{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:49:29Z","timestamp":1793245769570,"version":"4.5.0"},"reference-count":136,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.clim.2025.110549","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T19:28:03Z","timestamp":1750793283000},"page":"110549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Etiopathogenesis of Beh\u00e7et's disease: A systematic literature review"],"prefix":"10.1016","volume":"279","author":[{"given":"Nabil","family":"Belfeki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouha","family":"Ghriss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Le Joncour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Saadoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2025.110549_bb0005","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMra2305712","article-title":"Beh\u00e7et\u2019s Syndrome","volume":"390","author":"Saadoun","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2025.110549_bb0010","first-page":"2008","article-title":"The impact of environmental factors on aetiopathogenesis and clinical manifestations of Beh\u00e7et\u2019s syndrome","volume":"42","author":"Di Cianni","year":"2024","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0015","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.3389\/fimmu.2019.01067","article-title":"Beh\u00e7et\u2019s disease: an overview of Etiopathogenesis","volume":"10","author":"Leccese","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0020","first-page":"462","article-title":"Epigenetics and Beh\u00e7et\u2019s disease: DNA methylation specially highlighted","volume":"18","author":"Farhadi","year":"2019","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0025","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s10067-009-1261-5","article-title":"Neutrophil hyperchemotaxis in Beh\u00e7et\u2019s disease: a possible role for monocytes orchestrating bacterial-induced innate immune responses","volume":"28","author":"Neves","year":"2009","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2022.151956","article-title":"Immunopathogenesis of Beh\u00e7et\u2019s disease and treatment modalities","volume":"52","author":"van der Houwen","year":"2022","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.clim.2025.110549_bb0035","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"8","author":"Moher","year":"2010","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.clim.2025.110549_bb0040","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1093\/hmg\/dds384","article-title":"Interrogating the major histocompatibility complex with high-throughput genomics","volume":"21","author":"de Bakker","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.clim.2025.110549_bb0045","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0140-6736(73)93343-6","article-title":"Hl-A5 and Behcet\u2019s disease","volume":"302","author":"Ohno","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2025.110549_bb0050","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/archopht.1982.01030040433013","article-title":"Close association of HLA-Bw51 with Beh\u00e7et\u2019s disease","volume":"100","author":"Ohno","year":"1982","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.clim.2025.110549_bb0055","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.reuma.2022.12.005","article-title":"Beh\u00e7et disease in Latin American countries: a systematic literature review of demographic and clinical features, and HLA-B*51 allele frequency","volume":"19","author":"Mu\u00f1oz","year":"2023","journal-title":"Reumatol. Clin. (Engl. Ed.)"},{"key":"10.1016\/j.clim.2025.110549_bb0060","first-page":"1921","article-title":"Association of MICA gene and HLA-B*5101 with Beh\u00e7et\u2019s disease in Greece","volume":"40","author":"Yabuki","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.clim.2025.110549_bb0065","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s002510050656","article-title":"MIC-A allele profiles and HLA class I associations in Beh\u00e7et\u2019s disease","volume":"49","author":"Wallace","year":"1999","journal-title":"Immunogenetics"},{"key":"10.1016\/j.clim.2025.110549_bb0070","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.arcmed.2010.02.002","article-title":"TNF polymorphisms in patients with Beh\u00e7et disease: a meta-analysis","volume":"41","author":"Touma","year":"2010","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.clim.2025.110549_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102100","article-title":"Epistatic interaction of ERAP1 and HLA-B in Beh\u00e7et disease: a replication study in the Spanish population","volume":"9","author":"Conde-Jald\u00f3n","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.clim.2025.110549_bb0080","doi-asserted-by":"crossref","first-page":"9680","DOI":"10.1074\/jbc.M117.789180","article-title":"The Beh\u00e7et\u2019s disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing","volume":"292","author":"Guasp","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2025.110549_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109305","article-title":"Characterization of immune responses associated with ERAP-1 expression in HSV-induced Beh\u00e7et\u2019s disease mouse model","volume":"250","author":"Ryu","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0090","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9348697","article-title":"Global Meta-analysis on the association between Behcet syndrome and polymorphisms from the HLA class I (a, B, and C) and class II (DRB1, DQB1, and DPB1) genes","volume":"2021","author":"Capittini","year":"2021","journal-title":"Dis. Markers"},{"key":"10.1016\/j.clim.2025.110549_bb0095","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1365-2133.2004.06003.x","article-title":"Increased advanced oxidation protein products in Beh\u00e7et\u2019s disease: a new activity marker?","volume":"151","author":"Yazici","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.clim.2025.110549_bb0100","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ng.2520","article-title":"Genome-wide association analysis identifies new susceptibility loci for Beh\u00e7et\u2019s disease and epistasis between HLA-B*51 and ERAP1","volume":"45","author":"Kirino","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2025.110549_bb0105","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.dld.2023.10.021","article-title":"Genome-wide association analysis reveals the associations of NPHP4, TYW1-AUTS2 and SEMA6D for Beh\u00e7et\u2019s disease and HLA-B*46:01 for its intestinal involvement","volume":"56","author":"Jung","year":"2024","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.clim.2025.110549_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1206959","article-title":"Advances in pathogenesis and treatment of ocular involvement in Behcet\u2019s disease","volume":"14","author":"Lin","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.109189","article-title":"Deregulated DNA damage response network in Behcet\u2019s disease","volume":"246","author":"Vlachogiannis","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.reuma.2018.06.006","article-title":"Methylation status of interleukin-6 gene promoter in patients with Beh\u00e7et\u2019s disease","volume":"16","author":"Alipour","year":"2020","journal-title":"Reumatol. Clin. (Engl. Ed.)"},{"key":"10.1016\/j.clim.2025.110549_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3234","article-title":"Evaluation of DNA methylation status of toll-like receptors 2 and 4 promoters in Behcet\u2019s disease","volume":"22","author":"Kolahi","year":"2020","journal-title":"J. Gene Med."},{"key":"10.1016\/j.clim.2025.110549_bb0130","first-page":"2014","article-title":"HLA-B gene methylation and expression in Beh\u00e7et\u2019s syndrome: a potential role of epigenetics in the pathogenesis","volume":"42","author":"\u00d6zk\u0131l\u0131n\u00e7 \u00d6nen","year":"2024","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0135","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jaut.2013.01.011","article-title":"SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2\/Stat5 signaling","volume":"42","author":"Gardner","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2025.110549_bb0140","article-title":"Genetics in Behcet\u2019s disease: an update review","volume":"2","author":"Gao","year":"2022","journal-title":"Front. Ophthalmol. (Lausanne)"},{"key":"10.1016\/j.clim.2025.110549_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1249826","article-title":"The role of miRNAs in Beh\u00e7et\u2019s disease","volume":"14","author":"Gu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0150","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1089\/jir.2018.0116","article-title":"Role of serum miR-181b, Proinflammatory cytokine, and adhesion molecules in Beh\u00e7et\u2019s disease","volume":"39","author":"El Boghdady","year":"2019","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.clim.2025.110549_bb0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/BOR.0000000000001067","article-title":"Omics studies in Beh\u00e7et\u2019s disease","volume":"37","author":"Ozguler","year":"2025","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0160","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.3390\/ijms16047413","article-title":"The relevance of miRNA-21 in HSV-induced inflammation in a mouse model","volume":"16","author":"Choi","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.clim.2025.110549_bb0165","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s10067-024-07291-x","article-title":"New insights into the interplay between MALAT1 and miRNA-155 to unravel potential diagnostic and prognostic biomarkers of Beh\u00e7et\u2019s disease","volume":"44","author":"Sayed","year":"2025","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-023-05420-x","article-title":"Single-cell chromatin accessibility and transcriptomic characterization of Behcet\u2019s disease","volume":"6","author":"Shi","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.clim.2025.110549_bb0175","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.autrev.2017.12.006","article-title":"Beh\u00e7et\u2019s disease: new insights into pathophysiology, clinical features and treatment options","volume":"17","author":"Greco","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2025.110549_bb0180","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3349\/ymj.1997.38.6.411","article-title":"Epidemiological features of Adamantiades-Beh\u00e7et\u2019s disease in Germany and in Europe","volume":"38","author":"Zouboulis","year":"1997","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.clim.2025.110549_bb0185","first-page":"2008","article-title":"The impact of environmental factors on aetiopathogenesis and clinical manifestations of Beh\u00e7et\u2019s syndrome","volume":"42","author":"Di Cianni","year":"2024","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0190","first-page":"1029","article-title":"Induction of Beh\u00e7et\u2019s disease symptoms after dental treatment and streptococcal antigen skin test","volume":"15","author":"Mizushima","year":"1988","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0195","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.revmed.2013.10.012","article-title":"Pathophysiology of Beh\u00e7et\u2019s disease","volume":"35","author":"Houman","year":"2014","journal-title":"Rev. Med. Interne"},{"key":"10.1016\/j.clim.2025.110549_bb0200","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/rheumatology\/27.4.300","article-title":"Treatment with acyclovir does not affect orogenital ulcers in behc\u00e7et\u2019s syndrome: A randomized double-blind trial","volume":"27","author":"Davies","year":"1988","journal-title":"Rheumatology"},{"key":"10.1016\/j.clim.2025.110549_bb0205","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.survophthal.2005.04.009","article-title":"Current concepts in the etiology and treatment of Beh\u00e7et disease","volume":"50","author":"Evereklioglu","year":"2005","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.clim.2025.110549_bb0210","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.berh.2011.05.002","article-title":"Beh\u00e7et\u2019s syndrome and micro-organisms","volume":"25","author":"Hatemi","year":"2011","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0215","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3349\/ymj.1997.38.6.444","article-title":"Streptococcal infection in the pathogenesis of Beh\u00e7et\u2019s disease and clinical effects of minocycline on the disease symptoms","volume":"38","author":"Kaneko","year":"1997","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.clim.2025.110549_bb0220","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1001\/jamaophthalmol.2020.6985","article-title":"Tuberculosis exposure with risk of Beh\u00e7et disease among patients with uveitis","volume":"139","author":"Zhong","year":"2021","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.clim.2025.110549_bb0225","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3390\/biomedicines12081760","article-title":"The potential role of butyrate in the pathogenesis and treatment of autoimmune rheumatic diseases","volume":"12","author":"Coccia","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.clim.2025.110549_bb0230","first-page":"2093","article-title":"Microbiome and Beh\u00e7et\u2019s disease: a systematic review","volume":"41","author":"Joubert","year":"2023","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0235","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.3389\/fimmu.2020.01192","article-title":"Beh\u00e7et\u2019s disease under microbiotic surveillance? A combined analysis of two cohorts of Beh\u00e7et\u2019s disease patients","volume":"11","author":"van der Houwen","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109304","article-title":"Microbiome in Behcet\u2019s syndrome","volume":"250","author":"Bettiol","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0245","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13023-024-03484-4","article-title":"Specific plasma metabolite profile in intestinal Beh\u00e7et\u2019s syndrome","volume":"20","author":"Hou","year":"2025","journal-title":"Orphanet J. Rare Dis."},{"issue":"Suppl. 127","key":"10.1016\/j.clim.2025.110549_bb0250","first-page":"60","article-title":"Intestinal microbiota composition of patients with Beh\u00e7et\u2019s disease: differences between eye, mucocutaneous and vascular involvement. The Rheuma-BIOTA study","volume":"38","author":"Yasar Bilge","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0255","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4274\/balkanmedj.galenos.2023.2023-6-76","article-title":"Heat shock proteins in Beh\u00e7et syndrome","volume":"40","author":"Kire\u00e7tepe Ayd\u0131n","year":"2023","journal-title":"Balkan Med. J."},{"key":"10.1016\/j.clim.2025.110549_bb0260","article-title":"Innate and adaptive responses to heat shock proteins in Behcet\u2019s disease","volume":"2013","author":"Direskeneli","year":"2013","journal-title":"Genet. Res. Int."},{"key":"10.1016\/j.clim.2025.110549_bb0265","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/08830189709116842","article-title":"The role of heat shock protein, microbial and autoimmune agents in the Aetiology of Behget\u2019s disease","volume":"14","author":"Lehner","year":"1997","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0270","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4049\/jimmunol.164.1.13","article-title":"Cutting edge: heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells","volume":"164","author":"Kol","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0275","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1167\/iovs.09-4313","article-title":"Immune responses to Interphotoreceptor retinoid-binding protein and S-antigen in Beh\u00e7et\u2019s patients with uveitis","volume":"51","author":"Takeuchi","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.clim.2025.110549_bb0280","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/1521-4141(200002)30:2<594::AID-IMMU594>3.0.CO;2-1","article-title":"Heat shock proteins generate beta-chemokines which function as innate adjuvants enhancing adaptive immunity","volume":"30","author":"Lehner","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0285","first-page":"S19","article-title":"Neutrophil activation in Beh\u00e7et\u2019s disease","volume":"19","author":"Eksioglu-Demiralp","year":"2001","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0290","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fimmu.2019.01085","article-title":"Beh\u00e7et\u2019s syndrome as a model of Thrombo-inflammation: the role of neutrophils","volume":"10","author":"Emmi","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0295","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s13075-017-1443-5","article-title":"Soluble CD40L is associated with increased oxidative burst and neutrophil extracellular trap release in Beh\u00e7et\u2019s disease","volume":"19","author":"Perazzio","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2025.110549_bb0300","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s10067-009-1261-5","article-title":"Neutrophil hyperchemotaxis in Beh\u00e7et\u2019s disease: a possible role for monocytes orchestrating bacterial-induced innate immune responses","volume":"28","author":"Neves","year":"2009","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0305","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1093\/rheumatology\/keab052","article-title":"Distinct transcriptional profile of blood mononuclear cells in Beh\u00e7et\u2019s disease: insights into the central role of neutrophil chemotaxis","volume":"60","author":"Verrou","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2025.110549_bb0310","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jdermsci.2018.08.010","article-title":"Neutrophils contribute to vasculitis by increased release of neutrophil extracellular traps in Beh\u00e7et\u2019s disease","volume":"92","author":"Safi","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.clim.2025.110549_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109318","article-title":"Neutrophil, NETs and Beh\u00e7et\u2019s disease: a review","volume":"250","author":"Le Joncour","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0320","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/art.42486","article-title":"Reduction of neutrophil activation by phosphodiesterase 4 blockade in Beh\u00e7et\u2019s disease","volume":"75","author":"Le Joncour","year":"2023","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.109161","article-title":"Transcriptional analysis of neutrophils from patients with Beh\u00e7et\u2019s disease reveals activation and chemotaxis of neutrophils","volume":"245","author":"Yu","year":"2022","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0330","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2133.1982.tb04556.x","article-title":"Quantitative electron microscopy microscopical analysis of leukocyte infiltration in oral ulcers of Beh\u00e7et\u2019s syndrome","volume":"106","author":"M\u00fcller","year":"1982","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.clim.2025.110549_bb0335","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/j.1365-2133.1995.tb16946.x","article-title":"Immunohistology of skin pathergy reaction in Beh\u00e7et\u2019s disease","volume":"132","author":"G\u00fcl","year":"1995","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.clim.2025.110549_bb0340","doi-asserted-by":"crossref","first-page":"R16","DOI":"10.1186\/ar2367","article-title":"Association of reduced heme oxygenase-1 with excessive toll-like receptor 4 expression in peripheral blood mononuclear cells in Beh\u00e7et\u2019s disease","volume":"10","author":"Kirino","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2025.110549_bb0345","first-page":"553","article-title":"Expression of precerebellins in cultured rat calvaria osteoblast-like cells","volume":"22","author":"Rucinski","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.clim.2025.110549_bb0350","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ng.624","article-title":"Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Beh\u00e7et\u2019s disease susceptibility loci","volume":"42","author":"Mizuki","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2025.110549_bb0355","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ng.625","article-title":"Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Beh\u00e7et\u2019s disease","volume":"42","author":"Remmers","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2025.110549_bb0360","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1093\/rheumatology\/keaa251","article-title":"Leukocyte toll-like receptorexpression in pathergy positive and negative Beh\u00e7et\u2019s disease patients","volume":"59","author":"van der Houwen","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2025.110549_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2021.108683","article-title":"Aberrant monocyte subsets in patients with Beh\u00e7et\u2019s disease","volume":"225","author":"Li","year":"2021","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0370","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2020.35.e213","article-title":"Neutrophil-mediated thrombosis and NETosis in Beh\u00e7et\u2019s disease: a hypothesis","volume":"35","author":"Batu","year":"2020","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.clim.2025.110549_bb0375","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/1568010053622894","article-title":"Beh\u00e7et\u2019s disease as an autoinflammatory disorder","volume":"4","author":"Gul","year":"2005","journal-title":"Current Drug Targets - Inflammation & Allergy"},{"key":"10.1016\/j.clim.2025.110549_bb0380","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s12026-022-09298-5","article-title":"Effect of different cytokines in combination with IL-15 on the expression of activating receptors in NK cells of patients with Beh\u00e7et\u2019s disease","volume":"70","author":"Sallakci","year":"2022","journal-title":"Immunol. Res."},{"key":"10.1016\/j.clim.2025.110549_bb0385","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.coi.2015.03.007","article-title":"Regulation of human helper T cell subset differentiation by cytokines","volume":"34","author":"Schmitt","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0390","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nature07036","article-title":"Induction and effector functions of TH17 cells","volume":"453","author":"Bettelli","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.clim.2025.110549_bb0395","first-page":"393","article-title":"The changes of Th lymphocyte subsets in patients with Behcet disease","volume":"47","author":"Liang","year":"2011","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"10.1016\/j.clim.2025.110549_bb0400","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1080\/03009740600905380","article-title":"Expression of cytokines, chemokines, and chemokine receptors in oral ulcers of patients with Behcet\u2019s disease (BD) and recurrent aphthous stomatitis is Th1-associated, although Th2-association is also observed in patients with BD","volume":"35","author":"Dalghous","year":"2006","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0405","first-page":"S27","article-title":"A Th1 but not a Th17 response is present in the gastrointestinal involvement of Beh\u00e7et\u2019s disease","volume":"28","author":"Ferrante","year":"2010","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0410","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1038\/s41598-017-03251-5","article-title":"Enhancement of Th1\/Th17 inflammation by TRIM21 in Beh\u00e7et\u2019s disease","volume":"7","author":"Ahn","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.clim.2025.110549_bb0415","article-title":"Genetic variations of IL-12B, IL-12R\u03b21, IL-12R\u03b22 in Behcet\u2019s disease and VKH syndrome","volume":"9","author":"Li","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.clim.2025.110549_bb0420","first-page":"S34","article-title":"Dendritic cell subsets and type I interferon system in Beh\u00e7et\u2019s disease: does functional abnormality in plasmacytoid dendritic cells contribute to Th1 polarization?","volume":"25","author":"Pay","year":"2007","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0425","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.autrev.2014.08.019","article-title":"Th17 cells in inflammation and autoimmunity","volume":"13","author":"Singh","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2025.110549_bb0430","unstructured":"Wu Y, Ning K, Huang Z, Chen B, Chen J, Wen Y, et al. NETs-CD44-IL-17A feedback loop drives Th17-mediated inflammation in Beh\u00e7et\u2019s uveitis, Adv. Sci. (Weinh)."},{"key":"10.1016\/j.clim.2025.110549_bb0435","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/cei.13049","article-title":"Is Beh\u00e7et\u2019s disease a \u201cclass 1-opathy\u201d? The role of HLA-B*51 in the pathogenesis of Beh\u00e7et\u2019s disease","volume":"191","author":"Giza","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0440","doi-asserted-by":"crossref","first-page":"CR227","DOI":"10.12659\/MSM.881720","article-title":"Expression of Th-17 and ROR\u03b3t mRNA in Beh\u00e7et\u2019s disease","volume":"17","author":"Hamzaoui","year":"2011","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.clim.2025.110549_bb0445","first-page":"2071","article-title":"Associations between circulating interleukin-17 levels and Behcet\u2019s disease and between IL-17 gene polymorphisms and disease susceptibility: a meta-analysis","volume":"41","author":"Lee","year":"2023","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0450","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3109\/09273948.2016.1158276","article-title":"Analysis of Th cell-related cytokine production in Beh\u00e7et disease patients with uveitis before and after infliximab treatment","volume":"25","author":"Takeuchi","year":"2017","journal-title":"Ocul. Immunol. Inflamm."},{"key":"10.1016\/j.clim.2025.110549_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2023.101216","article-title":"Risk factors, clinical features and treatment of Beh\u00e7et\u2019s disease uveitis","volume":"97","author":"Zhong","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.clim.2025.110549_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100866","article-title":"Activation of the interleukin-23\/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis","volume":"80","author":"Zhong","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.clim.2025.110549_bb0465","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.immuni.2011.02.011","article-title":"Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2","volume":"34","author":"Chen","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2025.110549_bb0470","doi-asserted-by":"crossref","first-page":"746","DOI":"10.55563\/clinexprheumatol\/lnn76t","article-title":"Low-dose IL-2 effectively restored decreased regulatory T cells in patients with Beh\u00e7et\u2019s disease","volume":"39","author":"Liu","year":"2021","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0475","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jaci.2011.05.029","article-title":"Critical role of IL-21 in modulating TH17 and regulatory T cells in Beh\u00e7et disease","volume":"128","author":"Geri","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0480","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000005516","article-title":"Cytotoxic Th1 and Th17 cells infiltrate the intestinal mucosa of Behcet patients and exhibit high levels of TNF-\u03b1 in early phases of the disease","volume":"95","author":"Emmi","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.clim.2025.110549_bb0485","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.4049\/jimmunol.175.9.6133","article-title":"CD8brightCD56+ T cells are cytotoxic effectors in patients with active Behcet\u2019s uveitis","volume":"175","author":"Ahn","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0490","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/705831","article-title":"Gamma Delta (\u03b3\u03b4) T cells and their involvement in Beh\u00e7et\u2019s disease","volume":"2015","author":"Hasan","year":"2015","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.clim.2025.110549_bb0495","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/1547691X.2017.1346008","article-title":"Genetics and immunodysfunction underlying Beh\u00e7et\u2019s disease and immunomodulant treatment approaches","volume":"14","author":"Salmaninejad","year":"2017","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.clim.2025.110549_bb0500","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3389\/fimmu.2019.00665","article-title":"Immunopathogenesis of Behcet\u2019s disease","volume":"10","author":"Tong","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0505","first-page":"826","article-title":"Phenotypic characteristics of B cells in Beh\u00e7et\u2019s disease: increased activity in B cell subsets","volume":"26","author":"Ek\u015fioglu-Demiralp","year":"1999","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0510","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1756-185X.2010.01546.x","article-title":"Rituximab in intractable ocular lesions of Behcet\u2019s disease; randomized single-blind control study (pilot study)","volume":"13","author":"Davatchi","year":"2010","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.clim.2025.110549_bb0515","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/380405","article-title":"Expression of TNF-\u03b1, April and BCMA in Behcet\u2019s disease","volume":"2014","author":"Shaker","year":"2014","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.clim.2025.110549_bb0520","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/rheumatology\/kew366","article-title":"Chronic signs of memory B cell activation in patients with Beh\u00e7et\u2019s disease are partially restored by anti-tumour necrosis factor treatment","volume":"56","author":"van der Houwen","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2025.110549_bb0525","doi-asserted-by":"crossref","first-page":"19651","DOI":"10.1038\/srep19651","article-title":"Two genetic variations in the IRF8 region are associated with Beh\u00e7et\u2019s disease in Han Chinese","volume":"6","author":"Jiang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.clim.2025.110549_bb0530","doi-asserted-by":"crossref","first-page":"51277","DOI":"10.18632\/oncotarget.17235","article-title":"Ocular Behcet\u2019s disease is associated with aberrant methylation of interferon regulatory factor 8 (IRF8) in monocyte-derived dendritic cells","volume":"8","author":"Qiu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.clim.2025.110549_bb0535","first-page":"S37","article-title":"Pronounced interferon-alpha production from plasmacytoid dendritic cells in patients with Beh\u00e7et\u2019s disease following CpG D ODN stimulation","volume":"27","author":"Pay","year":"2009","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109303","article-title":"Interferon-\u03b12a induces CD4+ T cell apoptosis and suppresses Th1\/Th17 responses via upregulating IRF1-mediated PDL1 expression in dendritic cells from Behcet\u2019s uveitis","volume":"250","author":"Zhu","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0545","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1590\/abd1806-4841.20198169","article-title":"High levels of endothelial progenitor cells and circulating endothelial cells in patients with Beh\u00e7et\u2019s disease and their relationship to disease activity","volume":"94","author":"Arica","year":"2019","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.clim.2025.110549_bb0550","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.3389\/fimmu.2019.02877","article-title":"Stem-cell-derived circulating progenitors dysfunction in Beh\u00e7et\u2019s syndrome patients correlates with oxidative stress","volume":"10","author":"Emmi","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0555","doi-asserted-by":"crossref","first-page":"5345","DOI":"10.1007\/s10238-023-01173-3","article-title":"Assessment of \u03b19\u03b21 \u0131ntegr\u0131n as a new d\u0131agnost\u0131c and therapeut\u0131c target \u0131n Behcet\u2019s d\u0131sease","volume":"23","author":"Ellergezen","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.clim.2025.110549_bb0560","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/cei.13243","article-title":"Beh\u00e7et\u2019s syndrome as a tool to dissect the mechanisms of thrombo-inflammation: clinical and pathogenetic aspects","volume":"195","author":"Becatti","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0565","first-page":"234","article-title":"Evaluation of mean platelet volume in patients with Behcet\u2019s disease as an Indicator of vascular thrombosis","volume":"21","author":"Ata\u015f","year":"2018","journal-title":"Arch. Iran. Med."},{"key":"10.1016\/j.clim.2025.110549_bb0570","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1620\/tjem.221.119","article-title":"Increased mean platelet volume in Beh\u00e7et\u2019s disease with thrombotic tendency","volume":"221","author":"Acikgoz","year":"2010","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.clim.2025.110549_bb0575","first-page":"1","article-title":"The role of platelets in immune-mediated inflammatory diseases","author":"Scherlinger","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0580","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250181","article-title":"Comprehensive analysis of T-cell receptor repertoires reveals antigen-driven T-cell clusters in patients with Beh\u00e7et\u2019s syndrome","volume":"53","author":"Zou","year":"2023","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0585","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature22976","article-title":"Identifying specificity groups in the T cell receptor repertoire","volume":"547","author":"Glanville","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.clim.2025.110549_bb0590","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250181","article-title":"Comprehensive analysis of T-cell receptor repertoires reveals antigen-driven T-cell clusters in patients with Beh\u00e7et\u2019s syndrome","volume":"53","author":"Zou","year":"2023","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0595","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41586-019-1595-3","article-title":"Analysis of the B cell receptor repertoire in six immune-mediated diseases","volume":"574","author":"Bashford-Rogers","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.clim.2025.110549_bb0600","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/03009742.2017.1340510","article-title":"Association of killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands with susceptibility to Beh\u00e7et\u2019s disease","volume":"47","author":"Mohammad-Ebrahim","year":"2018","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0605","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.3389\/fimmu.2019.02755","article-title":"Association of Functional Polymorphisms of KIR3DL1\/DS1 with Beh\u00e7et\u2019s disease","volume":"10","author":"Casta\u00f1o-N\u00fa\u00f1ez","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0610","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMra2305712","article-title":"Beh\u00e7et\u2019s syndrome","volume":"390","author":"Saadoun","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2025.110549_bb0615","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1093\/rheumatology\/kead628","article-title":"Genetic testing of Beh\u00e7et\u2019s disease using next-generation sequencing to identify monogenic mimics and HLA-B*51","volume":"63","author":"Burleigh","year":"2024","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2025.110549_bb0620","first-page":"1999","article-title":"Beh\u00e7et\u2019s syndrome: one year in review 2024","volume":"42","author":"Hatemi","year":"2024","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0625","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/BOR.0000000000001067","article-title":"Omics studies in Beh\u00e7et\u2019s disease","volume":"37","author":"Ozguler","year":"2025","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0630","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.109895","article-title":"Proteomic profiling of aqueous humor-derived exosomes in Vogt-Koyanagi-Harada disease and Behcet\u2019s uveitis","volume":"259","author":"Zhang","year":"2024","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0635","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1074\/mcp.RA119.001617","article-title":"Identification of an unconventional Subpeptidome bound to the Beh\u00e7et\u2019s disease-associated HLA-B*51:01 that is regulated by endoplasmic reticulum aminopeptidase 1 (ERAP1)","volume":"19","author":"Chen","year":"2020","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.clim.2025.110549_bb0640","doi-asserted-by":"crossref","first-page":"11597","DOI":"10.1021\/acs.jmedchem.4c00840","article-title":"ERAP inhibitors in autoimmunity and Immuno-oncology: medicinal chemistry insights","volume":"67","author":"Fougiaxis","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.clim.2025.110549_bb0645","doi-asserted-by":"crossref","first-page":"130","DOI":"10.5152\/eurjrheum.2023.23062","article-title":"Comparative Metabolomic profiles of vascular involvement in Beh\u00e7et\u2019s disease","volume":"10","author":"Y\u00fccel","year":"2023","journal-title":"Eur. J. Rheumatol."},{"key":"10.1016\/j.clim.2025.110549_bb0650","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1002\/art.34437","article-title":"Association study of IL10 and IL23R\u2013IL12RB2 in Iranian patients with Beh\u00e7et\u2019s disease","volume":"64","author":"Xavier","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2025.110549_bb0655","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/ni.1803","article-title":"Mixed results with modulation of TH-17 cells in human autoimmune diseases","volume":"11","author":"Steinman","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2025.110549_bb0660","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s00439-012-1200-4","article-title":"Two-stage association study in Chinese Han identifies two independent associations in CCR1\/CCR3 locus as candidate for Beh\u00e7et\u2019s disease susceptibility","volume":"131","author":"Hou","year":"2012","journal-title":"Hum. Genet."},{"key":"10.1016\/j.clim.2025.110549_bb0665","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00439-012-1250-7","article-title":"TNFAIP3 gene polymorphisms confer risk for Behcet\u2019s disease in a Chinese Han population","volume":"132","author":"Li","year":"2013","journal-title":"Hum. Genet."},{"key":"10.1016\/j.clim.2025.110549_bb0670","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119085","article-title":"Genome-wide association study in an admixed case series reveals IL12A as a new candidate in Beh\u00e7et disease","volume":"10","author":"Kappen","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.clim.2025.110549_bb0675","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1158\/0008-5472.CAN-05-2776","article-title":"Identification of the NKG2D haplotypes associated with natural cytotoxic activity of peripheral blood lymphocytes and cancer immunosurveillance","volume":"66","author":"Hayashi","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.clim.2025.110549_bb0680","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/art.21060","article-title":"Whole-genome screening for susceptibility genes in multicase families with Beh\u00e7et\u2019s disease","volume":"52","author":"Karasneh","year":"2005","journal-title":"Arthritis Rheum."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152166162500124X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152166162500124X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T08:16:29Z","timestamp":1755504989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152166162500124X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":136,"alternative-id":["S152166162500124X"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2025.110549","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Etiopathogenesis of Beh\u00e7et's disease: A systematic literature review","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2025.110549","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110549"}}