{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T02:53:02Z","timestamp":1767495182248,"version":"3.44.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.clinbiochem.2008.12.005","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T04:40:21Z","timestamp":1230180021000},"page":"462-466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Amino acids levels and lipid peroxidation in maple syrup urine disease patients"],"prefix":"10.1016","volume":"42","author":[{"given":"Aleth\u00e9a G.","family":"Barschak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Sitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Deon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela N.B.","family":"Busanello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella M.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franciele","family":"Cipriani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos S.","family":"Dutra-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Giugliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moacir","family":"Wajner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen R.","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2008.12.005_bib1","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"1971","article-title":"Maple syrup urine disease (branched-chain ketoaciduria)","author":"Chuang","year":"2001"},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01800354","article-title":"Maple syrup urine disease: interrelationship between branched-chain amino-, oxo- and hydroxyacids; implications for treatment; associations with CNS dysmyelination","volume":"15","author":"Treacy","year":"1992","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ymgme.2004.01.016","article-title":"Dysmyelination in the brain of adolescents and young adults with maple syrup urine disease","volume":"82","author":"Sch\u00f6nberger","year":"2004","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1023\/A:1014004414733","article-title":"Stimulation of lipid peroxidation in vitro in rat brain by metabolites accumulating in maple syrup urine disease","volume":"17","author":"Fontella FU Gassen","year":"2002","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0736-5748(03)00074-1","article-title":"Induction of oxidative stress in rat brain by the metabolites accumulating in maple syrup urine disease","volume":"21","author":"Bridi","year":"2003","journal-title":"Int. J. Devl. Neuroscience"},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11011-005-4152-8","article-title":"Alpha-keto acids accumulating in maple syrup urine disease stimulate lipid peroxidation and reduce antioxidant defences in cerebral cortex from young rats","volume":"20","author":"Bridi","year":"2005","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/10715760400022350","article-title":"Evaluation of the mechanism involved in leucine-induced oxidative damage in cerebral c\u00f3rtex of young rats","volume":"39","author":"Bridi","year":"2005","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11011-006-9030-5","article-title":"Evidence that oxidative stress is increased in plasma from patients with maple syrup urine disease","volume":"20","author":"Barschak","year":"2006","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11011-007-9077-y","article-title":"Oxidative stress in plasma from maple syrup urine disease patients during treatment","volume":"23","author":"Barschak","year":"2008","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib10","series-title":"HPLC of small peptides","article-title":"Amino acids and small peptides","author":"Joseph","year":"1986"},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1023\/A:1005668431926","article-title":"Reduction of large neutral amino acid concentrations in plasma and CSF of patients with maple syrup urine disease during crises","volume":"23","author":"Wajner","year":"2000","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib12","series-title":"Techniques in diagnostic human biochemical genetics. A laboratory manual","article-title":"Organic acid analysis","author":"Sweetmann","year":"1995"},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microssomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib14","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Determination of serum proteins by means of the biuret reaction","volume":"177","author":"Gornall","year":"1949","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ijdevneu.2007.05.004","article-title":"Erythrocyte glutathione peroxidase activity and plasma selenium concentration are reduced in maple syrup urine disease patients during treatment","volume":"25","author":"Barschak","year":"2007","journal-title":"Int. J. Devl. Neuroscience"},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0197-0186(00)00100-5","article-title":"Reduction of large neutral amino acid level in plasma and brain of hyperleucinemic rats","volume":"38","author":"Ara\u00fajo","year":"2001","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-079X.1999.tb00611.x","article-title":"Melatonin and its precursors scavenge nitric oxide","volume":"27","author":"Noda","year":"1999","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-079X.2004.00177.x","article-title":"5-Hydroxytryptophan is a more potent in vitro hydroxyl radical scavenger than melatonin or vitamin C","volume":"38","author":"Keithahn","year":"2005","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.lfs.2006.01.030","article-title":"Melatonin directly scavenges free radicals generated in red blood cells in a cell-free system: chemiluminescence measurement and theoretical calculations","volume":"79","author":"Zavodnik","year":"2006","journal-title":"Life Sciences"},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.lfs.2007.05.013","article-title":"The effect of melatonin and structural analogues on the lipid peroxidation of triglycerides enriched in \u03c9-3 polyunsaturated fatty acids","volume":"81","author":"Fagali","year":"2007","journal-title":"Life Sciences"},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/14756360500381210","article-title":"Investigation of the in vitro antioxidant behavior of some 2-phenylindole derivatives: discussion on possible antioxidant mechanisms and comparison with melatonin","volume":"21","author":"Suzen","year":"2006","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3177\/jnsv.48.36","article-title":"L-tryptophan as an antioxidant in human placenta extract","volume":"48","author":"Watanabe","year":"2002","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib23","first-page":"596","article-title":"Behavioral, morphological and physiological shift in the rats administered with tryptophan deficient regimen","volume":"21","author":"Kanth","year":"2006","journal-title":"Nutr. Hosp."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib24","doi-asserted-by":"crossref","first-page":"15036","DOI":"10.1073\/pnas.93.26.15036","article-title":"Methionine residues as endogenous antioxidants in proteins","volume":"93","author":"Levine","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib25","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3349\/ymj.2004.45.5.776","article-title":"Antioxidant effects of sulfur-containing amino acids","volume":"45","author":"Atmaca","year":"2004","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.clinbiochem.2008.12.005_bib26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.abb.2003.10.001","article-title":"Cyclic oxidation and reduction of methionine residues of proteins in antioxidant defenses and cellular regulation","volume":"423","author":"Stadtman","year":"2004","journal-title":"Arch. Bioch. Biophys."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912008006243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912008006243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:29:02Z","timestamp":1757863742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912008006243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0009912008006243"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2008.12.005","relation":{},"ISSN":["0009-9120"],"issn-type":[{"type":"print","value":"0009-9120"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amino acids levels and lipid peroxidation in maple syrup urine disease patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2008.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}