{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:29:29Z","timestamp":1791156569335,"version":"4.1.0"},"reference-count":103,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.clinbiochem.2005.11.001","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T07:20:52Z","timestamp":1133853652000},"page":"249-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"title":["Gene mapping for primary open angle glaucoma"],"prefix":"10.1016","volume":"39","author":[{"given":"Bao Jian","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis Shun Chiu","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Pui","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2005.11.001_bib1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/jama.1991.03470030069026","article-title":"Racial variation in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey","volume":"266","author":"Tielsch","year":"1991","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archopht.1994.01090180121046","article-title":"The Barbados Eye Study: prevalence of open-angle glaucoma","volume":"112","author":"Leske","year":"1994","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib3","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1001\/archopht.118.8.1105","article-title":"The prevalence of glaucoma in Chinese residents of Singapore: a cross-sectional population survey of the Tanjong Pagar district","volume":"118","author":"Foster","year":"2000","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib4","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1001\/archopht.116.12.1640","article-title":"Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study","volume":"116","author":"Wolfs","year":"1998","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib5","first-page":"706","article-title":"Genetic and environmental risk factors for primary open-angle glaucoma","volume":"117","author":"Fan","year":"2004","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib6","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1464-5491.2004.01173.x","article-title":"Diabetes mellitus as a risk factor for primary open-angle glaucoma: a meta-analysis","volume":"21","author":"Bonovas","year":"2004","journal-title":"Diabet. Med."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.puhe.2003.09.009","article-title":"Epidemiological association between cigarette smoking and primary open-angle glaucoma: a meta-analysis","volume":"118","author":"Bonovas","year":"2004","journal-title":"Public Health"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib8","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0895-4356(01)00388-2","article-title":"Age-specific prevalence of open-angle glaucoma and its relationship to refraction among more than 60,000 asymptomatic Japanese subjects","volume":"54","author":"Yoshida","year":"2001","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib9","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/S0161-6420(95)30793-2","article-title":"Clinical features of five pedigrees genetically linked to the juvenile glaucoma locus on chromosome 1q21\u2013q31","volume":"102","author":"Wiggs","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib10","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0161-6420(96)30611-8","article-title":"Clinical phenotype of juvenile-onset primary open-angle glaucoma linked to chromosome 1q","volume":"103","author":"Johnson","year":"1996","journal-title":"Ophthalmology"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib11","first-page":"243","article-title":"The distinction between juvenile and adult-onset primary open-angle glaucoma","volume":"58","author":"Wiggs","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib12","first-page":"753","article-title":"Epidemiology of chronic open-angle glaucoma","volume":"vol. 2","author":"Wilson","year":"1996"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib13","first-page":"769","article-title":"Normal-tension glaucoma","volume":"vol. 2","author":"Werner","year":"1996"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib14","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/bjo.76.8.494","article-title":"Low tension glaucoma\u2014Its place in modern glaucoma practice","volume":"76","author":"Hitchings","year":"1992","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00004397-199403430-00016","article-title":"Low tension glaucoma","volume":"34","author":"Grosskreutz","year":"1994","journal-title":"Int. Ophthalmol. Clin."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrg1521","article-title":"Genome-wide association studies for common diseases and complex traits","volume":"6","author":"Hirschhorn","year":"2005","journal-title":"Nat. Rev., Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib17","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/35057050","article-title":"Human disease genes","volume":"409","author":"Jimenez-Sanchez","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib18","first-page":"425","article-title":"The dual role of dexamethasone on anti-inflammation and outflow resistance demonstrated in cultured human trabecular meshwork cells","volume":"9","author":"Leung","year":"2003","journal-title":"Mol. Vis."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng0593-47","article-title":"Genetic linkage of familial open angle glaucoma to chromosome 1q21\u2013q31","volume":"4","author":"Sheffield","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib20","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/hmg\/9.7.1109","article-title":"Genome-wide scan for adult onset primary open angle glaucoma","volume":"9","author":"Wiggs","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/geno.1996.0434","article-title":"Localization of a locus (GLC1B) for adult-onset primary open angle glaucoma to the 2cen\u2013q13 region","volume":"36","author":"Stoilova","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib22","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s00439-003-0910-z","article-title":"A genome-wide scan for primary open-angle glaucoma (POAG): the Barbados Family Study of Open-Angle Glaucoma","volume":"112","author":"Nemesure","year":"2003","journal-title":"Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00439-005-1296-x","article-title":"Evidence for a novel glaucoma locus at chromosome 3p21\u201322","volume":"117","author":"Baird","year":"2005","journal-title":"Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib24","first-page":"296","article-title":"Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q","volume":"60","author":"Wirtz","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/hmg\/ddi068","article-title":"Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1","volume":"14","author":"Monemi","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1001\/archopht.117.2.237","article-title":"GLC1F, a new primary open-angle glaucoma locus, maps to 7q35\u2013q36","volume":"117","author":"Wirtz","year":"1999","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0002-9394(98)00073-7","article-title":"A third locus (GLC1D) for adult-onset primary open-angle glaucoma maps to the 8q23 region","volume":"126","author":"Trifan","year":"1998","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib28","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1086\/421533","article-title":"A genomewide scan identifies novel early-onset primary open-angle glaucoma loci on 9q22 and 20p12","volume":"74","author":"Wiggs","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib29","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1086\/301767","article-title":"Localization of the fourth locus (GLC1E) for adult-onset primary open-angle glaucoma to the 10p15\u2013p14 region","volume":"62","author":"Sarfarazi","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib30","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1167\/iovs.04-1477","article-title":"Early adult-onset POAG linked to 15q11\u201313 using ordered subset analysis","volume":"46","author":"Allingham","year":"2005","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib31","first-page":"260","article-title":"Exclusion of 14 candidate loci for primary open angle glaucoma in Finnish families","volume":"10","author":"Lemmela","year":"2004","journal-title":"Mol. Vis."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib32","first-page":"62","article-title":"Mapping of a gene for autosomal dominant juvenile-onset open-angle glaucoma to chromosome 1q","volume":"54","author":"Richards","year":"1994","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/geno.1994.1269","article-title":"Genetic linkage of autosomal dominant juvenile glaucoma to 1q21\u2013q31 in three affected pedigrees","volume":"21","author":"Wiggs","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib34","first-page":"565","article-title":"Linkage between juvenile glaucoma and chromosome 1q in 2 French families","volume":"317","author":"Meyer","year":"1994","journal-title":"C. R. Acad. Sci., III"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib35","first-page":"1431","article-title":"A common gene for juvenile and adult-onset primary open-angle glaucomas confined on chromosome 1q","volume":"56","author":"Morissette","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib36","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF00210408","article-title":"Confirmation of linkage to 1q21\u201331 in a Danish autosomal dominant juvenile-onset glaucoma family and evidence of genetic heterogeneity","volume":"96","author":"Graff","year":"1995","journal-title":"Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib37","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0002-9394(14)70147-3","article-title":"Juvenile glaucoma linked to the GLC1A gene on chromosome 1q in a Panamanian family","volume":"123","author":"Lichter","year":"1997","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib38","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0161-6420(96)30611-8","article-title":"Clinical phenotype of juvenile-onset primary open-angle glaucoma linked to chromosome 1q","volume":"103","author":"Johnson","year":"1996","journal-title":"Ophthalmology"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib39","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1101\/gr.6.9.862","article-title":"Fine mapping of the autosomal dominant juvenile open angle glaucoma (GLC1A) region and evaluation of candidate genes","volume":"6","author":"Sunden","year":"1996","journal-title":"Genome Res."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib40","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.275.5300.668","article-title":"Identification of a gene that causes primary open angle glaucoma","volume":"275","author":"Stone","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib41","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1006\/geno.1997.4682","article-title":"A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping","volume":"41","author":"Kubota","year":"1997","journal-title":"Genomics"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib42","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000022812","article-title":"Adult-onset primary open angle glaucoma does not localize to chromosome 2cen\u2013q13 in North American families","volume":"48","author":"Allingham","year":"1998","journal-title":"Hum. Hered."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib43","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/sj.ejhg.5200645","article-title":"Genetic linkage of autosomal dominant primary open angle glaucoma to chromosome 3q in a Greek pedigree","volume":"9","author":"Kitsos","year":"2001","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib44","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j..2004.00182.x","article-title":"Refining the primary open-angle glaucoma GLC1C region on chromosome 3 by haplotype analysis","volume":"65","author":"Samples","year":"2004","journal-title":"Clin. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib45","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1006\/geno.2000.6229","article-title":"Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21\u2013q24","volume":"66","author":"Xu","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib46","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1066901","article-title":"Adult-onset primary open-angle glaucoma caused by mutations in optineurin","volume":"295","author":"Rezaie","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib47","article-title":"Genome scan of two large families with adult-onset primary open angle glaucoma (POAG) suggests a probable locus on 5q33\u2013q35","volume":"44","author":"Monemi","year":"2003","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib48","article-title":"GLC1G: mapping a new POAG locus on chormosome 5","volume":"45","author":"Samples","year":"2004","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib49","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1167\/iovs.04-0729","article-title":"A genetic contribution to intraocular pressure: the beaver dam eye study","volume":"46","author":"Duggal","year":"2005","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib50","first-page":"851","article-title":"Absence of myocilin and optineurin mutations in a large Philippine family with juvenile onset primary open angle glaucoma","volume":"10","author":"Wang","year":"2004","journal-title":"Mol. Vis."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib51","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1086\/302098","article-title":"Prevalence of mutations in TIGR\/Myocilin in patients with adult and juvenile primary open-angle glaucoma","volume":"63","author":"Wiggs","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib52","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/hmg\/8.5.899","article-title":"Analysis of myocilin mutations in 1703 glaucoma patients from five different populations","volume":"8","author":"Fingert","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib53","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1093\/hmg\/11.18.2077","article-title":"Founder TIGR\/myocilin mutations for glaucoma in the Quebec population","volume":"11","author":"Faucher","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib54","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0002-9394(00)00536-5","article-title":"Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma","volume":"130","author":"Shimizu","year":"2000","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib55","first-page":"1386","article-title":"Truncations in the TIGR gene in individuals with and without primary open-angle glaucoma","volume":"41","author":"Lam","year":"2000","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib56","first-page":"3231","article-title":"TIGR\/MYOC gene sequence alterations in individuals with and without primary open angle glaucoma","volume":"43","author":"Pang","year":"2002","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib57","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/humu.10053","article-title":"Differential occurrence of mutations causative of eye diseases in the Chinese population","volume":"19","author":"Pang","year":"2002","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib58","unstructured":"Fan BJ, Leung DYL, Wang DY, et al. A novel myocilin mutation in a Chinese family with juvenile-onset open angle glaucoma. Arch Ophthalmol [in press]."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib59","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0002-9394(03)00577-4","article-title":"Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma","volume":"136","author":"Alward","year":"2003","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib60","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1001\/archopht.121.8.1181","article-title":"Lack of association of mutations in optineurin with disease in patients with adult-onset primary open-angle glaucoma","volume":"121","author":"Wiggs","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib61","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s00439-003-0964-y","article-title":"The association between Japanese primary open-angle glaucoma and normal tension glaucoma patients and the optineurin gene","volume":"113","author":"Tang","year":"2003","journal-title":"Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib62","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1167\/iovs.02-0693","article-title":"Different optineurin mutation pattern in Chinese primary open angle glaucoma patients","volume":"44","author":"Leung","year":"2003","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib63","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1167\/iovs.04-1100","article-title":"Genetic polymorphisms in the angiotensin II receptor gene and their association with open-angle glaucoma in a Japanese population","volume":"46","author":"Hashizume","year":"2005","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib64","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1086\/340733","article-title":"Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene","volume":"70","author":"Copin","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib65","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1395-3907.2004.0180.x","article-title":"A codon 31ser-arg polymorphism of the WAF-1\/CIP-1\/p21\/tumour suppressor gene in Chinese primary open-angle glaucoma","volume":"82","author":"Tsai","year":"2004","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib66","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1086\/338709","article-title":"Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene","volume":"70","author":"Vincent","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib67","first-page":"431","article-title":"Association between glaucoma and gene polymorphism of endothelin type A receptor","volume":"11","author":"Ishikawa","year":"2005","journal-title":"Mol. Vis."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib68","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1006\/exer.2000.0899","article-title":"Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians","volume":"71","author":"Juronen","year":"2000","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib69","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/jcla.10106","article-title":"Insulin-like growth factor-II gene polymorphism is associated with primary open angle glaucoma","volume":"17","author":"Tsai","year":"2003","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib70","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1159\/000071352","article-title":"Association of interleukin 1beta and receptor antagonist gene polymorphisms with primary open-angle glaucoma","volume":"217","author":"Lin","year":"2003","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib71","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ajo.2004.09.081","article-title":"C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma","volume":"139","author":"Junemann","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib72","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1440-1681.1998.tb02138.x","article-title":"Association study of the 5\u2032 flanking regions of endothelial-nitric oxide synthase and endothelin-1 genes in familial primary open-angle glaucoma","volume":"25","author":"Tunny","year":"1998","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib73","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/bbrc.1996.0874","article-title":"The atrial natriuretic peptide gene in patients with familial primary open-angle glaucoma","volume":"223","author":"Tunny","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib74","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1076\/opge.24.3.141.15604","article-title":"Protein expression, genomic structure, and polymorphisms of oculomedin","volume":"24","author":"Fujiwara","year":"2003","journal-title":"Ophthalmic Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib75","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00439-001-0645-7","article-title":"A major marker for normal tension glaucoma: association with polymorphisms in the OPA1 gene","volume":"110","author":"Aung","year":"2002","journal-title":"Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib76","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF03260069","article-title":"Transporter associated with antigen processing gene 1 codon 333 and codon 637 polymorphisms are associated with primary open-angle glaucoma","volume":"8","author":"Lin","year":"2004","journal-title":"Mol. Diagn."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib77","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.eye.6700227","article-title":"Association of tumour necrosis factor alpha \u2212308 gene polymorphism with primary open-angle glaucoma in Chinese","volume":"17","author":"Lin","year":"2003","journal-title":"Eye"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib78","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/bjo.86.7.767","article-title":"Distributions of p53 codon 72 polymorphism in primary open angle glaucoma","volume":"86","author":"Lin","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib79","first-page":"389","article-title":"The apolipoprotein \u03b54 gene is associated with elevated risk of normal tension glaucoma","volume":"8","author":"Vickers","year":"2002","journal-title":"Mol. Vis."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib80","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/bjo.2003.023366","article-title":"Normal tension glaucoma is not associated with the common apolipoprotein E gene polymorphisms","volume":"88","author":"Lake","year":"2004","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib81","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1001\/archopht.122.2.258","article-title":"The role of apolipoprotein E gene polymorphisms in primary open-angle glaucoma","volume":"122","author":"Ressiniotis","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib82","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00439-002-0711-9","article-title":"Investigating the association between OPA1 polymorphisms and glaucoma: comparison between normal tension and high tension primary open angle glaucoma","volume":"110","author":"Aung","year":"2002","journal-title":"Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib83","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/bjo.87.2.149","article-title":"The phenotype of normal tension glaucoma patients with and without OPA1 polymorphisms","volume":"87","author":"Aung","year":"2003","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib84","first-page":"460","article-title":"Polymorphisms in OPA1 are associated with normal tension glaucoma","volume":"9","author":"Powell","year":"2003","journal-title":"Mol. Vis."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib85","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/01.ijg.0000137870.25779.40","article-title":"Investigation of the association between OPA1 polymorphisms and normal-tension glaucoma in Korea","volume":"13","author":"Woo","year":"2004","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib86","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/jmg.2004.020024","article-title":"CYP1B1 mutations in French patients with early-onset primary open-angle glaucoma","volume":"41","author":"Melki","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib87","first-page":"367","article-title":"Distribution of p53 codon 72 polymorphism in Indian primary open angle glaucoma patients","volume":"8","author":"Acharya","year":"2002","journal-title":"Mol. Vis."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib88","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1136\/jmg.2003.016089","article-title":"Primary open angle glaucoma is associated with a specific p53 gene haplotype","volume":"41","author":"Ressiniotis","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib89","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1167\/iovs.03-1403","article-title":"Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma","volume":"45","author":"Funayama","year":"2004","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib90","first-page":"3691","article-title":"cDNA microarray analysis of gene expression changes induced by dexamethasone in cultured human trabecular meshwork cells","volume":"43","author":"Ishibashi","year":"2002","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib91","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1167\/iovs.02-0444","article-title":"Tissue differential microarray analysis of dexamethasone induction reveals potential mechanisms of steroid glaucoma","volume":"44","author":"Lo","year":"2003","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib92","first-page":"352","article-title":"Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure","volume":"41","author":"Gonzalez","year":"2000","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib93","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/jcp.20030","article-title":"Genes expressed in the human trabecular meshwork during pressure-induced homeostatic response","volume":"201","author":"Vittitow","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib94","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1167\/iovs.02-1032","article-title":"Gene microarray analysis of experimental glaucomatous retina from cynomologous monkey","volume":"44","author":"Miyahara","year":"2003","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib95","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1167\/iovs.03-1123","article-title":"Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure","volume":"45","author":"Ahmed","year":"2004","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib96","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/glia.10051","article-title":"Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray","volume":"38","author":"Hernandez","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib97","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1152\/physiolgenomics.00182.2003","article-title":"DNA microarray analysis of gene expression in human optic nerve head astrocytes in response to hydrostatic pressure","volume":"17","author":"Yang","year":"2004","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib98","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1167\/iovs.04-0277","article-title":"Molecular and cellular reactions of retinal ganglion cells and retinal glial cells under centrifugal force loading","volume":"45","author":"Kashiwagi","year":"2004","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib99","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/01.ijg.0000133149.37063.84","article-title":"Polymorphisms in the myocilin promoter unrelated to the risk and severity of primary open angle glaucoma","volume":"13","author":"Fan","year":"2004","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib100","first-page":"625","article-title":"SNPs and interaction analyses of myocilin, optineurin and apolipoprotein E in primary open angle glaucoma patients","volume":"11","author":"Fan","year":"2005","journal-title":"Mol. Vis."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib101","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/ng1047","article-title":"Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction","volume":"32","author":"Ozaki","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib102","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.clinbiochem.2005.11.001_bib103","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1073\/pnas.0409806102","article-title":"Association of the NuMA region on chromosome 11q13 with breast cancer susceptibility","volume":"102","author":"Kammerer","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912005003085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912005003085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:23:46Z","timestamp":1757863426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912005003085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":103,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0009912005003085"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2005.11.001","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene mapping for primary open angle glaucoma","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2005.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}