{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:57:44Z","timestamp":1789192664872,"version":"build-2803163510"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871224"],"award-info":[{"award-number":["81871224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371817"],"award-info":[{"award-number":["82371817"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.clim.2025.110588","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T15:57:10Z","timestamp":1755878230000},"page":"110588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Ferroptosis in patients with rheumatoid arthritis"],"prefix":"10.1016","volume":"281","author":[{"given":"Yunping","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Guo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.clim.2025.110588_bb0005","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41584-022-00793-5","article-title":"Mechanisms of joint destruction in rheumatoid arthritis - immune cell-fibroblast-bone interactions","volume":"18","author":"Komatsu","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"issue":"10","key":"10.1016\/j.clim.2025.110588_bb0010","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1172\/JCI97965","article-title":"Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation","volume":"128","author":"Zou","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2025.110588_bb0015","article-title":"Rheumatoid arthritis: more than a joint disease","volume":"164","author":"Osipova","year":"2020","journal-title":"Ned. Tijdschr. Geneeskd."},{"issue":"10","key":"10.1016\/j.clim.2025.110588_bb0020","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1136\/annrheumdis-2020-217798","article-title":"Combination of human umbilical cord mesenchymal stem (stromal) cell transplantation with IFN-\u03b3 treatment synergistically improves the clinical outcomes of patients with rheumatoid arthritis","volume":"79","author":"He","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"11","key":"10.1016\/j.clim.2025.110588_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112857","article-title":"Management of Rheumatoid Arthritis: an overview","volume":"10","author":"Radu","year":"2021","journal-title":"Cells"},{"issue":"44","key":"10.1016\/j.clim.2025.110588_bb0030","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb0606","article-title":"Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts","volume":"6","author":"Yang","year":"2020","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.clim.2025.110588_bb0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol. Rev."},{"issue":"2","key":"10.1016\/j.clim.2025.110588_bb0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/cmi.2016.60","article-title":"uPAR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K\/Akt signaling pathway in patients with rheumatoid arthritis","volume":"15","author":"Liu","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.clim.2025.110588_bb0045","doi-asserted-by":"crossref","first-page":"1307748","DOI":"10.3389\/fimmu.2024.1307748","article-title":"Deconvolution of synovial myeloid cell subsets across pathotypes and role of COL3A1+ macrophages in rheumatoid arthritis remission","volume":"15","author":"Hu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110588_bb0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jare.2023.05.001","article-title":"Infusion of GMSCs relieves autoimmune arthritis by suppressing the externalization of neutrophil extracellular traps via PGE2-PKA-ERK axis","volume":"58","author":"Zhao","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.clim.2025.110588_bb0055","article-title":"Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen species, and neutrophil extracellular traps","volume":"11","author":"Wright","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110588_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102461","article-title":"The progress and prospect of regulatory T cells in autoimmune diseases","volume":"111","author":"Zhang","year":"2020","journal-title":"J. Autoimmun."},{"issue":"5","key":"10.1016\/j.clim.2025.110588_bb0065","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.33594\/000000080","article-title":"Helios but not CD226, TIGIT and Foxp3 is a potential marker for CD4(+) Treg cells in patients with rheumatoid arthritis","volume":"52","author":"Yang","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.clim.2025.110588_bb0070","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41584-020-0413-5","article-title":"Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes","volume":"16","author":"Nygaard","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"issue":"5","key":"10.1016\/j.clim.2025.110588_bb0075","first-page":"750","article-title":"Role of ceRNA network in inflammatory cells of rheumatoid arthritis","volume":"48","author":"He","year":"2023","journal-title":"Zhong nan da xue xue bao Yi xue ban = J. Cent. South Univ. Med. Sci."},{"issue":"9","key":"10.1016\/j.clim.2025.110588_bb0080","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1136\/annrheumdis-2011-201052","article-title":"Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells","volume":"71","author":"Kong","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2025.110588_bb0085","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ebiom.2019.04.058","article-title":"Human gingival tissue-derived MSC suppress osteoclastogenesis and bone erosion via CD39-adenosine signal pathway in autoimmune arthritis","volume":"43","author":"Luo","year":"2019","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.clim.2025.110588_bb0090","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/08923973.2020.1745830","article-title":"Cholinergic agonists inhibit proliferation of human fibroblast-like synoviocytes and monocytic cell lines and reduce VEGF and MMPs expression by these cells","volume":"42","author":"Arshadi","year":"2020","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.clim.2025.110588_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110502","article-title":"Schisandrin treatment suppresses the proliferation, migration, invasion, and inflammatory responses of fibroblast-like synoviocytes from rheumatoid arthritis patients and attenuates synovial inflammation and joint destruction in CIA mice","volume":"122","author":"Lin","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.clim.2025.110588_bb0100","doi-asserted-by":"crossref","first-page":"7112","DOI":"10.4049\/jimmunol.180.11.7112","article-title":"Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6","volume":"180","author":"Zheng","year":"2008","journal-title":"J. Immunol."},{"issue":"33","key":"10.1016\/j.clim.2025.110588_bb0105","doi-asserted-by":"crossref","first-page":"E3432","DOI":"10.1073\/pnas.1408780111","article-title":"Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions","volume":"111","author":"Lu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.clim.2025.110588_bb0110","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1002\/art.34513","article-title":"Antigen-specific transforming growth factor \u03b2-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17\/Treg cell balance from Th17 predominance to Treg cell predominance","volume":"64","author":"Kong","year":"2012","journal-title":"Arthrit. Rheum."},{"issue":"5","key":"10.1016\/j.clim.2025.110588_bb0115","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s10753-021-01459-2","article-title":"MLL3 inhibits apoptosis of rheumatoid arthritis fibroblast-like Synoviocytes and promotes secretion of inflammatory factors by activating CCL2 and the NF-\u03baB pathway","volume":"44","author":"Fan","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.clim.2025.110588_bb0120","doi-asserted-by":"crossref","first-page":"1260839","DOI":"10.3389\/fimmu.2023.1260839","article-title":"Ferroptosis as an emerging target in rheumatoid arthritis","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.clim.2025.110588_bb0125","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.clim.2025.110588_bb0130","doi-asserted-by":"crossref","first-page":"1255443","DOI":"10.3389\/fimmu.2023.1255443","article-title":"The crosstalk of CD8+ T cells and ferroptosis in cancer","volume":"14","author":"Lin","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.clim.2025.110588_bb0135","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrm3737","article-title":"Regulated necrosis: the expanding network of non-apoptotic cell death pathways","volume":"15","author":"Vanden Berghe","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.clim.2025.110588_bb0140","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.mehy.2017.02.017","article-title":"Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events","volume":"101","author":"Bertrand","year":"2017","journal-title":"Med. Hypotheses"},{"issue":"7","key":"10.1016\/j.clim.2025.110588_bb0145","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1007\/s10571-023-01388-8","article-title":"The mechanisms of Ferroptosis under hypoxia","volume":"43","author":"Gao","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.clim.2025.110588_bb0150","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210518","article-title":"Ferroptosis in infection, inflammation, and immunity","volume":"218","author":"Chen","year":"2021","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.clim.2025.110588_bb0155","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"12","key":"10.1016\/j.clim.2025.110588_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12123524","article-title":"Iron dysregulation in human Cancer: altered metabolism, biomarkers for diagnosis, prognosis, monitoring and rationale for therapy","volume":"12","author":"Leli\u00e8vre","year":"2020","journal-title":"Cancers"},{"issue":"18","key":"10.1016\/j.clim.2025.110588_bb0165","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1089\/ars.2011.4271","article-title":"Mammalian iron homeostasis in health and disease: uptake, storage, transport, and molecular mechanisms of action","volume":"18","author":"Lawen","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.clim.2025.110588_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.998736","article-title":"Application of genomic selection and experimental techniques to predict cell death and immunotherapeutic efficacy of ferroptosis-related CXCL2 in hepatocellular carcinoma","volume":"12","author":"Yi","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.clim.2025.110588_bb0175","article-title":"YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2025.110588_bb0180","doi-asserted-by":"crossref","first-page":"1292628","DOI":"10.3389\/fnut.2023.1292628","article-title":"Amino acid and fatty acid profiles of perennial Baki\u2122 bean","volume":"10","author":"Craine","year":"2023","journal-title":"Front. Nutr."},{"issue":"6","key":"10.1016\/j.clim.2025.110588_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103806","article-title":"Role of regulatory T cells in inflammatory liver diseases","volume":"24","author":"Yang","year":"2025","journal-title":"Autoimmun. Rev."},{"issue":"14","key":"10.1016\/j.clim.2025.110588_bb0190","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.4155\/fmc-2023-0125","article-title":"Exploring ACSL4\/LPCAT3\/ALOX15 and SLC7A11\/GPX4\/NFE2L2 as potential targets in ferroptosis-based cancer therapy","volume":"15","author":"Gupta","year":"2023","journal-title":"Future Med. Chem."},{"issue":"49","key":"10.1016\/j.clim.2025.110588_bb0195","first-page":"56834","article-title":"Multifunctional tumor-targeting carbon dots for tumor microenvironment activated Ferroptosis and immunotherapy in Cancer treatment","volume":"15","author":"Bao","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"10.1016\/j.clim.2025.110588_bb0200","doi-asserted-by":"crossref","first-page":"368","DOI":"10.21037\/atm-21-6942","article-title":"The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review","volume":"10","author":"Liu","year":"2022","journal-title":"Ann. Transl. Med."},{"issue":"1","key":"10.1016\/j.clim.2025.110588_bb0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s43556-023-00142-2","article-title":"The mechanism of ferroptosis and its related diseases","volume":"4","author":"Feng","year":"2023","journal-title":"Mol. Biomed."},{"issue":"7","key":"10.1016\/j.clim.2025.110588_bb0210","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41419-021-04008-9","article-title":"GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis","volume":"12","author":"Hu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.clim.2025.110588_bb0215","article-title":"The underlying pathological mechanism of ferroptosis in the development of cardiovascular disease","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.clim.2025.110588_bb0220","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.133","article-title":"Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells","volume":"8","author":"Basit","year":"2017","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.clim.2025.110588_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109235","article-title":"The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity","volume":"35","author":"Xu","year":"2021","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.clim.2025.110588_bb0230","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/mp.2016.196","article-title":"Glutathione peroxidase 4: a new player in neurodegeneration?","volume":"22","author":"Cardoso","year":"2017","journal-title":"Mol. Psychiatry"},{"issue":"7784","key":"10.1016\/j.clim.2025.110588_bb0235","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.clim.2025.110588_bb0240","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP Cyclohydrolase 1\/tetrahydrobiopterin counteract Ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.clim.2025.110588_bb0245","article-title":"Ferroptosis in rheumatoid arthritis: a potential therapeutic strategy","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.clim.2025.110588_bb0250","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s10067-019-04873-y","article-title":"Inflammatory anemia may be an indicator for predicting disease activity and structural damage in Chinese patients with rheumatoid arthritis","volume":"39","author":"Chen","year":"2020","journal-title":"Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.clim.2025.110588_bb0255","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/imj.1970.19.2.97","article-title":"The anaemia of rheumatoid arthritis: the significance of iron deposits in the synovial membrane","volume":"19","author":"Muirden","year":"1970","journal-title":"Australas. Ann. Med."},{"issue":"4","key":"10.1016\/j.clim.2025.110588_bb0260","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1136\/ard.51.4.516","article-title":"Effect of iron complexes on adjuvant arthritis in rats","volume":"51","author":"Dabbagh","year":"1992","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2025.110588_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103008","article-title":"Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis","volume":"69","author":"Liu","year":"2024","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.clim.2025.110588_bb0270","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/ard.27.1.49","article-title":"Concentration of iron in synovial membrane, synovial fluid, and serum in rheumatoid arthritis and other joint diseases","volume":"27","author":"Senator","year":"1968","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.clim.2025.110588_bb0275","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41467-021-27948-4","article-title":"TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models","volume":"13","author":"Wu","year":"2022","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.clim.2025.110588_bb0280","first-page":"354","article-title":"Effects of iron overload on the immune system","volume":"30","author":"Walker","year":"2000","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"7","key":"10.1016\/j.clim.2025.110588_bb0285","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00277-017-2985-y","article-title":"Reactive oxygen species mediated T lymphocyte abnormalities in an iron-overloaded mouse model and iron-overloaded patients with myelodysplastic syndromes","volume":"96","author":"Chen","year":"2017","journal-title":"Ann. Hematol."},{"issue":"29","key":"10.1016\/j.clim.2025.110588_bb0290","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1021\/bi300752r","article-title":"Mechanisms of mammalian iron homeostasis","volume":"51","author":"Pantopoulos","year":"2012","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.clim.2025.110588_bb0295","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/09273948.2016.1241282","article-title":"Clinical features and complications of Scleritis in Chinese patients","volume":"26","author":"Yang","year":"2018","journal-title":"Ocul. Immunol. Inflamm."},{"issue":"1","key":"10.1016\/j.clim.2025.110588_bb0300","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ygyno.2019.04.005","article-title":"Metastasis-associated protein 1, modulated by miR-30c, promotes endometrial cancer progression through AKT\/mTOR\/4E-BP1 pathway","volume":"154","author":"Xu","year":"2019","journal-title":"Gynecol. Oncol."},{"issue":"21","key":"10.1016\/j.clim.2025.110588_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/nu14214549","article-title":"L-Citrulline supplementation restrains Ferritinophagy-mediated Ferroptosis to alleviate Iron overload-induced Thymus oxidative damage and immune dysfunction","volume":"14","author":"Ba","year":"2022","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.clim.2025.110588_bb0310","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41419-022-05065-4","article-title":"Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis","volume":"13","author":"Cheng","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.clim.2025.110588_bb0315","doi-asserted-by":"crossref","first-page":"7536805","DOI":"10.1155\/2019\/7536805","article-title":"Oxidative stress in rheumatoid arthritis: what the future might hold regarding novel biomarkers and add-on therapies","volume":"2019","author":"da Fonseca","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.clim.2025.110588_bb0320","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s10753-020-01371-1","article-title":"Destructive roles of fibroblast-like Synoviocytes in chronic inflammation and joint damage in rheumatoid arthritis","volume":"44","author":"Masoumi","year":"2021","journal-title":"Inflammation"},{"issue":"11","key":"10.1016\/j.clim.2025.110588_bb0325","doi-asserted-by":"crossref","first-page":"21182","DOI":"10.1002\/jcp.28721","article-title":"HIF-1\u03b1 facilitates osteocyte-mediated osteoclastogenesis by activating JAK2\/STAT3 pathway in vitro","volume":"234","author":"Zhu","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.clim.2025.110588_bb0330","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1756-185X.2011.01630.x","article-title":"Oxidative stress in systemic lupus erythematosus and rheumatoid arthritis patients: relationship to disease manifestations and activity","volume":"14","author":"Hassan","year":"2011","journal-title":"Int. J. Rheum. Dis."},{"issue":"11","key":"10.1016\/j.clim.2025.110588_bb0335","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1093\/rheumatology\/keac069","article-title":"Glycine increased ferroptosis via SAM-mediated GPX4 promoter methylation in rheumatoid arthritis","volume":"61","author":"Ling","year":"2022","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.clim.2025.110588_bb0340","doi-asserted-by":"crossref","first-page":"2397572","DOI":"10.1080\/07853890.2024.2397572","article-title":"Analysis and identification of ferroptosis-related diagnostic markers in rheumatoid arthritis","volume":"56","author":"Cai","year":"2024","journal-title":"Ann. Med."},{"issue":"6","key":"10.1016\/j.clim.2025.110588_bb0345","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201958R","article-title":"Interaction between ferroptosis and TNF-\u03b1: impact in obesity-related osteoporosis","volume":"37","author":"Chen","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.clim.2025.110588_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2022.152079","article-title":"Causal association of diet-derived circulating antioxidants with the risk of rheumatoid arthritis: a Mendelian randomization study","volume":"56","author":"Zhou","year":"2022","journal-title":"Semin. Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.clim.2025.110588_bb0355","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/ard.62.4.297","article-title":"Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis","volume":"62","author":"Cutolo","year":"2003","journal-title":"Ann. Rheum. Dis."},{"issue":"7","key":"10.1016\/j.clim.2025.110588_bb0360","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1158\/0008-5472.CAN-20-1641","article-title":"MYCN-amplified neuroblastoma is addicted to Iron and vulnerable to inhibition of the system xc\u2212\/glutathione Axis","volume":"81","author":"Floros","year":"2021","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.clim.2025.110588_bb0365","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41584-021-00585-3","article-title":"The gut-joint axis in rheumatoid arthritis","volume":"17","author":"Zaiss","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"5","key":"10.1016\/j.clim.2025.110588_bb0370","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052668","article-title":"Hemochromatosis: ferroptosis, ROS, gut microbiome, and clinical challenges with alcohol as confounding variable","volume":"25","author":"Teschke","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.clim.2025.110588_bb0375","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1111\/brv.12407","article-title":"No effects without causes: the Iron dysregulation and dormant microbes hypothesis for chronic, inflammatory diseases","volume":"93","author":"Kell","year":"2018","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"issue":"Pt 1","key":"10.1016\/j.clim.2025.110588_bb0380","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.freeradbiomed.2022.10.270","article-title":"The gut microbiota metabolite glycochenodeoxycholate activates TFR-ACSL4-mediated ferroptosis to promote the development of environmental toxin-linked MAFLD","volume":"193","author":"Liu","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.clim.2025.110588_bb0385","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrrheum.2017.201","article-title":"The role of semaphorins in immune responses and autoimmune rheumatic diseases","volume":"14","author":"Nishide","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"issue":"6","key":"10.1016\/j.clim.2025.110588_bb0390","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/art.38425","article-title":"Secreted semaphorin 5A activates immune effector cells and is a biomarker for rheumatoid arthritis","volume":"66","author":"Gras","year":"2014","journal-title":"Arthrit. Rheumatol. (Hoboken, NJ)"},{"issue":"12","key":"10.1016\/j.clim.2025.110588_bb0395","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1093\/rheumatology\/keab133","article-title":"TSP1 is the essential domain of SEMA5A involved in pannus formation in rheumatoid arthritis","volume":"60","author":"Xiao","year":"2021","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"10.1016\/j.clim.2025.110588_bb0400","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nri846","article-title":"Apoptosis as a therapeutic tool in rheumatoid arthritis","volume":"2","author":"Pope","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.clim.2025.110588_bb0405","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1007\/s11010-023-04889-8","article-title":"Spermidine protects cartilage from IL-1\u03b2-mediated ferroptosis","volume":"479","author":"Cheng","year":"2024","journal-title":"Mol. Cell. Biochem."},{"issue":"10","key":"10.1016\/j.clim.2025.110588_bb0410","first-page":"2329","article-title":"Blockade of IL-17 alleviated inflammation in rat arthritis and MMP-13 expression","volume":"21","author":"Shui","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.clim.2025.110588_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102411","article-title":"TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKC\u03b1-NOX4 axis","volume":"55","author":"Zhou","year":"2022","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.clim.2025.110588_bb0420","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.ymthe.2020.04.003","article-title":"CD39 produced from human GMSCs regulates the balance of osteoclasts and osteoblasts through the Wnt\/\u03b2-catenin pathway in osteoporosis","volume":"28","author":"Wu","year":"2020","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.clim.2025.110588_bb0425","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00774-020-01162-6","article-title":"Osteoclast differentiation by RANKL and OPG signaling pathways","volume":"39","author":"Udagawa","year":"2021","journal-title":"J. Bone Miner. Metab."},{"issue":"10","key":"10.1016\/j.clim.2025.110588_bb0430","doi-asserted-by":"crossref","first-page":"706","DOI":"10.14348\/molcells.2017.0225","article-title":"Current understanding of RANK signaling in osteoclast differentiation and maturation","volume":"40","author":"Park","year":"2017","journal-title":"Mol. Cells"},{"issue":"6","key":"10.1016\/j.clim.2025.110588_bb0435","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1007\/s10565-023-09834-5","article-title":"NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis","volume":"39","author":"Zhang","year":"2023","journal-title":"Cell Biol. Toxicol."},{"issue":"5","key":"10.1016\/j.clim.2025.110588_bb0440","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/jleuko\/qiae011","article-title":"Myeloid zinc finger 1 knockdown promotes osteoclastogenesis and bone loss in part by regulating RANKL-induced ferroptosis of osteoclasts through Nrf2\/GPX4 signaling pathway","volume":"115","author":"Qu","year":"2024","journal-title":"J. Leukoc. Biol."},{"issue":"5","key":"10.1016\/j.clim.2025.110588_bb0445","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/JLB.3A0318-108R","article-title":"Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis","volume":"105","author":"Handa","year":"2019","journal-title":"J. Leukoc. Biol."},{"issue":"4","key":"10.1016\/j.clim.2025.110588_bb0450","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41419-022-04775-z","article-title":"Interaction between macrophages and ferroptosis","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.clim.2025.110588_bb0455","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ygyno.2023.11.035","article-title":"Corrigendum to \u201cMetastasis-associated protein 1, modulated by miR-30c, promotes endometrial cancer progression through AKT\/mTOR\/4E-BP1 pathway\u201d [Gynecol Oncol. 2019 Jul;154(1):207\u2013217. doi: 10.1016\/j.ygyno.2019.04.005. Epub 2019 Apr 9]","volume":"180","author":"Xu","year":"2024","journal-title":"Gynecol. Oncol."},{"issue":"7755","key":"10.1016\/j.clim.2025.110588_bb0460","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.clim.2025.110588_bb0465","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1016\/j.celrep.2019.10.070","article-title":"B1 and marginal zone B cells but not follicular B2 cells require Gpx4 to prevent lipid peroxidation and Ferroptosis","volume":"29","author":"Muri","year":"2019","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.clim.2025.110588_bb0470","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.bbrc.2018.07.100","article-title":"The ferroptosis inducer erastin promotes proliferation and differentiation in human peripheral blood mononuclear cells","volume":"503","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.clim.2025.110588_bb0475","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/s41590-021-00993-3","article-title":"Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity","volume":"22","author":"Li","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2025.110588_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.108965","article-title":"Interplay of redox imbalance with matrix gelatinases in neutrophils and their association with disease severity in rheumatoid arthritis patients","volume":"237","author":"Kaushal","year":"2022","journal-title":"Clin. Immunol. (Orlando, Fla)"},{"key":"10.1016\/j.clim.2025.110588_bb0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2021.102630","article-title":"Mitochondrial N-formyl methionine peptides associate with disease activity as well as contribute to neutrophil activation in patients with rheumatoid arthritis","volume":"119","author":"Duvvuri","year":"2021","journal-title":"J. Autoimmun."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625001639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625001639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T19:34:57Z","timestamp":1779737697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661625001639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":97,"alternative-id":["S1521661625001639"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2025.110588","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroptosis in patients with rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2025.110588","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110588"}}