{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:58:22Z","timestamp":1787752702118,"version":"build-2784847793"},"reference-count":179,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT107881"],"award-info":[{"award-number":["WT107881"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT219506"],"award-info":[{"award-number":["WT219506"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00002\/4"],"award-info":[{"award-number":["MC_UU_00002\/4"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00040\/01"],"award-info":[{"award-number":["MC_UU_00040\/01"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.clim.2024.110356","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T02:43:53Z","timestamp":1725417833000},"page":"110356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency"],"prefix":"10.1016","volume":"268","author":[{"given":"Thomas W.","family":"Willis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Effrossyni","family":"Gkrania-Klotsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Wareham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin F.","family":"McKinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth G.C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2024.110356_bb0005","doi-asserted-by":"crossref","DOI":"10.1007\/s10875-022-01289-3","article-title":"Human inborn errors of immunity: 2022 update on the classification from the international union of immunological societies expert committee","author":"Tangye","year":"2022","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2015.04.049","article-title":"Practice parameter for the diagnosis and management of primary immunodeficiency","volume":"136","author":"Bonilla","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-2249.2000.01131.x","article-title":"Selective IgA Deficiency (SIgAD) and Common Variable Immunodeficiency (CVID)","volume":"120","author":"Hammarstr\u00f6m","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/sji.12499","article-title":"Selective IgA Deficiency: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management","volume":"85","author":"Yazdani","year":"2017","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.autrev.2013.10.005","article-title":"IgA deficiency and autoimmunity","volume":"13","author":"Singh","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2024.110356_bb0030","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1023\/A:1023247117133","article-title":"Primary antibody deficiency in arabs: first report from Eastern Saudi Arabia","volume":"18","author":"Al-Attas","year":"1998","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0035","first-page":"17","article-title":"Selective IgA deficiency (SIgAD) in Eastern Nigeria","volume":"17","author":"Ezeoke","year":"1988","journal-title":"Afr. J. Med. Med. Sci."},{"key":"10.1016\/j.clim.2024.110356_bb0040","first-page":"81","article-title":"Selective IgA deficiency in japanese blood donors: frequency and statistical analysis1","volume":"50","author":"Kanoh","year":"1986","journal-title":"Vox Sang."},{"key":"10.1016\/j.clim.2024.110356_bb0045","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-3148.2011.01082.x","article-title":"Prevalence of Immunoglobulin A Deficiency in Chinese Blood Donors and Evaluation of Anaphylactic Transfusion Reaction Risk","volume":"21","author":"Feng","year":"2011","journal-title":"Transfus. Med."},{"key":"10.1016\/j.clim.2024.110356_bb0050","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0090-1229(86)90073-5","article-title":"The Human IgA System: A Reassessment","volume":"40","author":"Mestecky","year":"1986","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.clim.2024.110356_bb0055","doi-asserted-by":"crossref","first-page":"7809","DOI":"10.1073\/pnas.1503885112","article-title":"Relationship of the Quaternary Structure of Human Secretory IgA to Neutralization of Influenza Virus","volume":"112","author":"Suzuki","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2024.110356_bb0060","article-title":"The Effects of Secretory IgA in the Mucosal Immune System","volume":"2020","author":"Li","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.clim.2024.110356_bb0065","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1089\/dna.2014.2639","article-title":"The Unexplored Roles of Human Serum IgA","volume":"33","author":"Leong","year":"2014","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.clim.2024.110356_bb0070","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/mi.2011.41","article-title":"Secretory IgA\u2019s Complex Roles in Immunity and Mucosal Homeostasis in the Gut","volume":"4","author":"Mantis","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0075","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1084\/jem.20180427","article-title":"IgA Regulates the Composition and Metabolic Function of Gut Microbiota by Promoting Symbiosis between Bacteria","volume":"215","author":"Nakajima","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2024.110356_bb0080","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000499044","article-title":"The Heterogeneous Pathogenesis of Selective Immunoglobulin A Deficiency","volume":"179","author":"Bagheri","year":"2019","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1130","article-title":"Defective Formation of IgA Memory B Cells, Th1 and Th17 Cells in Symptomatic Patients with Selective IgA Deficiency","volume":"9","author":"Grosserichter-Wagener","year":"2020","journal-title":"Clinical Trans. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0090","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13223-023-00826-y","article-title":"Clinical Manifestation for Immunoglobulin A Deficiency: A Systematic Review and Meta-Analysis","volume":"19","author":"Vosughimotlagh","year":"2023","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0095","first-page":"626","article-title":"The Clinical Condition of IgA-deficient Patients Is Related to the Proportion of IgD- and IgM-producing Cells in Their Nasal Mucosa","volume":"67","author":"Brandtzaeg","year":"1987","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0100","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1023\/A:1012241117984","article-title":"Physiology of IgA and IgA Deficiency","volume":"21","author":"Cunningham-Rundles","year":"2001","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0105","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/ajcp\/80.2.210","article-title":"Selective IgA Deficiency in Blood Donors","volume":"80","author":"Clark","year":"1983","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.clim.2024.110356_bb0110","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1423-0410.1976.tb02811.x","article-title":"Familial Clustering of Selective IgA Deficiency","volume":"30","author":"Koistinen","year":"1976","journal-title":"Vox Sang."},{"key":"10.1016\/j.clim.2024.110356_bb0115","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/clin.1995.1142","article-title":"Family and Linkage Study of Selective IgA Deficiency and Common Variable Immunodeficiency","volume":"77","author":"Vo\u0159echovsk\u00fd","year":"1995","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.clim.2024.110356_bb0120","doi-asserted-by":"crossref","DOI":"10.1177\/2058738418779458","article-title":"Familial Inheritance and Screening of First-Degree Relatives in Common Variable Immunodeficiency and Immunoglobulin A Deficiency Patients","volume":"32","author":"Karaca","year":"2018","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.clim.2024.110356_bb0125","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0022-3476(69)80234-9","article-title":"IgA absence associated with short arm deletion of chromosome No. 18","volume":"74","author":"Ruvalcaba","year":"1969","journal-title":"J. Pediatr."},{"key":"10.1016\/j.clim.2024.110356_bb0130","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/adc.48.4.320","article-title":"Absence of IgA and growth hormone deficiency associated with short arm deletion of chromosome 18","volume":"48","author":"Leisti","year":"1973","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.clim.2024.110356_bb0135","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1001\/jama.1982.03330110055029","article-title":"Pernicious Anemia, 18q Deletion Syndrome, and IgA Deficiency","volume":"248","author":"Stricker","year":"1982","journal-title":"JAMA"},{"key":"10.1016\/j.clim.2024.110356_bb0140","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1744-313X.2007.00652.x","article-title":"Mapping Susceptibility Gene Locus for IgA Deficiency at Del(18)(Q22.3--Q23); Report of Familial Cryptic Chromosome t(18q; 10p) Translocations","volume":"34","author":"Dostal","year":"2007","journal-title":"Int. J. Immunogenet."},{"key":"10.1016\/j.clim.2024.110356_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.742834","article-title":"Immune dysregulation in patients with chromosome 18q deletions---searching for putative loci for autoimmunity and immunodeficiency","volume":"12","author":"Hogendorf","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0150","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0140-6736(68)91453-0","article-title":"IgA ABSENCE ASSOCIATED WITH A RING-18 CHROMOSOME","volume":"291","author":"Finley","year":"1968","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2024.110356_bb0155","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.4049\/jimmunol.163.4.2236","article-title":"A putative susceptibility locus on chromosome 18 is not a major contributor to human selective IgA deficiency: evidence from meiotic mapping of 83 multiple-case families","volume":"163","author":"Vorechovsk\u00fd","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0160","article-title":"Innate mechanisms in selective IgA deficiency","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0165","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.1073\/pnas.86.20.8015","article-title":"Individuals with IgA Deficiency and Common Variable Immunodeficiency Share Polymorphisms of Major Histocompatibility Complex Class III Genes","volume":"86","author":"Schaffer","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2024.110356_bb0170","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0167-5699(91)90098-E","article-title":"Is Selective IgA Deficiency Associated with Central HLA Genes or Alleles of the DR-DQ Region?","volume":"12","author":"Olerup","year":"1991","journal-title":"Immunol. Today"},{"key":"10.1016\/j.clim.2024.110356_bb0175","doi-asserted-by":"crossref","first-page":"10653","DOI":"10.1073\/pnas.89.22.10653","article-title":"Shared HLA Class II-associated Genetic Susceptibility and Resistance, Related to the HLA-DQB1 Gene, in IgA Deficiency and Common Variable Immunodeficiency","volume":"89","author":"Olerup","year":"1992","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.clim.2024.110356_bb0180","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1172\/JCI115797","article-title":"Major Histocompatibility Complex Class III Genes and Susceptibility to Immunoglobulin A Deficiency and Common Variable Immunodeficiency","volume":"89","author":"Volanakis","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2024.110356_bb0185","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/347289a0","article-title":"Different Amino Acids at Position 57 of the HLA-DQ\u03b2 Chain Associated with Susceptibility and Resistance to IgA Deficiency","volume":"347","author":"Olerup","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.clim.2024.110356_bb0190","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s10875-009-9336-2","article-title":"IgA deficiency and the MHC: Assessment of relative risk and microheterogeneity within the HLA A1 B8, DR3 (8.1) haplotype","volume":"30","author":"Mohammadi","year":"2010","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002476","article-title":"High-Density SNP Mapping of the HLA Region Identifies Multiple Independent Susceptibility Loci Associated with Selective IgA Deficiency","volume":"8","author":"Ferreira","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0200","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1080\/1744666X.2016.1198696","article-title":"Monogenic Mutations Associated with IgA Deficiency","volume":"12","author":"Abolhassani","year":"2016","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0205","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ng1601","article-title":"TACI Is Mutant in Common Variable Immunodeficiency and IgA Deficiency","volume":"37","author":"Castigli","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0210","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ng1600","article-title":"Mutations in TNFRSF13B Encoding TACI Are Associated with Common Variable Immunodeficiency in Humans","volume":"37","author":"Salzer","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0215","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/ng0407-430","article-title":"Reexamining the Role of TACI Coding Variants in Common Variable Immunodeficiency and Selective IgA Deficiency","volume":"39","author":"Castigli","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0220","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12026-007-8000-2","article-title":"TACI, Isotype Switching, CVID and IgAD","volume":"38","author":"Castigli","year":"2007","journal-title":"Immunol. Res."},{"key":"10.1016\/j.clim.2024.110356_bb0225","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng0407-429","article-title":"Reexamining the Role of TACI Coding Variants in Common Variable Immunodeficiency and Selective IgA Deficiency","volume":"39","author":"Pan-Hammarstr\u00f6m","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0230","article-title":"Causative mechanisms and clinical impact of immunoglobulin deficiencies in ataxia telangiectasia","volume":"0","author":"Takada","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0235","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ng.644","article-title":"Association of IFIH1 and Other Autoimmunity Risk Alleles with Selective IgA Deficiency","volume":"42","author":"Ferreira","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0240","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/ng.3675","article-title":"Common Variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A Are Associated with Selective IgA Deficiency","volume":"48","author":"Bronson","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0245","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/ng.2711","article-title":"Cross-disorder group of the psychiatric genomics consortium, genetic relationship between five psychiatric disorders estimated from genome-wide SNPs","volume":"45","author":"Lee","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0250","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/bimj.201900254","article-title":"Accurate Error Control in High-Dimensional Association Testing Using Conditional False Discovery Rates","volume":"63","author":"Liley","year":"2021","journal-title":"Biom. J."},{"key":"10.1016\/j.clim.2024.110356_bb0255","series-title":"Unique genetic insights from combining isolated population and national health register data","author":"FinnGen","year":"2022"},{"key":"10.1016\/j.clim.2024.110356_bb0260","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1038\/s41467-022-34456-6","article-title":"Genetic regulation of serum iga levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits","volume":"13","author":"Liu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2024.110356_bb0265","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13073-020-00820-8","article-title":"Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease","volume":"13","author":"Dennis","year":"2021","journal-title":"Genome Med."},{"key":"10.1016\/j.clim.2024.110356_bb0270","series-title":"Pan-UK Biobank","author":"Pan-UKB team","year":"2020"},{"key":"10.1016\/j.clim.2024.110356_bb0275","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/ng.3760","article-title":"Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease","volume":"49","author":"de Lange","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0280","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/annrheumdis-2020-218481","article-title":"Combined Genetic Analysis of Juvenile Idiopathic Arthritis Clinical Subtypes Identifies Novel Risk Loci, Target Genes and Key Regulatory Mechanisms","volume":"80","author":"L\u00f3pez-Isac","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2024.110356_bb0285","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav7188","article-title":"Multiple Sclerosis Genomic Map Implicates Peripheral Immune Cells and Microglia in Susceptibility","volume":"365","author":"INTERNATIONAL MULTIPLE SCLEROSIS GENETICS CONSORTIUM","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.clim.2024.110356_bb0290","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jhep.2021.04.055","article-title":"An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs","volume":"75","author":"Cordell","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.clim.2024.110356_bb0295","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng.3745","article-title":"Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease","volume":"49","author":"Ji","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0300","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature12873","article-title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery","volume":"506","author":"Okada","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.clim.2024.110356_bb0305","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/ng.3434","article-title":"Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus","volume":"47","author":"Bentham","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0310","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41586-021-03552-w","article-title":"Interpreting type 1 diabetes risk with genetics and single-cell epigenomics","volume":"594","author":"Chiou","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.clim.2024.110356_bb0315","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/s41467-021-21015-8","article-title":"GWAS for autoimmune addison\u2019s disease identifies multiple risk loci and highlights AIRE in disease susceptibility","volume":"12","author":"Eriksson","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2024.110356_bb0320","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/s41588-023-01422-x","volume":"55","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0325","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1038\/s41588-022-01213-w","article-title":"Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis","volume":"54","author":"Ishigaki","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0330","doi-asserted-by":"crossref","first-page":"D1005","DOI":"10.1093\/nar\/gky1120","article-title":"The NHGRI-EBI GWAS catalog of published genome-wide association studies, targeted arrays and summary statistics 2019","volume":"47","author":"Buniello","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2024.110356_bb0335","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gkj144","article-title":"The UCSC genome browser database: update 2006","volume":"34","author":"Hinrichs","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2024.110356_bb0340","doi-asserted-by":"crossref","unstructured":"M. Byrska-Bishop, U.S. Evani, X. Zhao, A.O. Basile, H.J. Abel, A.A. Regier, A. Corvelo, W.E. Clarke, R. Musunuri, K. Nagulapalli, S. Fairley, A. Runnels, L. Winterkorn, E. Lowy, Human Genome Structural Variation Consortium, Paul Flicek, S. Germer, H. Brand, I.M. Hall, M.E. Talkowski, G. Narzisi, M.C. Zody, (2022). High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios, Cell 185, 3426\u20133440.","DOI":"10.1016\/j.cell.2022.08.004"},{"key":"10.1016\/j.clim.2024.110356_bb0345","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/s41588-021-00945-5","article-title":"An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci","volume":"53","author":"Mountjoy","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0350","doi-asserted-by":"crossref","first-page":"D1311","DOI":"10.1093\/nar\/gkaa840","article-title":"Open targets genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics","volume":"49","author":"Ghoussaini","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"2023","key":"10.1016\/j.clim.2024.110356_bb0355","doi-asserted-by":"crossref","first-page":"D933","DOI":"10.1093\/nar\/gkac958","article-title":"Nucleic","volume":"51","author":"Martin","year":"2023","journal-title":"Acids Res."},{"key":"10.1016\/j.clim.2024.110356_bb0360","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Series B Stat. Methodology"},{"key":"10.1016\/j.clim.2024.110356_bb0365","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41576-019-0137-z","article-title":"Genetic Correlations of Polygenic Disease Traits: From Theory to Practice","volume":"20","author":"van Rheenen","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0370","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004269","article-title":"Statistical power to detect genetic (Co)variance of complex traits using snp data in unrelated samples","volume":"10","author":"Visscher","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010852","article-title":"Accurate detection of shared genetic architecture from GWAS summary statistics in the small-sample context","volume":"19","author":"Willis","year":"2023","journal-title":"PLoS Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0380","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nm.3933","article-title":"Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases","volume":"21","author":"Li","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2024.110356_bb0385","unstructured":"S. Purcell, C. Chang, PLINK 2.0, (n.d.)."},{"key":"10.1016\/j.clim.2024.110356_bb0390","doi-asserted-by":"crossref","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"Gigascience"},{"key":"10.1016\/j.clim.2024.110356_bb0395","doi-asserted-by":"crossref","first-page":"449","DOI":"10.12688\/wellcomeopenres.19995.2","article-title":"MendelianRandomization v0.9.0: updates to an R package for performing Mendelian randomization analyses using summarized data","volume":"8","author":"Patel","year":"2023","journal-title":"Wellcome Open Res"},{"key":"10.1016\/j.clim.2024.110356_bb0400","doi-asserted-by":"crossref","first-page":"k601","DOI":"10.1136\/bmj.k601","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians","volume":"362","author":"Davies","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.clim.2024.110356_bb0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009853","article-title":"Leveraging Auxiliary Data from Arbitrary Distributions to Boost GWAS Discovery with Flexible cFDR","volume":"17","author":"Hutchinson","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0410","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00104","article-title":"A20\/tumor necrosis factor \u03b1-induced protein 3 in immune cells controls development of autoinflammation and autoimmunity: lessons from mouse models","volume":"9","author":"Das","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0415","first-page":"1","article-title":"NF-\u03baB Signaling in Inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.clim.2024.110356_bb0420","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/annrheumdis-2020-219209","article-title":"Meta-analysis of 208370 east asians identifies 113 susceptibility loci for systemic lupus erythematosus","volume":"80","author":"Yin","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2024.110356_bb0425","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng.2467","article-title":"Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity","volume":"44","author":"Tsoi","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0430","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/ng.2770","volume":"45","author":"Beecham","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0435","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/ng.2779","article-title":"A Genome-Wide Association Study in Han Chinese Identifies a Susceptibility Locus for Primary Sj\u00f6gren\u2019s Syndrome at 7q11.23","volume":"45","author":"Li","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0440","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.jid.2018.11.033","article-title":"WAKMAR2, a long noncoding RNA downregulated in human chronic wounds, modulates keratinocyte motility and production of inflammatory chemokines","volume":"139","author":"Herter","year":"2019","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.clim.2024.110356_bb0445","doi-asserted-by":"crossref","first-page":"15328","DOI":"10.1038\/s41598-021-94784-3","article-title":"A prospective study revealing the role of an immune-related eRNA, WAKMAR2, in breast cancer","volume":"11","author":"Wang","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.clim.2024.110356_bb0450","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13059-014-0570-4","article-title":"Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin","volume":"16","author":"Tsoi","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.clim.2024.110356_bb0455","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"V\u00f5sa","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.06.045","article-title":"Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.clim.2024.110356_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.08.008","article-title":"The polygenic and monogenic basis of blood traits and diseases","volume":"182","author":"Vuckovic","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.clim.2024.110356_bb0470","doi-asserted-by":"crossref","first-page":"64007","DOI":"10.18632\/oncotarget.11746","article-title":"Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.clim.2024.110356_bb0475","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/ng.3459","article-title":"Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease","volume":"48","author":"Zhou","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0480","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/annrheumdis-2017-212403","article-title":"A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease","volume":"77","author":"Aeschlimann","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2024.110356_bb0485","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00277-022-04761-7","article-title":"ALPS, FAS, and beyond: From Inborn Errors of Immunity to Acquired Immunodeficiencies","volume":"101","author":"Consonni","year":"2022","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.clim.2024.110356_bb0490","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.immuni.2015.04.010","article-title":"FAS inactivation releases unconventional germinal center B cells that escape antigen control and drive ige and autoantibody production","volume":"42","author":"Butt","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2024.110356_bb0495","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1182\/blood-2015-04-642488","article-title":"Disturbed B-lymphocyte selection in autoimmune lymphoproliferative syndrome","volume":"127","author":"Janda","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.clim.2024.110356_bb0500","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20032000","article-title":"TACI and BAFF-R mediate isotype switching in B cells","volume":"201","author":"Castigli","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2024.110356_bb0505","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/ni.1914","article-title":"The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88","volume":"11","author":"He","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0510","doi-asserted-by":"crossref","first-page":"15401","DOI":"10.1073\/pnas.1200386109","article-title":"Deficiency in TNFRSF13B (TACI) expands t-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival","volume":"109","author":"Ou","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.clim.2024.110356_bb0515","doi-asserted-by":"crossref","first-page":"8383","DOI":"10.3390\/ijms21218383","article-title":"Trans-ancestral fine-mapping and epigenetic annotation as tools to delineate functionally relevant risk alleles at IKZF1 and IKZF3 in systemic lupus erythematosus","volume":"21","author":"Vyse","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.clim.2024.110356_bb0520","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.iac.2020.04.004","article-title":"IKAROS-associated diseases in primary immunodeficiency patients","volume":"40","author":"Nunes-Santos","year":"2020","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"10.1016\/j.clim.2024.110356_bb0525","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1084\/jem.20131735","article-title":"Ikaros Is absolutely required for pre-b cell differentiation by attenuating IL-7 signals","volume":"210","author":"Heizmann","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2024.110356_bb0530","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/ni.1626","article-title":"Regulation of B cell fate commitment and immunoglobulin VH gene rearrangements by ikaros","volume":"9","author":"Reynaud","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0535","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1073\/pnas.0911193107","article-title":"Critical role of IRF-5 in regulation OF B-cell differentiation","volume":"107","author":"Lien","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.clim.2024.110356_bb0540","first-page":"3580","article-title":"IRF5 loss impairs TLR9\/BCR-induced B cell activation, proliferation and plasmablast differentiation through Erk1-Myc signaling","volume":"130","author":"Barnes","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.clim.2024.110356_bb0545","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1158\/2326-6066.CIR-20-0555","article-title":"The IKZF1--IRF4\/IRF5 Axis controls polarization of myeloma-associated macrophages","volume":"9","author":"Mougiakakos","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.clim.2024.110356_bb0550","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/gene.2012.10","article-title":"Unique contribution of IRF-5-ikaros axis to the B-cell IgG2a response","volume":"13","author":"Fang","year":"2012","journal-title":"Genes Immun."},{"key":"10.1016\/j.clim.2024.110356_bb0555","doi-asserted-by":"crossref","first-page":"100625","DOI":"10.1016\/j.jbc.2021.100625","article-title":"The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination","volume":"296","author":"Zheng","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2024.110356_bb0560","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1177\/1947601911421925","article-title":"The c-rel transcription factor in development and disease","volume":"2","author":"Gilmore","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.clim.2024.110356_bb0565","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4049\/immunohorizons.1800027","article-title":"Inflammatory bowel disease susceptibility gene C1ORF106 regulates intestinal epithelial permeability","volume":"2","author":"Manzanillo","year":"2018","journal-title":"ImmunoHorizons"},{"key":"10.1016\/j.clim.2024.110356_bb0570","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.aan0814","article-title":"C1orf106 Is a colitis risk gene that regulates stability of epithelial adherens junctions","volume":"359","author":"Mohanan","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.clim.2024.110356_bb0575","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1172\/JCI86282","article-title":"An inflammatory bowel disease--risk variant in INAVA decreases pattern recognition receptor--induced outcomes","volume":"127","author":"Yan","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2024.110356_bb0580","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0585","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/ng.3245","article-title":"Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers","volume":"47","author":"Onengut-Gumuscu","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0590","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ng.2667","volume":"45","author":"Cortes","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0595","first-page":"83","article-title":"The association of autoimmune diseases and anti-iga antibodies in patients with selective IgA deficiency","volume":"37","author":"Petty","year":"1979","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0600","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.2119\/molmed.2011.00195","article-title":"Selective IgA Deficiency in Autoimmune Diseases","volume":"17","author":"Wang","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.clim.2024.110356_bb0605","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002254","article-title":"On B. of T.F.N. of consortia, pervasive sharing of genetic effects in autoimmune disease","volume":"7","author":"Cotsapas","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0610","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.it.2012.09.001","article-title":"Immune-Mediated Disease Genetics: The Shared Basis of Pathogenesis","volume":"34","author":"Cotsapas","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0615","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1126\/science.adg2992","article-title":"Common genetic factors among autoimmune diseases","volume":"380","author":"Harroud","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.clim.2024.110356_bb0620","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jcla.10071","article-title":"Significance of serum IgA levels and serum IgA\/C3 ratio in diagnostic analysis of patients with IgA nephropathy","volume":"17","author":"Maeda","year":"2003","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.clim.2024.110356_bb0625","first-page":"4501","article-title":"Pathogenesis of IgA nephropathy: current understanding and implications for development of disease-specific treatment","volume":"10","author":"Knoppova","year":"2021","journal-title":"J. Clin. Med. Res."},{"key":"10.1016\/j.clim.2024.110356_bb0630","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1056\/NEJMoa053750","article-title":"Inherited and somatic CD3\u03b6 mutations in a patient with T-cell deficiency","volume":"354","author":"Fr\u00e9d\u00e9ric","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2024.110356_bb0635","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s42003-021-02227-6","article-title":"Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK biobank","volume":"4","author":"Valette","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.clim.2024.110356_bb0640","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.jaci.2021.04.019","article-title":"Eight novel susceptibility loci and putative causal variants in atopic dermatitis","volume":"148","author":"Tanaka","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0645","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41586-020-2436-0","article-title":"FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease","volume":"584","author":"Saevarsdottir","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.clim.2024.110356_bb0650","article-title":"A rare IL2RA haplotype identifies SNP Rs61839660 as causal for autoimmunity","author":"Rainbow","year":"2017","journal-title":"bioRxiv [New Results]"},{"key":"10.1016\/j.clim.2024.110356_bb0655","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1093\/ecco-jcc\/jjab103","article-title":"A crohn\u2019s disease-associated IL2RA enhancer variant determines the balance of T cell immunity by regulating responsiveness to IL-2 signalling","volume":"15","author":"Goldberg","year":"2021","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.clim.2024.110356_bb0660","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/s41588-018-0121-0","article-title":"A genome-wide cross trait analysis from UK biobank highlights the shared genetic architecture of asthma and allergic diseases","volume":"50","author":"Zhu","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0665","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1093\/hmg\/ddz175","article-title":"Genome-wide association analysis of 350 000 caucasians from the UK biobank identifies novel loci for asthma, hay fever and eczema","volume":"28","author":"Johansson","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0670","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jaci.2006.10.007","article-title":"CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked--like syndrome, and defective IL-10 expression from CD4 lymphocytes","volume":"119","author":"Caudy","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0675","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/cei.12214","article-title":"Follicular bronchiolitis as phenotype associated with CD25 deficiency","volume":"175","author":"Bezrodnik","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0680","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S2213-2600(19)30055-4","article-title":"Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies","volume":"7","author":"Pividori","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.clim.2024.110356_bb0685","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10933","article-title":"Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia","volume":"7","author":"Berndt","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2024.110356_bb0690","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1093\/hmg\/ddq044","article-title":"Fine-scale mapping of the 6p25.3 chronic lymphocytic leukaemia susceptibility locus","volume":"19","author":"Crowther-Swanepoel","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0695","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s11515-014-1318-y","article-title":"IRF4 and IRF8: governing the virtues of B lymphocytes","volume":"9","author":"Shukla","year":"2014","journal-title":"Front. Biol."},{"key":"10.1016\/j.clim.2024.110356_bb0700","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/ni1357","article-title":"Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination","volume":"7","author":"Klein","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0705","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.32340","article-title":"IRF4 haploinsufficiency in a family with whipple\u2019s disease","volume":"7","author":"Gu\u00e9rin","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.clim.2024.110356_bb0710","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ajhg.2019.02.022","article-title":"Genetic architectures of childhood- and adult-onset asthma are partly distinct","volume":"104","author":"Ferreira","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0715","series-title":"Transcriptional Control of Lineage Differentiation in Immune Cells","first-page":"189","article-title":"Transcriptional Control of Pre-B Cell Development and Leukemia Prevention","author":"Pang","year":"2014"},{"key":"10.1016\/j.clim.2024.110356_bb0720","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/s41590-021-00951-z","article-title":"A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS","volume":"22","author":"Yamashita","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0725","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211118","article-title":"T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients","volume":"218","author":"Kuehn","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2024.110356_bb0730","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.866582","article-title":"AIOLOS variants causing immunodeficiency in human and mice","volume":"13","author":"Yamashita","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0735","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.998","article-title":"Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease","volume":"43","author":"Trynka","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0740","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cyto.2015.12.025","article-title":"TC-PTP and PTP1B: regulating JAK--STAT signaling, controlling lymphoid malignancies","volume":"82","author":"Pike","year":"2016","journal-title":"Cytokine"},{"key":"10.1016\/j.clim.2024.110356_bb0745","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jaut.2016.09.004","article-title":"PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity","volume":"76","author":"Wiede","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2024.110356_bb0750","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1172\/JCI123267","article-title":"Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity","volume":"129","author":"Svensson","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2024.110356_bb0755","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41586-020-2265-1","article-title":"Whole-genome sequencing of a sporadic primary immunodeficiency cohort","volume":"583","author":"Thaventhiran","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.clim.2024.110356_bb0760","doi-asserted-by":"crossref","first-page":"5502","DOI":"10.4049\/jimmunol.0901982","article-title":"FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling1","volume":"183","author":"Kochi","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0765","doi-asserted-by":"crossref","DOI":"10.1002\/eji.201243068","article-title":"FCRL3 Promotes TLR9-induced B cell activation and suppresses plasma cell differentiation","volume":"43","author":"Li","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0770","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2019.12.099","article-title":"Human Fc receptor-like 3 inhibits regulatory T cell function and binds secretory IgA","volume":"30","author":"Agarwal","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.clim.2024.110356_bb0775","doi-asserted-by":"crossref","DOI":"10.1111\/sji.13025","article-title":"Waiting in the wings: RUNX3 reveals hidden depths of immune regulation with potential implications for inflammatory bowel disease","volume":"93","author":"Dybska","year":"2021","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0780","doi-asserted-by":"crossref","first-page":"16016","DOI":"10.1073\/pnas.0407180101","article-title":"Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia","volume":"101","author":"Brenner","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.clim.2024.110356_bb0785","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4049\/jimmunol.1600397","article-title":"Transcriptional profiling of Th2 cells identifies pathogenic features associated with asthma","volume":"197","author":"Seumois","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0790","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00580","article-title":"Regulation of the development and function of B cells by ZBTB transcription factors","volume":"9","author":"Zhu","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0795","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s13023-018-0941-0","article-title":"In collaboration with the Plasma Protein Therapeutics Association (PPTA) Taskforce, The Burden of Common Variable Immunodeficiency Disorders: A Retrospective Analysis of the European Society for Immunodeficiency (ESID) Registry Data","volume":"13","author":"Odnoletkova","year":"2018","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.clim.2024.110356_bb0800","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/cei.13125","article-title":"The United Kingdom primary immune deficiency (UKPID) registry 2012 to 2017","volume":"192","author":"Shillitoe","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0805","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/(SICI)1521-4141(200004)30:4<1069::AID-IMMU1069>3.0.CO;2-M","article-title":"Impaired Up-regulation of CD86 in B cells of \u201ctype A\u201d common variable immunodeficiency patients","volume":"30","author":"Denz","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0810","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1365-2249.2002.01883.x","article-title":"Impaired Up-regulation of CD70 and CD86 in naive (CD27-) B cells from patients with common variable immunodeficiency (CVID)","volume":"129","author":"Groth","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0815","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.4049\/jimmunol.164.8.4408","article-title":"Fine mapping of IGAD1 in IgA deficiency and common variable immunodeficiency: identification and characterization of haplotypes shared by affected members of 101 multiple-case families12","volume":"164","author":"Vo\u0159echovsk\u00fd","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0820","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00439-005-0101-1","article-title":"Analysis of families with common variable immunodeficiency (CVID) and IgA deficiency suggests linkage of CVID to chromosome 16q","volume":"118","author":"Sch\u00e4ffer","year":"2006","journal-title":"Hum. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0825","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000135694","article-title":"Progression of selective IgA deficiency to common variable immunodeficiency","volume":"147","author":"Aghamohammadi","year":"2008","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0830","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0090-1229(88)90072-4","article-title":"Anti-IgA antibodies in selective IgA deficiency and in primary immunodeficient patients treated with \u03b3-globulin","volume":"47","author":"Ferreira","year":"1988","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.clim.2024.110356_bb0835","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/eji.200737927","article-title":"Antibody deficiency diseases","volume":"38","author":"Pan-Hammarstr\u00f6m","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0840","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1073\/pnas.0307348101","article-title":"Impaired IgA class switching in APRIL-deficient mice","volume":"101","author":"Castigli","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2024.110356_bb0845","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2020.03.025","article-title":"APRIL-dependent lifelong plasmacyte maintenance and immunoglobulin production in humans","volume":"146","author":"Yeh","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0850","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.ade2335","article-title":"IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation","volume":"8","author":"Conrey","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0855","series-title":"Inborn Errors of Immunity","first-page":"93","article-title":"Chapter 4 - predominantly antibody deficiencies","author":"Cheraghi","year":"2021"},{"key":"10.1016\/j.clim.2024.110356_bb0860","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1258\/000456307780117993","article-title":"The clinical significance of immunoglobulin A deficiency","volume":"44","author":"Latiff","year":"2007","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.clim.2024.110356_bb0865","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1002\/art.39110","article-title":"Brief report: IFIH1 mutation causes systemic lupus erythematosus with selective IgA deficiency","volume":"67","author":"Van Eyck","year":"2015","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2024.110356_bb0870","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1016\/j.bbagen.2016.06.014","article-title":"Understanding the genetic and epigenetic basis of common variable immunodeficiency disorder through omics approaches","volume":"1860","author":"Li","year":"2016","journal-title":"Biochimica et Biophysica Acta (BBA) - General Sub."},{"key":"10.1016\/j.clim.2024.110356_bb0875","doi-asserted-by":"crossref","first-page":"6804","DOI":"10.1038\/ncomms7804","article-title":"Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells","volume":"6","author":"Li","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2024.110356_bb0880","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.jaci.2014.12.1939","article-title":"Rare variants at 16p11.2 are associated with common variable immunodeficiency","volume":"135","author":"Maggadottir","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0885","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.jaci.2023.12.023","article-title":"Target genes regulated by CLEC16A intronic region associated with common variable immunodeficiency","volume":"153","author":"Huang","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2024.110356_bb0890","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.736235","article-title":"STXBP6 and B3GNT6 genes are associated with selective IgA deficiency","volume":"12","author":"Lim","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.clim.2024.110356_bb0895","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.29032.2","article-title":"Sustainable Data Analysis with Snakemake","volume":"10","author":"M\u00f6lder","year":"2021","journal-title":"F1000 Res."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624004650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661624004650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T11:33:24Z","timestamp":1729856004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661624004650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":179,"alternative-id":["S1521661624004650"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2024.110356","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.06.24.24309378","asserted-by":"object"}]},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2024.110356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110356"}}