{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:51:53Z","timestamp":1791831113798,"version":"4.3.4"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"am","delay-in-days":326,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ek0410111"],"award-info":[{"award-number":["JP23ek0410111"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20ek0410078"],"award-info":[{"award-number":["JP20ek0410078"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ek0109607"],"award-info":[{"award-number":["JP23ek0109607"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP 23ek0410111h"],"award-info":[{"award-number":["JP 23ek0410111h"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20ek0410078h"],"award-info":[{"award-number":["JP20ek0410078h"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.clim.2024.110224","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T06:03:06Z","timestamp":1713592986000},"page":"110224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Potential therapies targeting metabolic pathways in systemic lupus erythematosus"],"prefix":"10.1016","volume":"263","author":[{"given":"Ryo","family":"Hisada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihito","family":"Kono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2024.110224_bb0005","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41590-020-0677-6","article-title":"Autoimmunity and organ damage in systemic lupus erythematosus","volume":"21","author":"Tsokos","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0010","doi-asserted-by":"crossref","first-page":"274ra218","DOI":"10.1126\/scitranslmed.aaa0835","article-title":"Normalization of CD4+ T cell metabolism reverses lupus","volume":"7","author":"Yin","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.clim.2024.110224_bb0015","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/ndt\/gfq496","article-title":"The PI3K\/Akt\/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin","volume":"26","author":"Stylianou","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.clim.2024.110224_bb0020","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/art.40785","article-title":"Promotion of calcium\/calmodulin-dependent protein kinase 4 by GLUT1-dependent glycolysis in systemic lupus erythematosus","volume":"71","author":"Koga","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.clim.2024.110224_bb0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cmet.2014.05.004","article-title":"The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function","volume":"20","author":"Macintyre","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.clim.2024.110224_bb0030","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3389\/fimmu.2019.00833","article-title":"Targeting T cell activation and lupus autoimmune phenotypes by inhibiting glucose transporters","volume":"10","author":"Li","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0035","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1172\/JCI76012","article-title":"Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation","volume":"125","author":"Gerriets","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2024.110224_bb0040","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","article-title":"HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2024.110224_bb0045","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.4049\/jimmunol.1201785","article-title":"Calcium\/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus","volume":"189","author":"Koga","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0050","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.127395","article-title":"Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation","volume":"4","author":"Kono","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.clim.2024.110224_bb0055","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1172\/JCI73411","article-title":"CaMK4-dependent activation of AKT\/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance","volume":"124","author":"Koga","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2024.110224_bb0060","doi-asserted-by":"crossref","first-page":"eadc9657","DOI":"10.1126\/sciadv.adc9657","article-title":"Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity","volume":"8","author":"Scherlinger","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.clim.2024.110224_bb0065","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41584-019-0356-x","article-title":"T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy","volume":"16","author":"Sharabi","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2024.110224_bb0070","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/BOR.0000000000000685","article-title":"Metabolic control of T cells in autoimmunity","volume":"32","author":"Kono","year":"2020","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.clim.2024.110224_bb0075","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s10753-018-0815-6","article-title":"RNAi silencing of HIF-1alpha ameliorates lupus development in MRL\/lpr mice","volume":"41","author":"Zhao","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.clim.2024.110224_bb0080","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.aaf6284","article-title":"Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism","volume":"354","author":"Peng","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.clim.2024.110224_bb0085","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jaci.2015.05.004","article-title":"RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation","volume":"137","author":"Yang","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0090","doi-asserted-by":"crossref","first-page":"12993","DOI":"10.1038\/ncomms12993","article-title":"ICER is requisite for Th17 differentiation","volume":"7","author":"Yoshida","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2024.110224_bb0095","doi-asserted-by":"crossref","first-page":"9288","DOI":"10.1073\/pnas.1805717115","article-title":"Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation","volume":"115","author":"Kono","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.clim.2024.110224_bb0100","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.celrep.2019.12.014","article-title":"The CD38\/NAD\/SIRTUIN1\/EZH2 axis mitigates cytotoxic CD8 T cell function and identifies patients with SLE prone to infections","volume":"30","author":"Katsuyama","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.clim.2024.110224_bb0105","article-title":"Lipid metabolism: immune regulation and therapeutic prospectives in systemic lupus erythematosus","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0110","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1194\/jlr.TR120000658","article-title":"Lipid rafts as a therapeutic target","volume":"61","author":"Sviridov","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.clim.2024.110224_bb0115","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.2337\/db11-1437","article-title":"Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen species production in kidney cortical tubules in early diabetes","volume":"61","author":"Rosca","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.clim.2024.110224_bb0120","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.freeradbiomed.2020.12.006","article-title":"Oxidative stress-induced aberrant lipid metabolism is an important causal factor for dysfunction of immunocytes from patients with systemic lupus erythematosus","volume":"163","author":"Hu","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.clim.2024.110224_bb0125","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1038\/nm.3704","article-title":"De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells","volume":"20","author":"Berod","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2024.110224_bb0130","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1189\/jlb.3AB0417-159RR","article-title":"Fatty acid synthase regulates the pathogenicity of Th17 cells","volume":"102","author":"Young","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.clim.2024.110224_bb0135","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.clim.2013.07.002","article-title":"The peroxisome-proliferator activated receptor-gamma agonist pioglitazone modulates aberrant T cell responses in systemic lupus erythematosus","volume":"149","author":"Zhao","year":"2013","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0140","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1177\/0961203317701842","article-title":"Immunomodulation in systemic lupus erythematosus: induction of M2 population in monocyte-derived macrophages by pioglitazone","volume":"26","author":"Mohammadi","year":"2017","journal-title":"Lupus"},{"key":"10.1016\/j.clim.2024.110224_bb0145","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4049\/jimmunol.182.1.340","article-title":"The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin","volume":"182","author":"Aprahamian","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0150","doi-asserted-by":"crossref","first-page":"14787","DOI":"10.1074\/jbc.M111.218610","article-title":"Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage","volume":"286","author":"Zhu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2024.110224_bb0155","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1172\/JCI69571","article-title":"Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients","volume":"124","author":"McDonald","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2024.110224_bb0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/imm.12617","article-title":"Lipid rafts in immune signalling: current progress and future perspective","volume":"149","author":"Varshney","year":"2016","journal-title":"Immunology"},{"key":"10.1016\/j.clim.2024.110224_bb0165","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.intimp.2018.10.025","article-title":"Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome","volume":"65","author":"Peng","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.clim.2024.110224_bb0170","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.4049\/jimmunol.1403088","article-title":"Metformin suppresses systemic autoimmunity in Roquin(san\/san) mice through inhibiting B cell differentiation into plasma cells via regulation of AMPK\/mTOR\/STAT3","volume":"198","author":"Lee","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.623844","article-title":"Amino acid metabolism in lupus","volume":"12","author":"Kono","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0180","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/BOR.0000000000000685","article-title":"Metabolic control of T cells in autoimmunity","volume":"32","author":"Kono","year":"2020","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.clim.2024.110224_bb0185","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.molcel.2020.09.006","article-title":"Amino acids and their transporters in T cell immunity and cancer therapy","volume":"80","author":"Wang","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.clim.2024.110224_bb0190","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fimmu.2017.00247","article-title":"Nutrient and metabolic sensing in T cell responses","volume":"8","author":"Wei","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10100418","article-title":"Metabolite transporters as regulators of immunity","volume":"10","author":"Weiss","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.clim.2024.110224_bb0200","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1073\/pnas.1714717115","article-title":"Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells","volume":"115","author":"Kono","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.clim.2024.110224_bb0205","doi-asserted-by":"crossref","DOI":"10.20900\/immunometab20200009","article-title":"T cell metabolism in lupus","volume":"2","author":"Vukelic","year":"2020","journal-title":"Immunometabolism"},{"key":"10.1016\/j.clim.2024.110224_bb0210","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/25785826.2022.2140503","article-title":"New insights into the metabolism of Th17 cells","volume":"46","author":"Kono","year":"2023","journal-title":"Immunol. Med."},{"key":"10.1016\/j.clim.2024.110224_bb0215","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/art.41019","article-title":"Glutaminase 1 inhibition reduces glycolysis and ameliorates lupus-like disease in MRL\/lpr mice and experimental autoimmune encephalomyelitis","volume":"71","author":"Kono","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.clim.2024.110224_bb0220","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1038\/s41467-018-06686-0","article-title":"Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells","volume":"9","author":"Choi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2024.110224_bb0225","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1093\/rheumatology\/keab824","article-title":"An enhanced mitochondrial function through glutamine metabolism in plasmablast differentiation in systemic lupus erythematosus","volume":"61","author":"Sumikawa","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2024.110224_bb0230","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.immuni.2014.04.007","article-title":"Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation","volume":"40","author":"Nakaya","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2024.110224_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109133","article-title":"Inhibition of glutaminolysis ameliorates lupus by regulating T and B cell subsets and downregulating the mTOR\/P70S6K\/4EBP1 and NLRP3\/caspase-1\/IL-1beta pathways in MRL\/lpr mice","volume":"112","author":"Zhang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.clim.2024.110224_bb0240","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1002\/art.42112","article-title":"Role of glutaminase 2 in promoting CD4+ T cell production of Interleukin-2 by supporting antioxidant defense in systemic lupus erythematosus","volume":"74","author":"Hisada","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.clim.2024.110224_bb0245","series-title":"Metabolic Control of TH17 and Induced Treg Cell Balance by an Epigenetic Mechanism, Nature, Advance Online Publication","author":"Xu","year":"2017"},{"key":"10.1016\/j.clim.2024.110224_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106774","article-title":"Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice","volume":"26","author":"Gong","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.clim.2024.110224_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2022.102245","article-title":"Immunometabolic alterations in lupus: where do they come from and where do we go from there?","volume":"78","author":"Ma","year":"2022","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0260","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax2220","article-title":"Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice","volume":"12","author":"Choi","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.clim.2024.110224_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104241","article-title":"Microbiota-mediated skewing of tryptophan catabolism modulates CD4(+) T cells in lupus-prone mice","volume":"25","author":"Brown","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.clim.2024.110224_bb0270","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2022-000808","article-title":"Associations between circulating interferon and kynurenine\/tryptophan pathway metabolites: support for a novel potential mechanism for cognitive dysfunction in SLE","volume":"9","author":"Anderson","year":"2022","journal-title":"Lupus Sci. Med."},{"key":"10.1016\/j.clim.2024.110224_bb0275","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.703972","article-title":"Targeting mitochondrial-derived reactive oxygen species in T cell-mediated autoimmune diseases","volume":"12","author":"Chavez","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0280","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/1529-0131(200201)46:1<175::AID-ART10015>3.0.CO;2-H","article-title":"Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus","volume":"46","author":"Gergely","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2024.110224_bb0285","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/j.cell.2018.10.001","article-title":"Distinct regulation of Th17 and Th1 cell differentiation by glutaminase-dependent metabolism","volume":"175","author":"Johnson","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.clim.2024.110224_bb0290","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/art.34502","article-title":"N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial","volume":"64","author":"Lai","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2024.110224_bb0295","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1191\/096120301680416940","article-title":"Antioxidants suppress mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE)","volume":"10","author":"Suwannaroj","year":"2001","journal-title":"Lupus"},{"key":"10.1016\/j.clim.2024.110224_bb0300","doi-asserted-by":"crossref","DOI":"10.20900\/immunometab20200012","article-title":"Metabolic targets for treatment of autoimmune diseases","volume":"2","author":"Piranavan","year":"2020","journal-title":"Immunometabolism"},{"key":"10.1016\/j.clim.2024.110224_bb0305","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.autrev.2012.12.007","article-title":"Interaction between glutathione and apoptosis in systemic lupus erythematosus","volume":"12","author":"Shah","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2024.110224_bb0310","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1002\/art.40223","article-title":"Review: metabolic control of immune system activation in rheumatic diseases","volume":"69","author":"Perl","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.clim.2024.110224_bb0315","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X20953336","article-title":"Clinical efficacy and safety of sirolimus in systemic lupus erythematosus: a real-world study and meta-analysis","volume":"12","author":"Peng","year":"2020","journal-title":"Ther. Adv. Musculoskelet Dis."},{"key":"10.1016\/j.clim.2024.110224_bb0320","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41577-019-0128-5","article-title":"Itaconate: the poster child of metabolic reprogramming in macrophage function","volume":"19","author":"O\u2019Neill","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2024.110224_bb0325","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/s41467-023-36594-x","article-title":"Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming","volume":"14","author":"Aso","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2024.110224_bb0330","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1002\/art.42284","article-title":"Modulation of the itaconate pathway attenuates murine lupus","volume":"74","author":"Blanco","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.clim.2024.110224_bb0335","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1159\/000495400","article-title":"4-Octyl Itaconate activates Nrf2 signaling to inhibit pro-inflammatory cytokine production in peripheral blood mononuclear cells of systemic lupus erythematosus patients","volume":"51","author":"Tang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.clim.2024.110224_bb0340","doi-asserted-by":"crossref","first-page":"375","DOI":"10.46497\/ArchRheumatol.2021.8101","article-title":"Identification of sequence polymorphisms in the mitochondrial deoxyribonucleic acid displacement-loop region as risk factors for systemic lupus erythematosus","volume":"36","author":"Lai","year":"2021","journal-title":"Arch. Rheumatol."},{"key":"10.1016\/j.clim.2024.110224_bb0345","doi-asserted-by":"crossref","first-page":"ra115","DOI":"10.1126\/scisignal.aaf1933","article-title":"Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus","volume":"9","author":"Buskiewicz","year":"2016","journal-title":"Sci. Signal."},{"key":"10.1016\/j.clim.2024.110224_bb0350","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2020-000387","article-title":"Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice","volume":"7","author":"Fortner","year":"2020","journal-title":"Lupus Sci. Med."},{"key":"10.1016\/j.clim.2024.110224_bb0355","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/art.10968","article-title":"Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine","volume":"48","author":"Bednarski","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2024.110224_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103509","article-title":"Hydroxychloroquine inhibits the mitochondrial antioxidant system in activated T cells","volume":"24","author":"Kim","year":"2021","journal-title":"iScience"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624001153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624001153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T13:29:42Z","timestamp":1720790982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661624001153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":72,"alternative-id":["S1521661624001153"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2024.110224","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential therapies targeting metabolic pathways in systemic lupus erythematosus","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2024.110224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110224"}}