{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:31:47Z","timestamp":1780320707347,"version":"3.54.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016239","name":"UOEH","doi-asserted-by":"publisher","award":["19 K17919"],"award-info":[{"award-number":["19 K17919"]}],"id":[{"id":"10.13039\/100016239","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.clim.2026.110706","type":"journal-article","created":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T17:40:00Z","timestamp":1776015600000},"page":"110706","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Short-chain fatty acid deficiency drives aberrant B cell differentiation in systemic lupus erythematosus"],"prefix":"10.1016","volume":"285","author":[{"given":"Ryuichiro","family":"Kanda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Yamagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Todoroki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nagayasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurie","family":"Satoh-Kanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ippei","family":"Miyagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshiro","family":"Sonomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiya","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Nakayamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2026.110706_bb0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41590-021-01093-y","article-title":"Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease","volume":"23","author":"Kubo","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2026.110706_bb0010","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41576-024-00731-z","article-title":"Gene-environment interactions in human health","volume":"25","author":"Herrera-Luis","year":"2024","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.clim.2026.110706_bb0015","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41584-024-01152-2","article-title":"Systemic lupus erythematosus genetics: insights into pathogenesis and implications for therapy","volume":"20","author":"Ghodke-Puranik","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2026.110706_bb0020","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41584-023-00948-y","article-title":"Precision medicine in systemic lupus erythematosus","volume":"19","author":"Fasano","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2026.110706_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2022.101814","article-title":"Systemic lupus erythematosus","volume":"36","author":"Tanaka","year":"2022","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.clim.2026.110706_bb0030","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/ard-2023-224537","article-title":"Extracting immunological and clinical heterogeneity across autoimmune rheumatic diseases by cohort-wide immunophenotyping","volume":"83","author":"Tanaka","year":"2024","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2026.110706_bb0035","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1002\/art.40180","article-title":"Peripheral immunophenotyping identifies three subgroups based on t cell heterogeneity in lupus patients","volume":"69","author":"Kubo","year":"2017","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2026.110706_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20236021","article-title":"Multiple functions of b cells in the pathogenesis of systemic lupus erythematosus","volume":"20","author":"Ma","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.clim.2026.110706_bb0045","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41579-020-0367-2","article-title":"Host-microbiota interactions in immune-mediated diseases","volume":"18","author":"Ruff","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.clim.2026.110706_bb0050","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/annrheumdis-2021-221267","article-title":"Whole gut virome analysis of 476 japanese revealed a link between phage and autoimmune disease","volume":"81","author":"Tomofuji","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2026.110706_bb0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41577-022-00727-y","article-title":"The impact of the gut microbiome on extra-intestinal autoimmune diseases","volume":"23","author":"Miyauchi","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2026.110706_bb0060","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41582-022-00697-8","article-title":"The role of the gut microbiota in multiple sclerosis","volume":"18","author":"Correale","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.clim.2026.110706_bb0065","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2026.110706_bb0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41577-019-0144-5","article-title":"Mining the microbiota for microbial and metabolite-based immunotherapies","volume":"19","author":"Skelly","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2026.110706_bb0075","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nrrheum.2016.68","article-title":"The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventions","volume":"12","author":"Abdollahi-Roodsaz","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.clim.2026.110706_bb0080","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.3390\/nu11112676","article-title":"Protective effects of probiotic consumption in cardiovascular disease in systemic lupus erythematosus","volume":"11","author":"de la Visitaci\u00f3n","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.clim.2026.110706_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104055","article-title":"Gut dysbiosis in rheumatic diseases: a systematic review and meta-analysis of 92 observational studies","volume":"80","author":"Wang","year":"2022","journal-title":"eBioMedicine"},{"key":"10.1016\/j.clim.2026.110706_bb0090","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1136\/ard-2023-223929","article-title":"Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares","volume":"82","author":"Azzouz","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.clim.2026.110706_bb0095","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41467-019-13603-6","article-title":"B cell-intrinsic epigenetic modulation of antibody responses by dietary fibre-derived short -chain fatty acids","volume":"11","author":"Sanchez","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2026.110706_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-05901-2","article-title":"Microbiota-derived short-chain fatty acids promote th1 cell IL-10 production to maintain intestinal homeostasis","volume":"9","author":"Sun","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2026.110706_bb0105","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41586-020-2193-0","article-title":"Bacterial metabolism of bile acids promotes generation of peripheral regulatory t cells","volume":"581","author":"Campbell","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.clim.2026.110706_bb0110","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12916-025-04043-9","article-title":"Double-negative t cells in combination with ursodeoxycholic acid ameliorates immune-mediated cholangitis in mice","volume":"23","author":"Zhang","year":"2025","journal-title":"BMC Med."},{"key":"10.1016\/j.clim.2026.110706_bb0115","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cmet.2020.03.003","article-title":"Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory b cells","volume":"31","author":"Rosser","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.clim.2026.110706_bb0120","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature10491","article-title":"An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor","volume":"478","author":"Opitz","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.clim.2026.110706_bb0125","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1126\/science.aam5336","article-title":"The microbial metabolite desaminotyrosine protects from influenza through type i interferon","volume":"357","author":"Steed","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.clim.2026.110706_bb0130","doi-asserted-by":"crossref","first-page":"9282","DOI":"10.1038\/s41467-025-65180-6","article-title":"The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration","volume":"16","author":"G\u00f6ttert","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.clim.2026.110706_bb0135","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.biopha.2017.11.016","article-title":"Trimethylamine n-oxide promotes atherosclerosis via CD36-dependent MAPK\/JNK pathway","volume":"97","author":"Geng","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.clim.2026.110706_bb0140","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002767","article-title":"Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-\u03baB","volume":"5","author":"Seldin","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.clim.2026.110706_bb0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41579-020-0438-4","article-title":"Gut microbial metabolites as multi-kingdom intermediates","volume":"19","author":"Krautkramer","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.clim.2026.110706_bb0150","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s40265-025-02156-2","article-title":"Revolutionary changes in the management of lupus nephritis: towards De-glucocorticoid or no-glucocorticoid","volume":"85","author":"Tanaka","year":"2025","journal-title":"Drugs"},{"key":"10.1016\/j.clim.2026.110706_bb0155","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2024-005072","article-title":"Fine-tuning SLE treatment: the potential of selective TYK2 inhibition","volume":"10","author":"Satoh-Kanda","year":"2024","journal-title":"RMD Open"},{"key":"10.1016\/j.clim.2026.110706_bb0160","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(10)61354-2","article-title":"Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial","volume":"377","author":"Navarra","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2026.110706_bb0165","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa1912196","article-title":"Trial of anifrolumab in active systemic lupus erythematosus","volume":"382","author":"Morand","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2026.110706_bb0170","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.chom.2016.07.001","article-title":"Gut microbial metabolites fuel host antibody responses","volume":"20","author":"Kim","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.clim.2026.110706_bb0175","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2024-005122","article-title":"Association of peripheral CD8+ t cell activation with disease activity and treatment resistance in systemic lupus erythematosus","volume":"11","author":"Fujita","year":"2025","journal-title":"RMD Open"},{"key":"10.1016\/j.clim.2026.110706_bb0180","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2023-003991","article-title":"Modifying t cell phenotypes using TYK2 inhibitor and its implications for the treatment of systemic lupus erythematosus","volume":"10","author":"Satoh-Kanda","year":"2024","journal-title":"RMD Open"},{"key":"10.1016\/j.clim.2026.110706_bb0185","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/art.40930","article-title":"2019 European league against rheumatism\/American college of rheumatology classification criteria for systemic lupus erythematosus","volume":"71","author":"Aringer","year":"2019","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2026.110706_bb0190","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2024-004567","article-title":"Induction of interleukin 21 receptor expression via enhanced intracellular metabolism in b cells and its relevance to the disease activity in systemic lupus erythematosus","volume":"10","author":"Ueno","year":"2024","journal-title":"RMD Open"},{"key":"10.1016\/j.clim.2026.110706_bb0195","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/art.41208","article-title":"Methionine commits cells to differentiate into plasmablasts through epigenetic regulation of BTB and CNC homolog 2 by the methyltransferase EZH2","volume":"72","author":"Zhang","year":"2020","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2026.110706_bb0200","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1093\/rheumatology\/keab824","article-title":"An enhanced mitochondrial function through glutamine metabolism in plasmablast","volume":"61","author":"Sumikawa","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2026.110706_bb0205","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/1756-185X.12534","article-title":"Relevance of lymphocyte subsets to b cell-targeted therapy in systemic lupus erythematosus","volume":"18","author":"Nakayamada","year":"2015","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.clim.2026.110706_bb0210","doi-asserted-by":"crossref","unstructured":"M.C. Mulero, V.Y. Wang, T. Huxford, G. Ghosh, Genome reading by the NF-\u03baB transcription factors, Nucleic Acids Res. 47 (2019) 9967\u20139989, Doi: 10.1093\/ nar\/gkz739.","DOI":"10.1093\/nar\/gkz739"},{"key":"10.1016\/j.clim.2026.110706_bb0215","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","article-title":"Short-chain fatty acids: linking diet, the microbiome and immunity","volume":"24","author":"Mann","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2026.110706_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176356","article-title":"Short-chain fatty acids and their association with signalling pathways in inflammation, glucose and lipid metabolism","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.clim.2026.110706_bb0225","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.immuni.2019.06.002","article-title":"Microbiota-derived short-chain fatty acids promote the memory potential of antigen-activated CD8+ t cells","volume":"51","author":"Bachem","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2026.110706_bb0230","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13045-024-01551-8","article-title":"Advances in targeting histone deacetylase for treatment of solid tumors","volume":"17","author":"Shi","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.clim.2026.110706_bb0235","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12964-023-01219-9","article-title":"Short-chain fatty acids in diseases","volume":"21","author":"Zhang","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.clim.2026.110706_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116735","article-title":"GPR41 and GPR43: from development to metabolic regulation","volume":"175","author":"Lee","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.clim.2026.110706_bb0245","article-title":"\u0392-arrestin2: an emerging player and potential therapeutic target in inflammatory immune diseases","author":"Gao","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.clim.2026.110706_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108909","article-title":"Ginsenoside metabolite compound-K regulates macrophage function through inhibition of \u03b2-arrestin2","volume":"115","author":"Wang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.clim.2026.110706_bb0255","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.talanta.2018.12.049","article-title":"A sensitive GC\/MS detection method for analyzing microbial metabolites short chain fatty acids in fecal and serum samples","volume":"196","author":"Zhang","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.clim.2026.110706_bb0260","doi-asserted-by":"crossref","unstructured":"A. Koh, F. De Vadder, P. Kovatcheva-Datchary, F. B\u00e4ckhed, From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites, Cell 165 (2016) 1332\u20131345, http\/\/doi:org\/https:\/\/doi.org\/10.1016\/j.cell.2016.05.041.","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"10.1016\/j.clim.2026.110706_bb0265","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.clim.2026.110706_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106997","article-title":"Protective effect of microbiota-derived short-chain fatty acids on vascular dysfunction in mice with systemic lupus erythematosus induced by toll-like receptor 7 activation","volume":"198","author":"Mole\u00f3n","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.clim.2026.110706_bb0275","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fendo.2014.00085","article-title":"The SCFA receptor GPR43 and energy metabolism","volume":"5","author":"Kimura","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.clim.2026.110706_bb0280","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nri3795","article-title":"The generation of antibody-secreting plasma cells","volume":"15","author":"Nutt","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2026.110706_bb0285","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.cellsig.2014.05.014","article-title":"Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity","volume":"26","author":"Schafer","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.clim.2026.110706_bb0290","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.molcel.2020.01.022","article-title":"Dopamine uses the DRD5-ARRB2-PP2A signaling axis to block the TRAF6-mediated NF-\u03baB pathway and suppress systemic inflammation","volume":"78","author":"Wu","year":"2020","journal-title":"Mol. Cell"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661626000446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661626000446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:36:52Z","timestamp":1779190612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661626000446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":58,"alternative-id":["S1521661626000446"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2026.110706","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Short-chain fatty acid deficiency drives aberrant B cell differentiation in systemic lupus erythematosus","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2026.110706","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110706"}}