{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:59:05Z","timestamp":1779364745541,"version":"3.53.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007076","name":"Fondazione Italiana per la Ricerca sul Cancro Airc","doi-asserted-by":"publisher","award":["IG 23329"],"award-info":[{"award-number":["IG 23329"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011731","name":"Action for A-T","doi-asserted-by":"publisher","award":["1145303"],"award-info":[{"award-number":["1145303"]}],"id":[{"id":"10.13039\/100011731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.clim.2024.110233","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T16:48:37Z","timestamp":1714495717000},"page":"110233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Absence of ATM leads to altered NK cell function in mice"],"prefix":"10.1016","volume":"263","author":[{"given":"Daniela Angela","family":"Covino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Desimio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Giovinazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Sabino Pinho","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Merolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Marazziti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Doria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2024.110233_bb0005","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41580-021-00394-2","article-title":"Cellular functions of the protein kinase ATM and their relevance to human disease","volume":"22","author":"Lee","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.clim.2024.110233_bb0010","doi-asserted-by":"crossref","DOI":"10.1186\/s13023-016-0543-7","article-title":"Ataxia telangiectasia: a review","volume":"11","author":"Rothblum-Oviatt","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.clim.2024.110233_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2013.01.053","article-title":"Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity","volume":"131","author":"Driessen","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.clim.2017.01.009","article-title":"Ataxia-telangiectasia: immunodeficiency and survival","volume":"178","author":"van Os","year":"2017","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0025","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s10875-020-00881-9","article-title":"Variable abnormalities in T and B cell subsets in ataxia telangiectasia","volume":"41","author":"Moeini Shad","year":"2021","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0030","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/cei.12262","article-title":"Immune deficiency in ataxia-telangiectasia: a longitudinal study of 44 patients","volume":"176","author":"Chopra","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0035","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ppul.22817","article-title":"Infections of the respiratory system in patients with ataxia-telangiectasia","volume":"49","author":"Schroeder","year":"2014","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.clim.2024.110233_bb0040","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1007\/s10875-021-01090-8","article-title":"Simple measurement of IgA predicts immunity and mortality in ataxia-telangiectasia","volume":"41","author":"Zielen","year":"2021","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0045","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10875-022-01234-4","article-title":"Progressive depletion of B and T lymphocytes in patients with ataxia telangiectasia: results of the Italian primary immunodeficiency network","volume":"42","author":"Cirillo","year":"2022","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2021.108802","article-title":"Altered NK-cell compartment and dysfunctional NKG2D\/NKG2D-ligand axis in patients with ataxia-telangiectasia","volume":"230","author":"Desimio","year":"2021","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0055","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-immunol-032712-095951","article-title":"Regulation of ligands for the NKG2D activating receptor","volume":"31","author":"Raulet","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/imr.12600","article-title":"Dysregulated cellular functions and cell stress pathways provide critical cues for activating and targeting natural killer cells to transformed and infected cells","volume":"280","author":"Raulet","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.clim.2024.110233_bb0065","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1158\/2326-6066.CIR-15-0098","article-title":"NKG2D receptor and its ligands in host defense","volume":"3","author":"Lanier","year":"2015","journal-title":"Cancer. Immunol. Res."},{"key":"10.1016\/j.clim.2024.110233_bb0070","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3389\/fimmu.2018.00441","article-title":"NKG2D: a master regulator of immune cell responsiveness","volume":"9","author":"Wensveen","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0075","first-page":"8","article-title":"NKG2D ligands as therapeutic targets","volume":"13","author":"Spear","year":"2013","journal-title":"Cancer. Immun."},{"key":"10.1016\/j.clim.2024.110233_bb0080","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.3389\/fimmu.2018.02040","article-title":"NKG2D ligands-critical targets for cancer immune escape and therapy","volume":"9","author":"Schmiedel","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0085","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3389\/fimmu.2019.00661","article-title":"NKG2D\/NKG2-ligand pathway offers new opportunities in cancer treatment","volume":"10","author":"Frazao","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0090","doi-asserted-by":"crossref","first-page":"13930","DOI":"10.1038\/ncomms13930","article-title":"The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma","volume":"8","author":"Sheppard","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2024.110233_bb0095","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.1258867","article-title":"Antitumor immunity. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection","volume":"348","author":"Deng","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.clim.2024.110233_bb0100","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/sj.onc.1204111","article-title":"Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid","volume":"20","author":"Gatei","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.clim.2024.110233_bb0105","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.molcel.2004.10.029","article-title":"A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci","volume":"16","author":"Riballo","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.clim.2024.110233_bb0110","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1038\/s41418-018-0272-7","article-title":"GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells","volume":"26","author":"Pintado-Berninches","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.clim.2024.110233_bb0115","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.1523\/JNEUROSCI.0774-19.2019","article-title":"Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences","volume":"39","author":"Song","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.clim.2024.110233_bb0120","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)80086-0","article-title":"Atm-deficient mice: a paradigm of ataxia telangiectasia","volume":"86","author":"Barlow","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.clim.2024.110233_bb0125","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.dnarep.2013.04.014","article-title":"The appropriateness of the mouse model for ataxia-telangiectasia: neurological defects but no neurodegeneration","volume":"12","author":"Lavin","year":"2013","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.clim.2024.110233_bb0130","first-page":"2598","article-title":"Derivation of thymic lymphoma T-cell lines from Atm(\u2212\/\u2212) and p53(\u2212\/\u2212) mice","volume":"50","author":"Jinadasa","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.clim.2024.110233_bb0135","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2172-12-36","article-title":"Ten-color flow cytometry reveals distinct patterns of expression of CD124 and CD126 by developing thymocytes","volume":"12","author":"Tan","year":"2011","journal-title":"BMC Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0140","doi-asserted-by":"crossref","first-page":"13084","DOI":"10.1073\/pnas.93.23.13084","article-title":"Pleiotropic defects in ataxia-telangiectasia protein-deficient mice","volume":"93","author":"Elson","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.clim.2024.110233_bb0145","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1101\/gad.10.19.2411","article-title":"Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma","volume":"10","author":"Xu","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.clim.2024.110233_bb0150","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1182\/blood.V96.5.1940","article-title":"Abnormal rearrangement within the alpha\/delta T-cell receptor locus in lymphomas from Atm-deficient mice","volume":"96","author":"Liyanage","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.clim.2024.110233_bb0155","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s41375-019-0618-2","article-title":"ATM activity in T cells is critical for immune surveillance of lymphoma in vivo","volume":"34","author":"Riabinska","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.clim.2024.110233_bb0160","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/sji.12072","article-title":"Generation of soluble NKG2D ligands: proteolytic cleavage, exosome secretion and functional implications","volume":"78","author":"Chitadze","year":"2013","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0165","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1182\/blood-2008-10-187179","article-title":"Maturation of mouse NK cells is a 4-stage developmental program","volume":"113","author":"Chiossone","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.clim.2024.110233_bb0170","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.immuni.2008.02.016","article-title":"NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy","volume":"28","author":"Guerra","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2024.110233_bb0175","article-title":"Natural killer cells integrate signals received from tumour interactions and IL2 to induce robust and prolonged anti-tumour and metabolic responses","volume":"1","author":"Kedia-Mehta","year":"2019","journal-title":"Immunometabolism"},{"key":"10.1016\/j.clim.2024.110233_bb0180","article-title":"IL-10 enhances human natural killer cell effector functions via metabolic reprogramming regulated by mTORC1 signaling","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0185","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2174\/0929867043455972","article-title":"Cytokines in the thymus: production and biological effects","volume":"11","author":"Yarilin","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.clim.2024.110233_bb0190","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1159\/000448077","article-title":"TNF\u03b1 augments cytokine-induced NK cell IFN\u03b3 production through TNFR2","volume":"8","author":"Almishri","year":"2016","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.clim.2024.110233_bb0195","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/s41423-023-01071-4","article-title":"The TNF\u03b1\/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis","volume":"20","author":"Khan","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.clim.2024.110233_bb0200","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.4049\/jimmunol.143.4.1283","article-title":"Mechanisms of T cell activation by the calcium ionophore ionomycin","volume":"143","author":"Chatila","year":"1989","journal-title":"J. Immunol."},{"issue":"Pt 3","key":"10.1016\/j.clim.2024.110233_bb0205","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1042\/bj3000665","article-title":"Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane","volume":"300","author":"Morgan","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.clim.2024.110233_bb0210","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1182\/blood-2007-07-100057","article-title":"Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways","volume":"111","author":"Coudert","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.clim.2024.110233_bb0215","article-title":"Regulation of murine NK cell exhaustion through the activation of the DNA damage repair pathway","volume":"5","author":"Alvarez","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.clim.2024.110233_bb0220","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.150079","article-title":"Balanced engagement of activating and inhibitory receptors mitigates human NK cell exhaustion","volume":"7","author":"Myers","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.clim.2024.110233_bb0225","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.713158","article-title":"Leveraging NKG2D ligands in immuno-oncology","volume":"12","author":"Fuertes","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624003425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624003425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T19:44:30Z","timestamp":1715975070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661624003425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":45,"alternative-id":["S1521661624003425"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2024.110233","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Absence of ATM leads to altered NK cell function in mice","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2024.110233","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110233"}}