN-93, an inhibitor of calcium\/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3(+) regulatory T cells in MRL\/lpr mice","volume":"47","author":"Koga","year":"2014","journal-title":"Autoimmunity"},{"key":"10.1016\/j.clim.2024.110177_bb0205","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/art.39499","article-title":"Lupus nephritis IgG induction of calcium\/calmodulin-dependent protein kinase IV expression in podocytes and alteration of their function","volume":"68","author":"Ichinose","year":"2016","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2024.110177_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109222","article-title":"CaMK4 expression on effector memory T cells is associated with organ damage in systemic lupus erythematosus: a case report","volume":"247","author":"Koga","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0215","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s41467-024-45080-x","article-title":"CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses","volume":"15","author":"Scherlinger","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2024.110177_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2021.108680","article-title":"Current insights and future prospects for the pathogenesis and treatment for rheumatoid arthritis","volume":"225","author":"Koga","year":"2021","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110177_bb0225","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/rheumatology\/keac381","article-title":"Inhibition of calcium\/calmodulin-dependent protein kinase IV in arthritis: dual effect on Th17 cell activation and osteoclastogenesis","volume":"62","author":"Koga","year":"2023","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2024.110177_bb0230","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624000688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624000688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:03:27Z","timestamp":1778616207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661624000688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":46,"alternative-id":["S1521661624000688"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2024.110177","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding the pathogenic significance of altered calcium-calmodulin signaling in T cells in autoimmune diseases","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2024.110177","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110177"}}