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Exp. Med."},{"issue":"1","key":"10.1016\/j.clim.2025.110561_bb0515","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/eji.201444882","article-title":"SLy2 controls the antibody response to pneumococcal vaccine through an IL-5R\u03b1-dependent mechanism in B-1 cells","volume":"45","author":"Schmitt","year":"2015","journal-title":"Eur. J. 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J. Biol. Sci."},{"issue":"6068","key":"10.1016\/j.clim.2025.110561_bb0580","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.1215173","article-title":"Innate response activator B cells protect against microbial sepsis","volume":"335","author":"Rauch","year":"2012","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.clim.2025.110561_bb0585","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1084\/jem.188.12.2381","article-title":"A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection","volume":"188","author":"Boes","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2025.110561_bb0615","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.814857","article-title":"The role of B1 cells in systemic lupus erythematosus","volume":"13","author":"She","year":"2022","journal-title":"Front. 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Sci."},{"issue":"6","key":"10.1016\/j.clim.2025.110561_bb0635","first-page":"3628","article-title":"Defective B1 cell homing to the peritoneal cavity and preferential recruitment of B1 cells in the target organs in a murine model for systemic lupus erythematosus","volume":"172","author":"Ito","year":"2004","journal-title":"J. Immunol. Baltim. Md."},{"issue":"12","key":"10.1016\/j.clim.2025.110561_bb0640","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1172\/JCI42213","article-title":"The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis","volume":"120","author":"Moreth","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"5638","key":"10.1016\/j.clim.2025.110561_bb0645","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.clim.2025.110561_bb0650","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1002\/art.25015","article-title":"A novel subpopulation of B-1 cells is enriched with autoreactivity in normal and lupus-prone mice","volume":"60","author":"Zhong","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2025.110561_bb0660","doi-asserted-by":"crossref","first-page":"1259827","DOI":"10.3389\/fimmu.2023.1259827","article-title":"Human VH4-34 antibodies derived from B1 cells are more frequently autoreactive than VH4-34 antibodies derived from memory cells","volume":"14","author":"Ray","year":"2023","journal-title":"Front. 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