{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:07:16Z","timestamp":1761718036687,"version":"3.44.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"13-14","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.clinbiochem.2007.05.017","type":"journal-article","created":{"date-parts":[[2007,7,7]],"date-time":"2007-07-07T07:14:20Z","timestamp":1183792460000},"page":"1007-1014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Hyperhomocysteinemia and elevated ox-LDL in Tunisian type 2 diabetic patients: Role of genetic and dietary factors"],"prefix":"10.1016","volume":"40","author":[{"given":"N.","family":"Koubaa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nakbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Smaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Abid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Chaaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Abid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hammami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2007.05.017_bib1","first-page":"463","article-title":"Diabetes and atherosclerosis: an epidemiological review","volume":"3","author":"Pyroala","year":"1987","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib2","first-page":"958","article-title":"Cardiovascular disease and arterial calcification in IDDM: interrelations and risk factor profiles","volume":"11","author":"Masser","year":"1991","journal-title":"Atheroscler. Thromb."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib3","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","article-title":"A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes","volume":"274","author":"Boushey","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.ATV.18.1.133","article-title":"Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study","volume":"18","author":"Hoogeveen","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib5","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1001\/jama.290.7.932","article-title":"Emerging risk factors for atherosclerotic vascular disease. A critical review of the evidence","volume":"290","author":"Hackman","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib6","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1001\/jama.288.16.2023","article-title":"MTHFR 677C T polymorphism and risk of coronary heart disease. A meta analysis","volume":"28","author":"Klerk","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00041433-199702000-00007","article-title":"Homocysteine: an important risk factor for atherosclerotic vascular disease","volume":"8","author":"Barton Duell","year":"1997","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9150(01)00531-7","article-title":"Homocysteine and cardiovascular disease in diabetes mellitus","volume":"159","author":"Audelin","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/PL00014405","article-title":"Genetic determinants of hyperhomocysteinemia: the roles of cystathionine \u03b2 synthase and 5,10-methylenetetrahydrofolate reductase","volume":"159","author":"Blom","year":"2000","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jdiacomp.2003.12.003","article-title":"Total homocysteine levels relation with chronic complications of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2","volume":"19","author":"De Louis","year":"2005","journal-title":"J. Diabetes Its Complicat."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib12","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1042\/cs1020631","article-title":"Homocysteine, folate, methylenetetrahydrofolate reductase genotype and vascular morbidity in diabetic subjects","volume":"102","author":"Kaye","year":"2002","journal-title":"Clin. Sci."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib13","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/ndt\/gfg211","article-title":"Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy","volume":"18","author":"Dariusz","year":"2003","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/bj3320213","article-title":"Characterization of the stress-inducing effects of homocysteine","volume":"332","author":"Outinen","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib15","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/01.ATV.19.5.1263","article-title":"Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels","volume":"19","author":"Voutilainen","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib16","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1172\/JCI5549","article-title":"Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro","volume":"103","author":"Podrez","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib17","doi-asserted-by":"crossref","first-page":"20963","DOI":"10.1074\/jbc.272.34.20963","article-title":"Low density lipoprotein oxidation and its pathobiological significance","volume":"272","author":"Steinberg","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib18","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.2337\/diabetes.51.10.3102","article-title":"Evidence for increased oxidation of circulating LDL in impaired glucose tolerance","volume":"51","author":"Kopprasch","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib19","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1161\/01.ATV.20.10.2243","article-title":"Circulating oxidized low density lipoprotein levels: a biochemical risk marker for coronary heart disease","volume":"20","author":"Toshima","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib20","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1161\/01.ATV.21.5.844","article-title":"Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease","volume":"21","author":"Holvoet","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S1056-8727(03)00075-8","article-title":"Lipids and lipoprotein (a) concentration in Tunisian type 2 diabetic patients relationship to glycaemic control and coronary heart disease","volume":"18","author":"Smaoui","year":"2004","journal-title":"J. Diabetes Its Complicat."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1373\/clinchem.2003.021634","article-title":"Facts and recommendations about total homocysteine determination: an expert opinion","volume":"50","author":"Refsum","year":"2004","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0378-4347(99)00171-1","article-title":"Gas chromatographic-mass spectrometric determination of total homocysteine in human plasma by stable isotope dilution: method and clinical application","volume":"729","author":"Ducros","year":"1999","journal-title":"J. B. Chromatogr."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib25","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.diabres.2003.10.022","article-title":"Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients","volume":"64","author":"Sun","year":"2003","journal-title":"Diabetes Res. Clin Pract."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.numecd.2004.03.001","article-title":"Reduced homocysteine levels in type 2 diabetes","volume":"15","author":"Mazza","year":"2005","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2796.2005.01480.x","article-title":"Thermolabile methylenetetrahydrofolate reductase enzyme genotype is frequent in type 2 diabetic patients with normal fasting homocysteine levels","volume":"257","author":"Tutuncu","year":"2005","journal-title":"J. Int. Med."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib29","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1258\/000456306776865232","article-title":"Hyperhomocysteinemia, methylenetetrahydrofolate reductase polymorphism and risk of coronary artery disease","volume":"43","author":"Kerkeni","year":"2006","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib30","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1086\/301836","article-title":"Worldwide distribution of a common methylenetetrahydrofolate reductase mutation","volume":"62","author":"Schneider","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib31","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S1262-3636(07)70176-3","article-title":"Homocysteine concentrations and vascular complications in patients with type 2 diabetes","volume":"31","author":"Rudy","year":"2005","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1262-3636(07)70127-1","article-title":"C677T Methylenetetrahydrofolate reductase mutation in type 2 diabetic patients with and without hyperhomocysteinemia","volume":"30","author":"Buysschaert","year":"2004","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib33","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2362.2004.01319.x","article-title":"Correlates of total homocysteine plasma concentration in type 2 diabetes","volume":"34","author":"Russo","year":"2004","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib34","first-page":"537","article-title":"Homocysteinemia and degenerative complications in non insulin dependent diabetes mellitus","volume":"83","author":"Zied","year":"2005","journal-title":"Tunis Med."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib35","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.2337\/diacare.20.12.1805","article-title":"Elevated plasma homocysteine and diabetic vascular disease","volume":"20","author":"Coldwell","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0021-9150(95)05748-X","article-title":"Molecular and biochemical approaches in the identification of heterozygotes for homocystinuria","volume":"172","author":"Tsai","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib37","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1161\/01.ATV.17.10.2074","article-title":"Homocysteine as a risk factor for vascular disease, enhanced collagen production and accumulation by smooth muscle cells","volume":"17","author":"Majors","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib38","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.plefa.2006.02.003","article-title":"Association between dietary fat and antioxidant status of Tunisian type 2 diabetic patients","volume":"74","author":"Smaoui","year":"2006","journal-title":"Prostaglandins, Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib39","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1532-5415.1991.tb03595.x","article-title":"Increased serum conjugated dienes in elderly diabetic patients","volume":"39","author":"Mooradian","year":"1991","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib40","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1464-5491.1991.tb01695.x","article-title":"Relation of lipid peroxides to macrovascular disease in type 2 diabetes","volume":"88","author":"Velazquez","year":"1991","journal-title":"Diabet. Med."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib41","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/ajcn\/80.4.849","article-title":"Effect of interaction between adherence to Mediterranean diet and the methylenetetrahydrofolate reductase 677C T mutation on homocysteine concentration in healthy adults: the ATTICA Study","volume":"80","author":"Dedoussis","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib42","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/ajcn\/77.3.687","article-title":"Effect of the methylene tetrahydrofolate reductase C T mutation among folate intake and plasma folate and homocysteine concentrations in a general population sample","volume":"77","author":"De Bree","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib43","first-page":"82","article-title":"Anti-atherogenicity of nutritional antioxidants","volume":"4","author":"Furhman","year":"2001","journal-title":"Drugs"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib44","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.atherosclerosis.2004.12.036","article-title":"Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial","volume":"181","author":"Fito","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinbiochem.2007.05.017_bib45","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0021-9150(95)05546-9","article-title":"Low density lipoprotein oxidation is inhibited in vitro by olive oil constituents","volume":"117","author":"Visioli","year":"1995","journal-title":"Atherosclerosis"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912007002184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912007002184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:26:38Z","timestamp":1757863598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912007002184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":45,"journal-issue":{"issue":"13-14","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0009912007002184"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2007.05.017","relation":{},"ISSN":["0009-9120"],"issn-type":[{"type":"print","value":"0009-9120"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperhomocysteinemia and elevated ox-LDL in Tunisian type 2 diabetic patients: Role of genetic and dietary factors","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2007.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}