{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:20:30Z","timestamp":1783390830595,"version":"3.54.6"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019018","name":"CAMS Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.clim.2025.110458","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:09:47Z","timestamp":1739902187000},"page":"110458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Plasma extracellular vesicles promote follicular T helper cell expansion in primary Sj\u00f6gren's syndrome"],"prefix":"10.1016","volume":"273","author":[{"given":"Suying","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaowen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taibiao","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2025.110458_bb0005","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMcp1702514","article-title":"Primary Sj\u00f6gren\u2019s syndrome","volume":"378","author":"Mariette","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2025.110458_bb0010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41584-021-00634-x","article-title":"Current and future therapies for primary Sjogren syndrome","volume":"17","author":"Seror","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2025.110458_bb0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/annrheumdis-2019-216114","article-title":"EULAR recommendations for the management of Sjogren\u2019s syndrome with topical and systemic therapies","volume":"79","author":"Ramos-Casals","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2025.110458_bb0020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrrheum.2018.1","article-title":"B cells in the pathogenesis of primary Sjogren syndrome","volume":"14","author":"Nocturne","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2025.110458_bb0025","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1136\/annrheumdis-2019-216588","article-title":"Salivary gland epithelial cells from patients with Sjogren\u2019s syndrome induce B-lymphocyte survival and activation","volume":"79","author":"Rivi\u00e8re","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2025.110458_bb0030","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41584-021-00605-2","article-title":"Epithelial-immune cell interplay in primary Sjogren syndrome salivary gland pathogenesis","volume":"17","author":"Verstappen","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2025.110458_bb0035","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1136\/annrheumdis-2019-216428","article-title":"Elevated EPSTI1 promote B cell hyperactivation through NF-\u03baB signalling in patients with primary Sjogren\u2019s syndrome","volume":"79","author":"Sun","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2025.110458_bb0040","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/cei.12703","article-title":"A comprehensive investigation on the distribution of circulating follicular T helper cells and B cell subsets in primary Sjogren\u2019s syndrome and systemic lupus erythematosus","volume":"183","author":"Szab\u00f3","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2025.110458_bb0045","first-page":"1988","article-title":"CD4+CXCR5+ follicular helper T cells in salivary gland promote B cells maturation in patients with primary Sjogren\u2019s syndrome","volume":"7","author":"Jin","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.clim.2025.110458_bb0050","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbrc.2012.04.133","article-title":"Role of the frequency of blood CD4(+) CXCR5(+) CCR6(+) T cells in autoimmunity in patients with Sjogren\u2019s syndrome","volume":"422","author":"Li","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.clim.2025.110458_bb0055","doi-asserted-by":"crossref","first-page":"1216379","DOI":"10.3389\/fimmu.2023.1216379","article-title":"Unraveling the transcriptome-based network of tfh cells in primary sjogren syndrome: insights from a systems biology approach","volume":"14","author":"Luo","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110458_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102976","article-title":"T follicular helper cells in autoimmune diseases","volume":"134","author":"Wei","year":"2023","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2025.110458_bb0065","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41577-022-00693-5","article-title":"The link between circulating follicular helper T cells and autoimmunity","volume":"22","author":"Walker","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2025.110458_bb0070","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41577-022-00763-8","article-title":"The roles of extracellular vesicles in the immune system","volume":"23","author":"Buzas","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2025.110458_bb0075","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.cell.2023.03.010","article-title":"Review the role of extracellular vesicles in cancer","volume":"186","author":"Kalluri","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.clim.2025.110458_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102540","article-title":"Extracellular vesicles and lupus nephritis - new insights into pathophysiology and clinical implications","volume":"115","author":"Zhao","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2025.110458_bb0085","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/bs.acc.2016.06.005","article-title":"Microvesicles in autoimmune diseases","volume":"77","author":"Liu","year":"2016","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.clim.2025.110458_bb0090","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133497","article-title":"T cell exosome derived miR-142-3p impairs glandular cell function in Sjogren\u2019s syndrome","volume":"5","author":"Cortes-Troncoso","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.clim.2025.110458_bb0095","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ebiom.2016.06.041","article-title":"Targeting the ca(2+) sensor STIM1 by Exosomal transfer of Ebv-miR-BART13-3p is associated with Sjogren\u2019s syndrome","volume":"10","author":"Gallo","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.clim.2025.110458_bb0100","doi-asserted-by":"crossref","first-page":"R156","DOI":"10.1186\/ar2833","article-title":"Increased levels of circulating microparticles in primary Sjogren\u2019s syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity","volume":"11","author":"Sellam","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2025.110458_bb0105","doi-asserted-by":"crossref","first-page":"24858","DOI":"10.3402\/jev.v3.24858","article-title":"The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling","volume":"3","author":"Van Deun","year":"2014","journal-title":"J Extracell Vesicles."},{"key":"10.1016\/j.clim.2025.110458_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461773","article-title":"Modern isolation and separation techniques for extracellular vesicles","volume":"1636","author":"Liangsupree","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.clim.2025.110458_bb0115","doi-asserted-by":"crossref","first-page":"D127","DOI":"10.1093\/nar\/gkz757","article-title":"miRDB: an online database for prediction of functional microRNA targets","volume":"48","author":"Chen","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2025.110458_bb0120","doi-asserted-by":"crossref","first-page":"11673","DOI":"10.1093\/nar\/gks901","article-title":"miRmap: comprehensive prediction of microRNA target repression strength","volume":"40","author":"Vejnar","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2025.110458_bb0125","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA target predictions","volume":"37","author":"Krek","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2025.110458_bb0130","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1261\/rna.5248604","article-title":"Fast and effective prediction of microRNA\/target duplexes","volume":"10","author":"Rehmsmeier","year":"2004","journal-title":"RNA"},{"key":"10.1016\/j.clim.2025.110458_bb0135","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/rheumatology\/keac304","article-title":"TOX promotes follicular helper T cell differentiation in patients with primary Sj\u00f6gren\u2019s syndrome","volume":"62","author":"Liu","year":"2023","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2025.110458_bb0140","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/art.40165","article-title":"Attenuation of follicular helper T cell-dependent B cell hyperactivity by Abatacept treatment in primary Sjogren\u2019s syndrome","volume":"69","author":"Verstappen","year":"2017","journal-title":"Arthritis & Rheumatology."},{"key":"10.1016\/j.clim.2025.110458_bb0145","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13075-023-03109-4","article-title":"Iguratimod suppresses Tfh cell differentiation in primary Sjogren\u2019s syndrome patients through inhibiting Akt\/mTOR\/STAT3 signaling","volume":"25","author":"Lyu","year":"2023","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2025.110458_bb0150","doi-asserted-by":"crossref","first-page":"R179","DOI":"10.1186\/ar3504","article-title":"Impact of interleukin-21 in the pathogenesis of primary Sjogren\u2019s syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands","volume":"13","author":"Kang","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2025.110458_bb0155","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1136\/annrheumdis-2020-217646","article-title":"Unique expansion of IL-21+Tfh and Tph cells under control of ICOS identifies Sjogren\u2019s syndrome with ectopic germinal centres and MALT lymphoma","volume":"79","author":"Pontarini","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2025.110458_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154834","article-title":"Interleukin-21-mediated suppression of the Pax3-Id3 pathway exacerbates the development of Sjogren\u2019s syndrome via follicular helper T cells","volume":"125","author":"Park","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.clim.2025.110458_bb0165","article-title":"EZH2 promotes T follicular helper cell differentiation through enhancing STAT3 phosphorylation in patients with primary Sjogren\u2019s syndrome","volume":"13","author":"He","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110458_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrfmmm.2022.111802","article-title":"MicroRNA-501-3p targeting TM4SF1 facilitates tumor-related behaviors of gastric cancer cells via EMT signaling pathway","volume":"825","author":"Wei","year":"2022","journal-title":"Mutat Res-Fund Mol M."},{"key":"10.1016\/j.clim.2025.110458_bb0175","first-page":"671","article-title":"miR-501-3p promotes colorectal cancer progression via activation of Wnt\/\u03b2-catenin signaling","volume":"55","author":"Wu","year":"2019","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.clim.2025.110458_bb0180","doi-asserted-by":"crossref","first-page":"E1234","DOI":"10.1097\/DCR.0000000000002986","article-title":"M2 macrophage-derived extracellular vesicles containing MicroRNA-501-3p promote Colon Cancer progression through the SETD7\/DNMT1\/SOCS3 Axis","volume":"66","author":"Ding","year":"2023","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.clim.2025.110458_bb0185","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s13046-019-1313-x","article-title":"Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-\u03b2 signaling pathway","volume":"38","author":"Yin","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.clim.2025.110458_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.109935","article-title":"Osteosarcoma-derived exosomal miR-501-3p promotes osteoclastogenesis and aggravates bone loss","volume":"82","author":"Lin","year":"2021","journal-title":"Cell. Signal."},{"key":"10.1016\/j.clim.2025.110458_bb0195","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1042\/BCJ20230250","article-title":"MicroRNA, miR-501 regulate the V(D)J recombination in B cells","volume":"480","author":"Kumari","year":"2023","journal-title":"Biochem. J."},{"key":"10.1016\/j.clim.2025.110458_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103073","article-title":"Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP","volume":"139","author":"Karlsson","year":"2023","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2025.110458_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103260","article-title":"Exosomes as biomarkers and therapeutic delivery for autoimmune diseases: opportunities and challenges","volume":"22","author":"Fang","year":"2023","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2025.110458_bb0210","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1186\/s13287-021-02541-0","article-title":"Labial gland-derived mesenchymal stem cells and their exosomes ameliorate murine Sjogren\u2019s syndrome by modulating the balance of Treg and Th17 cells","volume":"12","author":"Li","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.clim.2025.110458_bb0215","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s10787-023-01189-x","article-title":"Immunomodulatory effects of umbilical mesenchymal stem cell-derived exosomes on CD4 T cells in patients with primary Sjogren's syndrome","volume":"31","author":"Ma","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.clim.2025.110458_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.871096","article-title":"Labial gland mesenchymal stem cell derived exosomes-mediated miRNA-125b attenuates experimental Sjogren\u2019s syndrome by targeting PRDM1 and suppressing plasma cells","volume":"13","author":"Xing","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110458_bb0225","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s12026-023-09390-4","article-title":"Extracellular vesicle-encapsulated miR-10a-5p derived from MDSCs restrains germinal center B cells in experimental Sjogren\u2019s syndrome","volume":"71","author":"Zhou","year":"2023","journal-title":"Immunol. Res."},{"key":"10.1016\/j.clim.2025.110458_bb0230","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41577-023-00893-7","article-title":"The role of transcription factors in shaping regulatory T cell identity","volume":"23","author":"Trujillo-Ochoa","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2025.110458_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.921375","article-title":"3D genome organization as an epigenetic determinant of transcription regulation in T cells","volume":"13","author":"Papadogkonas","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110458_bb0240","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.immuni.2021.12.007","article-title":"TGF-\u03b2-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures","volume":"55","author":"Chaurio","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2025.110458_bb0245","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.immuni.2016.12.015","article-title":"SATB1 expression governs epigenetic repression of PD-1 in tumor-reactive T cells","volume":"46","author":"Stephen","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2025.110458_bb0250","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12935-021-01783-5","article-title":"M2 macrophages-derived exosomal microRNA-501-3p promotes the progression of lung cancer via targeting WD repeat domain 82","volume":"21","author":"Lei","year":"2021","journal-title":"Cancer Cell Int."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625000336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625000336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T15:48:29Z","timestamp":1740757709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661625000336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":50,"alternative-id":["S1521661625000336"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2025.110458","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma extracellular vesicles promote follicular T helper cell expansion in primary Sj\u00f6gren's syndrome","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2025.110458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110458"}}