{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T20:04:28Z","timestamp":1779739468582,"version":"3.53.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences","doi-asserted-by":"publisher","award":["59269"],"award-info":[{"award-number":["59269"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.clim.2025.110606","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:40:36Z","timestamp":1759995636000},"page":"110606","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Altered methylation-related genes expression in B cells of systemic lupus erythematosus patients"],"prefix":"10.1016","volume":"281","author":[{"given":"Amin","family":"Azizan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Farhadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Tahereh","family":"Faezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Alikhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmadreza","family":"Jamshidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Vodjgani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.clim.2025.110606_bb0005","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1001\/jama.2024.2315","article-title":"Systemic lupus erythematosus: a review","volume":"331","author":"Siegel","year":"2024","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.clim.2025.110606_bb0010","first-page":"997","article-title":"Systemic lupus erythematosus: one year in review 2023","volume":"41","author":"Zucchi","year":"2023","journal-title":"Clin. Exp. Rheumatol."},{"issue":"1","key":"10.1016\/j.clim.2025.110606_bb0015","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/1744666X.2023.2145281","article-title":"B cell depletion and inhibition in systemic lupus erythematosus","volume":"19","author":"Krustev","year":"2023","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.clim.2025.110606_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102873","article-title":"B cell-targeted therapies in systemic lupus erythematosus","volume":"132","author":"Arbitman","year":"2022","journal-title":"J. Autoimmun."},{"issue":"12","key":"10.1016\/j.clim.2025.110606_bb0025","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1177\/0961203308095138","article-title":"Peripheral B cell abnormalities and disease activity in systemic lupus erythematosus","volume":"17","author":"Hostmann","year":"2008","journal-title":"Lupus"},{"key":"10.1016\/j.clim.2025.110606_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102861","article-title":"Autoantibodies in systemic lupus erythematosus: from immunopathology to therapeutic target","volume":"132","author":"Lou","year":"2022","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.clim.2025.110606_bb0035","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3109\/08830185.2013.786712","article-title":"Aberrant B cell selection and activation in systemic lupus erythematosus","volume":"32","author":"Kil","year":"2013","journal-title":"Int. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.clim.2025.110606_bb0040","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1615\/CritRevImmunol.v25.i2.30","article-title":"T- and B-cell abnormalities in systemic lupus erythematosus","volume":"25","author":"Nagy","year":"2005","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.clim.2025.110606_bb0045","article-title":"The role of Immunometabolism in the pathogenesis of systemic lupus erythematosus","volume":"12","author":"Robinson","year":"2021","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.clim.2025.110606_bb0050","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.4049\/jimmunol.1900620","article-title":"Targeting the immune complex-bound complement C3d ligand as a novel therapy for lupus","volume":"203","author":"Kulik","year":"2019","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.clim.2025.110606_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076578","article-title":"Advances in the pathogenesis and treatment of systemic lupus erythematosus","volume":"24","author":"Accapezzato","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.clim.2025.110606_bb0060","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s11926-021-01047-1","article-title":"TLR7 signaling in lupus B cells: new insights into synergizing factors and downstream signals","volume":"23","author":"Satterthwaite","year":"2021","journal-title":"Curr. Rheumatol. Rep."},{"issue":"7","key":"10.1016\/j.clim.2025.110606_bb0065","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.autrev.2007.01.017","article-title":"Immune complex clearance by monocytes and macrophages in systemic lupus erythematosus","volume":"6","author":"Kavai","year":"2007","journal-title":"Autoimmun. Rev."},{"issue":"2","key":"10.1016\/j.clim.2025.110606_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25021019","article-title":"Epigenetic dysregulation in the pathogenesis of systemic lupus erythematosus","volume":"25","author":"Araki","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.clim.2025.110606_bb0075","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ymeth.2020.10.002","article-title":"DNA methylation methods: global DNA methylation and methylomic analyses","volume":"187","author":"Li","year":"2021","journal-title":"Methods"},{"issue":"5","key":"10.1016\/j.clim.2025.110606_bb0080","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1074-7613(01)00227-8","article-title":"A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival","volume":"15","author":"Lee","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2025.110606_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109857","article-title":"Recent advances in the involvement of epigenetics in the pathogenesis of systemic lupus erythematosus","volume":"258","author":"Zhou","year":"2024","journal-title":"Clin. Immunol."},{"issue":"7","key":"10.1016\/j.clim.2025.110606_bb0090","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tig.2022.03.010","article-title":"DNA methylation: a historical perspective","volume":"38","author":"Mattei","year":"2022","journal-title":"Trends Genet."},{"key":"10.1016\/j.clim.2025.110606_bb0095","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/B978-0-12-387685-0.00009-3","article-title":"Regulation of expression and activity of DNA (cytosine-5) methyltransferases in mammalian cells","volume":"101","author":"Kinney","year":"2011","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"1","key":"10.1016\/j.clim.2025.110606_bb0100","first-page":"138","article-title":"DNA hypomethylation and human diseases","volume":"1775","author":"Wilson","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.clim.2025.110606_bb0105","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1191\/0961203303lu321oa","article-title":"DNA methylation in systemic lupus erythematosus","volume":"12","author":"Sekigawa","year":"2003","journal-title":"Lupus"},{"issue":"3","key":"10.1016\/j.clim.2025.110606_bb0110","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10238-006-0103-x","article-title":"DNA methylation: its contribution to systemic lupus erythematosus","volume":"6","author":"Sekigawa","year":"2006","journal-title":"Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.clim.2025.110606_bb0115","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41392-025-02168-0","article-title":"Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics","volume":"10","author":"Dai","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.clim.2025.110606_bb0120","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ydbio.2019.08.002","article-title":"Epigenetic factors Dnmt1 and Uhrf1 coordinate intestinal development","volume":"455","author":"Ganz","year":"2019","journal-title":"Dev. Biol."},{"issue":"5","key":"10.1016\/j.clim.2025.110606_bb0125","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1016\/j.apsb.2023.02.015","article-title":"UHRF1\/DNMT1-MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer","volume":"13","author":"Lin","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"7","key":"10.1016\/j.clim.2025.110606_bb0130","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1074\/jbc.M113.528893","article-title":"The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism","volume":"289","author":"Bashtrykov","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2025.110606_bb0135","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/B978-0-12-387685-0.00008-1","article-title":"Recruitment of Dnmt1 roles of the SRA protein Np95 (Uhrf1) and other factors","volume":"101","author":"Sharif","year":"2011","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"1","key":"10.1016\/j.clim.2025.110606_bb0140","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/s41467-020-15006-4","article-title":"Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation","volume":"11","author":"Nishiyama","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2025.110606_bb0145","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-3-031-11454-0_10","article-title":"Structure and function of TET enzymes","volume":"1389","author":"Yin","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.clim.2025.110606_bb0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fcell.2018.00022","article-title":"Tet enzymes, variants, and differential effects on function","volume":"6","author":"Melamed","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.clim.2025.110606_bb0155","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000438853","article-title":"TET family of dioxygenases: crucial roles and underlying mechanisms","volume":"146","author":"Li","year":"2015","journal-title":"Cytogenet. Genome Res."},{"issue":"1","key":"10.1016\/j.clim.2025.110606_bb0160","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev-immunol-080223-044610","article-title":"TET enzymes in the immune system: from DNA demethylation to immunotherapy, inflammation, and Cancer","volume":"42","author":"L\u00f3pez-Moyado","year":"2024","journal-title":"Annu. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.clim.2025.110606_bb0165","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1191\/096120399680411317","article-title":"The American College of Rheumatology criteria for the classification of systemic lupus erythematosus: strengths, weaknesses, and opportunities for improvement","volume":"8","author":"Smith","year":"1999","journal-title":"Lupus"},{"issue":"5845","key":"10.1016\/j.clim.2025.110606_bb0170","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1147939","article-title":"UHRF1 plays a role in maintaining DNA methylation in mammalian cells","volume":"317","author":"Bostick","year":"2007","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.clim.2025.110606_bb0175","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1093\/nar\/gky104","article-title":"Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation","volume":"46","author":"Li","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.clim.2025.110606_bb0180","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/0961203310381517","article-title":"Global DNA methylation, DNMT1, and MBD2 in patients with systemic lupus erythematosus","volume":"20","author":"Liu","year":"2011","journal-title":"Lupus"},{"issue":"6","key":"10.1016\/j.clim.2025.110606_bb0185","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-4632.2010.04804.x","article-title":"Analysis of associations between the patterns of global DNA hypomethylation and expression of DNA methyltransferase in patients with systemic lupus erythematosus","volume":"50","author":"Zhu","year":"2011","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.clim.2025.110606_bb0190","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1196\/annals.1422.015","article-title":"DNA methylation and systemic lupus erythematosus","volume":"1108","author":"Balada","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"10","key":"10.1016\/j.clim.2025.110606_bb0195","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/eci.12130","article-title":"Gene expression and regulation in systemic lupus erythematosus","volume":"43","author":"Frangou","year":"2013","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.clim.2025.110606_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1258700","article-title":"Conditional activation of an anti-IgM antibody-drug conjugate for precise B cell lymphoma targeting","volume":"14","author":"Schoenfeld","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.clim.2025.110606_bb0205","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13148-021-01007-7","article-title":"UHRF1 downregulation promotes T follicular helper cell differentiation by increasing BCL6 expression in SLE","volume":"13","author":"Liu","year":"2021","journal-title":"Clin. Epigenetics"},{"issue":"2","key":"10.1016\/j.clim.2025.110606_bb0210","first-page":"237","article-title":"Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus","volume":"45","author":"Januchowski","year":"2004","journal-title":"J. Appl. Genet."},{"issue":"24","key":"10.1016\/j.clim.2025.110606_bb0215","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1038\/sj.onc.1204341","article-title":"DNA methylation, methyltransferases, and cancer","volume":"20","author":"Robertson","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.clim.2025.110606_bb0220","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/B978-0-12-387685-0.00006-8","article-title":"Dnmt1 structure and function","volume":"101","author":"Svedru\u017ei\u0107","year":"2011","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"6","key":"10.1016\/j.clim.2025.110606_bb0225","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s10142-022-00918-9","article-title":"Regulatory mechanism and biological function of UHRF1-DNMT1-mediated DNA methylation","volume":"22","author":"Ren","year":"2022","journal-title":"Funct. Integr. Genomics"},{"key":"10.1016\/j.clim.2025.110606_bb0230","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/ncomms2562","article-title":"UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9","volume":"4","author":"Liu","year":"2013","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.clim.2025.110606_bb0235","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1038\/cr.2011.176","article-title":"S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance","volume":"21","author":"Zhang","year":"2011","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.clim.2025.110606_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107958","article-title":"Acetylation of UHRF1 regulates hemi-methylated DNA binding and maintenance of genome-wide DNA methylation","volume":"32","author":"Hahm","year":"2020","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.clim.2025.110606_bb0245","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jb\/mvv113","article-title":"Regulation of maintenance DNA methylation via histone ubiquitylation","volume":"159","author":"Nishiyama","year":"2016","journal-title":"J. Biochem."},{"issue":"2","key":"10.1016\/j.clim.2025.110606_bb0250","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1440-0960.2012.00968.x","article-title":"Associations between aberrant DNA methylation and transcript levels of DNMT1 and MBD2 in CD4+T cells from patients with systemic lupus erythematosus","volume":"54","author":"Qin","year":"2013","journal-title":"Australas. J. Dermatol."},{"issue":"3","key":"10.1016\/j.clim.2025.110606_bb0255","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2567.2007.02771.x","article-title":"Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus","volume":"124","author":"Balada","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.clim.2025.110606_bb0260","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jaut.2013.01.005","article-title":"Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus","volume":"41","author":"Zhang","year":"2013","journal-title":"J. Autoimmun."},{"issue":"3","key":"10.1016\/j.clim.2025.110606_bb0265","doi-asserted-by":"crossref","first-page":"237","DOI":"10.23736\/S0031-0808.20.03990-7","article-title":"Obesity promotes the global hypomethylation of CD4+ T cells in patients with systemic lupus erythematosus via downregulating DNMT1","volume":"66","author":"Hou","year":"2024","journal-title":"Panminerva Med."},{"issue":"11","key":"10.1016\/j.clim.2025.110606_bb0270","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.468","article-title":"A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus","volume":"41","author":"Gateva","year":"2009","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.clim.2025.110606_bb0275","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/gene.2010.66","article-title":"Two missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese","volume":"12","author":"Zhang","year":"2011","journal-title":"Genes Immun."},{"issue":"4","key":"10.1016\/j.clim.2025.110606_bb0280","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.it.2021.02.002","article-title":"Bcl6-mediated transcriptional regulation of follicular helper T cells (T(FH))","volume":"42","author":"Choi","year":"2021","journal-title":"Trends Immunol."},{"key":"10.1016\/j.clim.2025.110606_bb0285","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4174082","article-title":"Mesenchymal stem cells activate the MEK\/ERK signaling pathway and enhance DNA methylation via DNMT1 in PBMC from systemic lupus erythematosus","volume":"2020","author":"Xiong","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"4","key":"10.1016\/j.clim.2025.110606_bb0290","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/ced.12346","article-title":"17\u03b2-oestradiol enhances global DNA hypomethylation in CD4-positive T cells from female patients with lupus, through overexpression of oestrogen receptor-\u03b1-mediated downregulation of DNMT1","volume":"39","author":"Wu","year":"2014","journal-title":"Clin. Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.clim.2025.110606_bb0295","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jdermsci.2013.04.022","article-title":"Ultraviolet B enhances DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus via inhibiting DNMT1 catalytic activity","volume":"71","author":"Wu","year":"2013","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.clim.2025.110606_bb0300","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41392-023-01537-x","article-title":"TET (ten-eleven translocation) family proteins: structure, biological functions and applications","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.clim.2025.110606_bb0305","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-immunol-120419-022408","article-title":"Germinal centers","volume":"40","author":"Victora","year":"2022","journal-title":"Annu. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.clim.2025.110606_bb0310","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s41590-020-0700-y","article-title":"Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity","volume":"21","author":"Tanaka","year":"2020","journal-title":"Nat. Immunol."},{"issue":"18","key":"10.1016\/j.clim.2025.110606_bb0315","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1111\/febs.14934","article-title":"TET enzymes control antibody production and shape the mutational landscape in germinal Centre B cells","volume":"286","author":"Schoeler","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.clim.2025.110606_bb0320","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaut.2019.05.002","article-title":"Transitional B cells in quiescent SLE: an early checkpoint imprinted by IFN","volume":"102","author":"Dieudonn\u00e9","year":"2019","journal-title":"J. Autoimmun."},{"issue":"9","key":"10.1016\/j.clim.2025.110606_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9092709","article-title":"Glucocorticoids in systemic lupus erythematosus. Ten questions and some issues","volume":"9","author":"Porta","year":"2020","journal-title":"J. Clin. Med."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625001810?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661625001810?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T19:34:21Z","timestamp":1779737661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661625001810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":65,"alternative-id":["S1521661625001810"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2025.110606","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered methylation-related genes expression in B cells of systemic lupus erythematosus patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2025.110606","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110606"}}