{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:00:36Z","timestamp":1789416036531,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.clim.2024.110338","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T02:01:06Z","timestamp":1723514466000},"page":"110338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases"],"prefix":"10.1016","volume":"267","author":[{"given":"Hiroki","family":"Ohtani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Iwatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Takeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoh","family":"Hidaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2024.110338_bb0005","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1126\/science.1972595","article-title":"Autoimmune diseases: the failure of self tolerance","volume":"248","author":"Sinha","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.clim.2024.110338_bb0010","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1365-2249.2012.04646.x","article-title":"Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease","volume":"170","author":"Arakawa","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2024.110338_bb0015","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1365-2249.2010.04306.x","article-title":"Association of functional polymorphisms in promoter regions of IL5, IL6 and IL13 genes with development and prognosis of autoimmune thyroid diseases","volume":"163","author":"Inoue","year":"2011","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2024.110338_bb0020","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2249.2009.03884.x","article-title":"Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-thyrotropin receptor antibody","volume":"156","author":"Inoue","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2024.110338_bb0025","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s10875-012-9721-0","article-title":"Associations between autoimmune thyroid disease prognosis and functional polymorphisms of susceptibility genes, CTLA4, PTPN22, CD40, FCRL3, and ZFAT, previously revealed in genome-wide association studies","volume":"32","author":"Inoue","year":"2012","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110338_bb0030","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1507\/endocrj.K06-015","article-title":"Association between the severity of Hashimoto\u2019s disease and the functional +874A\/T polymorphism in the interferon-gamma gene","volume":"53","author":"Ito","year":"2006","journal-title":"Endocr. J."},{"key":"10.1016\/j.clim.2024.110338_bb0035","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2265.2011.04318.x","article-title":"Twin studies as a model for exploring the aetiology of autoimmune thyroid disease","volume":"76","author":"Brix","year":"2012","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.clim.2024.110338_bb0040","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fendo.2017.00149","article-title":"Epigenetics and autoimmune thyroid diseases","volume":"8","author":"Coppede","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.clim.2024.110338_bb0045","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrg2045","article-title":"Environmental epigenomics and disease susceptibility","volume":"8","author":"Jirtle","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.clim.2024.110338_bb0050","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.cell.2006.08.003","article-title":"Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis","volume":"126","author":"Zhang","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.clim.2024.110338_bb0055","first-page":"2163","article-title":"Chromosomal regulation by MeCP2: structural and enzymatic considerations","volume":"61","author":"Bowen","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.clim.2024.110338_bb0060","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/nbt.1685","article-title":"Epigenetic modifications and human disease","volume":"28","author":"Portela","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.clim.2024.110338_bb0065","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tig.2015.03.002","article-title":"The alternative role of DNA methylation in splicing regulation","volume":"31","author":"Lev Maor","year":"2015","journal-title":"Trends Genet."},{"key":"10.1016\/j.clim.2024.110338_bb0070","article-title":"DNA methylation subpatterns at distinct regulatory regions in human early embryos","volume":"8","author":"Luo","year":"2018","journal-title":"Open Biol."},{"key":"10.1016\/j.clim.2024.110338_bb0075","doi-asserted-by":"crossref","first-page":"28990","DOI":"10.18632\/oncotarget.15993","article-title":"Genome-wide DNA methylation analysis reveals molecular subtypes of pancreatic cancer","volume":"8","author":"Mishra","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.clim.2024.110338_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014524","article-title":"DNA methylation of the first exon is tightly linked to transcriptional silencing","volume":"6","author":"Brenet","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2024.110338_bb0085","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/embor.2009.221","article-title":"Modifications of RNA polymerase II are pivotal in regulating gene expression states","volume":"10","author":"Brookes","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.clim.2024.110338_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154770","article-title":"Association of IFNG gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid diseases","volume":"123","author":"Hashimoto","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.clim.2024.110338_bb0095","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/08916934.2019.1669568","article-title":"Association of IL6 gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid diseases","volume":"52","author":"Hirai","year":"2019","journal-title":"Autoimmunity"},{"key":"10.1016\/j.clim.2024.110338_bb0100","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/08916934.2018.1448078","article-title":"Methylation levels of the TNFA gene are different between Graves' and Hashimoto's diseases and influenced by the TNFA polymorphism","volume":"51","author":"Morita","year":"2018","journal-title":"Autoimmunity"},{"key":"10.1016\/j.clim.2024.110338_bb0105","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/35105024","article-title":"T-cell regulation by CD28 and CTLA-4","volume":"1","author":"Alegre","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2024.110338_bb0110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.19.1.225","article-title":"Complexities of CD28\/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation","volume":"19","author":"Salomon","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2024.110338_bb0115","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2567.2000.00121.x","article-title":"CD28, CTLA-4 and their ligands: who does what and to whom?","volume":"101","author":"Sansom","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.clim.2024.110338_bb0120","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nri727","article-title":"The B7-CD28 superfamily","volume":"2","author":"Sharpe","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2024.110338_bb0125","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.gene.2013.10.034","article-title":"Differential expression of alternative splice variants of CTLA4 in Kuwaiti autoimmune disease patients","volume":"534","author":"AlFadhli","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.clim.2024.110338_bb0130","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/cimm.2000.1649","article-title":"A native soluble form of CTLA-4","volume":"201","author":"Oaks","year":"2000","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.clim.2024.110338_bb0135","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jaut.2007.02.006","article-title":"The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future","volume":"28","author":"Jacobson","year":"2007","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2024.110338_bb0140","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature01621","article-title":"Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease","volume":"423","author":"Ueda","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.clim.2024.110338_bb0145","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12020-011-9510-1","article-title":"CD40 C\/T(\u22121) and CTLA-4 a\/G(49) SNPs are associated with autoimmune thyroid diseases in the Chinese population","volume":"41","author":"Yang","year":"2012","journal-title":"Endocrine"},{"key":"10.1016\/j.clim.2024.110338_bb0150","doi-asserted-by":"crossref","first-page":"46478","DOI":"10.1074\/jbc.M206894200","article-title":"A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele","volume":"277","author":"Anjos","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2024.110338_bb0155","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.gene.2016.02.027","article-title":"A novel approach to investigation of the pathogenesis of pterygium based on assessment of promoter hyper-methylation and expression profile of CTLA4 gene: a credible report of CTLA4 gene expression in human eye tissue","volume":"583","author":"Ebrahimi","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.clim.2024.110338_bb0160","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000010620","article-title":"CTLA-4 methylation regulates the pathogenesis of myasthenia gravis and the expression of related cytokines","volume":"97","author":"Fang","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.clim.2024.110338_bb0165","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.96793","article-title":"CTLA4 methylation predicts response to anti-PD-1 and anti-CTLA-4 immunotherapy in melanoma patients","volume":"3","author":"Goltz","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.clim.2024.110338_bb0170","doi-asserted-by":"crossref","first-page":"249","DOI":"10.15403\/jgld.2014.1121.233.dmkt","article-title":"Analysis of promoter methylation, polymorphism and expression profile of cytotoxic T-lymphocyte-associated antigen-4 in patients with gastric cancer","volume":"23","author":"Kordi-Tamandani","year":"2014","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"10.1016\/j.clim.2024.110338_bb0175","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1007\/s11033-013-2614-3","article-title":"Evaluation of polymorphism, hypermethylation and expression pattern of CTLA4 gene in a sample of Iranian patients with schizophrenia","volume":"40","author":"Kordi-Tamandani","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.clim.2024.110338_bb0180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ebiom.2018.01.016","article-title":"PD-1 (PDCD1) promoter methylation is a prognostic factor in patients with diffuse lower-grade gliomas harboring Isocitrate dehydrogenase (IDH) mutations","volume":"28","author":"Rover","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.clim.2024.110338_bb0185","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13148-018-0512-1","article-title":"DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer","volume":"10","author":"Sasidharan Nair","year":"2018","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.clim.2024.110338_bb0190","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/art.38715","article-title":"Treg cell function in rheumatoid arthritis is compromised by ctla-4 promoter methylation resulting in a failure to activate the indoleamine 2,3-dioxygenase pathway","volume":"66","author":"Cribbs","year":"2014","journal-title":"Arthritis. Rheum."},{"key":"10.1016\/j.clim.2024.110338_bb0195","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1007\/s00125-012-2815-7","article-title":"Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets","volume":"56","author":"Dayeh","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.clim.2024.110338_bb0200","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1093\/nar\/25.21.4422","article-title":"Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA","volume":"25","author":"Warnecke","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2024.110338_bb0205","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ebiom.2019.04.045","article-title":"Pan-cancer genomic analysis links 3'UTR DNA methylation with increased gene expression in T cells","volume":"43","author":"McGuire","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.clim.2024.110338_bb0210","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/cbic.201402449","article-title":"miRNA and methylation: a multifaceted liaison","volume":"16","author":"Chhabra","year":"2015","journal-title":"Chembiochem"},{"key":"10.1016\/j.clim.2024.110338_bb0215","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.clinbiochem.2015.11.021","article-title":"Differential DNA methylation of microRNAs within promoters, intergenic and intragenic regions of type 2 diabetic, pre-diabetic and non-diabetic individuals","volume":"49","author":"Pheiffer","year":"2016","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.clim.2024.110338_bb0220","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1101\/gad.473408","article-title":"Regulation of alternative polyadenylation by genomic imprinting","volume":"22","author":"Wood","year":"2008","journal-title":"Genes Dev."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624004479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624004479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T04:11:27Z","timestamp":1726373487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661624004479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":44,"alternative-id":["S1521661624004479"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2024.110338","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2024.110338","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110338"}}