{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:38:27Z","timestamp":1787701107494,"version":"build-2784847793"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012905","name":"Department of Science and Technology of Shandong Province","doi-asserted-by":"publisher","award":["tsqn201909141"],"award-info":[{"award-number":["tsqn201909141"]}],"id":[{"id":"10.13039\/100012905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2020YQ56"],"award-info":[{"award-number":["ZR2020YQ56"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073441"],"award-info":[{"award-number":["82073441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874244"],"award-info":[{"award-number":["81874244"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","award":["2020RC001"],"award-info":[{"award-number":["2020RC001"]}],"id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.clim.2024.110291","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T01:57:06Z","timestamp":1718935026000},"page":"110291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Targeted serum proteome profiling reveals nicotinamide adenine dinucleotide phosphate (NADPH)-related biomarkers to discriminate linear IgA bullous disorder from dermatitis herpetiformis"],"prefix":"10.1016","volume":"265","author":[{"given":"Tianyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongqi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guizhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.clim.2024.110291_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2020.11.076","article-title":"Subepithelial autoimmune blistering dermatoses: clinical features and diagnosis","volume":"85","author":"Montagnon","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2 Suppl","key":"10.1016\/j.clim.2024.110291_bb0010","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1016\/j.jaad.2004.01.059","article-title":"Unusual clinical manifestation of linear IgA dermatosis: a report of two cases","volume":"51","author":"Cauza","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.clim.2024.110291_bb0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0896-8411(91)90006-X","article-title":"Dermatitis herpetiformis and the mucosal immune response","volume":"4","author":"Hall","year":"1991","journal-title":"J. Autoimmun."},{"issue":"2 Pt 1","key":"10.1016\/j.clim.2024.110291_bb0020","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0190-9622(94)70015-X","article-title":"Drug-induced linear IgA bullous dermatosis: report of six cases and review of the literature","volume":"30","author":"Kuechle","year":"1994","journal-title":"J. Am. Acad. Dermatol."},{"issue":"6","key":"10.1016\/j.clim.2024.110291_bb0025","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1468-3083.2009.03188.x","article-title":"Italian group for cutaneous immunopathology. Guidelines for the diagnosis and treatment of dermatitis herpetiformis","volume":"23","author":"Caproni","year":"2009","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.clim.2024.110291_bb0030","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2147\/CCID.S69127","article-title":"The diagnosis and treatment of dermatitis herpetiformis","volume":"8","author":"Antiga","year":"2015","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"issue":"1","key":"10.1016\/j.clim.2024.110291_bb0035","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.clindermatol.2011.03.008","article-title":"Linear immunoglobulin A bullous dermatosis","volume":"30","author":"Fortuna","year":"2012","journal-title":"Clin. Dermatol."},{"issue":"10","key":"10.1016\/j.clim.2024.110291_bb0040","first-page":"43","article-title":"Linear IgA bullous dermatosis: a rare Clinicopathologic entity with an unusual presentation","volume":"8","author":"Chaudhari","year":"2015","journal-title":"J. Clin. Aesthet. Dermatol."},{"issue":"2","key":"10.1016\/j.clim.2024.110291_bb0045","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1365-2133.2011.10385.x","article-title":"Prevalence and incidence of dermatitis herpetiformis: a 40-year prospective study from Finland","volume":"165","author":"Salmi","year":"2011","journal-title":"Br. J. Dermatol."},{"issue":"7","key":"10.1016\/j.clim.2024.110291_bb0050","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1468-3083.2011.04204.x","article-title":"Dermatitis herpetiformis in China: a report of 22 cases","volume":"26","author":"Zhang","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.clim.2024.110291_bb0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000051808","article-title":"Dermatitis herpetiformis in Japan: an update","volume":"204","author":"Shibahara","year":"2022","journal-title":"Dermatology"},{"issue":"3","key":"10.1016\/j.clim.2024.110291_bb0060","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jid.2023.08.011","article-title":"A celiac gene HLA-DQB1\u221702:01 is associated with linear IgA bullous dermatosis in the Chinese population","volume":"144","author":"Li","year":"2024","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.clim.2024.110291_bb0065","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/1523-1747.ep12284056","article-title":"Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis","volume":"93","author":"Hall","year":"1989","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.clim.2024.110291_bb0070","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1001\/archderm.1977.01640020027002","article-title":"HLA-B8 and dermatitis herpetiformis in patients with IgA deposits in skin","volume":"113","author":"Katz","year":"1977","journal-title":"Arch. Dermatol."},{"issue":"3","key":"10.1016\/j.clim.2024.110291_bb0075","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1572-0241.2002.05471.x","article-title":"HLA-DQ typing in the diagnosis of celiac disease","volume":"97","author":"Kaukinen","year":"2002","journal-title":"Am. J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.clim.2024.110291_bb0080","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jid.2015.10.057","article-title":"The HLA alleles B*0801 and DRB1*0301 are associated with dermatitis Herpetiformis in a Chinese population","volume":"136","author":"Sun","year":"2016","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.clim.2024.110291_bb0085","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/bjd.18642","article-title":"Linear IgA\/IgG bullous dermatosis with autoantibodies directing the native and processed forms of BP180","volume":"182","author":"Inamura","year":"2020","journal-title":"Br. J. Dermatol."},{"issue":"6","key":"10.1016\/j.clim.2024.110291_bb0090","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1111\/jdv.17183","article-title":"S2k guidelines (consensus statement) for diagnosis and therapy of dermatitis herpetiformis initiated by the European Academy of Dermatology and Venereology (EADV)","volume":"35","author":"Gorog","year":"2021","journal-title":"J Eur Acad of Dermatol Venereol."},{"issue":"3","key":"10.1016\/j.clim.2024.110291_bb0095","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jaad.2011.06.032","article-title":"Definitions and outcome measures for bullous pemphigoid: recommendations by an international panel of experts","volume":"66","author":"Murrell","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.clim.2024.110291_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalabil ity","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.clim.2024.110291_bb0105","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100145R","article-title":"Neutrophil extracellular traps contribute to immune dysregulation in bullous pemphigoid via inducing B-cell differentiation and antibody production","volume":"35","author":"Fang","year":"2021","journal-title":"FASEB J."},{"issue":"11\u221212","key":"10.1016\/j.clim.2024.110291_bb0110","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s10354-018-0640-4","article-title":"The defense and signaling role of NADPH oxidases in eukaryotic cells: review","volume":"168","author":"Breitenbach","year":"2018","journal-title":"Wien. Med. Wochenschr."},{"key":"10.1016\/j.clim.2024.110291_bb0115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.freeradbiomed.2018.03.049","article-title":"Neutrophils and redox stress in the pathogenesis of autoimmune disease","volume":"125","author":"Glennon-Alty","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.clim.2024.110291_bb0120","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm3801","article-title":"Cellular mechanisms and physiological consequences of redox-dependent signalling","volume":"15","author":"Holmstr\u00f6m","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.clim.2024.110291_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103250","article-title":"Novel inhibitors of leukocyte transendothelial migration","volume":"92","author":"Getter","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"8","key":"10.1016\/j.clim.2024.110291_bb0130","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.4049\/jimmunol.1403250","article-title":"Endothelial actin-binding proteins and actin dynamics in leukocyte transendothelial migration","volume":"194","author":"Schnoor","year":"2015","journal-title":"J. Immunol."},{"issue":"14","key":"10.1016\/j.clim.2024.110291_bb0135","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1039\/C8LC00202A","article-title":"Real-time observation of leukocyte-endothelium interactions in tissue-engineered blood vessel","volume":"18","author":"Chen","year":"2018","journal-title":"Lab Chip"},{"issue":"7","key":"10.1016\/j.clim.2024.110291_bb0140","doi-asserted-by":"crossref","first-page":"8991","DOI":"10.1002\/cam4.5597","article-title":"Role of NCF2 as a potential prognostic factor and immune infiltration indicator in hepatocellular carcinoma","volume":"12","author":"Huang","year":"2023","journal-title":"Cancer Med."},{"issue":"4","key":"10.1016\/j.clim.2024.110291_bb0145","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1083\/jcb.200101113","article-title":"Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing","volume":"154","author":"Witke","year":"2001","journal-title":"J. Cell Biol."},{"issue":"Pt 3","key":"10.1016\/j.clim.2024.110291_bb0150","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1042\/bj2960557","article-title":"p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains","volume":"296","author":"Wientjes","year":"1993","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.clim.2024.110291_bb0155","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0022-2143(96)90043-8","article-title":"Interactions between the components of the human NADPH oxidase: intrigues in the phox family","volume":"128","author":"Leusen","year":"1996","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.clim.2024.110291_bb0160","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1600-065X.1994.tb00850.x","article-title":"The genetic basis of chronic granulomatous disease","volume":"138","author":"Roos","year":"1994","journal-title":"Immunol. Rev."},{"issue":"10","key":"10.1016\/j.clim.2024.110291_bb0165","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1007\/s00262-021-02877-9","article-title":"Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival","volume":"70","author":"Yang","year":"2021","journal-title":"Cancer Immunol. Immunother."},{"issue":"12","key":"10.1016\/j.clim.2024.110291_bb0170","first-page":"3033","article-title":"High expression of neutrophil cytosolic factor 2 (NCF2) is associated with aggressive features and poor prognosis of esophageal squamous cell carcinoma","volume":"13","author":"Qin","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.clim.2024.110291_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.941556","article-title":"Novel macrophage-related gene prognostic index for glioblastoma associated with M2 macrophages and T cell dysfunction","volume":"13","author":"Ji","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110291_bb0180","article-title":"Methylation of immune-related genes in peripheral blood leukocytes and breast cancer","volume":"12","author":"Tian","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.clim.2024.110291_bb0185","doi-asserted-by":"crossref","first-page":"8528976","DOI":"10.1155\/2020\/8528976","article-title":"Association of NCF2, NCF4, and CYBA gene polymorphisms with rheumatoid arthritis in a Chinese population","volume":"2020","author":"Zhang","year":"2020","journal-title":"J Immunol Res"},{"issue":"10","key":"10.1016\/j.clim.2024.110291_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002341","article-title":"Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus","volume":"7","author":"Cunninghame Graham","year":"2011","journal-title":"PLoS Genet."},{"issue":"7","key":"10.1016\/j.clim.2024.110291_bb0195","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1136\/gutjnl-2011-300078","article-title":"NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2","volume":"61","author":"Muise","year":"2012","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.clim.2024.110291_bb0200","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1053\/j.gastro.2018.02.016","article-title":"Clinical and genomic correlates of neutrophil reactive oxygen species production in pediatric patients with Crohn\u2019s disease","volume":"154","author":"Denson","year":"2018","journal-title":"Gastroenterology"},{"issue":"29","key":"10.1016\/j.clim.2024.110291_bb0205","doi-asserted-by":"crossref","first-page":"17946","DOI":"10.1016\/S0021-9258(18)38255-3","article-title":"Purification and expression of gCap39. An intracellular and secreted Ca2(+)-dependent actin-binding protein enriched in mononuclear phagocytes","volume":"265","author":"Johnston","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.clim.2024.110291_bb0210","first-page":"38","article-title":"Actin-related proteins localized in the nucleus: from discovery to novel roles in nuclear organization","volume":"2","author":"Oma","year":"2011","journal-title":"Nucleus"},{"issue":"11","key":"10.1016\/j.clim.2024.110291_bb0215","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/ncb2364","article-title":"Nuclear actin and myosins: life without filaments","volume":"13","author":"de Lanerolle","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.clim.2024.110291_bb0220","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2021.02.038","article-title":"The migration behavior of human glioblastoma cells is influenced by the redox-sensitive human macrophage capping protein CAPG","volume":"167","author":"Prescher","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.clim.2024.110291_bb0225","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12957-022-02808-7","article-title":"CapG promoted nasopharyngeal carcinoma cell motility involving rho motility pathway independent of ROCK","volume":"20","author":"Fu","year":"2022","journal-title":"World J. Surg. Oncol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624004005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624004005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T16:54:23Z","timestamp":1731603263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661624004005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":45,"alternative-id":["S1521661624004005"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2024.110291","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted serum proteome profiling reveals nicotinamide adenine dinucleotide phosphate (NADPH)-related biomarkers to discriminate linear IgA bullous disorder from dermatitis herpetiformis","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2024.110291","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110291"}}