{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:48:29Z","timestamp":1794271709936,"version":"4.9.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.clim.2025.110571","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T16:52:34Z","timestamp":1753116754000},"page":"110571","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Mitochondrial bioenergetic failure in SLE immunocytes: Targeting fitness for therapy"],"prefix":"10.1016","volume":"280","author":[{"given":"Anjali S.","family":"Yennemadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Diong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Keane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Leisching","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.clim.2025.110571_bb0005","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1177\/09612033231164635","article-title":"Mitochondrial bioenergetic changes in systemic lupus erythematosus immune cell subsets: contributions to pathogenesis and clinical applications","volume":"32","author":"Yennemadi","year":"2023","journal-title":"Lupus"},{"issue":"3","key":"10.1016\/j.clim.2025.110571_bb0010","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbamcr.2012.11.014","article-title":"Biogenesis of mitochondrial carrier proteins: molecular mechanisms of import into mitochondria","volume":"1833","author":"Ferramosca","year":"2013","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"issue":"8","key":"10.1016\/j.clim.2025.110571_bb0015","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/08916934.2022.2112181","article-title":"Mitochondria as a key player in systemic lupus erythematosus","volume":"55","author":"Quintero-Gonz\u00e1lez","year":"2022","journal-title":"Autoimmunity"},{"key":"10.1016\/j.clim.2025.110571_bb0020","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.biocel.2014.05.019","article-title":"Mitochondria in monocytes and macrophages-implications for translational and basic research","volume":"53","author":"Ravi","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"50","key":"10.1016\/j.clim.2025.110571_bb0025","doi-asserted-by":"crossref","first-page":"12565","DOI":"10.1073\/pnas.1814589115","article-title":"ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses","volume":"115","author":"Tokuyama","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"D1","key":"10.1016\/j.clim.2025.110571_bb0030","doi-asserted-by":"crossref","first-page":"D1251","DOI":"10.1093\/nar\/gkv1003","article-title":"MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins","volume":"44","author":"Calvo","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"274","key":"10.1016\/j.clim.2025.110571_bb0035","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa0835","article-title":"Normalization of CD4+ T cell metabolism reverses lupus","volume":"7","author":"Yin","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.clim.2025.110571_bb0040","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4049\/jimmunol.1501537","article-title":"Glucose oxidation is critical for CD4+ T cell activation in a mouse model of systemic lupus erythematosus","volume":"196","author":"Yin","year":"2016","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.clim.2025.110571_bb0045","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.4049\/jimmunol.0803600","article-title":"Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1\/Rab4-regulated lysosomal degradation","volume":"182","author":"Fernandez","year":"2009","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2025.110571_bb0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1089\/ars.2013.5702","article-title":"Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus","volume":"21","author":"Doherty","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.clim.2025.110571_bb0055","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nprot.2014.018","article-title":"Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis","volume":"9","author":"Salabei","year":"2014","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.clim.2025.110571_bb0060","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13059-025-03559-w","article-title":"Filtering cells with high mitochondrial content depletes viable metabolically altered malignant cell populations in cancer single-cell studies","volume":"26","author":"Yates","year":"2025","journal-title":"Genome Biol."},{"issue":"3","key":"10.1016\/j.clim.2025.110571_bb0065","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/mds.27604","article-title":"Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich\u2019s ataxia","volume":"34","author":"Alfedi","year":"2019","journal-title":"Mov. Disord."},{"issue":"6","key":"10.1016\/j.clim.2025.110571_bb0070","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrd4023","article-title":"Pharmacological approaches to restore mitochondrial function","volume":"12","author":"Andreux","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.clim.2025.110571_bb0075","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2020-000387","article-title":"Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice","volume":"7","author":"Fortner","year":"2020","journal-title":"Lupus Sci. Med."},{"issue":"10","key":"10.1016\/j.clim.2025.110571_bb0080","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1136\/annrheumdis-2013-203794","article-title":"HRES-1\/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE","volume":"73","author":"Caza","year":"2014","journal-title":"Ann. Rheum. Dis."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625001469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625001469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T18:41:04Z","timestamp":1759862464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661625001469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":16,"alternative-id":["S1521661625001469"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2025.110571","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.06.10.658845","asserted-by":"object"}]},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial bioenergetic failure in SLE immunocytes: Targeting fitness for therapy","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2025.110571","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110571"}}