{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:20:19Z","timestamp":1783146019416,"version":"3.54.6"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273537"],"award-info":[{"award-number":["82273537"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.clim.2026.110726","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T02:29:10Z","timestamp":1779676150000},"page":"110726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["CLIC1 acts as a compensatory protective molecule to regulate the vascular endothelial barrier integrity in cutaneous inflammation"],"prefix":"10.1016","volume":"286","author":[{"given":"Xinlin","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.clim.2026.110726_bb0005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jaci.2024.05.008","article-title":"Inflammatory memory in psoriasis: from remission to recurrence","volume":"154","author":"Francis","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.clim.2026.110726_bb0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/srt.12271","article-title":"Clinical, ultrasound, and videodermatoscopy monitoring of psoriatic patients following biological treatment","volume":"22","author":"Micali","year":"2016","journal-title":"Skin Res. Technol."},{"issue":"6","key":"10.1016\/j.clim.2026.110726_bb0015","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/ced.12036","article-title":"Videocapillaroscopic findings in the microcirculation of the psoriatic plaque during etanercept therapy","volume":"38","author":"Stinco","year":"2013","journal-title":"Clin. Exp. Dermatol."},{"issue":"2 Suppl","key":"10.1016\/j.clim.2026.110726_bb0020","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1038\/jid.1989.2","article-title":"Ultrastructure and organization of the cutaneous microvasculature in normal and pathologic states","volume":"93","author":"Braverman","year":"1989","journal-title":"J. Invest. Dermatol."},{"issue":"9","key":"10.1016\/j.clim.2026.110726_bb0025","doi-asserted-by":"crossref","DOI":"10.1172\/JCI160451","article-title":"An IGFBP7hi endothelial cell subset drives T cell extravasation in psoriasis via endothelial glycocalyx degradation","volume":"133","author":"Li","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.clim.2026.110726_bb0030","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3390\/ijms20061475","article-title":"Psoriasis pathogenesis and treatment","volume":"20","author":"Rendon","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.clim.2026.110726_bb0035","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1111\/bph.70152","article-title":"Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitors reduce vascular inflammation in vitro and in vivo","volume":"182","author":"Chaudhry","year":"2025","journal-title":"Br. J. Pharmacol."},{"issue":"21","key":"10.1016\/j.clim.2026.110726_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222112035","article-title":"Angiogenesis in chronic inflammatory skin disorders","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.clim.2026.110726_bb0045","doi-asserted-by":"crossref","DOI":"10.1186\/2040-2384-2-23","article-title":"Chloride intracellular channel 1 functions in endothelial cell growth and migration","volume":"2","author":"Tung","year":"2010","journal-title":"J. Angiogenes. Res."},{"issue":"25","key":"10.1016\/j.clim.2026.110726_bb0050","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1021\/bi100111c","article-title":"Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction","volume":"49","author":"Goodchild","year":"2010","journal-title":"Biochemistry"},{"issue":"9","key":"10.1016\/j.clim.2026.110726_bb0055","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1073\/pnas.89.9.3716","article-title":"A ubiquitous 64-kDa protein is a component of a chloride channel of plasma and intracellular membranes","volume":"89","author":"Redhead","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"22","key":"10.1016\/j.clim.2026.110726_bb0060","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1242\/jcs.189795","article-title":"Emerging biological roles of Cl\u2212 intracellular channel proteins","volume":"129","author":"Argenzio","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.clim.2026.110726_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-46301-z","article-title":"Chloride intracellular channel (CLIC) proteins function as fusogens","volume":"15","author":"Manori","year":"2024","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.clim.2026.110726_bb0070","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/bioinformatics\/btm623","article-title":"Structural systems identification of genetic regulatory networks","volume":"24","author":"Xiong","year":"2008","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.clim.2026.110726_bb0075","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"issue":"3","key":"10.1016\/j.clim.2026.110726_bb0080","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb.)"},{"key":"10.1016\/j.clim.2026.110726_bb0085","author":"Wickham"},{"key":"10.1016\/j.clim.2026.110726_bb0090","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12964-023-01196-z","article-title":"Neutrophil extracellular traps promote angiogenesis in gastric cancer","volume":"21","author":"Yang","year":"2023","journal-title":"Cell Commun. & Signal.: CCS"},{"key":"10.1016\/j.clim.2026.110726_bb0095","series-title":"R: A Language and Environment for Statistical Computing [Internet]","author":"R Core Team","year":"2025"},{"issue":"13","key":"10.1016\/j.clim.2026.110726_bb0100","article-title":"ROS-triggered endothelial cell death mechanisms: focus on pyroptosis, parthanatos, and ferroptosis","author":"Zheng","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.clim.2026.110726_bb0105","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/joim.12331","article-title":"Endothelial barrier dysfunction in septic shock","volume":"277","author":"Opal","year":"2015","journal-title":"J. Intern. Med."},{"issue":"10","key":"10.1016\/j.clim.2026.110726_bb0110","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.clim.2026.110726_bb0115","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.RES.51.5.657","article-title":"Role of endothelial cell cytoskeleton in control of endothelial permeability","volume":"51","author":"Shasby","year":"1982","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.clim.2026.110726_bb0120","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jaci.2006.04.025","article-title":"Role of vasculature in atopic dermatitis","volume":"118","author":"Steinhoff","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.clim.2026.110726_bb0125","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/bjd\/ljac017","article-title":"Granzyme K contributes to endothelial microvascular damage and leakage during skin inflammation","volume":"189","author":"Turner","year":"2023","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.clim.2026.110726_bb0130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.yadr.2008.09.010","article-title":"Application of angiogenesis to clinical dermatology","volume":"24","author":"Fried","year":"2008","journal-title":"Adv. Dermatol."},{"issue":"2","key":"10.1016\/j.clim.2026.110726_bb0135","first-page":"127","article-title":"Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene","volume":"48","author":"Qiu","year":"2010","journal-title":"Genesis"},{"issue":"10","key":"10.1016\/j.clim.2026.110726_bb0140","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1161\/01.ATV.19.10.2286","article-title":"Histamine induces tyrosine phosphorylation of endothelial cell-to-cell Adherens junctions","volume":"19","author":"Andriopoulou","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.clim.2026.110726_bb0145","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrm1357","article-title":"Endothelial cell\u2013cell junctions: happy together","volume":"5","author":"Dejana","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.clim.2026.110726_bb0150","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2019.1593775","article-title":"Chloride intracellular channel protein 2 in cancer and non-cancer human tissues: relationship with tight junctions","volume":"7","author":"Ueno","year":"2019","journal-title":"Tissue Barriers"},{"issue":"1","key":"10.1016\/j.clim.2026.110726_bb0155","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10456-011-9247-8","article-title":"CLT1 targets angiogenic endothelium through CLIC1 and fibronectin","volume":"15","author":"Knowles","year":"2012","journal-title":"Angiogenesis"},{"issue":"21","key":"10.1016\/j.clim.2026.110726_bb0160","article-title":"CLIC1 drives angiogenesis in hepatocellular carcinoma by modulating VEGFA","author":"Wei","year":"2022","journal-title":"Technol. Cancer Res. Treat."},{"issue":"23","key":"10.1016\/j.clim.2026.110726_bb0165","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.3390\/cancers14235981","volume":"14","author":"Ferician","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.clim.2026.110726_bb0170","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/kjm2.12287","article-title":"Exosomal CLIC1 released by CLL promotes HUVECs angiogenesis by regulating ITG\u03b21-MAPK\/ERK axis","volume":"37","author":"Geng","year":"2021","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"1","key":"10.1016\/j.clim.2026.110726_bb0175","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/jgh.12668","article-title":"Chloride intracellular channel 1 participates in migration and invasion of hepatocellular carcinoma by targeting maspin","volume":"30","author":"Wei","year":"2015","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.clim.2026.110726_bb0180","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1161\/ATVBAHA.123.319206","article-title":"CLIC4 regulates endothelial barrier control by mediating PAR1 signaling via RhoA","volume":"43","author":"Kleinjan","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661626000641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661626000641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:00:32Z","timestamp":1783144832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661626000641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":36,"alternative-id":["S1521661626000641"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2026.110726","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CLIC1 acts as a compensatory protective molecule to regulate the vascular endothelial barrier integrity in cutaneous inflammation","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2026.110726","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110726"}}