{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:42:01Z","timestamp":1780526521603,"version":"3.54.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program Key Projects","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.clim.2025.110604","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:50:58Z","timestamp":1760140258000},"page":"110604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Glial-derived neurotrophic factor promotes aberrant basal cell hyperplasia in nasal polyps"],"prefix":"10.1016","volume":"281","author":[{"given":"Yilin","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingchao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HongYi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.clim.2025.110604_bb0005","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/lary.27852","article-title":"Cost burden and resource utilization in patients with chronic rhinosinusitis and nasal polyps","volume":"129","author":"Bhattacharyya","year":"2019","journal-title":"Laryngoscope"},{"issue":"Suppl S29","key":"10.1016\/j.clim.2025.110604_bb0010","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"issue":"4","key":"10.1016\/j.clim.2025.110604_bb0015","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaip.2016.04.012","article-title":"Chronic rhinosinusitis with nasal polyps","volume":"4","author":"Stevens","year":"2016","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"7720","key":"10.1016\/j.clim.2025.110604_bb0020","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41586-018-0449-8","article-title":"Allergic inflammatory memory in human respiratory epithelial progenitor cells","volume":"560","author":"Ordovas-Montanes","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.clim.2025.110604_bb0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41572-020-00218-1","article-title":"Adult chronic rhinosinusitis","volume":"6","author":"Bachert","year":"2020","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"6","key":"10.1016\/j.clim.2025.110604_bb0030","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/all.13074","article-title":"Increase of poorly proliferated p63(+) \/Ki67(+) basal cells forming multiple layers in the aberrant remodeled epithelium in nasal polyps","volume":"72","author":"Zhao","year":"2017","journal-title":"Allergy"},{"issue":"3","key":"10.1016\/j.clim.2025.110604_bb0035","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jaci.2023.11.016","article-title":"Neutrophil extracellular traps promote \u0394Np63+ basal cell hyperplasia in chronic rhinosinusitis","volume":"153","author":"Lim","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110604_bb0040","first-page":"53212","article-title":"The reversible effects of glial cell line-derived neurotrophic factor (GDNF) in the human brain","author":"Ayanlaja","year":"2018","journal-title":"Semin. Cancer Biol."},{"issue":"4","key":"10.1016\/j.clim.2025.110604_bb0045","doi-asserted-by":"crossref","first-page":"748","DOI":"10.4103\/1673-5374.322446","article-title":"GDNF to the rescue: GDNF delivery effects on motor neurons and nerves, and muscle re-innervation after peripheral nerve injuries","volume":"17","author":"Cintron-Colon","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.clim.2025.110604_bb0050","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ydbio.2016.06.004","article-title":"Regulators of gene expression in enteric neural crest cells are putative Hirschsprung disease genes","volume":"416","author":"Schriemer","year":"2016","journal-title":"Dev. Biol."},{"issue":"4","key":"10.1016\/j.clim.2025.110604_bb0055","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00467-013-2635-0","article-title":"Gene regulatory network of renal primordium development","volume":"29","author":"Marcotte","year":"2014","journal-title":"Pediatr. Nephrol."},{"issue":"4","key":"10.1016\/j.clim.2025.110604_bb0060","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/exd.14526","article-title":"GDNF neurotrophic factor signalling determines the fate of dermal fibroblasts in wound-induced hair neogenesis and skin regeneration","volume":"31","author":"Vishlaghi","year":"2022","journal-title":"Exp. Dermatol."},{"issue":"12","key":"10.1016\/j.clim.2025.110604_bb0065","doi-asserted-by":"crossref","first-page":"8184","DOI":"10.1002\/jcp.30489","article-title":"Glial-derived neurotrophic factor in human airway smooth muscle","volume":"236","author":"Bhallamudi","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.clim.2025.110604_bb0070","doi-asserted-by":"crossref","first-page":"L684","DOI":"10.1152\/ajplung.00101.2024","article-title":"Effects of glial-derived neurotrophic factor on remodeling and mitochondrial function in human airway smooth muscle cells","volume":"327","author":"Drake","year":"2024","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.clim.2025.110604_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.anai.2025.04.007","article-title":"Proteomic profiling of nasal fluids and serum for type 2 nasal polyps diagnosis","author":"Hou","year":"2025","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"1","key":"10.1016\/j.clim.2025.110604_bb0080","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41385-018-0063-y","article-title":"Neuro-immune regulation of mucosal physiology","volume":"12","author":"Chesn\u00e9","year":"2019","journal-title":"Mucosal Immunol."},{"issue":"4","key":"10.1016\/j.clim.2025.110604_bb0085","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.cell.2016.04.041","article-title":"Neuro-immune interactions at barrier surfaces","volume":"165","author":"Veiga-Fernandes","year":"2016","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.clim.2025.110604_bb0090","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000534226","article-title":"Comparing protein and gene expression signature between nasal polyps and nasal fluids in chronic rhinosinusitis","volume":"185","author":"Hou","year":"2024","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"6","key":"10.1016\/j.clim.2025.110604_bb0095","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jaci.2011.09.001","article-title":"Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis","volume":"128","author":"Lai","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110604_bb0100","first-page":"18462","article-title":"Air-liquid interface (ALI) impact on different respiratory cell cultures","author":"Silva","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"2","key":"10.1016\/j.clim.2025.110604_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020835","article-title":"Air-liquid-Interface differentiated human nose epithelium: a robust primary tissue culture model of SARS-CoV-2 infection","volume":"23","author":"Tran","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.clim.2025.110604_bb0110","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41590-022-01312-0","article-title":"Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis","volume":"23","author":"Wang","year":"2022","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.clim.2025.110604_bb0115","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13758","article-title":"Glial cell line derived neurotrophic factor (GDNF) induces mucosal healing via intestinal stem cell niche activation","volume":"58","author":"H\u00f6rner","year":"2025","journal-title":"Cell Prolif."},{"issue":"10","key":"10.1016\/j.clim.2025.110604_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103586","article-title":"APE1 promotes pancreatic Cancer proliferation through GFR\u03b11\/Src\/ERK Axis-Cascade signaling in response to GDNF","volume":"21","author":"Choi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.clim.2025.110604_bb0125","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/10717540500177009","article-title":"Air-liquid interface culture of serially passaged human nasal epithelial cell monolayer for in vitro drug transport studies","volume":"12","author":"Lee","year":"2005","journal-title":"Drug Deliv."},{"issue":"9","key":"10.1016\/j.clim.2025.110604_bb0130","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1007\/s43032-023-01204-0","article-title":"Linc-ROR promotes EMT by targeting miR-204-5p\/SMAD4 in endometriosis","volume":"30","author":"Yi","year":"2023","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.clim.2025.110604_bb0135","first-page":"194108618","article-title":"Hippocampal miR-211-5p regulates neurogenesis and depression-like behaviors in the rat","author":"Li","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.clim.2025.110604_bb0140","first-page":"172383","article-title":"Paroxetine attenuates chondrocyte Pyroptosis and inhibits osteoclast formation by inhibiting NF-\u03baB pathway activation to delay osteoarthritis progression","author":"Zheng","year":"2023","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.clim.2025.110604_bb0145","first-page":"111638","article-title":"PGAM5-CypD pathway is involved in bromocriptine-induced RIP3\/MLKL-dependent necroptosis of prolactinoma cells","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.clim.2025.110604_bb0150","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1165\/rcmb.2015-0015OC","article-title":"Brain-derived neurotrophic factor expression in asthma. Association with severity and type 2 inflammatory processes","volume":"53","author":"Watanabe","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.clim.2025.110604_bb0155","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1164\/ajrccm.158.6.9803023","article-title":"Neurotrophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation","volume":"158","author":"Virchow","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.clim.2025.110604_bb0160","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1183\/09031936.02.00205402","article-title":"Nerve growth factor levels and localisation in human asthmatic bronchi","volume":"20","author":"Olgart H\u00f6glund","year":"2002","journal-title":"Eur. Respir. J."},{"issue":"3","key":"10.1016\/j.clim.2025.110604_bb0165","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.20010897","article-title":"The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma","volume":"198","author":"Nassenstein","year":"2003","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.clim.2025.110604_bb0170","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3240::AID-IMMU3240>3.0.CO;2-U","article-title":"Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma","volume":"28","author":"Braun","year":"1998","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"10.1016\/j.clim.2025.110604_bb0175","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/rccm.200202-134OC","article-title":"Augmentation of allergic early-phase reaction by nerve growth factor","volume":"166","author":"P\u00e4th","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.clim.2025.110604_bb0180","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pharmthera.2014.02.006","article-title":"Brain-derived neurotrophic factor in the airways","volume":"143","author":"Prakash","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.clim.2025.110604_bb0185","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nn.2136","article-title":"Absolute requirement of GDNF for adult catecholaminergic neuron survival","volume":"11","author":"Pascual","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.clim.2025.110604_bb0190","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbrc.2010.01.136","article-title":"Beyond the cell surface: new mechanisms of receptor function","volume":"396","author":"Ib\u00e1\u00f1ez","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.clim.2025.110604_bb0195","first-page":"108110721","article-title":"GDNF promotes the proliferation and osteogenic differentiation of jaw bone marrow mesenchymal stem cells via the Nr4a1\/PI3K\/Akt pathway","author":"Wang","year":"2023","journal-title":"Cell. Signal."},{"issue":"3","key":"10.1016\/j.clim.2025.110604_bb0200","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jaci.2014.05.049","article-title":"Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation","volume":"134","author":"Georas","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.clim.2025.110604_bb0205","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/j.jaci.2017.04.010","article-title":"Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases","volume":"139","author":"Schleimer","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.clim.2025.110604_bb0210","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1177\/1945892420964169","article-title":"TRPV4-mediated epithelial junction disruption in allergic rhinitis triggered by house dust mites","volume":"35","author":"Lee","year":"2021","journal-title":"Am. J. Rhinol. Allergy"},{"issue":"3","key":"10.1016\/j.clim.2025.110604_bb0215","doi-asserted-by":"crossref","first-page":"G171","DOI":"10.1152\/ajpgi.00048.2015","article-title":"Homeostasis of the gut barrier and potential biomarkers","volume":"312","author":"Wells","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"2","key":"10.1016\/j.clim.2025.110604_bb0220","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.canlet.2012.08.016","article-title":"The PI3K\/Akt\/mTOR signaling pathway mediates insulin-like growth factor 1-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells","volume":"326","author":"Lau","year":"2012","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.clim.2025.110604_bb0225","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.chom.2011.04.012","article-title":"Invasive bacterial pathogens exploit TLR-mediated downregulation of tight junction components to facilitate translocation across the epithelium","volume":"9","author":"Clarke","year":"2011","journal-title":"Cell Host Microbe"},{"issue":"14","key":"10.1016\/j.clim.2025.110604_bb0230","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/pros.24046","article-title":"Tight junction protein claudin-1 is downregulated by TGF-\u03b21 via MEK signaling in benign prostatic epithelial cells","volume":"80","author":"Wang","year":"2020","journal-title":"Prostate"},{"key":"10.1016\/j.clim.2025.110604_bb0235","first-page":"86106696","article-title":"The neuro-immune interaction in airway inflammation through TRPA1 expression in CD4+ T cells of asthmatic mice","author":"Li","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.clim.2025.110604_bb0240","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.jaci.2023.08.017","article-title":"Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms, and therapeutic targets in atopic diseases","volume":"153","author":"Kim","year":"2024","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625001792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625001792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T19:35:35Z","timestamp":1779737735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661625001792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":48,"alternative-id":["S1521661625001792"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2025.110604","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glial-derived neurotrophic factor promotes aberrant basal cell hyperplasia in nasal polyps","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2025.110604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110604"}}