{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:15:27Z","timestamp":1782753327600,"version":"3.54.5"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"am","delay-in-days":296,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institutes of Health National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI182085"],"award-info":[{"award-number":["1R01AI182085"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institutes of Health National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI134023"],"award-info":[{"award-number":["R01AI134023"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AI027767"],"award-info":[{"award-number":["P30 AI027767"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012051","name":"Lupus Research Alliance","doi-asserted-by":"publisher","award":["P30 AI027767"],"award-info":[{"award-number":["P30 AI027767"]}],"id":[{"id":"10.13039\/100012051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012051","name":"Lupus Research Alliance","doi-asserted-by":"publisher","award":["P30-AR-048311"],"award-info":[{"award-number":["P30-AR-048311"]}],"id":[{"id":"10.13039\/100012051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5I01BX006099"],"award-info":[{"award-number":["5I01BX006099"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.clim.2025.110472","type":"journal-article","created":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T16:22:09Z","timestamp":1741537329000},"page":"110472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["IL-4 alters TLR7-induced B cell developmental program in lupus"],"prefix":"10.1016","volume":"275","author":[{"given":"Changming","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanrun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Winn","family":"Chatham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chen","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Mountz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2025.110472_bb0005","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.immuni.2018.08.015","article-title":"Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus","volume":"49","author":"Jenks","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2025.110472_bb0010","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.41641","article-title":"IFNgamma induces epigenetic programming of human T-bet(hi) B cells and promotes TLR7\/8 and IL-21 induced differentiation","volume":"8","author":"Zumaquero","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.clim.2025.110472_bb0015","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41590-020-0677-6","article-title":"Autoimmunity and organ damage in systemic lupus erythematosus","volume":"21","author":"Tsokos","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.602539","article-title":"Single-cell transcriptomic analyses define distinct peripheral B cell subsets and discrete development pathways","volume":"12","author":"Stewart","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.611004","article-title":"B cell subsets as severity-associated signatures in COVID-19 patients","volume":"11","author":"Sosa-Hernandez","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0030","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202217341","article-title":"Functions of double-negative B cells in autoimmune diseases, infections, and cancers","volume":"15","author":"Chung","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.clim.2025.110472_bb0035","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1182\/blood-2011-01-331462","article-title":"Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c(+) B-cell population is important for the development of autoimmunity","volume":"118","author":"Rubtsov","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.clim.2025.110472_bb0040","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s12026-012-8365-8","article-title":"TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice","volume":"55","author":"Rubtsov","year":"2013","journal-title":"Immunol. Res."},{"key":"10.1016\/j.clim.2025.110472_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109842","article-title":"Increased development of T-bet+CD11c+ B cells predisposes to lupus in females: analysis in BXD2 mouse and genetic crosses","volume":"257","author":"Sullivan","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0050","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.4049\/jimmunol.1700888","article-title":"Cutting edge: endogenous IFN-beta regulates survival and development of transitional B cells","volume":"199","author":"Hamilton","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0055","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.4049\/jimmunol.1800791","article-title":"Cutting edge: intracellular IFN-beta and distinct type I IFN expression patterns in circulating systemic lupus erythematosus B cells","volume":"201","author":"Hamilton","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0060","doi-asserted-by":"crossref","first-page":"442","DOI":"10.4049\/jimmunol.0900870","article-title":"Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity","volume":"184","author":"Wang","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0065","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/art.30231","article-title":"Type I interferon-dependent CD86(high) marginal zone precursor B cells are potent T cell costimulators in mice","volume":"63","author":"Wang","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2025.110472_bb0070","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.4049\/jimmunol.2200409","article-title":"IL-4-induced quiescence of resting naive B cells is disrupted in systemic lupus erythematosus","volume":"209","author":"Gao","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0075","doi-asserted-by":"crossref","first-page":"e234","DOI":"10.1111\/1346-8138.16356","article-title":"Facial discoid lupus erythematosus during dupilumab treatment for atopic dermatitis","volume":"49","author":"Maeno","year":"2022","journal-title":"J. Dermatol."},{"key":"10.1016\/j.clim.2025.110472_bb0080","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/1346-8138.16322","article-title":"Development of systemic lupus erythematosus after dupilumab treatment in a case of atopic dermatitis","volume":"49","author":"Okune","year":"2022","journal-title":"J. Dermatol."},{"key":"10.1016\/j.clim.2025.110472_bb0085","first-page":"201","article-title":"Subacute cutaneous lupus erythematosus induced by dupilumab: a novel possible association with specific pathogenetic mechanisms","volume":"157","author":"Paolino","year":"2022","journal-title":"Ital J. Dermatol. Venerol."},{"key":"10.1016\/j.clim.2025.110472_bb0090","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/intimm\/dxh042","article-title":"Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB","volume":"16","author":"Dedeoglu","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0095","doi-asserted-by":"crossref","first-page":"346","DOI":"10.4049\/jimmunol.2000280","article-title":"IL-23 promotes a coordinated B cell germinal center program for class-switch recombination to IgG2b in BXD2 mice","volume":"205","author":"Hong","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0100","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2025.110472_bb0105","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/acr.23317","article-title":"Developing and refining new candidate criteria for systemic lupus erythematosus classification: an international collaboration","volume":"70","author":"Tedeschi","year":"2018","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.clim.2025.110472_bb0110","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1038\/s41598-017-07328-z","article-title":"IL-4 as a repurposed biological drug for myocardial infarction through augmentation of reparative cardiac macrophages: proof-of-concept data in mice","volume":"7","author":"Shintani","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.clim.2025.110472_bb0115","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.4049\/jimmunol.1300479","article-title":"IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells","volume":"191","author":"Ding","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0120","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ni1552","article-title":"Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice","volume":"9","author":"Hsu","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0125","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1172\/JCI81059","article-title":"Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus","volume":"125","author":"Li","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2025.110472_bb0130","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.clim.2025.110472_bb0135","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.clim.2025.110472_bb0140","series-title":"TriMap: Large-scale Dimensionality Reduction Using Triplets","author":"Amid","year":"2019"},{"key":"10.1016\/j.clim.2025.110472_bb0145","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.2200409","article-title":"IL-4-induced quiescence of resting naive B cells is disrupted in systemic lupus erythematosus","volume":"209","author":"Gao","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0150","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1039\/C5MB00663E","article-title":"ReactomePA: an R\/Bioconductor package for reactome pathway analysis and visualization","volume":"12","author":"Yu","year":"2016","journal-title":"Mol. BioSyst."},{"key":"10.1016\/j.clim.2025.110472_bb0155","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.clim.2025.110472_bb0160","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.clim.2025.110472_bb0165","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/j.immuni.2021.08.028","article-title":"Follicular dendritic cells restrict interleukin-4 availability in germinal centers and foster memory B cell generation","volume":"54","author":"Duan","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2025.110472_bb0170","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/s41590-020-0713-6","article-title":"The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development","volume":"21","author":"Laidlaw","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0175","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/imr.12741","article-title":"Extrafollicular responses in humans and SLE","volume":"288","author":"Jenks","year":"2019","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.clim.2025.110472_bb0180","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.immuni.2010.06.011","article-title":"Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming","volume":"32","author":"Elo","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2025.110472_bb0185","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.4049\/jimmunol.1002544","article-title":"Cyclin-dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1","volume":"186","author":"Xu","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0190","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4049\/jimmunol.1002362","article-title":"Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans","volume":"188","author":"Cuda","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.908034","article-title":"Alternative B cell differentiation during infection and inflammation","volume":"13","author":"Courey-Ghaouzi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0200","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.4049\/jimmunol.1501027","article-title":"Fc receptor-like 5 expression distinguishes two distinct subsets of human circulating tissue-like memory B cells","volume":"196","author":"Li","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0205","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.4049\/jimmunol.1600522","article-title":"Cutting edge: IL-4, IL-21, and IFN-gamma interact to govern T-bet and CD11c expression in TLR-activated B cells","volume":"197","author":"Naradikian","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.109130","article-title":"IL-4 receptor blockade is a global repressor of naive B cell development and responses in a dupilumab-treated patient","volume":"244","author":"Mountz","year":"2022","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0215","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s41590-019-0419-9","article-title":"Epigenetic programming underpins B cell dysfunction in human SLE","volume":"20","author":"Scharer","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051343","article-title":"MHC class II-restricted presentation of the major house dust mite allergen Der p 1 is GILT-dependent: implications for allergic asthma","volume":"8","author":"West","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2025.110472_bb0225","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1101\/gad.14.9.1156","article-title":"CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex","volume":"14","author":"Masternak","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.clim.2025.110472_bb0230","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fimmu.2012.00037","article-title":"Antigen processing and remodeling of the endosomal pathway: requirements for antigen cross-presentation","volume":"3","author":"Compeer","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0235","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.4049\/jimmunol.1502163","article-title":"CD83 modulates B cell activation and germinal center responses","volume":"196","author":"Krzyzak","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0240","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1126\/science.286.5446.1949","article-title":"Requirement for B cell linker protein (BLNK) in B cell development","volume":"286","author":"Pappu","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.clim.2025.110472_bb0245","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.immuni.2011.01.014","article-title":"Nuclear export of the NF-kappaB inhibitor IkappaBalpha is required for proper B cell and secondary lymphoid tissue formation","volume":"34","author":"Wuerzberger-Davis","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2025.110472_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020523","article-title":"MYC\u2019s fine line between B cell development and malignancy","volume":"9","author":"de Barrios","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.clim.2025.110472_bb0255","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2019.07.007","article-title":"Differential activation of the transcription factor IRF1 underlies the distinct immune responses elicited by type I and type III interferons","volume":"51","author":"Forero","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2025.110472_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/cells10081864","article-title":"A multitasking antiviral factor","volume":"10","author":"Pagani","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.clim.2025.110472_bb0265","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ni.3440","article-title":"Interferon-induced guanylate-binding proteins in inflammasome activation and host defense","volume":"17","author":"Kim","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0270","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tube.2014.10.005","article-title":"Human B cells produce chemokine CXCL10 in the presence of Mycobacterium tuberculosis specific T cells","volume":"95","author":"Hoff","year":"2015","journal-title":"Tuberculosis (Edinb.)"},{"key":"10.1016\/j.clim.2025.110472_bb0275","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.4161\/onci.22354","article-title":"Why do human B cells secrete granzyme B? Insights into a novel B-cell differentiation pathway","volume":"1","author":"Hagn","year":"2012","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.clim.2025.110472_bb0280","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.4049\/jimmunol.173.7.4692","article-title":"The role of the Th2 CC chemokine ligand CCL17 in pulmonary fibrosis","volume":"173","author":"Belperio","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0285","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.4049\/jimmunol.1601609","article-title":"IL-4-induced gene 1: a negative immune checkpoint controlling B cell differentiation and activation","volume":"200","author":"Bod","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110472_bb0290","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1084\/jem.181.2.713","article-title":"T cell genetic background determines default T helper phenotype development in vitro","volume":"181","author":"Hsieh","year":"1995","journal-title":"J. Exp. Med."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625000476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625000476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T13:19:53Z","timestamp":1746105593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661625000476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":58,"alternative-id":["S1521661625000476"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2025.110472","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-4 alters TLR7-induced B cell developmental program in lupus","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2025.110472","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110472"}}